PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED

Gambassi, G.

doi:10.1016/j.archger.2009.09.018

Cited by 94Musculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED

Gambassi, G.·2009·Archives of Gerontology and Geriatrics

DOI 10.1016/j.archger.2009.09.018

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Abstract

The prevalence of pain in depressed individuals and the prevalence of depression in patients with pain are higher than when these conditions are considered individually. When pain is severe, impairs function, and/or is refractory to treatment, it is associated with more depressive symptoms and worse depression outcomes. Similarly, depression in patients with pain is associated with more complaints and greater functional impairment. Whether alleviation of pain helps depressive symptoms or, likewise, whether relief of depression improves pain, are questions still incompletely clarified. However, there is growing evidence that depression and pain share genetic factors, biological pathways and neurotransmitters. Thus, the most promising area of future research is elucidating the neurobiological alterations in pain pathways that intersect with those involved in depression.

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When depression and/or anxiety coexist with chronic musculoskeletal pain, standard orthopedic treatment is less effective.
“when this occurs, standard orthopedic treatment is less effective.”
From A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study (2022) · cites this paper as [5]
Chronic pain and psychological impairment such as depression and anxiety are driven by shared biological pathways and neurotransmitters.
“Chronic pain and psychological impairment such as depression and anxiety are driven by shared biological pathways and neurotransmitters”
From A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study (2022) · cites this paper as [5]

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Authors: Gambassi, G.
Affiliations: Università Cattolica del Sacro Cuore (IT)
Corresponding author: Gambassi, G.
Venue: Archives of Gerontology and Geriatrics
Publisher: Elsevier BV
Published: 2009-01
Volume: 49
Pages: 103-112
ISSN: 0167-4943 (ISSN-L)
DOI: 10.1016/j.archger.2009.09.018
OpenAlex: W2040569989
Cited by: 93
References: 32
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 1 · 2014: 10 · 2013: 8 · 2012: 2
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Gerontology and Geriatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: pain, depression, comorbidities, refractory pain, functional disability, genetic factors, neurotransmitters, neurobiological pathways, pain pathways, elderly patients
MeSH terms: Depression, Humans, Pain, Pain Measurement, Prognosis, Psychometrics, Prevalence

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PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED

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