Cited by 123Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

The DOI matches its Crossref record; 97 of the 98 references it cites were found in a registry or an index.

Does cellular iron dysregulation play a causative role in Parkinson’s disease?

Kaur, Deepinder, Andersen, Julie·2004·Ageing Research Reviews

DOI 10.1016/j.arr.2004.01.003

Open this paper in CoChat — free account

Abstract

Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the neuronal cell loss. Here we review evidence for loss of iron homeostasis as a causative factor in disease-associated neurodegeneration and the primary players which may be involved. A series of recent studies suggest that iron regulatory proteins (IRPs) coordinate both cellular iron levels and energy metabolism, both of which are disrupted in Parkinson's disease (PD) and may in turn contribute to increased levels of oxidative stress associated with the disease. Iron has also been recently been implicated in promotion of alpha-synuclein aggregation either directly or via increasing levels of oxidative stress suggesting an important role for it in Lewy body formation, another important hallmark of the disease.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2004.01.003

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650
Anesthesiology
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,153
Parkinson's Disease
Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions
Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,567
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
Parkinson's disease. Second of two parts.
Lang, A., & Lozano, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391607 · Cited by 1,193

Flagged first, then by citations

Show all 98 references

1 of the 98 references couldn’t be matched to a known paper.

Sorted by citations

The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G. L., & Smith, M. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 884
Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications
Zaveri, N. T. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.006 · Cited by 811
Oxidative Stress and Antioxidants in Neurodegenerative Disorders
Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. M. D. (2023) · Antioxidants · doi:10.3390/antiox12020517 · Cited by 752
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526
The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases
Cannon, J. R., & Greenamyre, J. T. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr239 · Cited by 475
Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach
Baltazar, M. T., Dinis‐Oliveira, R. J., Bastos, M. D. L., Tsatsakis, A. M., Duarte, J. A., & Carvalho, F. D. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.039 · Cited by 410
The proteasomal system
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 401
SOD2 in mitochondrial dysfunction and neurodegeneration
Flynn, J. M., & Melov, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.027 · Cited by 390
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
High‐field magnetic resonance imaging of brain iron: birth of a biomarker?
Schenck, J. F., & Zimmerman, E. A. (2004) · NMR in Biomedicine · doi:10.1002/nbm.922 · Cited by 335
Redox imbalance in Parkinson's disease
Chinta, S. J., & Andersen, J. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.02.005 · Cited by 303
Self-citation
Oxidative Stress in Neurodegeneration
Shukla, V., Mishra, S. K., & Pant, H. C. (2011) · Advances in Pharmacological Sciences · doi:10.1155/2011/572634 · Cited by 303
Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease
Simmons, D. A., Casale, M., Alcon, B., Pham, N., Narayan, N., & LYNCH, G. S. (2007) · Glia · doi:10.1002/glia.20526 · Cited by 277
The transition metals copper and iron in neurodegenerative diseases
Rivera-Mancía, S., Pérez‐Neri, I., Ríos, C., Tristán-López, L. A., Rivera-Espinosa, L., & Montes, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.010 · Cited by 247
Brain iron metabolism: Neurobiology and neurochemistry
Ke, Y., & Qian, Z. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.07.009 · Cited by 239
Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications
Hidalgo, C., & Donoso, P. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1886 · Cited by 199
Brain Iron Metabolism Dysfunction in Parkinson’s Disease
Jiang, H. F., Wang, J., Rogers, J. T., & Xie, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9879-1 · Cited by 188
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells
Sun, Y., He, L., Wang, T., Wan, H., Qin, H., Wang, J., Wang, L., Gu, W., Li, T., Li, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02049-3 · Cited by 163
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke
Speer, R. E., Karuppagounder, S. S., Basso, M., Sleiman, S. F., Kumar, A., Brand, D., Smirnova, N., Gazaryan, I. G., Khim, S. J., & Ratan, R. R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.026 · Cited by 157
