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Cited by 14Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging, Health, and Disability

The relationship between cognition and depressive symptoms, and factors modifying this association, in Alzheimer’s disease: A multivariate multilevel model

Yang, Bei, Yu, Hongmei, Xing, Min, He, Runlian, Liang, Ruifeng, Zhou, Liye·2017·Archives of Gerontology and Geriatrics
DOI 10.1016/j.archger.2017.05.003
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Abstract

Objectives To examine whether there was a bidirectional association between cognition and depressive symptoms in Alzheimer's disease (AD), and to explore the role of socio-demographic factors and daily performance in this association.Methods We conducted a longitudinal study of 104 community-dwelling patients with confirmed AD from Taiyuan, China. We assessed cognition and depressive symptoms (dependent variables) with the Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale-30 (GDS-30), respectively. Socio-demographic information and daily performance were treated as explanatory variables. A multivariate multilevel model was built to investigate the interrelationship between patients' cognition and depression, as well as the effect of related factors on both outcomes.Results MoCA scores were negatively correlated with GDS-30 both at the subject level (correlation coefficient r 3=-0.68, χ 2=19.26, P<0.001) and time point level (r 2=-0.35, χ 2=35.68, P<0.001) in patients with AD. Multivariate analysis showed several significant factors for cognitive function, including educational level, personality, hobbies, exercise, reading, aluminum utensil use, dietary restriction and hypertension (regression coefficients: 0.60, 0.52, 0.51, 0.48, 0.45, -0.48, 0.67, and -0.74, respectively). Significant factors for depressive symptoms included family status, employment before retirement, homemaking, reading, aluminum utensil use, dietary restriction, and hypertension (regression coefficients: 3.09, -1.33, -1.62, -1.31, 0.96, -1.15, and 1.14, respectively).Conclusion These findings indicated that cognition was negatively associated with depression in patients with AD, and both were influenced by reading, aluminum utensil use, dietary restriction, and hypertension. Considering patient factors may help to slow the progression of dementia.

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  • Dietary aspects and diet components (e.g., vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes.

    “dietary aspects and diet components (ex. vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes [161,208,236,312,396,402,403,404,405,406,407,408,409,410,411,412,413,414,415,416,417,418,419,420,421,422,423,424,425,426,427,428].”

    From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [236]

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Authors
Yang, B., Yu, H., Xing, M., He, R., Liang, R., & Zhou, L.
Affiliations
  • Shanxi Medical University (CN)
  • Binzhou Medical University (CN)
  • Taiyuan Central Hospital (CN)
Corresponding author
Yu, Hongmei
ORCID
Venue
Archives of Gerontology and Geriatrics
Publisher
Elsevier BV
Published
2017-09
Volume
72
Pages
25-31
ISSN
0167-4943 (ISSN-L)
DOI
10.1016/j.archger.2017.05.003
OpenAlex
W2612435699
Cited by
14
References
44
Citations by year
2024: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Gerontology and Geriatrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81373106, 81673277)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
Alzheimer's disease, cognitive function, depressive symptoms, bidirectional relationship, sociodemographic factors, daily performance, reading, dietary restriction, hypertension, dementia progression, community-dwelling older adults
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Depression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Multilevel Analysis

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