Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works

Drug repurposing: progress, challenges and recommendations

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., et al. (2019) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.168 · Cited by 4,718 · see citing works

Pathology of Neurodegenerative Diseases

Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665 · see citing works

Current Cancer Epidemiology

Mattiuzzi, C., & Lippi, G. (2019) · Journal of Epidemiology and Global Health · doi:10.2991/jegh.k.191008.001 · Cited by 1,493 · see citing works

Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery

Yang, X. Y., Wang, Y., Byrne, R., Schneider, G., & Yang, S. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00728 · Cited by 1,045 · see citing works

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3516 · Cited by 1,031 · see citing works

The Drug Repurposing Hub: a next-generation drug library and information resource

Corsello, S. M., Bittker, J. A., Liu, Z., Gould, J., McCarren, P. R., Hirschman, J., Johnston, S. E., Vrcic, A., Wong, B., Khan, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4306 · Cited by 1,028 · see citing works

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

Hicks, J. K., Sangkuhl, K., Swen, J. J., Ellingrod, V. L., Dj, M., Shimoda, K., Bishop, J., Kharasch, E. D., Skaar, T. C., Gaedigk, A., et al. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.597 · Cited by 686 · see citing works

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

Sanz, M. A., Fenaux, P., Tallman, M. S., Estey, E. H., Löwenberg, B., Naoe, T., Lengfelder, E., Döhner, H., Burnett, A. K., Chen, S.-J., et al. (2019) · Blood · doi:10.1182/blood-2019-01-894980 · Cited by 664 · see citing works

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

Efferth, T. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.009 · Cited by 632 · see citing works

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer

Murphy, J. E., Wo, J. Y.-L., Ryan, D. P., Clark, J. W., Jiang, W., Yeap, B. Y., Drapek, L. C., Ly, L., Baglini, C. V., Blaszkowsky, L. S., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.0892 · Cited by 525 · see citing works

Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval

Prasad, V. K., & Mailankody, S. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.3601 · Cited by 503 · see citing works

Aspirin and colorectal cancer: the promise of precision chemoprevention

Drew, D. A., Cao, Y., & Chan, A. T. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.4 · Cited by 452 · see citing works

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

Tiberi, S., du Plessis, N., Walzl, G., Vjecha, M. J., Rao, M., Ntoumi, F., Mfinanga, S., Kapata, N., Mwaba, P., McHugh, T. D., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30110-5 · Cited by 403 · see citing works

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

Jahchan, N. S., Dudley, J. T., Mazur, P. K., Flores, N. M., Yang, D., Palmerton, A., Zmoos, A., Vaka, D., Tran, K. Q. T., Zhou, M. J., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0183 · Cited by 358 · see citing works

Drug repurposing in cancer

Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329 · see citing works

Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer

Guglin, M. E., Krischer, J. P., Tamura, R., Fink, A., Bello-Matricaria, L., McCaskill‐Stevens, W., & Münster, P. N. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.495 · Cited by 288 · see citing works

Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab

Abaza, Y., Kantarjian, H. M., Garcia‐Manero, G., Estey, E. H., Borthakur, G. M., Jabbour, E. J., Faderl, S. H., O'Brien, S. M., Wierda, W. G., Pierce, S. A., et al. (2016) · Blood · doi:10.1182/blood-2016-09-736686 · Cited by 287 · see citing works

Repositioning metformin for cancer prevention and treatment

Quinn, B. J., Kitagawa, H., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.004 · Cited by 284 · see citing works

Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

Yang, L., Wang, H., Xiang, Y., Wu, Q., An, P., Jin, X., Liu, W., Huang, X., Li, Y., Yan, S., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00253-0 · Cited by 283 · see citing works

Machine and deep learning approaches for cancer drug repurposing

Issa, N. T., Stathias, V., Schürer, S. C., & Dakshanamurthy, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.011 · Cited by 280 · see citing works

Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis

Ishay-Ronen, D., Diepenbruck, M., Kalathur, R. K. R., Sugiyama, N., Tiede, S., Ivánek, R., Bantug, G. R., Morini, M. F., Wang, J., Hess, C., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2018.12.002 · Cited by 270 · see citing works

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

Zhao, Y., Cao, J., Melamed, A., Worley, M. J., Gockley, A. A., Jones, D., Nia, H. T., Zhang, Y., Stylianopoulos, T., Kumar, A. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818357116 · Cited by 262 · see citing works

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

Wong, Y. K., Xu, C., Kalesh, K., He, Y., Lin, Q., Wong, W. S. F., Shen, H., & Wang, J. (2017) · Medicinal Research Reviews · doi:10.1002/med.21446 · Cited by 241 · see citing works

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

Smith, M. P., Brunton, H., Rowling, E. J., Ferguson, J., Arozarena, I., Miskolczi, Z., Lee, J. L., Girotti, M. R., Marais, R., Levesque, M. P., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.003 · Cited by 239 · see citing works

Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology

Jiao, X., Nawab, O., Patel, T. A., Kossenkov, A. V., Halama, N., Jaeger, D., & Pestell, R. G. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1167 · Cited by 232 · see citing works

CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization

Wang, H., Xu, X., Nguyen, C. M., Liu, Y., Gao, Y., Lin, X., Daley, T., Kipniss, N. H., Russa, M. F. L., & Qi, L. S. (2018) · Cell · doi:10.1016/j.cell.2018.09.013 · Cited by 215 · see citing works

A genome-wide positioning systems network algorithm for in silico drug repurposing

Cheng, F., Lu, W., Liu, C., Fang, J., Hou, Y., Handy, D. E., Wang, R., Zhao, Y., Yang, Y., Huang, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10744-6 · Cited by 215 · see citing works

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

Chen, K., Lu, P., Beeraka, N. M., Sukocheva, O. A., Madhunapantula, S. V., Liu, J., Sinelnikov, M. Y., Nikolenko, V. N., Bulygin, K. V., Михалева, Л. М., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.09.012 · Cited by 196 · see citing works

Propranolol for Off-label Treatment of Patients With Melanoma

GIORGI, V. D., Grazzini, M., Benemei, S., Marchionni, N., Botteri, E., Pennacchioli, E., Geppetti, P., & Gandini, S. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.2908 · Cited by 194 · see citing works

Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma

Chen, Y., Chen, H., Wang, K., Zhang, L., Huang, Z., Liu, J., Zhang, Z., Luo, M., Lei, Y., Peng, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.022 · Cited by 192 · see citing works

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Shchors, K., Massaras, A., & Hanahan, D. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.08.012 · Cited by 186 · see citing works

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment

Platz, E. A., Yegnasubramanian, S., Liu, J. O., Chong, C. R., Shim, J. S., Kenfield, S. A., Stampfer, M. J., Willett, W. C., Giovannucci, E. L., & Nelson, W. G. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0020 · Cited by 184 · see citing works

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

Nowak-Sliwinska, P. M., Scapozza, L., & Altaba, A. R. I. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.005 · Cited by 183 · see citing works

Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer

Antonarakis, E. S., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Ajiboye, A. S., Zhao, M., et al. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-314 · Cited by 180 · see citing works

Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking

Liu, R., Li, J., Zhang, T., Zou, L., Chen, Y., Wang, K., Lei, Y., Yuan, K., Li, Y., Lan, J., et al. (2014) · Autophagy · doi:10.4161/auto.28912 · Cited by 178 · see citing works

Drug repurposing for breast cancer therapy: Old weapon for new battle

Aggarwal, S., Verma, S. S., Aggarwal, S. S., & Gupta, S. C. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.012 · Cited by 170 · see citing works

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

Lu, L., Dong, J., Wang, L., Xia, Q., Zhang, D., Kim, H.-J., Yin, T., Fan, S., & Shen, Q. (2018) · Oncogene · doi:10.1038/s41388-018-0340-y · Cited by 166 · see citing works

Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.