Redox Control of the Survival of Healthy and Diseased Cells
Zhang, Y., Du, Y., Le, W., Wang, K., Kieffer, N., & Zhang, J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3685 · Cited by 161
Iron in neuronal function and dysfunction
Salvador, G. A. (2010) · BioFactors · doi:10.1002/biof.80 · Cited by 154
Low plasma uric acid level in Parkinson's disease
Annanmäki, T., Muuronen, A., & Murros, K. E. (2007) · Movement Disorders · doi:10.1002/mds.21502 · Cited by 141
Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
Cantu, D., Schaack, J. B., & Patel, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007095 · Cited by 142
Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts
Michaeli, S., Öz, G., Sorce, D. J., Garwood, M., Uǧurbil, K., Majestic, S., & Tuite, P. (2006) · Movement Disorders · doi:10.1002/mds.21227 · Cited by 141
Prevention and restoration of lactacystin‐induced nigrostriatal dopamine neuron degeneration by novel brain‐permeable iron chelators
Zhu, W., Xie, W., Pan, T., Xu, P., Fridkin, M., Zheng, H., Jankovic, J. J., Youdim, M. B. H., & Le, W. (2007) · The FASEB Journal · doi:10.1096/fj.07-8386com · Cited by 137
Metal ions and oxidative protein modification in neurological disease.
Sayre, L. M., Moreira, P. I., Smith, M. A., & Perry, G. L. (2005) · PubMed · Cited by 135
Iron and Mechanisms of Neurotoxicity
Salvador, G. A., Uranga, R. M., & Giusto, N. M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2011/720658 · Cited by 131
Volume and iron content in basal ganglia and thalamus
Péran, P., Cherubini, A., Luccichenti, G., Hagberg, G. E., Démonet, J., Rascol, O., Celsis, P., Caltagirone, C., Spalletta, G., & Sabatini, U. (2009) · Human Brain Mapping · doi:10.1002/hbm.20698 · Cited by 116
The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease
Weng, M., Xie, X., Liu, C., Lim, K., Zhang, C., & Li, L. (2018) · Parkinson s Disease · doi:10.1155/2018/9163040 · Cited by 117
Characterization of α‐synuclein aggregation and synergistic toxicity with protein tau in yeast
Zabrocki, P., Pellens, K., Vanhelmont, T., Vandebroek, T., Griffioen, G., Wera, S., LEUVEN, F. V., & Winderickx, J. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04571.x · Cited by 111
Impaired iron status in aging research
Xu, J., Jia, Z., Knutson, M. D., & Leeuwenburgh, C. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13022368 · Cited by 103
Interactions between iron and α-synuclein pathology in Parkinson's disease
Chen, B., Wen, X., Jiang, H. F., Wang, J., Song, N., & Xie, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.06.024 · Cited by 107
Physiological and Pathological Role of Alpha-synuclein in Parkinson’s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element
Olivares, D., Huang, X., Branden, L., Greig, N. H., & Rogers, J. T. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10031226 · Cited by 93
Nutraceuticals against Neurodegeneration: A Mechanistic Insight
Dadhania, V. P., Trivedi, P. P., Vikram, A., & Tripathi, D. N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160104142223 · Cited by 93
Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort
Guerreiro, R. J., Brás, J., Santana, I. J., Januário, C., Santiago, B., Morgadinho, A., Ribeiro, M. H., Hardy, J., Singleton, A., & Oliveira, C. R. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-24 · Cited by 89
Voxel‐based analysis of R2* maps in the healthy human brain
Péran, P., Hagberg, G. E., Luccichenti, G., Cherubini, A., Brainovich, V., Celsis, P., Caltagirone, C., & Sabatini, U. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21204 · Cited by 88
Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping
Azuma, M., Hirai, T., Yamada, K., Yamashita, S., Ando, Y., Tateishi, M., Iryo, Y., Yoneda, T., Kitajima, M., Wang, Y., et al. (2016) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4645 · Cited by 88
Coal cleaning residues and Fe-minerals implications
Silva, L. F. O., Macı́as, F., Oliveira, M. L. S., da Boit, M. K., & Waanders, F. B. (2010) · Environmental Monitoring and Assessment · doi:10.1007/s10661-010-1340-8 · Cited by 87
Magnesium deficiency over generations in rats with special references to the pathogenesis of the parkinsonism–dementia complex and amyotrophic lateral sclerosis of Guam
Oyanagi, K., Kawakami, E., Kikuchi‐Horie, K., Ohara, K., Ogata, K., Takahama, S., Wada, M., Kihira, T., & YASUI, M. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00672.x · Cited by 85
Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload
Jiang, H., Luan, Z., Wang, J., & XIE, J. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.015 · Cited by 81
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
Tardiff, D. F., Tucci, M. L., Caldwell, K. A., Caldwell, G. A., & Lindquist, S. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.308668 · Cited by 78
