The DOI matches its Crossref record; 97 of the 98 references it cites were found in a registry or an index.
Does cellular iron dysregulation play a causative role in Parkinson’s disease?
Abstract
Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the neuronal cell loss. Here we review evidence for loss of iron homeostasis as a causative factor in disease-associated neurodegeneration and the primary players which may be involved. A series of recent studies suggest that iron regulatory proteins (IRPs) coordinate both cellular iron levels and energy metabolism, both of which are disrupted in Parkinson's disease (PD) and may in turn contribute to increased levels of oxidative stress associated with the disease. Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease.
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In the citing paper
“When ferritin H was transgenically overexpressed into Parkinson disease (PD) model mice, reduced oxidative stress was found (159).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [159]
In the citing paper
“In addition, overexpression of ferritin H protected cells from the toxicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a drug used to create experimental models of PD) (159).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [159]
In the citing paper
“Chelation of “labile iron” also protected cells from this toxicity, suggesting that iron may play a role in the pathogenesis of PD, at least in the MPTP model (159).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [159]
In the citing paper
“Chelation of “labile iron” also protected cells from this toxicity, suggesting that iron may play a role in the pathogenesis of PD, at least in the MPTP model (159).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [159]
Citations
Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,153
Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
Parkinson's disease. Second of two parts.
Lang, A., & Lozano, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391607 · Cited by 1,193
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Doença de Parkinson em idosos: ingestão alimentar e estado nutricional
Morais, M. B., Fracasso, B. D. M., Busnello, F. M., Mancopes, R., & Rabito, E. I. (2013) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/s1809-98232013000300009 · Cited by 6
Evidence-Based Discriminant Analysis
Tripathi, C. B., Gangania, M. K., Kushwaha, S. S., & Agarwal, R. (2021) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_419_20 · Cited by 3
Neuropathology and Iron: Central Nervous System Iron Homeostasis
Texel, S. J., Xu, X., Pin, S., & Harris, Z. L. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_23 · Cited by 2
Unlocking molecular secrets: The role of miRNAs in Parkinson's disease dynamics
Abdelhamid, R., Abobakr, M., Mohamed, M., Hussieny, A., Mohamed, A., tarek, M., & Elshaer, S. S. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110542 · Cited by 1
Role of Nicotine in Oxidative Stress
Kacham, R., Tobwala, S., & Nuran Ercal, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.709 · Cited by 1
Oxidative stress in the pathogenesis of neurodegenerative diseases
Jovanović, Z. (2011) · Medicinski casopis · doi:10.5937/medcas1101016j · Cited by 1
Gal-Ben-Ari, S., & Youdim, M. B. H. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_211 · Cited by 1
Changes in Brain Gene Expression in Nutrient Deficiencies: An Example with Iron
Unger, E. L., Hegde, N. V., & Connor, J. R. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_77
Spurenelemente und ihre potentielle Rolle bei Neurodegeneration
Borgmann, M. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-10263
Comparison of the effect of glutamate, oxyferriscorbone and deprenyl on Parkinsonian Syndrome
Atadzhanov, M. (2010) · Medical Journal of Zambia · doi:10.4314/mjz.v36i2.56058
Participação do sistema colinérgico em déficits cognitivos no modelo animal de sobrecarga do ferro
Perez, V. P. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Alanazi, A. A. (2011) · Cardinal Scholar (Ball State University)
Kp, M., Eivaz-Mohammadi, S., & González-Ibarra, F. P. (2012)
Structural andT hermodynamic Studies of a-Synuclein Proteins Related to Parkinson’s Disease
(2011) · CRC Press eBooks · doi:10.1201/b10835-3
Nitric Oxide Synthase, Green Tea Catechins and Parkinson’s Disease
Kim, J. S., Oh, E., & Kim, J. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384937-3.00119-1
Syntaxin4 and Synapsin3 mRNA Levels Induced by Long-Term Iron Toxicity in Rat (Rattus norvegicus)
Tunç, A., & Erdoğan, O. (2017) · Journal of the Institute of Science and Technology · doi:10.21597/jist.2017.168
Clardy, S. L., Connor, J. R., & Beard, J. (2009) · Elsevier eBooks · doi:10.1016/b978-075067518-5.10009-6
Gal-Ben-Ari, S., & Youdim, M. B. H. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_211-1
Ramos, P. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/fhtf-e228
Bikri, S., Aboussaleh, Y., & Fouad, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00011-7
Al-Razaq, Z. N. A., Hameed, R. M., Odda, A. H., & Alhaideri, A. F. (2026) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_1454_23
Nanozymes in neurochemistry: From dopamine biosensing to neuroprotective antioxidant therapy
Ullah, H., Khan, R., Islam, N. U., Khan, A. A., Khaliq, N., Shakir, I., Maqbool, M., Ali, G., & Xie, Y. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100893
Metadata
- Authors
- Kaur, D., & Andersen, J.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Andersen, Julie
- ORCID
- Andersen, Julie
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 3
- Issue
- 3
- Pages
- 327-343
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W1998032181
- Cited by
- 123
- References
- 98
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 8 · 2012: 7
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG-12141)
- National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Parkinson's disease, iron homeostasis, iron regulatory proteins, oxidative stress, dopaminergic neuron loss, neurodegeneration, alpha-synuclein aggregation, Lewy bodies, energy metabolism
- MeSH terms
- Animals, Homeostasis, Humans, Iron, Mesencephalon, Mitochondria, Models, Biological, Nerve Tissue Proteins, Parkinson Disease, Protein Binding, Oxidative Stress, Neurodegenerative Diseases, Iron-Regulatory Proteins, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Synucleins, alpha-Synuclein
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