Sarcopenia and polypharmacy among older adults: A scoping review of the literature
Abstract
Background Sarcopenia and polypharmacy are both prevalent conditions in the geriatric population, leading to poor quality of life and adverse outcomes. Objective To explore the evidence on the relationship between sarcopenia and polypharmacy and to summarize the findings and the gaps from the existing literature. Method A systematic scoping review was conducted between March and May 2021, with no restriction on publication date, using the Arksey and O'Malley framework and reported according to PRISMA-ScR. Four bibliographic databases, PubMed, Web of Science, Scopus, Proquest One Academic, and four sources of gray literature were searched for studies written in English or Greek. Data were extracted quantitatively and using thematic analysis. Results Of the 397 initially retrieved records, 22 studies were finally included in this review, 20 published articles and 2 posters-presentations. Most of the studies used cross-sectional data. The relationship between sarcopenia and polypharmacy should be interpreted on the basis of the definition of polypharmacy, the diagnostic criteria of sarcopenia used, and the population setting. Sarcopenia or risk for sarcopenia are associated with polypharmacy or the number of medications in community-dwelling older adults, regardless of diagnostic criteria used for sarcopenia. Conclusion There is an association between sarcopenia or risk for sarcopenia and polypharmacy or the number of medications in community-dwelling older adults but not among…
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Polypharmacy has been associated with sarcopenia.
“Polypharmacy has been associated with sarcopenia [174], which could result in insufficiency of some electrolytes or micronutrients [175].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [174]
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- Authors
- Pana, A., Sourtzi, P., Kalokairinou, A., & Velonaki, V. S.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Pana, Anastasia
- Venue
- Archives of Gerontology and Geriatrics
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 98
- Pages
- 104520
- ISSN
- 0167-4943 (ISSN-L)
- OpenAlex
- W3199744740
- Cited by
- 57
- References
- 64
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 15 · 2023: 13 · 2022: 13 · 2021: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Archives of Gerontology and Geriatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- sarcopenia, polypharmacy, older adults, community-dwelling older adults, nursing home residents, medication burden, sarcopenia diagnostic criteria, sarcopenia assessment
- MeSH terms
- Aged, Cross-Sectional Studies, Humans, Quality of Life, Polypharmacy, Sarcopenia, Independent Living
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