Influence of aging on thermal and vibratory thresholds of quantitative sensory testing
Abstract
Abstract Quantitative sensory testing has become a common approach to evaluate thermal and vibratory thresholds in various types of neuropathies. To understand the effect of aging on sensory perception, we measured warm, cold, and vibratory thresholds by performing quantitative sensory testing on a population of 484 normal subjects (175 males and 309 females), aged 48.61 ± 14.10 (range 20–86) years. Sensory thresholds of the hand and foot were measured with two algorithms: the method of limits (Limits) and the method of level (Level). Thresholds measured by Limits are reaction‐time‐dependent, while those measured by Level are independent of reaction time. In addition, we explored (1) the correlations of thresholds between these two algorithms, (2) the effect of age on differences in thresholds between algorithms, and (3) differences in sensory thresholds between the two test sites. Age was consistently and significantly correlated with sensory thresholds of all tested modalities measured by both algorithms on multivariate regression analysis compared with other factors, including gender, body height, body weight, and body mass index. When thresholds were plotted against age, slopes differed between sensory thresholds of the hand and those of the foot: for the foot, slopes were steeper compared with those for the hand for each sensory modality. Sensory thresholds of both test sites measured by Level were highly correlated with those measured by Limits, and thresholds measured by Limits were higher than those measured by Level. Differences in sensory thresholds between the two algorithms were also correlated with age: thresholds of the foot were higher than those of the hand for each sensory modality. This difference in thresholds (measured with both Level and Limits) between the hand and foot was also correlated with age. These findings suggest that age is the most significant factor in determining sensory thresholds compared with the other factors of gender and anthropometric parameters, and this provides a foundation for investigating the neurobiologic significance of aging on the processing of sensory stimuli.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The decline in touch sensitivity is more severe for the lower extremities.
“this decline is more severe for the lower extremities (Kenshalo, 1986; Lin et al., 2005)”
From Design Principles to Accommodate Older Adults (2012) · cites this paper as Lin et al., 2005
Cites
Mapping cortical change across the human life span
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328 · see citing works
The physiological basis of transcranial motor cortex stimulation in conscious humans
Lazzaro, V. D., Oliviero, A., Pilato, F., Saturno, E., Dileone, M., Mazzone, P., Insola, A., Tonali, P. A., & Rothwell, J. C. (2003) · Clinical Neurophysiology · doi:10.1016/j.clinph.2003.10.009 · Cited by 583 · see citing works
Rowland, L. P. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62285-x · Cited by 581 · see citing works
Epidermal Nerve Fiber Density: Normative Reference Range and Diagnostic Efficiency
McArthur, J. C., Stocks, E. A., Hauer, P., Cornblath, D. R., & Griffin, J. W. (1998) · Archives of Neurology · doi:10.1001/archneur.55.12.1513 · Cited by 560 · see citing works
Neural Events and the Psychophysical Law
Stevens, S. S. (1970) · Science · doi:10.1126/science.170.3962.1043 · Cited by 551 · see citing works
Shy, M. E., Frohman, E. M., So, Y. T., Arezzo, J. C., Cornblath, D. R., Giuliani, M. J., Kincaid, J. C., Ochoa, J. L., Parry, G. J., & Weimer, L. H. (2003) · Neurology · doi:10.1212/01.wnl.0000058546.16985.11 · Cited by 515 · see citing works
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
Brooks, J. C. W., Nurmikko, T. J., Bimson, W. E., Singh, K. D., & Roberts, N. (2002) · NeuroImage · doi:10.1006/nimg.2001.0974 · Cited by 402 · see citing works
Periquet, M. I., Novak, V., Collins, M. P., Nagaraja, H. N., Erdem‐Özdamar, S., Nash, S. M., Freimer, M. L., Sahenk, Z., Kissel, J. T., & Mendell, J. R. (1999) · Neurology · doi:10.1212/wnl.53.8.1641 · Cited by 375 · see citing works
Edwards, R. R., Fillingim, R. B., & Ness, T. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00324-x · Cited by 356 · see citing works
Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments
Shun, C., Chang, Y., Wu, H., Hsieh, S., Lin, W., Lin, Y., Tai, T., & Hsieh, S. (2004) · Brain · doi:10.1093/brain/awh180 · Cited by 356 · see citing works
Self-citationNational Cancer Institute (2020) · Definitions · doi:10.32388/jzk490 · Cited by 356 · see citing works
Thermal testing: normative data and repeatability for various test algorithms
Yarnitsky, D., & Sprecher, E. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90239-9 · Cited by 303 · see citing works
Bell-Krotoski, J. A., Weinstein, S., & Weinstein, C. D. (1993) · Journal of Hand Therapy · doi:10.1016/s0894-1130(12)80292-4 · Cited by 299 · see citing works
Quantitative measurement of pain sensation in patients with Parkinson disease
Djaldetti, R., Shifrin, A., Rogowski, Z., Sprecher, E., Melamed, E., & Yarnitsky, D. (2004) · Neurology · doi:10.1212/01.wnl.0000130455.38550.9d · Cited by 290 · see citing works
The innervation of human epidermis
Kennedy, W. R., & Wendelschafer‐Crabb, G. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90223-l · Cited by 277 · see citing works
Variables influencing neuropathic endpoints
Dyck, P. J. B., Litchy, W. J., Lehman, K. A., Hokanson, J. L., Low, P. A., & O’Brien, P. C. (1995) · Neurology · doi:10.1212/wnl.45.6.1115 · Cited by 274 · see citing works
What does chronic electrical stimulation teach us about muscle plasticity?