Li, H., Xiao, H., Lin, L., Jou, D., Kumari, V., Lin, J., & Li, C.-L. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401144z · Cited by 155 · see citing works

Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma

Haas, N. B., Appleman, L. J., Stein, M. N., Redlinger, M., Wilks, M., Xu, X., Onorati, A., Kalavacharla, A., Kim, T., Zhen, C. J., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2204 · Cited by 155 · see citing works

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6

Luo, Y., Xie, C., Brocker, C. N., Fan, J., Wu, X., Feng, L., Wang, Q., Zhao, J., Lu, D., Tandon, M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.057 · Cited by 155 · see citing works

Effects of statins on cancer mortality and progression: A systematic review and meta‐analysis of 95 cohorts including 1,111,407 individuals

Mei, Z., Liang, M., Li, L., Zhang, Y., Wang, Q., & Yang, W. (2016) · International Journal of Cancer · doi:10.1002/ijc.30526 · Cited by 146 · see citing works

Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature

Guerini, A. E., Triggiani, L., Maddalo, M., Bonù, M. L., Frassine, F., Baiguini, A., Alghisi, A., Tomasini, D., Borghetti, P., Pasinetti, N., et al. (2019) · Cancers · doi:10.3390/cancers11091284 · Cited by 146 · see citing works

Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

Liu, P., Tsai, K.-L., Hsu, C., Tsai, W.-L., Cheng, J., Chang, H., Shiau, C., Goan, Y.-G., Tseng, H., Wu, C.-H., et al. (2017) · Theranostics · doi:10.7150/thno.22012 · Cited by 142 · see citing works

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Ellegaard, A., Dehlendorff, C., Vind, A., Anand, A., Cederkvist, L., Petersen, N. H. T., Nylandsted, J., Stenvang, J., Mellemgaard, A., Østerlind, K., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.06.013 · Cited by 141 · see citing works

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

Li, W., Zheng, M., Wu, S., Gao, S., Yang, M., Li, Z., Min, Q., Sun, W., Chen, L., Xiang, G., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0530-4 · Cited by 141 · see citing works

Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells

Salcher, S., Spoden, G. A., Huber, J., Golderer, G., Lindner, H. H., Ausserlechner, M. J., Kiechl‐Kohlendorfer, U., Geiger, K., & Obexer, P. (2019) · Cells · doi:10.3390/cells9010001 · Cited by 134 · see citing works

Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade

Partecke, L. I., Speerforck, S., Käding, A., Seubert, F., Kühn, S., Lorenz, E., Schwandke, S., Sendler, M., Keßler, W., Trung, D. N., et al. (2016) · Pancreatology · doi:10.1016/j.pan.2016.03.005 · Cited by 132 · see citing works

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Fiorillo, M., Lamb, R., Tanowitz, H. B., Cappello, A. R., Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2016) · Aging · doi:10.18632/aging.100983 · Cited by 127 · see citing works

Novel prospects of statins as therapeutic agents in cancer

Pisanti, S., Picardi, P., Ciaglia, E., D’Alessandro, A., & Bifulco, M. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.06.013 · Cited by 126 · see citing works

Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats

Gozari, M., Alborz, M., El-Seedi, H. R., & Jassbi, A. R. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112957 · Cited by 125 · see citing works

Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target

Wiklund, E. D., Catts, V. S., Catts, S. V., Ng, T. F., Whitaker, N. J., Brown, A. J., & Lutze-Mann, L. H. (2009) · International Journal of Cancer · doi:10.1002/ijc.24813 · Cited by 119 · see citing works

Repurposing of drugs as STAT3 inhibitors for cancer therapy

Thilakasiri, P. S., Dmello, R. S., Nero, T. L., Parker, M. W., Ernst, M., & Chand, A. L. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.022 · Cited by 111 · see citing works

Expanding Role of NMDA Receptor Antagonists in the Management of Pain

Kreutzwiser, D., & Tawfic, Q. A. (2019) · CNS Drugs · doi:10.1007/s40263-019-00618-2 · Cited by 107 · see citing works

Novel Drug Candidates for the Treatment of Metastatic Colorectal Cancer through Global Inverse Gene-Expression Profiling

van Noort, V., Schölch, S., Iskar, M., Zeller, G., Ostertag, K., Schweitzer, C., Werner, K., Weitz, J., Koch, M., & Peer Bork, B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3540 · Cited by 105 · see citing works

Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer

Luo, F., Luo, M., Rong, Q., Zhang, H., Chen, Z., Wang, F., Zhao, H.-Y., & Fu, L. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0733-7 · Cited by 105 · see citing works

Repurposing of approved cardiovascular drugs

Ishida, J., Konishi, M., Ebner, N., & Springer, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1031-5 · Cited by 103 · see citing works

β-blockers: Their new life from hypertension to cancer and migraine

Fumagalli, C., Maurizi, N., Marchionni, N., & Fornasari, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104587 · Cited by 102 · see citing works

The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer

Fendrich, V., Chen, N., Neef, M., Waldmann, J., Buchholz, M., Feldmann, G., Slater, E. P., Maitra, A., & Bartsch, D. K. (2009) · Gut · doi:10.1136/gut.2009.188961 · Cited by 101 · see citing works

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling

Chen, B., Wei, W., Ma, L., Yang, B., Gill, R. M., Chua, M., Butte, A. J., & So, S. K. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.02.039 · Cited by 100 · see citing works

Repurposing old drugs to fight multidrug resistant cancers

Dinić, J., Efferth, T., García‐Sosa, A. T., Grahovac, J., Padrón, J. M., Pajeva, I. K., Rizzolio, F., Saponara, S., Spengler, G., & Tsakovska, I. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100713 · Cited by 100 · see citing works

Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

Liu, Q., Tong, D., Liu, G., Gao, J., Wang, L.-A., Xu, J., Yang, X., Xie, Q., Huang, Y., Pang, J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0420 · Cited by 98 · see citing works

Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis

Jin, K., Pandey, N. B., & Popel, A. S. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0981-3 · Cited by 94 · see citing works

Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells

Kumar, S., Bryant, C. S., Chamala, S., Qazi, A. M., Seward, S. M., Pal, J., Steffes, C. P., Weaver, D. W., Morris, R. T., Malone, J. M., et al. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-26 · Cited by 92 · see citing works

Repurposing psychiatric drugs as anti-cancer agents

Huang, J., Zhao, D., Liu, Z., & Liu, F. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.058 · Cited by 89 · see citing works

Repurposing quinacrine for treatment-refractory cancer

Oien, D. B., Pathoulas, C. L., Ray, U., Thirusangu, P., Kalogera, E., & Shridhar, V. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.021 · Cited by 87 · see citing works

