The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation
Open accessAbstract
Although several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer, their inefficient therapeutic outcomes, serious adverse effects, and high cost of mass production remain crucial challenges. Herein, we developed an alternative strategy to specifically trigger apoptosis of breast tumors and inhibit their lung metastasis by using natural nanovehicles from tea flowers (TFENs). These nanovehicles had desirable particle sizes (131 nm), exosome-like morphology, and negative zeta potentials. Furthermore, TFENs were found to contain large amounts of polyphenols, flavonoids, functional proteins, and lipids. Cell experiments revealed that TFENs showed strong cytotoxicities against cancer cells due to the stimulation of reactive oxygen species (ROS) amplification. The increased intracellular ROS amounts could not only trigger mitochondrial damage, but also arrest cell cycle, resulting in the in vitro anti-proliferation, anti-migration, and anti-invasion activities against breast cancer cells. Further mice investigations demonstrated that TFENs after intravenous (i.v.) injection or oral administration could accumulate in breast tumors and lung metastatic sites, inhibit the growth and metastasis of breast cancer, and modulate gut microbiota. This study brings new insights to the green production of natural exosome-like nanoplatform for the inhibition of breast cancer and its lung metastasis via i.v. and oral routes.
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Cites
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Cited by
Alzahrani, F. A., Khan, M. I., Kameli, N., Alsahafi, E., & Riza, Y. M. (2023) · Biomolecules · doi:10.3390/biom13050839 · Cited by 143
“Tea flowerderived EVs, after intravenous injection or oral administration, accumulate in breast tumors and lung metastatic sites, inhibit the growth and spread of breast cancer, and regulate the gut microbiome [53].”
BackgroundPlant-Derived Nanovesicles: Further Exploration of Biomedical Function and Application Potential
Li, A., Li, D., Gu, Y., Liu, R., Tang, X., Zhao, Y., Qi, F., Wei, J., & Liu, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.022 · Cited by 137
Liu, J., Xiang, J., Jin, C., Ye, L., Wang, L., Gao, Y., Lv, N., Zhang, J., You, F., Qiao, H., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01835-0 · Cited by 132
Li, B., Zu, M., Jiang, A., Cao, Y., Wu, J., Shahbazi, M.-A., Shi, X., Reis, R. L., Kundu, S. C., & Xiao, B. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122530 · Cited by 67
Self-citationFu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
Metadata
- Authors
- Chen, Q., Li, Q., Liang, Y., Zu, M., Chen, N., Canup, B. S. B., Luo, L., Wang, C., Zeng, L., & Xiao, B.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 12
- Issue
- 2
- Pages
- 907-923
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W3194029913
- Cited by
- 361
- References
- 59
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, Q., Li, Q., Liang, Y., Zu, M., Chen, N., Canup, B. S. B., Luo, L., Wang, C., Zeng, L., & Xiao, B. (2022). Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2021.08.016
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