Pette, D., & Vrbov�, G. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199906)22:6 · Cited by 246 · see citing works
WARM AND COLD SPECIFIC SOMATOSENSORY SYSTEMS
Yarnitsky, D., & Ochoa, J. L. (1991) · Brain · doi:10.1093/brain/114.4.1819 · Cited by 229 · see citing works
Effects of age and sex on volumes of the thalamus, pons, and cortex
Sullivan, E. V., Rosenbloom, M. J., Serventi, K. L., & Pfefferbaum, A. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00044-7 · Cited by 217 · see citing works
Cool, warm, and heat‐pain detection thresholds
Dyck, P. J., Zimmerman, I. R., Gillen, D. A., Johnson, D. M., Karnes, J. L., & O’Brien, P. C. (1993) · Neurology · doi:10.1212/wnl.43.8.1500 · Cited by 209 · see citing works
Similarities between hearing and skin sensations.
von Békésy, G. (1959) · Psychological Review · doi:10.1037/h0046967 · Cited by 207 · see citing works
The effect of age and gender on epidermal nerve fiber density
Gøransson, L. G., Mellgren, S. I., Lindal, S., & Omdal, R. (2004) · Neurology · doi:10.1212/01.wnl.0000113732.41127.8f · Cited by 207 · see citing works
Quantification of myelinated endings and mechanoreceptors in human digital skin
Nolano, M., Provitera, V., Crisci, C., Stancanelli, A., Wendelschafer‐Crabb, G., Kennedy, W. R., & Santoro, L. (2003) · Annals of Neurology · doi:10.1002/ana.10615 · Cited by 201 · see citing works
Dyck, P. J., Dyck, P. J., Larson, T. S., O’Brien, P. C., & Velosa, J. A. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.510 · Cited by 190 · see citing works
Impact of Age, Gender and Cognitive Functioning on Pain Perception
Pickering, G. P., Jourdan, D., Eschalier, A., & Dubray, C. (2002) · Gerontology · doi:10.1159/000048937 · Cited by 185 · see citing works
Dyck, P. J. B., Bushek, W., Spring, E. M., Karnes, J. L., Litchy, W. J., O'Brien, P. C., & Service, F. J. (1987) · Diabetes Care · doi:10.2337/diacare.10.4.432 · Cited by 183 · see citing works
Gruener, G., & Dyck, P. J. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199411000-00004 · Cited by 174 · see citing works
Cutaneous innervation in Guillain-Barre syndrome: pathology and clinical correlations
Pan, C. (2003) · Brain · doi:10.1093/brain/awg039 · Cited by 170 · see citing works
Enzyme replacement therapy improves function of C-, Aδ-, and Aβ-nerve fibers in Fabry neuropathy
Hilz, M. J., Bryś, M., Marthol, H., Stemper, B., & Dütsch, M. (2004) · Neurology · doi:10.1212/01.wnl.0000118207.84514.40 · Cited by 169 · see citing works
Peyron, R., Garcı́a-Larrea, L., Grégoire, M., Convers, P., Richard‐Mornas, A., Lavenne, F., Barral, F.-G., Mauguı̀ere, F., Michel, D., & Laurent, B. (2000) · Pain · doi:10.1016/s0304-3959(99)00190-6 · Cited by 162 · see citing works
Clinical applications of quantitative sensory testing (QST)
Zaslansky, R., & Yarnitsky, D. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00293-1 · Cited by 160 · see citing works
Dyck, P. J. (1988) · Journal of Sound and Vibration · doi:10.1016/0022-460x(88)90273-8 · Cited by 156 · see citing works
Green, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works
Procedures for setting normal values
O’Brien, P. C., & Dyck, P. J. (1995) · Neurology · doi:10.1212/wnl.45.1.17 · Cited by 147 · see citing works
Meier, P. M., Berde, C. B., DiCanzio, J., Zurakowski, D., & Sethna, N. F. (2001) · Muscle & Nerve · doi:10.1002/mus.1153 · Cited by 147 · see citing works
Age-Associated Differences in Responses to Noxious Stimuli
Edwards, R. R., & Fillingim, R. B. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m180 · Cited by 144 · see citing works
Luebke, J. I., Chang, Y., Moore, T. L., & Rosene, D. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.035 · Cited by 142 · see citing works
Self-citationReview: Neural Coding and the Basic Law of Psychophysics
Johnson, K. O., Hsiao, S. S., & Yoshioka, T. (2002) · The Neuroscientist · doi:10.1177/107385840200800207 · Cited by 140 · see citing works