Preparation of tissue samples for X-ray fluorescence microscopy
Chwiej, J. G., Szczerbowska‐Boruchowska, M., Lankosz, M., Wojcik, S., Falkenberg, G., Stęgowski, Z., & Setkowicz, Z. (2005) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2005.10.002 · Cited by 79
Chelators in the Treatment of Iron Accumulation in Parkinson's Disease
Mounsey, R. B., & Teismann, P. (2012) · International Journal of Cell Biology · doi:10.1155/2012/983245 · Cited by 83
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
Xu, J., Marzetti, E., Seo, A. Y., Kim, J., Prolla, T. A., & Leeuwenburgh, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.04.007 · Cited by 77
GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism
Smeyne, M., Boyd, J. D., Shepherd, K. R., Jiao, Y., Pond, B. B., Hatler, M., Wolf, C. R., Henderson, C. J., & Smeyne, R. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610978104 · Cited by 77
Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease
Wang, N., Jin, X., Guo, D., Tong, G., & Zhu, X. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b01547 · Cited by 71
Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease
SUN, F., KANTHASAMY, A. G., ANANTHARAM, V., & KANTHASAMY, A. G. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.001 · Cited by 69
Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease
Friedrich, I., Reimann, K., Jankuhn, S., Kirilina, E. P., Stieler, J., Sonntag, M., Meijer, J., Weiskopf, N., Reinert, T., Arendt, T., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01145-2 · Cited by 70
Iron Chelators as Potential Therapeutic Agents for Parkinsons Disease
Perez, C., Tong, Y., & Guo, M. (2008) · Current Bioactive Compounds · doi:10.2174/157340708786305952 · Cited by 62
Mitochondrial aconitase knockdown attenuates paraquat‐induced dopaminergic cell death via decreased cellular metabolism and release of iron and H2O2
Cantu, D., Fulton, R. E., Drechsel, D. A., & Patel, M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07290.x · Cited by 54
Nutritional habits, risk, and progression of Parkinson disease
Erro, R., Brigo, F., Tamburin, S., Zamboni, M. M., Antonini, A., & Tinazzi, M. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8639-0 · Cited by 56
Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality
Shaeib, F., Banerjee, J., Maitra, D., Diamond, M. P., & Abu‐Soud, H. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.007 · Cited by 50
Overdosing on iron: Elevated iron and degenerative brain disorders
D’Mello, S. R., & Kindy, M. S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220953065 · Cited by 49
Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity
Hašková, P., Kovařı́ková, P., Koubková, L., Jirkovská, A., Macková, E., & Šimůnek, T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.004 · Cited by 49
Iron transport in Parkinson's disease
Hirsch, É. C. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70816-8 · Cited by 46
Selegiline protects against recognition memory impairment induced by neonatal iron treatment
DELIMA, M., Laranja, D. C., Caldana, F., Grazziotin, M. M., GARCIA, V., Dal‐Pizzol, F., Bromberg, E., & Schröder, N. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.017 · Cited by 45
Systemic iron status
Beard, J., & Han, O. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.005 · Cited by 45
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
Gutbier, S., Kyriakou, S., Schildknecht, S., Ückert, A., Brüll, M., Lewis, F. W., Dickens, D., Pearson, L. T., Elson, J. L., Michel, S., et al. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02826-y · Cited by 42
Ferritin confers protection against iron-mediated neurotoxicity and ferroptosis through iron chelating mechanisms in MPP+-induced MES23.5 dopaminergic cells
Zhang, N., Yu, X., Song, L., Xiao, Z., Xie, J., & Xu, H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.018 · Cited by 41
The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease
MAZZIO, E. A., Close, F. T., & Soliman, K. F. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12010506 · Cited by 41
Late-life hemoglobin and the incidence of Parkinson's disease
Abbott, R. D., Ross, G. W., Tanner, C. M., Andersen, J. K., Masaki, K., Rodríguez, B. L., White, L. R., & Petrovitch, H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.023 · Cited by 40
Self-citation
Blood donations, iron stores, and risk of Parkinson's disease
Logroscino, G., Chen, H., Wing, A., & Ascherio, A. (2006) · Movement Disorders · doi:10.1002/mds.20826 · Cited by 38
Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy
Mills, J. D., Kim, W. S., Halliday, G. M., & Janitz, M. (2014) · Neurogenetics · doi:10.1007/s10048-014-0430-0 · Cited by 38
Investigations of differences in iron oxidation state inside single neurons from substantia nigra of Parkinson’s disease and control patients using the micro-XANES technique
