The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Dysregulation of human Toll-like receptor function in aging
Open accessAbstract
Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses. In particular, aging results in alterations in the function of Toll-like receptors (TLRs), the first described pattern recognition receptor family of the innate immune system. Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models. In general, these studies show that human TLR function is impaired in the context of aging, and in addition there is evidence for inappropriate persistence of TLR activation in specific systems. These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients.
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“Age-related variations in cytokine production are seen in the APC isolated from older donors and efficient TLR stimulation may overcome the age associated TLR signaling dysfunction (219).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [219]
In the citing paper
“Age-related variations in cytokine production are seen in the APC isolated from older donors and efficient TLR stimulation may overcome the age associated TLR signaling dysfunction (219).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [219]
In the citing paper
“In addition, age-related alterations in pathogen recognition, decreased PRR expression, and diminished responses to secondary signaling may underlie increased susceptibility of older persons to infectious stimuli (109).”
From Aging and Lung Disease (2020) · cites this paper as [109]
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Citations
Cites
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
Kollmann, T. R., Levy, O., Montgomery, R. R., & Goriely, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.014 · Cited by 591
Self-citationSolana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Metadata
- Authors
- Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Shaw, Albert C.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 10
- Issue
- 3
- Pages
- 346-353
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC3633557
- OpenAlex
- W1968377406
- Cited by
- 215
- References
- 91
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 20 · 2020: 13 · 2019: 16 · 2018: 19 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 21 · 2012: 13
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01ai50031-6-0-1)
- National Institute on Aging (T32 AG1934, P30AG021342)
- National Institute of Allergy and Infectious Diseases (N01 AI500031, R01AI041440, N01 AI050031, N01-AI-50031, R01AI032947, U19AI089992)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Toll-like receptors, immunosenescence, aging, innate immunity, pattern recognition receptors, elderly patients
- MeSH terms
- Aged, Aged, 80 and over, Aging, Dendritic Cells, Humans, Immunity, Innate, Macrophages, Signal Transduction, Toll-Like Receptors
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