Quantitative sensory testing: effect of site and skin temperature on thermal thresholds
Hagander, L. G., Midani, H. A., Kuskowski, M. A., & Parry, G. J. G. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00192-3 · Cited by 133 · see citing works
(1993) · Neurology · doi:10.1212/wnl.43.5.1050 · Cited by 131 · see citing works
Simovic, D., Isner, J. M., Ropper, A. H., Pieczek, A., & Weinberg, D. H. (2001) · Archives of Neurology · doi:10.1001/archneur.58.5.761 · Cited by 118 · see citing works
A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain
Wallace, M. S., Rowbotham, M. C., Katz, N., Dworkin, R. H., Dotson, R. M., Galer, B. S., Rauck, R. L., Backonja, M. M., Quessy, S. N., & Meisner, P. D. (2002) · Neurology · doi:10.1212/01.wnl.0000036273.98213.34 · Cited by 115 · see citing works
Wellmer, A., Misra, V. P., Sharief, M. K., Kopelman, P. G., & Anand, P. (2001) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2001.01019.x · Cited by 110 · see citing works
Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy
Chiang, M., Lin, Y.-H., Pan, C., Tseng, T.-J., Lin, W. ‐., & Hsieh, S. (2002) · Neurology · doi:10.1212/wnl.59.7.1094 · Cited by 103 · see citing works
Self-citationQuantitative Thermal Perception Testing in Adults
Hilz, M. J., Stemper, B., Axelrod, F. B., Kolodny, E. H., & Neundörfer, B. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199909000-00008 · Cited by 100 · see citing works
A standard test of heat-pain responses using CASE IV
Dyck, P. J. B., Zimmerman, I. R., Johnson, D. M., Gillen, D. A., Hokanson, J. L., Karnes, J. L., Gruener, G., & O’Brien, P. C. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00277-9 · Cited by 96 · see citing works
Plastic Changes in Nociceptive Transmission of the Rat Spinal Cord With Advancing Age
Iwata, K., Fukuoka, T., Kondo, E., Tsuboi, Y., Tashiro, A., Noguchi, K., Masuda, Y., Morimoto, T., & Kanda, K. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00243.2001 · Cited by 94 · see citing works
Effects of aging on human skin innervation
Chang, Y., Lin, W., & Hsieh, S. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00029 · Cited by 83 · see citing works
Self-citationResidual neuropathy in long-term population-based follow-up of Guillain–Barre syndrome
de la Cour, C. D., & Jakobsen, J. (2005) · Neurology · doi:10.1212/01.wnl.0000149521.65474.83 · Cited by 83 · see citing works
Effect of aging on sensory nerve conduction study parameters
Tong, H. C., Werner, R. A., & Franzblau, A. (2004) · Muscle & Nerve · doi:10.1002/mus.20026 · Cited by 81 · see citing works
Arnett, B. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.6.898 · Cited by 78 · see citing works
Altered Cutaneous Sensation in Trigeminal Neuralgia
Nurmikko, T. J. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530170087025 · Cited by 73 · see citing works
Degeneration of nociceptive nerve terminals in human peripheral neuropathy
Pan, C., Lin, Y.-H., Lin, W.-M., Tai, T., & Hsieh, S. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00034 · Cited by 69 · see citing works
Self-citationQuantitative sensory testing: high sensitivity in small fiber neuropathy with normal NCS/EMG
Magda, P., Latov, N., Renard, M. V., & Sander, H. W. (2002) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2002.02029.x · Cited by 61 · see citing works
Comparison of algorithms of testing for use in automated evaluation of sensation
Dyck, P. J. B., Karnes, J. L., Gillen, D. A., O’Brien, P. C., Zimmerman, I. R., & Johnson, D. M. (1990) · Neurology · doi:10.1212/wnl.40.10.1607 · Cited by 54 · see citing works
Lipton, R. B., Galer, B. S., Dutcher, J. P., Portenoy, R. K., Berger, A., Arezzo, J. C., Mizruchi, M. S., Wiernik, P. H., & Schaumburg, H. H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520210044017 · Cited by 35 · see citing works
Aging and quantitative sensory thresholds.