Chwiej, J. G., Adamek, D., Szczerbowska‐Boruchowska, M., Krygowska‐Wajs, A., Wojcik, S., Falkenberg, G., Manka, A., & Lankosz, M. (2006) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-006-0179-5 · Cited by 38
Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseases
Mariani, S., Ventriglia, M., Simonelli, I., Spalletta, G., Bucossi, S., Siotto, M., Assogna, F., Melgari, J.-M., Vernieri, F., & Squitti, R. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00037 · Cited by 35
Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease
Carroll, C., Zeissler, M., Chadborn, N., Gibson, K., Williams, G. T., Zajicek, J., Morrison, K. E., & Hanemann, C. O. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.006 · Cited by 34
Targeting ferroptosis and mitophagy with neutrophil-inspired nanozyme for Parkinson's disease therapy
Tian, Y. Q., Wang, F., Ma, J., Huang, W., Zhang, X., Du, C., Wei, P., Huang, W., Zhu, Y., & Lin, Y. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113950 · Cited by 33
Determination of trace elements in the human substantia nigra
Morawski, M., Meinecke, C., Reinert, T., Dörffel, A. C., Riederer, P. F., Arendt, T., & Butz, T. (2005) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2005.01.061 · Cited by 33
New face of neuromelanin
Double, K. L., & Halliday, G. M. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_19 · Cited by 31
X‐ray fluorescence spectrometry, an analytical tool in neurochemical research
Szczerbowska‐Boruchowska, M. (2007) · X-Ray Spectrometry · doi:10.1002/xrs.1007 · Cited by 31
Baicalein Significantly Protects Human Retinal Pigment Epithelium Cells Against H 2 O 2 -Induced Oxidative Stress by Scavenging Reactive Oxygen Species and Downregulating the Expression of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor
Liu, J., Wann, H., Chen, M., Pan, W. H. T., Chen, Y.-C., Liu, C.-M., Yeh, M., Tsai, S., Young, M. S., Chuang, H., et al. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0063 · Cited by 31
Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome
Mills, J. D., Ward, M., Kim, W. S., Halliday, G. M., & Janitz, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.042 · Cited by 30
Detection of neuronal loss using T1ρ MRI assessment of 1H2O spin dynamics in the aphakia mouse
Michaeli, S., Burns, T. C., Kudishevich, E., Harel, N., Hanson, T., Sorce, D. J., Garwood, M., & Low, W. C. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.10.025 · Cited by 30
A Cross-Sectional Community Study of Serum Iron Measures and Cognitive Status in Older Adults
Milward, E. A., Bruce, D. G., Knuiman, M. W., Divitini, M., Cole, M., Inderjeeth, C. A., Clarnette, R., Maier, G., Jablensky, A. V., & Olynyk, J. K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1402 · Cited by 25
The impact of iron deposition on the fear circuit of the brain in patients with Parkinson’s disease and anxiety
Chen, K., Zhang, L., Mao, H., Chen, K., Shi, Y., Meng, X., Wang, F., Hu, X., & Fang, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1116516 · Cited by 24
Iron-generated hydroxyl radicals kill retinal cells in vivo: effect of ferulic acid
Chao, H., Chen, Y.-H., Liu, H., Lee, S., Lee, F.-L., Chang, Y.-C., Yeh, P., Pan, W., Chi, C. ‐., Liu, T.-Y., et al. (2008) · Human & Experimental Toxicology · doi:10.1177/0960327108092294 · Cited by 24
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson’s Disease
Liu, X., Zheng, Z., Xue, C., Wang, X., Li, J., Liu, Z., Xin, W., Xu, X., Zhou, D., Yao, L., et al. (2025) · Inflammation · doi:10.1007/s10753-025-02291-8 · Cited by 26
Iron Concentration Does Not Differ in Blood but Tends to Decrease in Cerebrospinal Fluid in Parkinson’s Disease
Shen, X., Yang, H., Zhang, D., & Jiang, H. F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00939 · Cited by 21
In vivo monitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques
Su, C., Sun, Y., Tzeng, S., Yang, C., Wang, C., & Yang, M.-H. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20240 · Cited by 22
Correlations between abnormal iron metabolism and non-motor symptoms in Parkinson’s disease
Xu, W., Zhi, Y., Yuan, Y., Zhang, B., Shen, Y., Zhang, H., Zhang, K., & Xu, Y. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1889-x · Cited by 21
Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes
Chen, Y., Li, Y., Wang, S., Zhou, T.-T., Chen, N., & Yuan, Y. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03564-6 · Cited by 22
Neuropharmacological approach against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine)-induced mouse model of Parkinson’s disease
Yokoyama, H., Kuroiwa, H., Kasahara, J., & Araki, T. (2011) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2011-1847 · Cited by 21
Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells
Wang, R., Qing, H., Liu, X., Zheng, X., & Deng, Y. (2008) · Neuroscience Bulletin · doi:10.1007/s12264-008-1214-z · Cited by 20
Calorie Restriction Down-Regulates Expression of the Iron Regulatory Hormone Hepcidin in Normal and d -Galactose–Induced Aging Mouse Brain
Wei, S., Shi, W., Li, M., & Gao, Q. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1450 · Cited by 20
Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron Overload
Enein, A. A., Dessouky, N. A. E., Mohamed, K. S., Botros, S. K. A., Gawad, M. F. A. E., Hamdy, M. M., & Dyaa, N. (2016) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2016.055 · Cited by 20
The role of α-synuclein in neurodegeneration — An update
Jellinger, K. A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0013-1 · Cited by 19
Effect of dietary iron overload in rat brain: oxidative stress, neurotransmitter level and serum metal ion in relation to neurodegenerative disorders.
Elseweidy, M. M., & El-Baky, A. E. A. (2008) · PubMed · Cited by 19
In vitro ischemia suppresses hypoxic induction of hypoxia‐inducible factor‐1α by inhibition of synthesis and not enhanced degradation
Karuppagounder, S. S., Basso, M., Sleiman, S. F., Ma, T. C., Speer, R. E., Smirnova, N. A., Gazaryan, I. G., & Ratan, R. R. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23204 · Cited by 17
Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure
Zhang, Y., Cui, Y., Cheng, Y., Zhu, W., Zhang, M., Li, S., Liu, W., Xin, W., Huang, W., & Sun, H. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105123 · Cited by 16
The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases
Bjørklund, G., Oliinyk, P., Khavrona, O. P., Lozynska, I., Lysiuk, R., Darmohray, R., Antonyak, H., Dub, N., Zayachuk, V. Y., Antoniv, О., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04321-2 · Cited by 17
Iron as a trigger of neurodegeneration in Parkinson's disease
Friedman, A., Gałązka-Friedman, J., & Bauminger, E. R. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)83023-5 · Cited by 16
Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration
Speer, R. E., & Ratan, R. R. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-7678-9_16 · Cited by 16
Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats?
Xiao, J., Yin, M., Wang, Z., & Wang, X. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/618631 · Cited by 14
Clinical Characteristics, Iron Metabolism and Neuroinflammation: New Insight into Excessive Daytime Sleepiness in Parkinson’s Disease
Hu, Y., Guo, P. F., Lian, T., Zuo, L.-J., Yu, S., Liu, L., Jin, Z. Y., Yu, Q.-J., Wang, R., Li, L., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s272110 · Cited by 14
Pharmacological manipulation of ataxia-telangiectasia kinase activity as a treatment for Parkinson’s disease
Shackelford, R. E., Manuszak, R. P., Heard, S. C., Link, C. J., & Wang, S. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.029 · Cited by 14
Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein
Rebelo, S., Henriques, A. G., Silva, E. F. D. C. E., & Silva, O. A. B. D. C. E. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20091 · Cited by 13
Multiple System Atrophy: Many Lessons from the Transcriptome
Curry‐Hyde, A., Chen, B. J., Ueberham, U., Arendt, T., & Janitz, M. (2017) · The Neuroscientist · doi:10.1177/1073858417723915 · Cited by 7
Clinical and Genetic Analysis of Costa Rican Patients With Parkinson's Disease
Acosta, G. T., Yu, E., Lobo-Prada, T., Ruiz‐Martínez, J., Pagola, A. G., Gan‐Or, Z., Carazo-Céspedes, K., Trempe, J.-F., Mata, I. F., & Trías, J. F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.656342 · Cited by 8

Authors: Kaur, D., & Andersen, J.
Affiliations: Buck Institute for Research on Aging (US)
Corresponding author: Andersen, Julie
ORCID: Andersen, Julie
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2004-07
Volume: 3
Issue: 3
Pages: 327-343
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2004.01.003
OpenAlex: W1998032181
Cited by: 123
References: 98
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 8 · 2012: 7
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG-12141)
National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Parkinson's disease, iron homeostasis, iron regulatory proteins, oxidative stress, dopaminergic neuron loss, neurodegeneration, alpha-synuclein aggregation, Lewy bodies, energy metabolism
MeSH terms: Animals, Homeostasis, Humans, Iron, Mesencephalon, Mitochondria, Models, Biological, Nerve Tissue Proteins, Parkinson Disease, Protein Binding, Oxidative Stress, Neurodegenerative Diseases, Iron-Regulatory Proteins, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Synucleins, alpha-Synuclein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Does cellular iron dysregulation play a causative role in Parkinson’s disease?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks