Heart rate, lifespan, and mortality risk

Zhang, Gus Q.; Zhang, Weiguo

doi:10.1016/j.arr.2008.10.001

Cited by 139Heart Rate Variability and Autonomic ControlGenetics, Aging, and Longevity in Model OrganismsHeart rate and cardiovascular health

Heart rate, lifespan, and mortality risk

Zhang, Gus Q., Zhang, Weiguo·2009·Ageing Research Reviews

DOI 10.1016/j.arr.2008.10.001

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Abstract

An increasing body of scientific research and observational evidence indicates that resting heart rate (HR) is inversely related to the lifespan among homeothermic mammals and within individual species. In numerous human studies with patients stratified by resting HR, increased HR is universally associated with greater risk of death. The correlation between HR and maximum lifespan seems to be due to both basal metabolic rate and cardiovascular-related mortality risk. Both intrinsic and extrinsic factors are already postulated to determine how the biological clock works, through regulating and modulating the processes such as protein oxidation, free radical production, inflammation and telomere shortening. Given the remarkable correlation between HR and lifespan, resting HR should be seriously considered as another possible cap on maximum lifespan. Future research is needed to determine whether deliberate cardiac slowing, through methods like lifestyle modification, pharmacological intervention, or medical devices, can decelerate biological clock of aging, reduce cardiovascular mortality and increase maximum lifespan in humans in general.

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High resting heart rate is associated with increased mortality risk.
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From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [226]
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Right phrenic nerve injury with diaphragmatic paralysis, pericarditis, SVC stenosis, and cardiac tamponade during pericardial balloon placement requiring open-chest repair have all been reported.
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Funck‐Brentano, C. (2006) · European Heart Journal Supplements · doi:10.1093/eurheartj/sul010 · Cited by 21 · see citing works
Therapeutic effects of If blockade: Evidence and perspective
Borer, J. S. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.03.017 · Cited by 20 · see citing works
Nitric Oxide Pathway as New Drug Targets for Refractory Hypertension
Augustyniak, R. A., Thomas, G. D., Victor, R. G., & Zhang, W. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774424672 · Cited by 20 · see citing works
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Hypertension and Counter-Hypertension Mechanisms in Giraffes
Zhang, Q. (2006) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152906776092640 · Cited by 19 · see citing works
Specific and selective If inhibition: expected clinical benefits from pure heart rate reduction in coronary patients
Ferrari, R., Campo, G. C., Gardini, E., Pasanisi, G., & Ceconi, C. (2005) · European Heart Journal Supplements · doi:10.1093/eurheartj/sui048 · Cited by 17 · see citing works
Heart rate-lowering calcium antagonists in hypertensive post-myocardial infarction patients
Messerli, F. H., Hansen, J. F., Gibson, R. S., Schechtman, K. B., & Boden, W. E. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00019 · Cited by 16 · see citing works
Beta‐Blocker Therapy for Heart Failure: Should the Therapeutic Target Be Dose or Heart Rate Reduction?
Huang, R. L., Listerman, J., Goring, J., Giesberg, C., Nading, M. A., & Butler, J. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2006.05477.x · Cited by 15 · see citing works
Presynaptic interactions between acetylcholine and adrenergic antagonists on norepinephrine release.
Kalsner, S., & Quillan, M. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24618-3 · Cited by 14 · see citing works
Resetting baroreceptors to a lower arterial pressure level by enalapril avoids baroreflex mediated activation of sympathetic nervous system by nifedipine
Zhang, W., & Wang, Z. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01078-5 · Cited by 13 · see citing works
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CAN WE USE CALCIUM ANTAGONIST BETTER IN ANTIHYPERTENSIVE THERAPY? CIRCADIAN CONSIDERATION
Zhang, W. (1996) · Pharmacological Research · doi:10.1006/phrs.1996.0087 · Cited by 12 · see citing works
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Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs
Gare, M., Mraović, B., Kehl, F., Kersten, J. R., Warltier, D. C., & Pagel, P. S. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00030-x · Cited by 11 · see citing works
Direct interaction between the sympathetic and renin–angiotensin system in myocardial tissue: a microdialysis study in anaesthetised rats
Teisman, A. C. H., Westerink, B. H. C., van Veldhuisen, D. J., Scholtens, E., de Zeeuw, D., & van Gilst, W. H. (2000) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(99)00066-1 · Cited by 10 · see citing works
Cardiac beat frequency and oxygen supply: A comparative study
Poupa, O., & Brix, O. (1984) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(84)90082-3 · Cited by 8 · see citing works
Improved Control of Resistant Hypertension With Device‐Mediated Electrical Carotid Sinus Baroreflex Stimulation
Sloand, J. A., Illig, K. A., & Bisognano, J. D. (2007) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.07159.x · Cited by 8 · see citing works
Effects of hydralazine on renal sympathetic nerve activity in normal and congestive heart failure rats
ZHANG, W., SUN, X., ZHAO, X.-Y. S. X.-H., Thorén, P., & Hedner, T. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00151.x · Cited by 7 · see citing works
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Characterizing Blood Pressure, Heart Rate, Physical Activity, Circadian Rhythm and their Response to NOS Inhibitor and Substrate in CHF Rats with Telemetry
Zhang, W., Wang, Z., & Zhang, W. (2008) · Vascular Disease Prevention · doi:10.2174/1567270000401010019 · Cited by 4 · see citing works
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Characterizing Blood Pressure, Heart Rate, Physical Activity, Circadian Rhythm and their Response to NOS Inhibitor and Substrate in CHF Rats with Telemetry
Zhang, W., Wang, Z., & Zhang, W. (2004) · Vascular Disease Prevention · doi:10.2174/1567270043405222 · Cited by 4 · see citing works
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Synthetic Retinoids Improve Survival in Rodent Model of Endotoxic Shock
Gidlöf, W. Z. A. C. (2000) · The European Journal of Surgery · doi:10.1080/110241500750009537 · Cited by 3 · see citing works