Mp, M., & Sc, T. (1990) · PubMed · Cited by 30 · see citing works
Clinical versus quantitative vibration assessment: improving clinical performance
Burns, T. M., Taly, A., O’Brien, P. C., & Dyck, P. J. B. (2002) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2002.02016.x · Cited by 28 · see citing works
Quantitative sensory testing: effect of site and pressure on vibration thresholds
Hagander, L. G., Midani, H. A., Kuskowski, M. A., & Parry, G. J. G. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00278-9 · Cited by 25 · see citing works
Sedehizade, F., Klocke, R., & Jockusch, H. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199702)20:2 · Cited by 23 · see citing works
Sensory Testing in Human Immunodeficiency Virus Type 1-Infected Men
Gulevich, S. J., Kalmijn, J. A., Thal, L. J., Iragui‐Madoz, V., McCutchan, J. A., Kennedy, C. J., & Grant, I. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530360083022 · Cited by 20 · see citing works
Quantitative sensation testing in small‐diameter sensory fiber neuropathy
Dyck, P. J., & O’Brien, P. C. (2002) · Muscle & Nerve · doi:10.1002/mus.10255 · Cited by 17 · see citing works
Role of insulin‐like growth factor‐I in the treatment of painful small fiber predominant neuropathy
Windebank, A. J., Sorenson, E. J., Civil, R. H., & O’Brien, P. C. (2004) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2004.09311.x · Cited by 16 · see citing works
Diagnostic yield by testing small fiber function in patients examined for polyneuropathy
Sindrup, S. H., Gaist, D., Johannsen, L. G., Havsager, A., Homburg, A.-M. F., Kjeldsen, M. J., Madsen, C., Dalsgaard, N. J., Ellemann, K., & Smith, T. (2001) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2001.01022.x · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Magerl, W., Krumova, E. K., Baron, R., Tölle, T. R., Treede, R., & Maier, C. (2010) · Pain · doi:10.1016/j.pain.2010.07.026 · Cited by 604 · see citing works
Lautenbacher, S., Peters, J. H., Heesen, M., Scheel, J., & Kunz, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.039 · Cited by 536 · see citing works
Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., Smith, A. G., Hsieh, S., Mellgren, S. I., Umapathi, T., et al. (2010) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2010.00271.x · Cited by 518 · see citing works
Self-citationMultisensory design: Reaching out to touch the consumer
Spence, C. J., & Gallace, A. (2011) · Psychology and Marketing · doi:10.1002/mar.20392 · Cited by 416 · see citing works
(2010) · PubMed Central · Cited by 267 · see citing works
Thermal sensitivity in the elderly: A review
Guergova, S., & Dufour, A. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.009 · Cited by 258 · see citing works
Intraepidermal nerve fiber density and its application in sarcoidosis
Bakkers, M., Merkies, I. S. J., Lauria, G., Devigili, G., Penza, P., Lombardi, R., Hermans, M. C. E., van Nes, S. I., Baets, M. H. D., & Faber, C. G. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bacf05 · Cited by 249 · see citing works
Design Principles to Accommodate Older Adults
Farage, M. A., Miller, K. W., Ajayi, F., & Hutchins, D. (2012) · Global Journal of Health Science · doi:10.5539/gjhs.v4n2p2 · Cited by 233 · see citing works
“By comparison, the sensitivity to touch on the hands and feet declines rapidly (Dyck, Karnes, O'Brien, & Zimmerman, 1993); this decline is more severe for the lower extremities (Kenshalo, 1986; Lin et al., 2005), which may reflect the longer neural pathway that the sensory input must travel.”
BackgroundCore outcomes for adult burn survivors: A clinical overview
Falder, S., Browne, A. L., Edgar, D. W., Staples, E., Fong, J., Rea, S. M., & Wood, F. M. (2008) · Burns · doi:10.1016/j.burns.2008.09.002 · Cited by 221 · see citing works
Interoceptive awareness declines with age
Khalsa, S. S., Rudrauf, D., & Tranel, D. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00859.x · Cited by 211 · see citing works
Løseth, S., Stålberg, E., Jorde, R., & Mellgren, S. I. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0872-0 · Cited by 181 · see citing works
Advances in Screening, Early Diagnosis and Accurate Staging of Diabetic Neuropathy
Carmichael, J., Fadavi, H., Ishibashi, F., Shore, A. C., & Tavakoli, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.671257 · Cited by 190 · see citing works
Elderly Use Proprioception Rather than Visual and Vestibular Cues for Postural Motor Control
Wiesmeier, I. K., Dalin, D., & Maurer, C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00097 · Cited by 157 · see citing works
Age and race effects on pain sensitivity and modulation among middle-aged and older adults
Riley, J. L., Cruz-Almeida, Y., Glover, T. L., King, C. D., Goodin, B. R., Sibille, K. T., Bartley, E. J., Herbert, M. S., Sotolongo, A., Fessler, B. J., et al. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2013.10.015 · Cited by 142 · see citing works
