Atrial fibrillation and risk of dementia in non-demented elderly subjects with and without mild cognitive impairment (MCI)

Forti, P.; Maioli, F.; Pisacane, N.; Rietti, E.; Montesi, F.; Ravaglia, G.

doi:10.1016/j.archger.2007.01.023

Cited by 60Dementia and Cognitive Impairment ResearchAtrial Fibrillation Management and OutcomesNeurological Disease Mechanisms and Treatments

Atrial fibrillation and risk of dementia in non-demented elderly subjects with and without mild cognitive impairment (MCI)

Forti, P., Maioli, F., Pisacane, N., Rietti, E., Montesi, F., Ravaglia, G.·2007·Archives of Gerontology and Geriatrics

DOI 10.1016/j.archger.2007.01.023

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Abstract

MCI is regarded as a precursor of dementia, but not all patients with MCI actually develop dementia. As Alzheimer and vascular dementia (AD and VD, respectively) are thought to share many common etiopathogenetic mechanisms, we investigated whether the vascular risk factor atrial fibrillation affect the risk of conversion to dementia for different MCI subtypes diagnosed according to international criteria. One-hundred-eighty elderly outpatients with MCI and 431 elderly outpatients with a normal cognition were followed-up for a mean of 3 and 4 years, respectively. The risk of conversion to dementia associated with atrial fibrillation was studied in both samples using a Cox proportional-hazards model adjusted for sociodemographic and medical variables. Overall conversion rate to dementia was 10.5 (8.0-13.8) per 100 person-years in the MCI group and 2.2 (1.5-3.1) per 100 person-years in the normal cognition group. Atrial fibrillation was significantly associated with conversion to dementia (hazard ratio=HR=4.63, 95% confidence interval=Cl=1.72-12.46) in the MCI group, but not in the cognitively normal group (HR=1.10, 95% Cl=0.40-3.03). Current diagnostic criteria for MCI subtypes define heterogeneous populations, but atrial fibrillation can be useful in identifying people with increased risk of conversion to dementia.

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Women generally have reduced ventricular wall thickness and smaller left atria and ventricles compared with men.
“Women generally have reduced ventricular wall thickness and smaller left atria and ventricles compared with men.138–141”
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Self-citation
PW01-85 - Atrial Fibrillation And The Risk For Conversion From Mild Cognitive Impairment To Dementia In Subjects Aged Over 65
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Conversion of Mild Cognitive Impairment to Dementia: Predictive Role of Mild Cognitive Impairment Subtypes and Vascular Risk Factors
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Self-citation
The association between atrial fibrillation and dementia: A UK linked electronic health records cohort study
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Authors: Forti, P., Maioli, F., Pisacane, N., Rietti, E., Montesi, F., & Ravaglia, G.
Affiliations: IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
ORCID: Forti, P.
Maioli, F.
Venue: Archives of Gerontology and Geriatrics
Publisher: Elsevier BV
Published: 2007-01
Volume: 44
Pages: 155-165
ISSN: 0167-4943 (ISSN-L)
DOI: 10.1016/j.archger.2007.01.023
OpenAlex: W2025585710
Cited by: 60
References: 27
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 6
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Gerontology and Geriatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: atrial fibrillation, mild cognitive impairment, conversion to dementia, Alzheimer's disease, vascular dementia, vascular risk factors, older adults, MCI subtypes
MeSH terms: Aged, Alzheimer Disease, Atrial Fibrillation, Cardiovascular Diseases, Cerebrovascular Disorders, Cognition Disorders, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Severity of Illness Index, Dementia, Vascular, Incidence

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Atrial fibrillation and risk of dementia in non-demented elderly subjects with and without mild cognitive impairment (MCI)

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