Plant-Derived Nanovesicles: Further Exploration of Biomedical Function and Application Potential
Open accessAbstract
Extracellular vesicles (EVs) are phospholipid bilayer vesicles actively secreted by cells, that contain a variety of functional nucleic acids, proteins, and lipids, and are important mediums of intercellular communication. Based on their natural properties, EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers. Among them, plant-derived nanovesicles (PNVs) are characterized as natural disease therapeutics with many advantages such as simplicity, safety, eco-friendliness, low cost, and low toxicity due to their abundant resources, large yield, and low risk of immunogenicity in vivo. This review systematically introduces the biogenesis, isolation methods, physical characterization, and components of PNVs, and describes their administration and cellular uptake as therapeutic agents. We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers, including anti-inflammatory, anticancer, wound healing, regeneration, and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19. Finally, the toxicity and immunogenicity, the current clinical application, and the possible challenges in the future development of PNVs were analyzed. We expect the functions of PNVs to be further explored to promote clinical translation, thereby facilitating the development of a new framework for the treatment of human diseases.
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The lack of significant increase in skin quality in the placebo control may be due to poor epidermis penetration of plant extracts and other water-soluble compounds.
“This may be due to the poor epidermis penetration of plant extracts and other water-soluble compounds [14].”
From A 28-Day Pilot Study of the Effects on Facial Skin Hydration, Elasticity, and Texture of a Centella asiatica Extracellular Vesicle-Based Skin Care Formulation (2025) · cites this paper as [14]
The drug-delivery-carriers section says aloe-derived nanovesicles penetrate the skin barrier and have better transdermal properties than liposomes. It does not address whether plant extracts or other water-soluble compounds penetrate the epidermis poorly, or whether poor penetration explains a placebo group's skin-quality result. Searches for those terms found no supporting passage in our copy. (LLM, conf=0.73)
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Applications of Plant-Derived Extracellular Vesicles in Medicine
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- Authors
- Li, A., Li, D., Gu, Y., Liu, R., Tang, X., Zhao, Y., Qi, F., Wei, J., & Liu, J.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Jiangsu Cancer Hospital (CN)
- Corresponding author
- Wei, Jifu
- Liu, Jiyong
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 13
- Issue
- 8
- Pages
- 3300-3320
- ISSN
- 2211-3835 (ISSN-L)
- PMC
- PMC10465964
- OpenAlex
- W4323364511
- Cited by
- 137
- References
- 171
- Citations by year
- 2026: 54 · 2025: 52 · 2024: 28 · 2023: 3
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82074272, 82274103)
- Science and Technology Commission of Shanghai Municipality (20S21900300)
- Program of Shanghai Academic Research Leader (21XD1403400)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- plant-derived nanovesicles, extracellular vesicles, drug carriers, vesicle biogenesis, vesicle isolation, cellular uptake, anti-inflammatory therapy, cancer therapy, wound healing, tissue regeneration, anti-aging, liver disease, COVID-19 pandemic, immunogenicity, toxicity, clinical translation
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