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Socio‐economic differentials in peripheral biology: Cumulative allostatic load
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A., & McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05341.x · Cited by 579 · see citing works
Telomere shortening rate predicts species life span
Whittemore, K., Vera, E., Martínez-Nevado, E., Sanpera, C., & Blasco, M. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902452116 · Cited by 373 · see citing works
Calcific aortic valve disease: mechanisms, prevention and treatment
Moncla, L.-H. M., Briend, M., Bossé, Y., & Mathieu, P. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00845-7 · Cited by 319 · see citing works
Antihypertensive effects and mechanisms of chlorogenic acids
Zhao, Y., Wang, J., Ballèvre, O. P., Luo, H., & Zhang, W. (2011) · Hypertension Research · doi:10.1038/hr.2011.195 · Cited by 297 · see citing works
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The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging
Bruins, M. J., Dael, P. V., & Eggersdorfer, M. L. (2019) · Nutrients · doi:10.3390/nu11010085 · Cited by 231 · see citing works
Cardiac electrophysiology in mice: a matter of size
Kaese, S., & Verheule, S. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00345 · Cited by 196 · see citing works
Wearable triboelectric nanogenerators for heart rate monitoring
Shen, S., Xiao, X., Xiao, X., & Chen, J. (2021) · Chemical Communications · doi:10.1039/d1cc02091a · Cited by 133 · see citing works
Dysregulated physiological stress systems and accelerated cellular aging
Révész, D., Verhoeven, J. E., Milaneschi, Y., de Geus, E. J. C., Wolkowitz, O. M., & Penninx, B. W. J. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.027 · Cited by 112 · see citing works
Sensing with Earables
Röddiger, T., Clarke, C., Breitling, P., Schneegans, T., Zhao, H., Gellersen, H. W., & Beigl, M. (2022) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3550314 · Cited by 104 · see citing works
The vertebrate heart: an evolutionary perspective
Stephenson, A., Adams, J. W., & Vaccarezza, M. (2017) · Journal of Anatomy · doi:10.1111/joa.12687 · Cited by 101 · see citing works
ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.56 · Cited by 98 · see citing works
The role of cardiovascular activity in fibromyalgia and conditioned pain modulation
Chalaye, P., Lafrenaye, S., Goffaux, P., & Marchand, S. (2013) · Pain · doi:10.1016/j.pain.2013.12.023 · Cited by 77 · see citing works
Respiratory sinus arrhythmia (RSA), vagal tone and biobehavioral integration: Beyond parasympathetic function
Grossman, P. (2023) · Biological Psychology · doi:10.1016/j.biopsycho.2023.108739 · Cited by 73 · see citing works
Metabolic syndrome is associated with and predicted by resting heart rate: a cross-sectional and longitudinal study
Jiang, X., Liu, X., Wu, S., Zhang, G. Q., Peng, M., Wu, Y., Zheng, X., Ruan, C., & Zhang, W. (2014) · Heart · doi:10.1136/heartjnl-2014-305685 · Cited by 68 · see citing works
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Biomolecular and Clinical Aspects of Chinese Wolfberry
Bucheli, P., Gao, Q., Redgwell, R., Vidal, K., Wang, J., & Zhang, W. (2011) · Oxidative stress and disease · doi:10.1201/b10787-15 · Cited by 63 · see citing works
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Association between resting heart rate and arterial stiffness in Korean adults
Park, B., Lee, H.-R., Shim, J., Lee, J., Jung, D., & Lee, Y. (2010) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2010.03.004 · Cited by 61 · see citing works
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
Pillinger, T., Arumuham, A., McCutcheon, R. A., D’Ambrosio, E., Basdanis, G., Branco, M., Carr, R., Finelli, V., Furukawa, T. A., Gee, S., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01293-0 · Cited by 64 · see citing works
Sinus Tachycardia: a Multidisciplinary Expert Focused Review