Cavazzana, A., Röhrborn, A., Garthus‐Niegel, S., Larsson, M. U., Hummel, T. R., & Croy, I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202969 · Cited by 137 · see citing works
Sensitivity Mapping of the Human Foot: Thresholds at 30 Skin Locations
Hennig, E. M., & Sterzing, T. (2009) · Foot & Ankle International · doi:10.3113/fai.2009.0986 · Cited by 94 · see citing works
Chronic Pain is Associated with a Brain Aging Biomarker in Community-Dwelling Older Adults
Cruz-Almeida, Y., Fillingim, R., Riley, J., Woods, A., Porges, E., Cohen, R., & Cole, J. (2019) · Pain · doi:10.1097/j.pain.0000000000001491 · Cited by 91 · see citing works
Heldestad, V., Linder, J., Sellersjö, L., & Nordh, E. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.03.055 · Cited by 91 · see citing works
Ragé, M., Acker, N. V., Knaapen, M., Timmers, M., Streffer, J. R., Hermans, M. P., Sindic, C., Meert, T. F., & Plaghki, L. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6031-z · Cited by 92 · see citing works
Chao, C., Hsieh, S., Tseng, M.-T., Yang-Chyuan, C., & Hsieh, S.-T. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.11.043 · Cited by 90 · see citing works
Self-citationGierthmühlen, J., Enax‐Krumova, E., Attal, N., Bouhassira, D., Cruccu, G., Finnerup, N. B., Haanpää, M., Hansson, P. T., Jensen, T. S., Freynhagen, R., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000227 · Cited by 89 · see citing works
Age Differences in Orofacial Sensory Thresholds
Heft, M. W., & Robinson, M. E. (2010) · Journal of Dental Research · doi:10.1177/0022034510375287 · Cited by 89 · see citing works
Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, S. W. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.02.001 · Cited by 84 · see citing works
Skin blister and skin biopsy to quantify epidermal nerves
Panoutsopoulou, I. G., Wendelschafer‐Crabb, G., Hodges, J. S., & Kennedy, W. R. (2008) · Neurology · doi:10.1212/01.wnl.0000340984.74563.1c · Cited by 83 · see citing works
Effect of ageing on tactile transduction processes
Decorps, J., Saumet, J. L., Sommer, P., Sigaudo-Roussel, D., & Fromy, B. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.003 · Cited by 83 · see citing works
A Genetic Basis for Mechanosensory Traits in Humans
Frenzel, H., Bohlender, J. E., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S. G., Schiska, D., Jaijo, T., Rüschendorf, F., Saar, K., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001318 · Cited by 78 · see citing works
Physiological correlates of age-related decline in vibrotactile sensitivity
Deshpande, N., Metter, E. J., Ling, S. M., CONWIT, R. A., & Ferrucci, L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.002 · Cited by 73 · see citing works
Skin denervation and cutaneous vasculitis in systemic lupus erythematosus
Tseng, M., Hsieh, S., Shun, C., Lee, K., Pan, C., Lin, W., Lin, Y.-H., Yu, C., & Hsieh, S. (2006) · Brain · doi:10.1093/brain/awl010 · Cited by 72 · see citing works
Self-citationSomatosensory Information Processing in the Aging Population
Zhang, Z., Francisco, E., Holden, J. K., Dennis, R. G., & Tommerdahl, M. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00018 · Cited by 69 · see citing works
Chao, C., Hsieh, S., Chiu, M., Tseng, M., & Chang, Y. (2007) · Muscle & Nerve · doi:10.1002/mus.20815 · Cited by 65 · see citing works
Self-citationEffects of surface characteristics on the plantar shape of feet and subjects’ perceived sensations
Witana, C. P., Goonetilleke, R. S., Xiong, S., & Au, E. Y. L. (2008) · Applied Ergonomics · doi:10.1016/j.apergo.2008.04.014 · Cited by 65 · see citing works
Jürgens, T. P., Leone, M., Cecchini, A. P., Busch, V., Mea, E., Bussone, G., & May, A. (2009) · Pain · doi:10.1016/j.pain.2009.07.006 · Cited by 59 · see citing works
The Fine Tuning of Pain Thresholds: A Sophisticated Double Alarm System
Plaghki, L., Decruynaere, C., Dooren, P. M. V., & Bars, D. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010269 · Cited by 57 · see citing works
Székely, M., & Garai, J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00023-0 · Cited by 57 · see citing works
Skin nerve pathology: Biomarkers of premanifest and manifest amyloid neuropathy
Chao, C., Hsueh, H., Kan, H., Liao, C., Jiang, H., Chiang, H., Lin, W., Yeh, T., Lin, Y.-H., Cheng, Y., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25433 · Cited by 54 · see citing works
Self-citationEffects of changes in plantar sensory feedback on human gait characteristics: a systematic review
Alfuth, M., & Rosenbaum, D. (2012) · Footwear Science · doi:10.1080/19424280.2011.653990 · Cited by 53 · see citing works
Jiménez‐Andrade, J. M., Mantyh, W. G., Bloom, A. P., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A., & Mantyh, P. W. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.008 · Cited by 53 · see citing works
Age-dependent Intrathecal Opioid Escalation in Chronic Noncancer Pain Patients
Hayek, S. M., Veizi, E., Narouze, S., & Mekhail, N. A. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01188.x · Cited by 52 · see citing works
