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Cited by 57Treatment of Major DepressionMusculoskeletal pain and rehabilitationHealth and Well-being Studies

Depression and pain impair daily functioning and quality of life in patients with major depressive disorder

Lin, Ching-Hua, Yen, Yung-Chieh, Chen, Ming-Chao, Chen, Cheng-Chung·2014·Journal of Affective Disorders
DOI 10.1016/j.jad.2014.03.039
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Abstract

Background Depression and pain frequently occur together. The objective of this study was to investigate the effects of depression and pain on the impairment of daily functioning and quality of life (QOL) of depressed patients.Methods We enrolled 131 acutely ill inpatients with major depressive disorder. Depression, pain, and daily functioning were assessed using the 17-item Hamilton Depression Rating Scale, the Short-Form 36 (SF-36) Body Pain Index, and the Work and Social Adjustment Scale. Health-related QOL was assessed using three primary domains of the SF-36: social functioning, vitality, and general health perceptions. Pearson׳s correlation and structural equation modeling were used to examine relationships among the study variables. Five models were proposed.Results In all, 129 patients completed all the measures. Model 5, both depression and pain impaired daily functioning and QOL, was the most fitted structural equation model (χ(2)=9.2, df=8, p=0.33, GFI=0.98, AGFI=0.94, TLI=0.99, CFI=0.99, RMSEA=0.03). The correlation between pain and depression was weak (r=-0.27, z=-2.95, p=0.003).Limitation This was a cross-sectional study with a small sample size.Conclusion Depression and pain exert a direct influence on the impairment of daily functioning and QOL of depressed patients; this impairment could be expected regardless of increased pain, depression, or both pain and depression. Pain had a somewhat separate entity from depression.

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Authors
Lin, C.-H., Yen, Y.-C., Chen, M.-C., & Chen, C.-C.
Affiliations
  • Kaohsiung Medical University (TW)
  • E-Da Hospital (TW)
Corresponding author
Chen, Cheng-Chung
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2014-09
Volume
166
Pages
173-178
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2014.03.039
OpenAlex
W2008456432
Cited by
57
References
80
Citations by year
2026: 2 · 2025: 8 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 1
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
Keywords
major depressive disorder, pain, daily functioning, quality of life, comorbidities, work and social adjustment, social functioning, vitality, hospitalized patients
MeSH terms
Activities of Daily Living, Adult, Cross-Sectional Studies, Depression, Major Depressive Disorder, Female, Health Status, Humans, Interpersonal Relations, Male, Middle Aged, Pain, Quality of Life, Social Adjustment

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