Mayuga, K. A., Fedorowski, A., Ricci, F., Gopinathannair, R., Dukes, J. W., Gibbons, C., Hanna, P., Sorajja, D., Chung, M., Benditt, D., et al. (2022) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.121.007960 · Cited by 59 · see citing works
Electro-fluid-mechanics of the heart
Verzicco, R. (2022) · Journal of Fluid Mechanics · doi:10.1017/jfm.2022.272 · Cited by 55 · see citing works
Impact of changes in heart rate with age on all-cause death and cardiovascular events in 50-year-old men from the general population
Chen, X.-J., Barywani, S. B., Hansson, P.-O., Östgärd Thunström, E., Rosengren, A., Ergatoudes, C., Mandalenakis, Z., Caidahl, K., & Fu, M. L. (2019) · Open Heart · doi:10.1136/openhrt-2018-000856 · Cited by 54 · see citing works
The association between three major physiological stress systems and oxidative DNA and lipid damage
Black, C. N., Bot, M., Révész, D., Scheffer, P. G., & Penninx, B. W. J. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.003 · Cited by 52 · see citing works
Machine learning in biosignals processing for mental health: A narrative review
Sajno, E., Bartolotta, S., Tuena, C., Cipresso, P., Pedroli, E., & Riva, G. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1066317 · Cited by 50 · see citing works
Getting to the Heart of the Matter: Age-related Changes in Diastolic Heart Function in the Longest-lived Rodent, the Naked Mole Rat
Grimes, K. M., Lindsey, M. L., Gelfond, J., & Buffenstein, R. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr222 · Cited by 44 · see citing works
How scaling approaches can reveal fundamental principles in physiology and biomechanics
Clemente, C. J., & Dick, T. J. M. (2023) · Journal of Experimental Biology · doi:10.1242/jeb.245310 · Cited by 42 · see citing works
Resting Heart Rate Percentiles and Associated Factors in Children and Adolescents
Sarganas, G., Rosario, A. S., & Neuhauser, H. K. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.05.021 · Cited by 42 · see citing works
Combined effect of resting heart rate and physical activity on ischaemic heart disease: mortality follow-up in a population study (the HUNT study, Norway)
Nauman, J., Nilsen, T. I. L., Wisløff, U., & Vatten, L. J. (2010) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2009.093088 · Cited by 41 · see citing works
Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials
Hidayat, K., Yang, J., Zhang, Z., Chen, G., Qin, L., Eggersdorfer, M. L., & Zhang, W. (2017) · European Journal of Clinical Nutrition · doi:10.1038/s41430-017-0052-3 · Cited by 39 · see citing works
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Associations of Neuropsychiatric Symptoms and Antidepressant Prescription with Survival in Alzheimer’s Disease
Mueller, C., Huntley, J. D., Stubbs, B., Sommerlad, A., Carvalho, A. F., Perera, G., Stewart, R. J., & Veronese, N. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.07.001 · Cited by 38 · see citing works
Resting heart rate is associated with metabolic syndrome and predicted 10‐year risk of cardiovascular disease: a cross‐sectional study
Wu, X., Du, R., Hu, C., Cheng, D., Ma, L., Li, M., Xu, Y., Xu, M., Chen, Y., Li, D., et al. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12927 · Cited by 30 · see citing works
A Systematic Review and Meta-Analysis of Tai Chi Training in Cardiorespiratory Fitness of Elderly People
Tan, T., Meng, Y., Lyu, J., Zhang, C., Wang, C., Liu, M., Zhao, X., Lyu, T., & Wei, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4041612 · Cited by 27 · see citing works
Heritability of heart rate recovery and vagal rebound after exercise
Nederend, I., Schutte, N. M., Bartels, M., ten Harkel, A. D. J., & de Geus, E. J. C. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3459-y · Cited by 26 · see citing works
Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats
Hassan, H. A., & Abdel-Wahhab, M. A. (2011) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-011-0137-8 · Cited by 26 · see citing works