Imaging signatures of altered brain responses in small-fiber neuropathy
Hsieh, P.-C., Tseng, M., Chao, C., Lin, Y.-H., Tseng, W. I., Liu, K.-H., Chiang, M., & Hsieh, S. (2015) · Pain · doi:10.1097/j.pain.0000000000000128 · Cited by 51 · see citing works
Self-citationTemperature threshold testing: a systematic review
Bakkers, M., Faber, C. G., Peters, M. J. H., Reulen, J. P. H., Franssen, H., Fischer, T. Z., & Merkies, I. S. J. (2013) · Journal of the Peripheral Nervous System · doi:10.1111/jns5.12001 · Cited by 49 · see citing works
Santos, T. R. M., de Melo, J. V., Leite, N. C., Salles, G. F., & Cardoso, C. R. L. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.05.010 · Cited by 50 · see citing works
Glycemic control is related to the severity of impaired thermal sensations in type 2 diabetes
Chao, C., Hsieh, S., Yang, W., Lin, Y., Lin, W., Tai, T., & Hsieh, S. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.734 · Cited by 48 · see citing works
Self-citationKemp, J., Després, O., Pébayle, T., & Dufour, A. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.08.020 · Cited by 43 · see citing works
A novel NGFB point mutation: a phenotype study of heterozygous patients
Minde, J., Andersson, T., Fulford, M., Aguirre, M., Nennesmo, I., Remahl, I. N., Svensson, O., Holmberg, M., Toolanen, G., & Solders, G. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.136051 · Cited by 41 · see citing works
Effect of aging on the cerebral processing of thermal pain in the human brain
Tseng, M., Chiang, M.-C., Yazhuo, K., Chao, C., Tseng, W. I., & Hsieh, S. (2013) · Pain · doi:10.1016/j.pain.2013.06.041 · Cited by 40 · see citing works
Self-citationInfluence of age on thermal thresholds, thermal pain thresholds, and reaction time
Huang, H.-W., Wang, W.-C., & Lin, C. K. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.10.003 · Cited by 40 · see citing works
Kuhtz-Buschbeck, J. P., Andresen, W., Göbel, S., Gilster, R., & Stick, C. (2010) · AJP Advances in Physiology Education · doi:10.1152/advan.00002.2010 · Cited by 40 · see citing works
Dahlin, L. B., Thrainsdottir, S., Cederlund, R. I., Thomsen, N., Eriksson, K. F., Rosén, I., Speidel, T., & Sundqvist, G. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02433.x · Cited by 39 · see citing works
Painful neuropathy with skin denervation after prolonged use of linezolid
Chao, C.-C., Sun, H.-Y., Chang, Y.-C., & Hsieh, S.-T. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.127910 · Cited by 39 · see citing works
Self-citationQuantitative Sensory Testing in the Oropharynx
Hagander, L. G., Harlid, R., & Svanborg, E. (2009) · CHEST Journal · doi:10.1378/chest.08-2747 · Cited by 34 · see citing works
Geriatric pain management, pharmacological and nonpharmacological considerations.
Kaye, A. D., Baluch, A., Kaye, R. J., Niaz, R. S., Kaye, A. J., Liu, H., & Fox, C. J. (2014) · Psychology & Neuroscience · doi:10.3922/j.psns.2014.1.04 · Cited by 34 · see citing works
FMRI reveals abnormal central processing of sensory and pain stimuli in ill Gulf War veterans
Gopinath, K., Gandhi, P., Goyal, A., Jiang, L., Fang, Y., Ouyang, L., Ganji, S., Buhner, D. M., Ringe, W. K., Spence, J. S., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.01.014 · Cited by 34 · see citing works
Pathology and functional diagnosis of small-fiber painful neuropathy.
Hsieh, S. (2010) · PubMed · Cited by 34 · see citing works
Self-citationA link between frontal white matter integrity and dizziness in cerebral small vessel disease
Ibitoye, R. T., Castro, P., Cooke, J., Allum, J. H. J., Arshad, Q., Murdin, L. J., Wardlaw, J. M., Kaski, D. N., Sharp, D. J., & Bronstein, A. M. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103098 · Cited by 31 · see citing works
Small fiber pathology in autism and clinical implications
Chien, Y.-L., Chao, C.-C., Wu, S.-W., Hsueh, H.-W., Chiu, Y.-N., Tsai, W.-C., Gau, S. S.-F., & Hsieh, S.-T. (2020) · Neurology · doi:10.1212/wnl.0000000000010932 · Cited by 30 · see citing works
Self-citationChao, C., Tseng, M., Hsieh, P.-C., Lin, C., Huang, S., Hsieh, S., & Chiang, M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab754 · Cited by 31 · see citing works
Self-citationSomatosensory function in old age
Heft, M. W., & Robinson, M. E. (2017) · Journal of Oral Rehabilitation · doi:10.1111/joor.12488 · Cited by 31 · see citing works
Chao, C., Tseng, M., Lin, Y.-H., Hsieh, P.-C., Lin, C., Huang, S., Hsieh, S., & Chiang, M. (2020) · Pain · doi:10.1097/j.pain.0000000000002155 · Cited by 30 · see citing works
Self-citationLeong, G., Lauschke, J. L., Rutowski, S. B., & Waite, P. M. E. (2010) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2010.11689702 · Cited by 29 · see citing works
Optimizing temperature threshold testing in small-fiber neuropathy
Bakkers, M., Faber, C. G., Reulen, J. P. H., Hoeijmakers, J. G. J., Vanhoutte, E. K., & Merkies, I. S. J. (2014) · Muscle & Nerve · doi:10.1002/mus.24473 · Cited by 29 · see citing works
