Cited by 137Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryPharmacology and Nanomedicine Research

Plant-Derived Nanovesicles: Further Exploration of Biomedical Function and Application Potential

Open access
Li, Aixue, Li, Dan, Gu, Yongwei, Liu, Rongmei, Tang, Xiaomeng, Zhao, Yunan, Qi, Fu, Wei, Jifu +1 more·2023·Acta Pharmaceutica Sinica B

Abstract

Extracellular vesicles (EVs) are phospholipid bilayer vesicles actively secreted by cells, that contain a variety of functional nucleic acids, proteins, and lipids, and are important mediums of intercellular communication. Based on their natural properties, EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers. Among them, plant-derived nanovesicles (PNVs) are characterized as natural disease therapeutics with many advantages such as simplicity, safety, eco-friendliness, low cost, and low toxicity due to their abundant resources, large yield, and low risk of immunogenicity in vivo. This review systematically introduces the biogenesis, isolation methods, physical characterization, and components of PNVs, and describes their administration and cellular uptake as therapeutic agents. We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers, including anti-inflammatory, anticancer, wound healing, regeneration, and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19. Finally, the toxicity and immunogenicity, the current clinical application, and the possible challenges in the future development of PNVs were analyzed. We expect the functions of PNVs to be further explored to promote clinical translation, thereby facilitating the development of a new framework for the treatment of human diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.apsb.2022.12.022

Cites

171 of 171 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The lack of significant increase in skin quality in the placebo control may be due to poor epidermis penetration of plant extracts and other water-soluble compounds.

    “This may be due to the poor epidermis penetration of plant extracts and other water-soluble compounds [14].”

    From A 28-Day Pilot Study of the Effects on Facial Skin Hydration, Elasticity, and Texture of a Centella asiatica Extracellular Vesicle-Based Skin Care Formulation (2025) · cites this paper as [14]

    The drug-delivery-carriers section says aloe-derived nanovesicles penetrate the skin barrier and have better transdermal properties than liposomes. It does not address whether plant extracts or other water-soluble compounds penetrate the epidermis poorly, or whether poor penetration explains a placebo group's skin-quality result. Searches for those terms found no supporting passage in our copy. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Li, A., Li, D., Gu, Y., Liu, R., Tang, X., Zhao, Y., Qi, F., Wei, J., & Liu, J.
Affiliations
  • Shanghai Medical College of Fudan University (CN)
  • Jiangsu Cancer Hospital (CN)
Corresponding author
  • Wei, Jifu
  • Liu, Jiyong
Venue
Acta Pharmaceutica Sinica B
Publisher
Elsevier BV
Published
2023-08
Volume
13
Issue
8
Pages
3300-3320
ISSN
2211-3835 (ISSN-L)
OpenAlex
W4323364511
Cited by
137
References
171
Citations by year
2026: 54 · 2025: 52 · 2024: 28 · 2023: 3
FWCI
3.60
Type
journal article
Language
en
Open access
Locations
  • Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82074272, 82274103)
  • Science and Technology Commission of Shanghai Municipality (20S21900300)
  • Program of Shanghai Academic Research Leader (21XD1403400)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords
plant-derived nanovesicles, extracellular vesicles, drug carriers, vesicle biogenesis, vesicle isolation, cellular uptake, anti-inflammatory therapy, cancer therapy, wound healing, tissue regeneration, anti-aging, liver disease, COVID-19 pandemic, immunogenicity, toxicity, clinical translation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review