Cited by 123Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

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Does cellular iron dysregulation play a causative role in Parkinson’s disease?

Kaur, Deepinder, Andersen, Julie·2004·Ageing Research Reviews

DOI 10.1016/j.arr.2004.01.003

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Abstract

Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the neuronal cell loss. Here we review evidence for loss of iron homeostasis as a causative factor in disease-associated neurodegeneration and the primary players which may be involved. A series of recent studies suggest that iron regulatory proteins (IRPs) coordinate both cellular iron levels and energy metabolism, both of which are disrupted in Parkinson's disease (PD) and may in turn contribute to increased levels of oxidative stress associated with the disease. Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease.

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Untitled work
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The Role of Oxidative Stress in Parkinson's Disease
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Oxidative Stress and Antioxidants in Neurodegenerative Disorders
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Authors: Kaur, D., & Andersen, J.
Affiliations: Buck Institute for Research on Aging (US)
Corresponding author: Andersen, Julie
ORCID: Andersen, Julie
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2004-07
Volume: 3
Issue: 3
Pages: 327-343
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2004.01.003
OpenAlex: W1998032181
Cited by: 123
References: 98
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 8 · 2012: 7
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG-12141)
National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Parkinson's disease, iron homeostasis, iron regulatory proteins, oxidative stress, dopaminergic neuron loss, neurodegeneration, alpha-synuclein aggregation, Lewy bodies, energy metabolism
MeSH terms: Animals, Homeostasis, Humans, Iron, Mesencephalon, Mitochondria, Models, Biological, Nerve Tissue Proteins, Parkinson Disease, Protein Binding, Oxidative Stress, Neurodegenerative Diseases, Iron-Regulatory Proteins, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Synucleins, alpha-Synuclein

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Does cellular iron dysregulation play a causative role in Parkinson’s disease?

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