Pharmacological pain management in the elderly patient
McCleane, G. J. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s1939 · Cited by 29 · see citing works
Wu, S., Wang, Y., Hsieh, P.-C., Tseng, M., Chiang, M., Chu, C.-P., Feng, F., Lin, Y.-H., Hsieh, S., & Chao, C. (2016) · Pain · doi:10.1097/j.pain.0000000000000791 · Cited by 28 · see citing works
Self-citationMethod-of-limits; Cold and warm perception thresholds at proximal and distal body regions
Heldestad, V., & Nordh, E. (2018) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2018.06.004 · Cited by 28 · see citing works
Pathophysiology of Small-Fiber Sensory System in Parkinson's Disease
Lin, C., Chao, C., Wu, S., Hsieh, P.-C., Feng, F., Lin, Y.-H., Chen, Y., Wu, R., & Hsieh, S. (2016) · Medicine · doi:10.1097/md.0000000000003058 · Cited by 27 · see citing works
Self-citationNormative data for cutaneous threshold and spatial discrimination in the feet
Rinkel, W. D., Aziz, M. H., Deelen, M. J. M. V., Willemsen, S. P., Cabezas, M. C., van Neck, J. W., & Coert, J. H. (2016) · Muscle & Nerve · doi:10.1002/mus.25512 · Cited by 27 · see citing works
Carlsson, D., Burström, L., Heldestad, V., Nilsson, T., Nordh, E., & Wahlström, J. (2014) · International Journal of Circumpolar Health · doi:10.3402/ijch.v73.23540 · Cited by 25 · see citing works
Perceptual Quality Assessment of Compressed Vibrotactile Signals Through Comparative Judgment
Muschter, E., Noll, A., Zhao, J., Hassen, R., Strese, M., Güleçyüz, B., Li, S., & Steinbach, E. G. (2021) · IEEE Transactions on Haptics · doi:10.1109/toh.2021.3077191 · Cited by 24 · see citing works
Sharma, S., Tobin, V., Vas, P. R. J., Malik, R. A., & Rayman, G. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193452 · Cited by 24 · see citing works
Nelander, J., Speidel, T., Björkman, A., & Dahlin, L. B. (2012) · Diabetic Medicine · doi:10.1111/dme.12024 · Cited by 23 · see citing works
Johnson, C., Hallemans, A., Verbecque, E., Vestel, C. D., Herssens, N., & Vereeck, L. (2020) · The Journal of International Advanced Otology · doi:10.5152/iao.2020.8287 · Cited by 23 · see citing works
Vibration perception threshold in relation to postural control and fall risk assessment in elderly
de Mettelinge, T. R., Calders, P., Palmans, T., Bossche, L. V., Noortgate, N. V. D., & Cambier, D. C. (2013) · Disability and Rehabilitation · doi:10.3109/09638288.2012.751136 · Cited by 23 · see citing works
How we perceive our own hands: Effects of attention, aging, and sex
Naveteur, J., Dupuy, M.-A., Gabrielli, F., & Michael, G. A. (2015) · Somatosensory & Motor Research · doi:10.3109/08990220.2015.1086326 · Cited by 22 · see citing works
Inhibitory Control Impairment on Somatosensory Gating Due to Aging: An Event-Related Potential Study
Terrasa, J. L., Montoya, P., González‐Roldán, A. M., & Sitges, C. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00280 · Cited by 22 · see citing works
Thermal perception thresholds among young adults exposed to hand-transmitted vibration
Nilsson, T., Burström, L., Hagberg, M., & Lundström, R. (2008) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-007-0258-0 · Cited by 21 · see citing works
Chiang, M., Yeh, T., Sung, J., Hsueh, H., Kao, Y., Hsueh, S., Chang, K., Feng, F., Lin, Y.-H., Chao, C., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14698 · Cited by 20 · see citing works
Self-citationLower thermal sensation in normothermic and mildly hyperthermic older adults
Takeda, R., Imai, D., Suzuki, A., Ota, A., Naghavi, N., Yamashina, Y., Hirasawa, Y., Yokoyama, H., Miyagawa, T., & Okazaki, K. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3364-4 · Cited by 20 · see citing works
Impaired brain network architecture as neuroimaging evidence of pain in diabetic neuropathy
Chao, C., Hsieh, P.-C., Lin, C.-H. J., Huang, S., Hsieh, S., & Chiang, M. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.109833 · Cited by 18 · see citing works
Self-citationProgress in the treatment of small fiber peripheral neuropathy
Chiang, M., Tseng, M., Pan, C., Chao, C., & Hsieh, S. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1013097 · Cited by 19 · see citing works
Self-citationPinto, M. C. M. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-12062018-134048 · Cited by 20 · see citing works
Advances in screening, early diagnosis, and accurate staging of diabetic neuropathy
Carmichael, J., Fadavi, H., Ishibashi, F., Shore, A. C., & Tavakoli, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820669-0.00018-9 · Cited by 21 · see citing works
Rinkel, W. D., Aziz, M. H., van Neck, J. W., Cabezas, M. C., van der Ark, L. A., & Coert, J. H. (2019) · Muscle & Nerve · doi:10.1002/mus.26628 · Cited by 17 · see citing works
Evaluation of small nerve fiber dysfunction in type 2 diabetes
Ekman, L., Thrainsdottir, S., Englund, E. M., Thomsen, N., Rosén, I., Hazer, D. B., Petersson, J., Eriksson, K., & Dahlin, L. B. (2019) · Acta Neurologica Scandinavica · doi:10.1111/ane.13171 · Cited by 17 · see citing works