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

Qiao, S., Tao, S., de la Vega, M. R., Park, S., Vonderfecht, A. A., Jacobs, S., Zhang, D. D., & Wondrak, G. T. (2013) · Autophagy · doi:10.4161/auto.26506 · Cited by 83 · see citing works

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation

Wang, C., Zhang, T., Liao, Q., Dai, M., Guo, J., Yang, X., Tan, W., Lin, D., Wu, C., & Zhao, Y. (2021) · Protein & Cell · doi:10.1007/s13238-020-00760-4 · Cited by 82 · see citing works

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

Varışlı, L., Çen, O., & Vlahopoulos, S. (2019) · Immunology · doi:10.1111/imm.13160 · Cited by 81 · see citing works

Albendazole as a promising molecule for tumor control

Castro, L. S. E. P. W., Kviecinski, M. R., Ourique, F., Parisotto, E. B., Grinevicius, V. M. A. S., Correia, J. F. G., Wilhelm Filho, D., & Pedrosa, R. C. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.013 · Cited by 81 · see citing works

Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κB/STAT3-regulated proteins

Yang, Y., Ma, L., Xu, Y., Liu, Y., Li, W., Cai, J., & Zhang, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2675-x · Cited by 81 · see citing works

Fluoxetine induces autophagic cell death via eEF 2K‐ AMPK ‐ mTOR ‐ ULK complex axis in triple negative breast cancer

Sun, D., Zhu, L., Zhao, Y., Jiang, Y., Chen, L., Yu, Y., & Ouyang, L. (2017) · Cell Proliferation · doi:10.1111/cpr.12402 · Cited by 77 · see citing works

Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers

Dong, Z., Abbas, M. N., Kausar, S., Yang, J., Li, L., Tan, L., & Cui, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143577 · Cited by 77 · see citing works

Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer

Zhen, Y., Zhao, R., Wang, M., Jiang, X., Gao, F., Fu, L., Zhang, L., & Zhou, X. (2020) · Theranostics · doi:10.7150/thno.43473 · Cited by 77 · see citing works

Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients

Gillis, R. D., Botteri, E., Chang, A., Ziegler, A. I., Chung, N.-C., Pon, C. K., Shackleford, D. M., Andreassen, B. K., Halls, M. L., Baker, J. G., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.01.029 · Cited by 76 · see citing works

The potential to treat lung cancer via inhalation of repurposed drugs

Lee, W., Loo, C., Ghadiri, M., Leong, C. R., Young, P. M., & Traini, D. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.012 · Cited by 75 · see citing works

Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells

Agnihotri, S., Mansouri, S., Burrell, K. E., Li, M., Mamatjan, Y., Liu, J., Nejad, R., Kumar, S., Jalali, S., Singh, S. K., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1854 · Cited by 73 · see citing works

Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca2+-and p38 MAP Kinase-Dependent ROS Generation

Cho, Y., Kim, E., Nyiramana, M. M., Shin, E., Jin, H., Ryu, J. H., Kang, K. R., Lee, G., Kim, H. J., Han, J., et al. (2019) · Cancers · doi:10.3390/cancers11010064 · Cited by 72 · see citing works

Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells

Qin, G., Zhao, C., Zhang, L., Liu, H., Quan, Y., Chai, L., Wu, S., Wang, X., & Chen, T. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1132-2 · Cited by 71 · see citing works

Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancer

Zhang, L., Guo, M., Li, J., Zheng, Y., Zhang, S., Xie, T., & Liu, B. (2015) · Molecular BioSystems · doi:10.1039/c5mb00466g · Cited by 69 · see citing works

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

Hu, Y., Zhang, M., Tian, N., Li, D., Wu, F., Hu, P., Wang, Z., Wang, L., Hao, W., Kang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124979 · Cited by 66 · see citing works

R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

Overman, J. P., Fontaine, F. R., Wylie‐Sears, J., Moustaqil, M. D., Huang, L. J., Meurer, M., Chiang, I. K., Lesieur, E., Patel, J., Zuegg, J., et al. (2019) · eLife · doi:10.7554/elife.43026 · Cited by 66 · see citing works

Repurposing drugs for glioblastoma: From bench to bedside

Basso, J., Miranda, A., Sousa, J., Pais, A. A. C. C., & Vitorino, C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.039 · Cited by 63 · see citing works

Synergy between Auranofin and Celecoxib against Colon Cancer In Vitro and In Vivo through a Novel Redox-Mediated Mechanism

Han, Y., Chen, P., Zhang, Y., Lu, W., Ding, W., Luo, Y., Wen, S., Xu, R., Liu, P., & Huang, P. (2019) · Cancers · doi:10.3390/cancers11070931 · Cited by 63 · see citing works

Lovastatin‐mediated MCF‐7 cancer cell death involves LKB1‐AMPK‐p38MAPK‐p53‐survivin signalling cascade

Huang, S., Chyuan, I., Shiue, C., Yu, M., Hsu, Y., & Hsu, M. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14879 · Cited by 60 · see citing works

Drug rechanneling: A novel paradigm for cancer treatment

Kaushik, I., Ramachandran, S., Prasad, S., & Srivastava, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.011 · Cited by 58 · see citing works

Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties

Zeng, L., Wang, Y., Kazemi, R., Xu, S., Xu, Z.-L., Sanchez, T. W., Yang, L.-M., Debnath, B., Odde, S., Xie, H., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300667v · Cited by 57 · see citing works

Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells

Zhao, L., Zhao, Y., Schwarz, B., Mysliwietz, J., Hartig, R., Čamaj, P., Bao, Q., Jauch, K., Guba, M., Ellwart, J. W., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3512 · Cited by 57 · see citing works

Nonsteroidal Anti-inflammatory Drugs and Endometrial Carcinoma Mortality and Recurrence

Brasky, T. M., Felix, A. S., Cohn, D. E., McMeekin, D. S., Mutch, D. G., Creasman, W. T., Thaker, P. H., Walker, J. L., Moore, R. G., Lele, S., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw251 · Cited by 56 · see citing works

Current state and future perspective of drug repurposing in malignant glioma

Siegelin, M. D., Schneider, E., Westhoff, M., Wirtz, C. R., & Karpel‐Massler, G. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.018 · Cited by 56 · see citing works

Atorvastatin exhibits anti-tumorigenic and anti-metastatic effects in ovarian cancer in vitro

Stine, J. E., Fang, Z., Sullivan, S. A., Gilliam, T. P., Clark, L., Tran, A.-Q., Sun, W., Zhou, C., Bae-Jump, V. L., & Jones, H. M. (2020) · Europe PMC (PubMed Central) · doi:10.17615/4kdt-6n93 · Cited by 56 · see citing works

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Jiao, Z., Cai, H., Yu, L., Sirka, O. K., Padmanaban, V., Ewald, A. J., & Devreotes, P. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917938117 · Cited by 52 · see citing works

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

Kahn, S. A., Costa, S. L., Gholamin, S., Nitta, R. T., Dubois, L. G., Fève, M., Zeniou, M., Coelho, P. L. C., El-Habr, E. A., Cadusseau, J., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505421 · Cited by 51 · see citing works