Heart rate reduction and longevity in mice
Gent, S., Kleinbongard, P., Dammann, P., Neuhäuser, M., & Heusch, G. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-014-0460-7 · Cited by 25 · see citing works
Dominant Parasympathetic Modulation of Heart Rate and Heart Rate Variability in a Wild-Caught Seabird
Carravieri, A., Müller, M. S., Yoda, K., Hayama, S., & Yamamoto, M. (2016) · Physiological and Biochemical Zoology · doi:10.1086/686894 · Cited by 22 · see citing works
Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction
Afanasiev, S. A., Pavlyukova, E. N., Kuzmichkina, M. A., Rebrova, Т. Y., Anfinogenova, Y., Сергеевич, Л. К., & Karpov, R. S. (2016) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12349 · Cited by 22 · see citing works
Association of Ambulatory Blood Pressure and Heart Rate With Advanced White Matter Lesions in Ischemic Stroke Patients
Kwon, H. S., Lim, Y., Kim, H. Y., Kim, H.-T., Kwon, H., Lim, J., Lee, Y., Kim, J. Y., & Kim, Y. S. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt199 · Cited by 21 · see citing works
The effect of exercises on left ventricular systolic and diastolic heart function in sedentary women: Step-aerobic vs core exercises
Çiçek, G., İmamoğlu, O., Güllü, A., Çelik, O., Özcan, O., Güllü, E., & Yamaner, F. (2017) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2017.07.002 · Cited by 21 · see citing works
The impact of changes in leisure time physical activity on changes in cardiovascular risk factors: results from The Finnmark 3 Study and SAMINOR 1, 1987–2003
Hermansen, R., Broderstad, A. R., Jacobsen, B. K., Mähönen, M., Wilsgaard, T., & Morseth, B. (2018) · International Journal of Circumpolar Health · doi:10.1080/22423982.2018.1459145 · Cited by 19 · see citing works
Heart rate effects on the ventricular hemodynamics and mitral valve kinematics
Meschini, V., Viola, F., & Verzicco, R. (2019) · Computers & Fluids · doi:10.1016/j.compfluid.2019.104359 · Cited by 19 · see citing works
Age-related attenuation of parasympathetic control of the heart in mice.
Freeling, J., & Li, Y. (2015) · PubMed Central · Cited by 19 · see citing works
Human Heart Cardiomyocytes in Drug Discovery and Research: New Opportunities in Translational Sciences
Abi‐Gerges, N., Miller, P. E., & Ghetti, A. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666191210142023 · Cited by 18 · see citing works
Ageing differently: Sex-dependent ageing rates in Daphnia magna
Constantinou, J. K., Sullivan, J., & Mirbahai, L. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.03.008 · Cited by 18 · see citing works
The Interplay of Aging, Aortic Stiffness and Blood Viscosity in Atherogenesis
Sloop, G. D., Weidman, J. J., Shecterle, L. M., & Cyr, J. A. S. (2015) · Journal of Cardiology and Therapy · doi:10.17554/j.issn.2309-6861.2015.02.77 · Cited by 17 · see citing works
Left ventricular hypertrophy induced by abdominal aortic banding and its prevention by angiotensin receptor blocker telmisartan—a proteomic analysis
Liu, L., Wang, W., Meng, X., Gao, J., Wu, H., Wang, P., Wu, W., Wang, L., Ma, L., & Zhang, W. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0039-1 · Cited by 17 · see citing works
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Unraveling the discrepancies between REDUCE-IT and STRENGTH trials with omega-3 fatty acids: new analytical approaches
Zhang, W., Gan, D., Huo, S., & Chen, P. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1490953 · Cited by 14 · see citing works
Self-citation
The Paradoxical Health Effects of Occupational Versus Leisure-Time Physical Activity
Holtermann, A., Coenen, P., & Krause, N. (2020) · Handbook series in occupational health sciences · doi:10.1007/978-3-030-31438-5_6 · Cited by 14 · see citing works
Human Heart Rate
Zhang, K., Deacon, D. C., Rao, F., Schork, A. J., Fung, M. M., Waalen, J., Schork, N. J., Nievergelt, C. M., Chi, N. C., & O’Connor, D. T. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.025 · Cited by 13 · see citing works
Heart rate awareness in patients with chronic stable heart failure. A multi-center observational study
Moran, D. H., Buckley, A., Daly, K. M., Meaney, B., Curtin, R. J., O’Neill, J., Colwell, N. S., Mahon, N., Murphy, N. F., O’Hanlon, R., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.119 · Cited by 13 · see citing works
Novel drugs for heart rate control in heart failure
Bielecka-Dabrowa, A. M., von Haehling, S., Rysz, J., & Banach, M. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9696-x · Cited by 12 · see citing works
Increased NT-proANP predicts risk of congestive heart failure in Cavalier King Charles spaniels with mitral regurgitation caused by myxomatous valve disease
Eriksson, A., Häggström, J. U., Pedersen, H. D., Hansson, K., Järvinen, A., Haukka, J. K., & Kvart, C. (2014) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2014.05.001 · Cited by 12 · see citing works
Assessment of potential cardiovascular risks of methylphenidate in comparison with sibutramine: do we need a SCOUT (trial)?
Antel, J., Albayrak, Ö., Heusch, G., Banaschewski, T., & Hebebrand, J. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0522-8 · Cited by 11 · see citing works
Ivabradine has a neutral effect on mortality in randomized controlled trials
Kang, S., Li, C.-J., & Zhang, X. (2017) · Medicine · doi:10.1097/md.0000000000008067 · Cited by 11 · see citing works
Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials
Nie, Z., Liu, Y., Zhang, M., Wu, C., Cao, Q., Xu, J., Zheng, Y., Min, Z., Zhang, W., & Han, S. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf220 · Cited by 10 · see citing works
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Requirements for essential micronutrients during caloric restriction and fasting
Zhang, W., Chen, P., Huo, S., Huang, X., & Zhao, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1363181 · Cited by 10 · see citing works
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Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals
Whittemore, K., Martínez‐Nevado, E., & Blasco, M. A. (2019) · Aging · doi:10.18632/aging.102430 · Cited by 9 · see citing works
Chronotropic effects and mechanisms of long-chain omega-3 polyunsaturated fatty acids on heartbeat: the latest insights
Zhang, W. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab009 · Cited by 11 · see citing works
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Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age
Wang, J., Huang, H. D., Yang, W., Dove, A., Ma, X., & Xu, W. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.76 · Cited by 10 · see citing works
Association between change in heart rate over years and life span in the Paris Prospective 1, the Whitehall 1, and Framingham studies
Gaye, B., Valentin, E., Xanthakis, V., Perier, M., Celermajer, D. S., Shipley, M. J., Marijon, É., Song, R. J., Empana, J. P., Vasan, R. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70806-8 · Cited by 9 · see citing works
Life Expectancy in Marine Mammals Is Unrelated to Telomere Length but Is Associated With Body Size
Buddhachat, K., Brown, J. L., Kaewkool, M., Poommouang, A., Kaewmong, P., Kittiwattanawong, K., & Nganvongpanit, K. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.737860 · Cited by 9 · see citing works
Two New Calibration Techniques of Lumped‐Parameter Mathematical Models for the Cardiovascular System
Tonini, A., Regazzoni, F., Salvador, M., Dede’, L., Scrofani, R., Fusini, L., Cogliati, C. B., Pontone, G., Vergara, C., & Quarteroni, A. M. (2025) · International Journal for Numerical Methods in Engineering · doi:10.1002/nme.7648 · Cited by 8 · see citing works
Applied Healthspan Engineering
Larrick, J. W., & Mendelsohn, A. R. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0969 · Cited by 8 · see citing works
The Impact of Carvedilol and Metoprolol on Serum Lipid Concentrations and Symptoms in Patients with Hyperthyroidism
Ozbilen, S., Eren, M. A., Turan, M. N., & Sabuncu, T. (2012) · Endocrine Research · doi:10.3109/07435800.2011.643436 · Cited by 8 · see citing works
Nurse-led lifestyle intervention in a cohort of schizophrenia patients treated with clozapine
Mallorquí, A., Oliveira, C., Ríos, J., Isla-Pera, M. P., Gil-Badenes, J., Amoretti, S., Bernardo, M., Vieta, E., Parellada, E., Garriga, M., et al. (2023) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2023.06.008 · Cited by 7 · see citing works
Differences in heart rate responses to upright posture are associated with variations in the high-frequency power of heart rate variability
Bouquin, H., Koskela, J., Tikkakoski, A., Honkonen, M., Hiltunen, T. P., Mustonen, J. T., & Pörsti, I. H. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2023 · Cited by 7 · see citing works
The Paradoxical Health Effects of Occupational Versus Leisure-Time Physical Activity
Holtermann, A., Coenen, P., & Krause, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-05031-3_6-1 · Cited by 7 · see citing works
Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
Okada, H., Tanaka, M., Yasuda, T., Okada, Y., Norikae, H., Fujita, T., Nishi, T., Oyamada, H., Yamane, T., & Fukui, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-81702-w · Cited by 7 · see citing works
The effect of 8 weeks moderate-intensity continuous training on central hemodynamics and VO2max in non-athlete male
Javad, M. (2021) · Physical Education of Students · doi:10.15561/20755279.2021.0305 · Cited by 7 · see citing works
Heart rate variability and its modulation by nutrients: a narrative review on implications for cardiovascular aging
Zhao, Y., Chen, P., Zhang, Y., Huo, S., Yu, D., Zeng, X., & Zhang, W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1654796 · Cited by 6 · see citing works
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A meta-analysis and systematic review of randomized clinical trials on the effect of coffee consumption on heart rate
Han, S., Qiu, Y., Zhang, G. Q., Lian, F., & Zhang, W. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad110 · Cited by 6 · see citing works
Self-citation
Resting Pulse Rate as a Potentially Useful Autonomic Marker for Neurologically-Based Chiropractic Practice
(2013) · The Internet Journal of Chiropractic · doi:10.5580/2ccc · Cited by 6 · see citing works
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies
Alizadeh, E. A., Trautmann, T., Krause, F., Knoeferl, B., Guns, P., Meyer, G. R. Y. D., Guth, B. D., & Markert, M. (2023) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2023.107263 · Cited by 6 · see citing works
Peto’s “Paradox” and Six Degrees of Cancer Prevalence
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Md, P. P. (2016)
Freqüência cardíaca e risco cardiovascular
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(2016)
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Authors: Zhang, G. Q., & Zhang, W.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Zhang, Weiguo
ORCID: Zhang, Weiguo
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2009-01
Volume: 8
Issue: 1
Pages: 52-60
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2008.10.001
OpenAlex: W2009328775
Semantic Scholar: 0ba98846db474ce32a32a0feaf7580ec7842b8e3
Cited by: 139
References: 103
Citations by year: 2026: 6 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 3 · 2019: 13 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 8
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords: resting heart rate, lifespan, mortality risk, maximum lifespan, basal metabolic rate, cardiovascular mortality, biological clock, aging, telomere shortening, free radicals, protein oxidation, inflammation, cardiac slowing
MeSH terms: Anti-Arrhythmia Agents, Cardiovascular Diseases, Heart Rate, Humans, Longevity, Exercise, Survival Rate, Risk Assessment

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