Cited by 218Immune Response and InflammationImmune responses and vaccinationsGenetics, Aging, and Longevity in Model Organisms

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Dysregulation of human Toll-like receptor function in aging

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Shaw, Albert C., Panda, Alexander, Joshi, Samit R., Qian, Feng, Allore, Heather G., Montgomery, Ruth R.·2011·Ageing Research Reviews

DOI 10.1016/j.arr.2010.10.007PMC PMC3633557

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Abstract

Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses. In particular, aging results in alterations in the function of Toll-like receptors (TLRs), the first described pattern recognition receptor family of the innate immune system. Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models. In general, these studies show that human TLR function is impaired in the context of aging, and in addition there is evidence for inappropriate persistence of TLR activation in specific systems. These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients.

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Authors: Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R.
Affiliations: Yale University (US)
Corresponding author: Shaw, Albert C.
ORCID: Shaw, Albert C.
Joshi, Samit R.
Qian, Feng
Allore, Heather G.
Montgomery, Ruth R.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2011-07
Volume: 10
Issue: 3
Pages: 346-353
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2010.10.007
PMC: PMC3633557
OpenAlex: W1968377406
Cited by: 215
References: 91
Citations by year: 2026: 5 · 2025: 7 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 20 · 2020: 13 · 2019: 16 · 2018: 19 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 21 · 2012: 13
FWCI: 1.02
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (n01ai50031-6-0-1)
National Institute on Aging (T32 AG1934, P30AG021342)
National Institute of Allergy and Infectious Diseases (N01 AI500031, R01AI041440, N01 AI050031, N01-AI-50031, R01AI032947, U19AI089992)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: Toll-like receptors, immunosenescence, aging, innate immunity, pattern recognition receptors, elderly patients
MeSH terms: Aged, Aged, 80 and over, Aging, Dendritic Cells, Humans, Immunity, Innate, Macrophages, Signal Transduction, Toll-Like Receptors

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Dysregulation of human Toll-like receptor function in aging

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