Efflux mechanism and pathway of verapamil pumping by human P-glycoprotein

Wang, L., & Sun, Y. P. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108675 · Cited by 51 · see citing works

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent

Ji, H. Y., Byrom, M., Mead, P. E., Ellington, A. D., Wallingford, J. B., & Marcotte, E. M. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001379 · Cited by 50 · see citing works

Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer

Jones, M. R., Schrader, K. A., Shen, Y., Pleasance, E., Ch’ng, C., Dar, N. A., Yip, S., Renouf, D. J., Schein, J., Mungall, A. J. J., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw060 · Cited by 50 · see citing works

Celecoxib suppresses proliferation and metastasis of pancreatic cancer cells by down-regulating STAT3 / NF-kB and L1CAM activities

Zuo, C., Hong, Y., Qiu, X., Yang, D., Liu, N., Sheng, X., Zhou, K., Tang, B., Xiong, S., Ma, M., et al. (2018) · Pancreatology · doi:10.1016/j.pan.2018.02.006 · Cited by 50 · see citing works

Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells

Okubo, K., Isono, M., Miyai, K., Asano, T., & Sato, A. (2019) · Cancer Science · doi:10.1111/cas.14225 · Cited by 49 · see citing works

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

Sogawa, C. A., Tran, M. T., Ishige, M., Trin, K., Okusha, Y., Taha, E. A., Lu, Y., Kawai, H., Sogawa, N., Takigawa, M., et al. (2020) · Cancers · doi:10.3390/cancers12020523 · Cited by 48 · see citing works

Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps

Abbruzzese, C., Matteoni, S., Persico, M., Villani, V., & Paggi, M. G. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-1534-z · Cited by 47 · see citing works

Can cardiovascular drugs support cancer treatment? The rationale for drug repurposing

Regulska, K., Regulski, M., Karolak, B., Murias, M., & Stanisz, B. J. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.03.010 · Cited by 46 · see citing works

The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility

Kim, J., Grotegut, C. A., Wisler, J. W., Mao, L., Rosenberg, P. B., Rockman, H. A., & Lefkowitz, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920310117 · Cited by 46 · see citing works

Topically Applied Carvedilol Attenuates Solar Ultraviolet Radiation Induced Skin Carcinogenesis

Huang, K. M., Liang, S., Yeung, S., Oiyemhonlan, E., Cleveland, K. H., Parsa, C., Orlando, R., Meyskens, F. L., Andresen, B. T., & Huang, Y. S. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0132 · Cited by 46 · see citing works

Repositioning antipsychotic fluphenazine hydrochloride for treating triple negative breast cancer with brain metastases and lung metastases.

Xu, F., Xia, Y., Feng, Z., Lin, W., Xue, Q., Jiang, J., Yu, X., Peng, C., Luo, M., Yang, Y., et al. (2019) · Europe PMC (PubMed Central) · Cited by 45 · see citing works

Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers

Kaushik, V., Azad, N., Yakisich, J. S., & Iyer, A. K. V. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.9 · Cited by 44 · see citing works

Repurposing antidepressant sertraline as a pharmacological drug to target prostate cancer stem cells: dual activation of apoptosis and autophagy signaling by deregulating redox balance.

Chinnapaka, S., Bakthavachalam, V., & Munirathinam, G. (2020) · PubMed Central · Cited by 44 · see citing works

Ciprofloxacin Enhances the Chemosensitivity of Cancer Cells to ABCB1 Substrates

Gupta, P., Gao, H., Ashar, Y. V., Karadkhelkar, N. M., Yoganathan, S., & Chen, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020268 · Cited by 43 · see citing works

Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Muniyan, S., Rachagani, S., Parte, S. C., Halder, S., Seshacharyulu, P., Kshirsagar, P., Siddiqui, J. A., Vengoji, R., Rauth, S., Islam, R., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1569 · Cited by 42 · see citing works

Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion

Wan, Z., Shi, W., Shao, B., Shi, J.-L., Shen, A.-G., Ma, Y.-Y., Chen, J., & Lan, Q. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0637-9 · Cited by 41 · see citing works

Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma

Bergès, R., Denicolaï, E., Tchoghandjian, A., Baeza, N., Honoré, S., Figarella‐Branger, D., & Braguer, D. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1018-7 · Cited by 41 · see citing works

Carvedilol in glioma treatment alone and with imatinib in vitro

Ergüven, M. (2010) · International Journal of Oncology · doi:10.3892/ijo_00000563 · Cited by 41 · see citing works

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment

Dilly, S. J., Clark, A. J., Marsh, A., Mitchell, D. A., Cain, R. M., Fishwick, C. W. G., & Taylor, P. C. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.01.042 · Cited by 40 · see citing works

Glutamate release inhibitor, Riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production

Seol, H. S., Lee, S. E., Song, J. S., Lee, H. Y., Park, S., Kim, I., Singh, S. R., Chang, S., & Jang, S. J. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.028 · Cited by 40 · see citing works

Immunomodulatory effects of renin–angiotensin system inhibitors on T lymphocytes in mice with colorectal liver metastases

Vallejo-Ardila, D. L., Walsh, K. A., Fifis, T., Paolini, R. A., Kastrappis, G., Christophi, C., & Perini, M. V. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000487 · Cited by 39 · see citing works

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

Wang, M., Shim, J. S., Li, R., Dang, Y., He, Q., Das, M., & Liu, J. O. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12800 · Cited by 38 · see citing works

Comparative Study of Lipophilic Statin Activity in 2D and 3D in vitro Models of Human Breast Cancer Cell Lines MDA-MB-231 and MCF-7

Bytautaitė, M., & Petrikaitė, V. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s283033 · Cited by 36 · see citing works

Angiotensin II receptor blockers valsartan and losartan improve survival rate clinically and suppress tumor growth via apoptosis related to PI3K/AKT signaling in nasopharyngeal carcinoma

Lin, Y., Wang, H., Tsai, M., Su, Y.-Y., Yang, M., & Chien, C. (2021) · Cancer · doi:10.1002/cncr.33391 · Cited by 35 · see citing works

Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRPα and TIGIT/PVR Pathways for Cancer Immuno-Therapy

Zhou, X., Jiao, L., Qian, Y., Dong, Q., Sun, Y., Zheng, W., Zhao, W., Zhai, W., Qiu, L., Wu, Y., et al. (2021) · Biomolecules · doi:10.3390/biom11050706 · Cited by 34 · see citing works

Simvastatin Suppresses Human Breast Cancer Cell Invasion by Decreasing the Expression of Pituitary Tumor-Transforming Gene 1

Yin, L., He, Z., Yi, B., Xue, L., & Sun, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.574068 · Cited by 33 · see citing works

All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action

Mezquita, B., Mezquita, P., Pau, M., Gasa, L., Navarro, L., Samitier, M., Pons, M., & Mezquita, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-25526-1 · Cited by 32 · see citing works

Combination of Arsenic Trioxide and Valproic Acid Efficiently Inhibits Growth of Lung Cancer Cells via G2/M-Phase Arrest and Apoptotic Cell Death

Park, H., Han, B., & Park, W. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072649 · Cited by 32 · see citing works

Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells

Howard, C. M., Estrada, M. D., Terrero, D., Tiwari, A. K., & Raman, D. (2020) · Cancers · doi:10.3390/cancers12082169 · Cited by 31 · see citing works