Jung, J., Kim, M.-G., Kang, Y. J., Min, K. W., Han, K.-A., & Choi, H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18116046 · Cited by 17 · see citing works
Environment discrimination with vibration feedback to the foot, arm, and fingertip
Gurari, N., Smith, K., Madhav, M. S., & Okamura, A. M. (2009) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2009.5209508 · Cited by 17 · see citing works
Tsubaki, A., Kubo, M., Kobayashi, R., Jigami, H., & He, T. (2009) · PubMed · Cited by 17 · see citing works
Age-Related Reductions in Tactile and Motor Inhibitory Function Start Early but Are Independent
Ruitenberg, M. F. L., Cassady, K. E., Reuter‐Lorenz, P. A., Tommerdahl, M., & Seidler, R. D. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00193 · Cited by 16 · see citing works
Borrelli, J. R., Creath, R. A., Westlake, K. P., & Rogers, M. W. (2021) · Human Movement Science · doi:10.1016/j.humov.2021.102914 · Cited by 12 · see citing works
Vibrotactile sense in patients with diabetes and carpal tunnel syndrome
Thomsen, N., Cederlund, R. I., Speidel, T., & Dahlin, L. B. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03308.x · Cited by 14 · see citing works
Long-term effect of hand-arm vibration on thermotactile perception thresholds
Lundström, R., Baloch, A. N., Hagberg, M., Nilsson, T., & Gerhardsson, L. (2018) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-018-0201-1 · Cited by 13 · see citing works
The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin
Spencer, P. S., & Chen, X. (2021) · Toxics · doi:10.3390/toxics9050098 · Cited by 13 · see citing works
Thermal and mechanical quantitative sensory testing values among healthy African American adults
Powell-Roach, K. L., Yao, Y., Rutherford, J. N., Schlaeger, J. M., Patil, C. L., Suarez, M. L., Shuey, D. A., Angulo, V., Carrasco, J. D., Ezenwa, M. O., et al. (2019) · Journal of Pain Research · doi:10.2147/jpr.s211855 · Cited by 13 · see citing works
Lin, Y., Hsueh, H., Su, M.-Y. M., Cheng, M., Chiang, M., Juang, J. J., Kao, Y., Chang, K., Feng, F., Hsieh, S., et al. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51635 · Cited by 12 · see citing works
Self-citationPain Management in Elderly Patients
Hix, M. D. (2007) · Journal of Pharmacy Practice · doi:10.1177/0897190007304369 · Cited by 12 · see citing works
Visual-Somatosensory Integration in Older Adults: Links to Sensory Functioning
Dumas, K., Holtzer, R., & Mahoney, J. R. (2015) · Multisensory Research · doi:10.1163/22134808-00002521 · Cited by 12 · see citing works
Neuropeptide Y – Its role in human performance and extreme environments
Kienast, C., Gunga, H., & Steinach, M. (2019) · REACH · doi:10.1016/j.reach.2019.100032 · Cited by 12 · see citing works
Hashiguchi, N., Kumamoto, T., Chishaki, A. S., & Tochihara, Y. (2011) · Journal of the Human-Environment System · doi:10.1618/jhes.14.9 · Cited by 12 · see citing works
Five‐Year Follow‐Up of a Cordotomy
Meeuse, J. J., Vervest, A. C. M., van der Hoeven, J. H., & Reyners, A. K. L. (2008) · Pain Research and Management · doi:10.1155/2008/635197 · Cited by 12 · see citing works
Morozumi, T., Preziosa, P., Meani, A., Pessina, G., Pagani, E., Azzimonti, M., Filippi, M., & Rocca, M. A. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241260145 · Cited by 10 · see citing works
Evaluation and optimization of a vibrotactile signal in an autonomous driving context
Duthoit, V., Sieffermann, J., Enrègle, É., Michon, C., & Blumenthal, D. (2017) · Journal of Sensory Studies · doi:10.1111/joss.12308 · Cited by 10 · see citing works
Kaliappan, S., Simone, D. A., & Banik, R. K. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.04.002 · Cited by 10 · see citing works
- Authors
- Lin, Y., Hsieh, S., Chao, C., Chang, Y., & Hsieh, S.
- Affiliations
- National Taiwan University Hospital (TW)
- National Taiwan University (TW)
- Corresponding author
- Hsieh, Sung‐Tsang
- Venue
- Journal of the Peripheral Nervous System
- Publisher
- Wiley
- Published
- 2005-09
- Volume
- 10
- Issue
- 3
- Pages
- 269-281
- ISSN
- 1085-9489 (ISSN-L)
- 1529-8027
- OpenAlex
- W2100986954
- Cited by
- 176
- References
- 65
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 11
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Peripheral Nervous System (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health Research Institutes
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- aging, temperature thresholds, vibratory threshold, quantitative sensory testing, method of limits, reaction time, age-related sensory decline, neuropathy
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Algorithms, Analysis of Variance, Body Weight, Differential Threshold, Female, Foot, Hand, Humans, Male, Middle Aged, Reference Values, Sensory Thresholds, Sex Factors, Statistics as Topic, Thermosensing, Vibration, Pain Threshold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