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Cerles, O., Gonçalves, T. C., Chouzenoux, S., Benoit, É., Schmitt, A., Saidu, N. E. B., Kavian, N., Chéreau, C., Chenevier‐Gobeaux, C., Weill, B. J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0657-y · Cited by 30 · see citing works

Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma

­Kim, H., Chong, K., Ryu, B., Park, K.-J., Yu, M. O., Lee, J., Chung, S. H., Choi, S., Park, M. J., Chung, Y.-G., et al. (2019) · Cancers · doi:10.3390/cancers11091310 · Cited by 30 · see citing works

CB13, a novel PPARγ ligand, overcomes radio-resistance via ROS generation and ER stress in human non-small cell lung cancer

Kim, T. W., Hong, D., & Hong, S. H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03065-w · Cited by 29 · see citing works

Cardiac glycoside sensitized hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK, mitochondrial transition, and autophagy mediation

Rasheduzzaman, M., Yin, H., & Park, S. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23096 · Cited by 28 · see citing works

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

Ma, L., Meng, Y., Tu, C., Cao, X., Wang, H., Li, Y., Man, S., Zhou, J., Li, M., Liu, Z., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.019 · Cited by 27 · see citing works

Cardiac glycosides and breast cancer risk: A systematic review and meta‐analysis of observational studies

Karasneh, R. A., Murray, L., & Cardwell, C. R. (2016) · International Journal of Cancer · doi:10.1002/ijc.30520 · Cited by 26 · see citing works

High-Dose Citalopram and Escitalopram and the Risk of Out-of-Hospital Death

Ray, W. A., Chung, C. P., Murray, K. T., Hall, K., & Stein, C. M. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10324 · Cited by 25 · see citing works

Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats

Priyanka, H. P., Singh, R. V., Mishra, M., & ThyagaRajan, S. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.11.018 · Cited by 24 · see citing works

Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

Parris, A. B., Zhao, Q., Howard, E. W., Zhao, M., Ma, Z., & Yang, X. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0498-0 · Cited by 23 · see citing works

Drug Repositioning to Alleviate Systemic Inflammatory Response Syndrome Caused by Gram‐Negative Bacterial Outer Membrane Vesicles

Kim, J. H., Lee, J., Park, K., Hong, S., & Gho, Y. S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701476 · Cited by 22 · see citing works

Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer

Fan, M., Chen, S., Weng, Y., Li, X., Jiang, Y., Wang, X., Bie, M., An, L., Zhang, M., Chen, B., et al. (2020) · Oncology Reports · doi:10.3892/or.2020.7602 · Cited by 22 · see citing works

Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma

Rauschenbach, L., Wieland, A., Reinartz, R., Kebir, S., Till, A., Oppong, M. D., Dobersalske, C., Ullrich, V., Ahmad, A., Jabbarli, R., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.017 · Cited by 22 · see citing works

Repurposing Antibacterial AM404 As a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells

Ahmed, M., Jinks, N., Babaei‐Jadidi, R., Kashfi, H., Castellanos‐Uribe, M., May, S. T., Mukherjee, A., & Nateri, A. S. (2019) · Cancers · doi:10.3390/cancers12010106 · Cited by 22 · see citing works

Teaching an Old Dog New Tricks: Drug Repositioning in Small Cell Lung Cancer

Wang, J., & Byers, L. A. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0790 · Cited by 21 · see citing works

A new horizon for the old antibacterial drug clofoctol

Bailly, C., & Vergoten, G. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.02.004 · Cited by 20 · see citing works

Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats

de Souza, C. O., Kurauti, M. A., Silva, F. D. F., de Morais, H., Curi, R., Hirabara, S. M., Neto, J. C. R., & de Souza, H. M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430326 · Cited by 20 · see citing works

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

Nguyen, C. H., Bauer, K., Hackl, H., Schlerka, A., Koller, E., Hladik, A., Stoiber, D., Zuber, J., Staber, P., Hoelbl-Kovacic, A., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2172-2 · Cited by 18 · see citing works

Antidepressants and Antipsychotic Agents as Repurposable Oncological Drug Candidates

Antoszczak, M., Markowska, A., Markowska, J., & Huczyński, A. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200907141452 · Cited by 18 · see citing works

Efavirenz and Lopinavir/Ritonavir Alter Cell Cycle Regulation in Lung Cancer

Marima, R. M., Hull, R., Dlamini, Z., & Penny, C. B. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01693 · Cited by 15 · see citing works

Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?

Cilibrasi, C., Butta, V., Riva, G., & Bentivegna, A. (2016) · PPAR Research · doi:10.1155/2016/7175067 · Cited by 13 · see citing works

Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer

Meyn, R. E., Krishnan, S., & Skinner, H. D. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0024 · Cited by 5 · see citing works

Fluvastatin combined with benazepril may contribute to the favorable prognosis of patients with atrial fibrillation

Yao, H., Jiang, L., Lin, X. M., & Liang, Z. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.07.031 · Cited by 4 · see citing works

Study finds possible role for aspirin as treatment for colon cancer

Kmietowicz, Z. (2012) · BMJ · doi:10.1136/bmj.e2988 · Cited by 4 · see citing works

Thalidomide for myeloma: still here?

Dimopoulos, M. A., & Kastritis, E. (2018) · The Lancet Haematology · doi:10.1016/s2352-3026(18)30154-6 · Cited by 2 · see citing works

Drug repurposing for cancer therapy

Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443 · see citing works

Pharmacogenomic landscape of head and neck squamous cell carcinoma informs precision oncology therapy

Gu, Z., Yao, Y., Yang, G., Zhu, G.-P., Tian, Z., Wang, R., Wu, Q., Wang, Y.-J., Wu, Y.-P., Chen, L., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo5987 · Cited by 52 · see citing works

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

Ahmed, F., Kang, I. S., Kim, K. H., Asif, A., Rahim, C. S. A., Samantasinghar, A., Memon, F. H., & Choi, K. H. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28693 · Cited by 75 · see citing works

The clinical application of artificial intelligence in cancer precision treatment

Wang, J., Zeng, Z., Li, Z., Liu, G., Zhang, S., Luo, C., Hu, S., Wan, S., & Zhao, L.-Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06139-5 · Cited by 79 · see citing works

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Wang, H., Zhou, X., Li, C., Yan, S., Feng, C., He, J., Li, Z., & Tu, C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01365-6 · Cited by 67 · see citing works

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Duraj, T., Kalamian, M., Zuccoli, G., Maroon, J. C., D’Agostino, D. P., Scheck, A. C., Poff, A. M., Winter, S. F., Hu, J. L., Klement, R. J., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03775-4 · Cited by 64 · see citing works

Repurposing antifungal drugs for cancer therapy

Weng, N., Zhang, Z., Tan, Y., Zhang, X., Wei, X., & Zhu, Q. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2022.08.018 · Cited by 60 · see citing works

Drug Repurposing for Cancer Treatment: A Comprehensive Review

Khzem, A. H. A., Gomaa, M. S., Alturki, M. S., Tawfeeq, N., Sarafroz, M., Alonaizi, S. M., Faran, A. A., Alrumaihi, L. A., AlAnsari, F., & Alghamdi, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212441 · Cited by 55 · see citing works

Overcoming Therapy Resistance in Colon Cancer by Drug Repurposing

Zarif, T. E., Yibirin, M., Oliveira-Gomes, D. D., Machaalani, M., Nawfal, R., Carlini, G. B., Bahmad, H. F., & Bitar, N. (2022) · Cancers · doi:10.3390/cancers14092105 · Cited by 38 · see citing works

Targeting breast cancer and their stem cell population through AMPK activation: novel insights

Uprety, B., & Abrahamse, H. (2022) · Cells · doi:10.3390/cells11030576 · Cited by 33 · see citing works

Nanostructures as Photothermal Agents in Tumor Treatment

Chen, Y., Zhou, F., Wang, C., Hu, L., & Guo, Z.-Y. (2022) · Molecules · doi:10.3390/molecules28010277 · Cited by 34 · see citing works

QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma

Shah, S., Famta, P., Kumar, R., Vambhurkar, G. B., Pandey, G., Shinde, A., Prasad, S. B., Sharma, A., Sharma, A., Kanaujiya, S., et al. (2025) · BioNanoScience · doi:10.1007/s12668-025-01833-6 · Cited by 25 · see citing works

Canonical and Non-Canonical Antipsychotics’ Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia

de Bartolomeis, A., Ciccarelli, M., Simone, G. D., Mazza, B., Barone, A., & Vellucci, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065945 · Cited by 25 · see citing works

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

Thuru, X., Magnez, R., Bouazzati, H. E., Vergoten, G., Quesnel, B., & Bailly, C. (2022) · Cancers · doi:10.3390/cancers14143368 · Cited by 22 · see citing works

Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential

Chen, S., Zhang, L., Chen, Y., & Fu, L. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01097 · Cited by 18 · see citing works

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

Liu, H., Huang, Q., Fan, Y., Li, B., Liu, X., & Hu, C. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.05.015 · Cited by 15 · see citing works

A Strategy Utilizing Protein–Protein Interaction Hubs for the Treatment of Cancer Diseases

Carels, N., Sgariglia, D., Vieira, M. G., Lima, C. R., Carneiro, F. R. G., da Silva, G. F., da Silva, F. A. B., Scardini, R., Tuszyński, J. A., de Andrade, C. V., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216098 · Cited by 16 · see citing works

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

Barbălată, C. I., Porfire, A. S., Casian, T., Muntean, D. M., Rus, I., Tertiş, M., Cristea, C., Pop, A., Cherfan, J., Loghin, F., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15101211 · Cited by 14 · see citing works

PDE5 inhibitors against cancer via mediating immune cells in tumor microenvironment: AI‐based approach for future drug repurposing exploration

Zhang, Z., Huang, D., Feng, J., Li, W., Wang, Z., Lu, M., Luo, Y., Yang, W., Xu, Z., Xie, Q., et al. (2024) · Interdisciplinary medicine · doi:10.1002/inmd.20230062 · Cited by 14 · see citing works

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

Li, J., Wang, X., Zhang, H., Hu, X., Peng, X., Jiang, W., Zhuo, L., Peng, Y., Zeng, G., & Wang, Z. (2024) · Medicinal Research Reviews · doi:10.1002/med.22079 · Cited by 14 · see citing works

Reprogramming cancer therapeutics through artificial intelligence-guided drug repurposing: Computational innovation, experimental validation, and translational challenges

Fawzy, M. P., Nafie, M. S., Nabih, N. W., Diab, M. K., Babker, A. M. A., Mohamed, H., Hassan, H. A. F. M., & Fahmy, S. A. (2026) · Artificial Intelligence in the Life Sciences · doi:10.1016/j.ailsci.2026.100168 · Cited by 15 · see citing works

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

Chen, X., Yang, L., Wu, Y., Wang, L., & Li, H. (2023) · ACS Omega · doi:10.1021/acsomega.3c06944 · Cited by 13 · see citing works

Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies

Mukhtar, R. M., Abdelmoniem, N., Elrufaie, H. A., Edris, A., Ghaboosh, H., Mahgoub, M. A., Garelnabi, E. A. E., Osman, W., Sherif, A. E., Ashour, A. A., et al. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1205724 · Cited by 12 · see citing works

Wnt/β-catenin targeting in liver carcinoma through nanotechnology-based drug repurposing: A review

Mohapatra, P., & Chandrasekaran, N. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113713 · Cited by 12 · see citing works

Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing

Kaur, R., & Suresh, P. K. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04595-7 · Cited by 12 · see citing works

Advanced coacervation-driven nanoscale polymeric assemblies for biomedical applications

Shu, L., Gong, Y., Lin, M., Sun, J., & Chen, X. (2024) · Applied Physics Reviews · doi:10.1063/5.0197742 · Cited by 12 · see citing works

Structure-based drug repurposing targeting pathogenic virus superfamily 1 helicase: An integrated multi-computational screening and bioactivity identification strategy

Li, Z., Ding, Y., Tuo, X., Hu, J., Zhang, T., Zhou, X., Liu, L., & Yang, S. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110737 · Cited by 11 · see citing works

H1 Antihistamines—Promising Candidates for Repurposing in the Context of the Development of New Therapeutic Approaches to Cancer Treatment

Trybus, E., & Trybus, W. (2024) · Cancers · doi:10.3390/cancers16244253 · Cited by 11 · see citing works

Non-oncology drug (meticrane) shows anti-cancer ability in synergy with epigenetic inhibitors and appears to be involved passively in targeting cancer cells

Wang, Y., Sharma, A., Ge, F., Chen, P., Yang, Y., Liu, H., Liu, H., Zhao, C., Mittal, L., Asthana, S., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1157366 · Cited by 11 · see citing works

Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential

Ceci, C., Ruffini, F., Falconi, M., Atzori, M. G., Falzon, A., Lozzi, F., Iacovelli, F., D’Atri, S., Graziani, G., & Lacal, P. M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116766 · Cited by 10 · see citing works

Flubendazole Enhances the Inhibitory Effect of Paclitaxel via HIF1α/PI3K/AKT Signaling Pathways in Breast Cancer

Zhou, Y., Liao, M., Li, Z., Ye, J., Wu, L., Mou, Y., Fu, L., & Zhen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015121 · Cited by 10 · see citing works

Novel Anticancer Triple Formula Based on Aptamer-Conjugated PEGylated Nanoliposomes

Al-Samydai, A. M., Nsairat, H., Alqaraleh, M., Hajleh, M. N. A., Jaber, A. M., Al‐Halaseh, L. K., Azzam, H., Alazzawi, Q. K., Al-Ani, I. H., Carradori, S., et al. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251356548 · Cited by 9 · see citing works

Drug repurposing in oncology: a path beyond the bottleneck

Sajwani, N., Suchitha, G. P., Prasad, T. S. K., & Dagamajalu, S. (2025) · Medical Oncology · doi:10.1007/s12032-025-02994-w · Cited by 9 · see citing works

Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting.

Pawar, V. A., Tyagi, A., Verma, C., Sharma, K. P., Ansari, S., Mani, I., Srivastva, S. K., Shukla, P. K., Kumar, A., & Kumar, V. (2023) · PubMed Central · Cited by 8 · see citing works

Drug repurposing: a retrospective revolution in breast cancer medicine

Dave, S. A., Patel, M., Anand, N., Nandita, C., & Jignesh, S. (2024) · Discover Medicine · doi:10.1007/s44337-024-00012-y · Cited by 8 · see citing works

Repurposing of neprilysin inhibitor ‘sacubitrilat’ as an anti-cancer drug by modulating epigenetic and apoptotic regulators

Kumbhar, N., Nimal, S., Patil, D., Kaiser, V. F., Haupt, J., & Gacche, R. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-36872-0 · Cited by 8 · see citing works

Old Drugs, New Battles: Unleashing Repurposed Drug Classes in Triple-Negative Breast Cancer Treatment

Tshimweneka, V. S., & Mhlanga, T. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211196 · Cited by 6 · see citing works

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Sherif, A. Y., Harisa, G. I., Shahba, A. A.-W., Nasr, F. A., Taha, E. I., & Alqahtani, A. S. (2023) · Drug Development Research · doi:10.1002/ddr.22097 · Cited by 6 · see citing works

Small-molecule inhibitor of Fam20C in combination with paclitaxel suppresses tumor growth by LIF-JAK2/STAT3-modulated apoptosis in triple-negative breast cancer

Yuan, Z., Zhen, Y., Chen, S., Li, Z., & Fu, L. (2023) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2023.104673 · Cited by 6 · see citing works

Drug repurposing for cancer

Banerjee, J., Tiwari, A. K., & Banerjee, S. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.03.032 · Cited by 6 · see citing works

Advantages, Challenges, and Impact of Drug Repurposing for Cancer Treatment

Zafar, R., Safdar, I., Munir, A., Zahid, M. R., & Serfraz, S. (2025) · Pharmaceutical science. · doi:10.5772/intechopen.1008768 · Cited by 5 · see citing works

Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods

Lei, C., Chen, Z., Ma, C., Xie, L., Wu, D., Chen, J., & Chen, J. (2026) · Chinese Medicine · doi:10.1186/s13020-025-01320-w · Cited by 5 · see citing works

Reimagining old drugs with new tricks: Mechanisms, strategies and notable success stories in drug repurposing for neurological diseases

Rani, N., Kaushik, A., Kardam, S., Kag, S., Raj, V. S., Ambasta, R. K., & Kumar, P. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.03.029 · Cited by 4 · see citing works

Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy

Rauf, A., Joshi, P. B., Olatunde, A., Hafeez, N., Ahmad, Z., Hemeg, H. A., Aljohani, A. S. M., Abdulmonem, W. A., Thiruvengadam, M., Viswanathan, D., et al. (2024) · Medical Oncology · doi:10.1007/s12032-024-02368-8 · Cited by 4 · see citing works

Searching for the Holy Grail − Highly Potent Bridged Endoperoxides for Targeted Cancer Therapy

Tiwari, M. K., & Gośliński, T. A. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107893 · Cited by 4 · see citing works

Small-molecule self-assembled nanodrugs: Molecular design, assembly dynamics and biomedical applications

Li, Y., Shi, J., Sun, X., Zhang, Z., Sun, J., He, Z., Luo, C., & Zhang, S. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.112266 · Cited by 3 · see citing works

Impact of renin–angiotensin system inhibitors on the clinical outcomes of nivolumab therapy in metastatic non–small cell lung cancer

Ozkan, E. M., Karadağ, İ., Sahın, E., Cengi̇z, A. N., Cengiz, M., Güven, D. C., Bozkurt, O., Inanc, M. P., Özkan, M., Kefeli, U., et al. (2026) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2026.2615853 · Cited by 3 · see citing works

Chitosan capped-NLCs enhanced codelivery of gefitinib and simvastatin into MDR HCC: impact of compositions on cell death, JNK3, and Telomerase

Alzhrani, R. F., Alluhaidan, A. A., ALAMRI, S. M., Harisa, G. I., Bakheit, A. H. H., Asiri, H. H., & Attia, S. M. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.053337 · Cited by 3 · see citing works

Unraveling new avenues in pancreatic cancer treatment: A comprehensive exploration of drug repurposing using transcriptomic data

Sunildutt, N., Ahmed, F., Salih, A. R. C., Kim, H. C., & Choi, K. H. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109481 · Cited by 3 · see citing works

Vortioxetine: A Potential Drug for Repurposing for Glioblastoma Treatment via a Microsphere Local Delivery System

Wang, Y., Siebzehnrubl, D., Weller, M., Weiss, T., Siebzehnrübl, F. A., & Newland, B. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00068 · Cited by 3 · see citing works

Development and characterization of novel intranasal in situ thermoreversible ketoprofen-loaded nanoemulgels for the treatment of glioblastoma

Pires, P. C., Magalhães, M., Cabral, C., Veiga, F., Mazzola, P. G., & Paiva‐Santos, A. C. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107580 · Cited by 2 · see citing works

Drug repurposing in oncology: a systematic review of anticancer effects of Lanatoside C at the molecular level

Olayode, O. O., Oladosu, T. J., Abioye, A. I., Oladeji, E. O., & Ogunoye, B. T. (2025) · BMC Cancer · doi:10.1186/s12885-025-15062-3 · Cited by 2 · see citing works

Deep learning for small-molecule drug discovery: From molecular design to clinical translation

Oliveira, R. I., Pereira, T., Abbasi, M., Salvador, J. A. R., & Arrais, J. P. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101533 · Cited by 3 · see citing works

Structure-based discovery of a novel allosteric activator of ATG4B for the treatment of triple-negative breast cancer

Jin, W., Li, Z., Li, Z., Song, J., Liu, H., Liu, Q., Gao, F., & Zhang, L. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118686 · Cited by 2 · see citing works

Regulating the Cytotoxicity of Anticancer Drugs by Pillar[6]arene‐based Host‐Guest Complex

Jia, X., Wei, H., Huang, Y., Duan, W., & Liu, L. (2025) · Chemistry - A European Journal · doi:10.1002/chem.202404763 · Cited by 2 · see citing works

Design, Synthesis, and Biological Evaluation of Novel Quinazoline Derivatives Possessing a Trifluoromethyl Moiety as Potential Antitumor Agents

Chen, M., Cheng, S., Dai, X., Yu, J., Wang, H., Xu, B., Luo, H., & Xu, G. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301776 · Cited by 2 · see citing works

Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for the Treatment of Glioma

Pires, P. C., Correia, M., Veiga, F., & Paiva‐Santos, A. C. (2023) · International Electronic Conference on Applied Sciences (ASEC) · doi:10.3390/asec2023-15345 · Cited by 1 · see citing works

Nanovectorization of metformin with phytochemicals for cancer therapy: A scoping review

Wall‐Medrano, A., Ruiz-Rodríguez, G., Olivas-Aguirre, M., Olivas-Aguirre, F. J., García‐Gurrola, A., & Escobar‐Puentes, A. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106277 · Cited by 1 · see citing works

In silico screening of potential FGF2 inhibitors for cancer therapy

Senrung, A. (2025) · In Silico Pharmacology · doi:10.1007/s40203-025-00495-2 · Cited by 1 · see citing works

G protein subtype preference dictates paroxetine-enhanced serotonin receptor response in non-malignant breast epithelial cells

Lengyel, M., Árkosy, P., & Uray, I. P. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117584 · Cited by 1 · see citing works

Antitumor Immunotherapy of Sialic Acid and/or GM1 Modified Coenzyme Q10 Submicron Emulsion

Meng, X., Yan, N. J., Guo, T., Chen, M., Sui, D., Wang, M., Zhang, K., Liu, X., Deng, Y., & Song, Y. (2022) · AAPS PharmSciTech · doi:10.1208/s12249-022-02426-2 · Cited by 1 · see citing works

COMPUTER-AIDED DRUG DESIGN AND ITS APPLICATIONS IN CANCER RESEARCH: A REVIEW

CHANDRA, K., SHARMA, S., AHLAWAT, M., CHAUHAN, S., & SHARMA, A. (2025) · Innovare Journal of Medical Sciences · doi:10.22159/ijms.2024v13i2.53888 · Cited by 1 · see citing works

Beta-blokerlerin yeniden konumlandırılması: Meme kanseri uygulamaları

ÇİTLER, G. N., & İşeri, Ö. D. (2023) · Frontiers in Life Sciences and Related Technologies · doi:10.51753/flsrt.1152416

Phase II Clinical Trial Resources

Peterson, B., Pauly, B., Haijema, B. J., & Ruwe, F. (2024) · doi:10.58647/rexpo.24000055.v1

Drug Repurposing: A strategic approach to addressing unmet medical needs

Goel, G. (2024) · International Journal of Pharma Professional’s Research (IJPPR) · doi:10.69580/ijppr.15.2.2024.154-163

Artificial intelligence: A regulatory perspective

Branco, F., & Sousa, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91819-0.00002-6

Small Molecule Targeted Compounds for Cancer Therapy Through Different Pathways

Yassin, N. Y. S., Ahmed, N. A., Khalil, R. G., & Ahmed, O. M. (2024) · Springer eBooks · doi:10.1007/978-981-96-0301-5_2

G protein subtype preference dictates paroxetine-enhanced serotonin receptor response in normal breast epithelial cellsPreprint

Lengyel, M., Arkosy, P., & Uray, I. P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658790

G Protein Subtype Preference Dictates Paroxetine-Enhanced Serotonin Receptor Response in Non-Malignant Breast Epithelial CellsPreprint

Máté, L., Péter, Á., & Uray, I. P. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5377139

Enhancing Triple-Negative Breast Cancer Radiotherapy via EZH2-Targeted Nanoplatform and Radionuclide Therapy

Wu, R., Hou, Y., Gai, Y., Tan, J., Zhou, Y. F., Jiang, D., Wang, K., Gao, Z., & Xia, X. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01145

Repurposing of Therapeutics for Anticancer Activity

Singh, S., Mishra, N., Alka, Verma, A., Nisha, R., Singh, N., & Saraf, S. A. (2026) · Springer eBooks · doi:10.1007/978-981-95-4522-3_11

Drug repurposing reveals Fmoc-l-leucine as an adipose thermogenesis activator in cold-exposed mice by targeting PPARγ/UCP1

Feng, M., Jia, G., Li, Q., Li, J., Wang, C., Han, W., Shi, J., Yan, C. H., Han, Y., & Zhou, Z. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124259

AI-driven drug repurposing strategies for hepatocellular carcinoma: Unlocking new therapeutic potential

Manoharan, S., Santhakumar, A., & Perumal, E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44121-9.00010-x

Antihistamine drug terfenadine suppressed the cycle progression of gastric cancer cells by targeting PI3K/AKT/mTOR signaling

Zhu, Y., Ma, Y., Si, Z., Zhou, Z., Tian, Y., Zhao, Y., Liu, H., Zhu, H., Zhang, Y., Liu, J., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1723444

Sulfonylureas beyond diabetes: A comprehensive review on anticancer and off-target effects (1956–2025)

Tomczyk, M. D., Wawrzynosek, C., de Carrillo, D. G., Krzystanek, M., Pantziarka, P., & Jędrzejowska–Szypułka, H. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119009

Structure-based discovery of a novel small-molecule inhibitor of ATG4B that modulates autophagy in esophageal squamous cell carcinoma therapy

Jin, W., Liu, H. F., Li, Z., Li, Z., Li, Z., Gao, F., Liu, Q., & Zhang, L. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110185

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Li, L., Li, D., Chen, D., Dian, Y., Yao, L., Su, H., Guo, Z., Zhao, D., Wu, Z., Zeng, F., et al. (2026) · Advanced Science · doi:10.1002/advs.76408

Drugging ERK1/2 in Cancer: A Glimpse of Small‐Molecule Inhibitors

Peng, Z., Fu, Y., Chen, Y., Fan, B., & Liu, B. (2026) · Medicinal Research Reviews · doi:10.1002/med.70084

Synergistic attack of “old drugs for new uses”: repositioning strategies in cancer combination therapy

Yan, J., Wei, X., Zhang, X., Zhang, S., Xia, D., Tang, Z., Yang, Z., & Zhang, C. (2026) · Exploration of Drug Science · doi:10.37349/eds.2026.1008176

Simvastatin as an immunomodulator and anti-myeloma agent – epidemiological, in vitro and murine model studies

Lion, A., Israel, A. Y., Merzon, E., Oster, H. S., Weizman, A., Luboshits, G., Bogen, B., Mittelman, M., & Firer, M. A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1882291

MircoRNAs as regulators of regulated cell death in cancer progression: a focus on ferroptosis, anoikis and pyroptosis

Xiao, D., 罗炎洲, Liu, L., Lu, Y., Xie, X., Zhou, Z., Ma, B., & Peng, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1862213

Repurposing butoconazole as a GRP78 substrate-binding domain (SBD) inhibitor to induce endoplasmic reticulum stress–mediated apoptosis in triple-negative breast cancer

Song, Y., Yuan, Z., Li, Z., Huang, Y., Lu, Y., Yang, Q., Wang, Y., Zhang, L., & Ma, W. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110447

BindingDB Entry 50017434: Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.

BindingDB (2023) · UC San Diego · doi:10.7270/q2x352hg

The evolution of therapeutics: A comparative review of small-molecule drugs and RNA-based medicines

Raj, S. A., & Rao, A. M. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100902

Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics

Singhal, S., Maheshwari, P., Krishnamurthy, P. T., & Patil, V. M. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220317140557 · Cited by 18 · see citing works

Drug repurposing a compelling cancer strategy with bottomless opportunities

Dash, R., Yadav, M., Biswal, J., Samanta, S., Sharma, T., & Mohapatra, S. (2023) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_626_22 · Cited by 8 · see citing works

Overcoming cancer therapeutic bottleneck by drug repurposing

Zhang, Z., Zhou, L., Xie, N., Nice, E. C., Zhang, T., Cui, Y., & Huang, C. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00213-8 · Cited by 521 · see citing works

Cancer drug discovery by repurposing: teaching new tricks to old dogs

Gupta, S. C., Sung, B., Prasad, S., Webb, L. J., & Aggarwal, B. B. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.06.005 · Cited by 340 · see citing works

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

Würth, R., Thellung, S., Bajetto, A., Mazzanti, M., Florio, T., & Barbieri, F. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.09.017 · Cited by 145 · see citing works