Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
Open accessAbstract
Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic mechanisms. However, the precise nature of the molecular cues involved in this process remains incompletely defined. Here we report that the accumulation of prelamin A isoforms at the nuclear lamina triggers an ATM- and NEMO-dependent signaling pathway that leads to NF-κB activation and secretion of high levels of proinflammatory cytokines in two different mouse models of accelerated aging (Zmpste24−/− and Lmna G609G/G609G mice). Causal involvement of NF-κB in accelerated aging was demonstrated by the fact that both genetic and pharmacological inhibition of NF-κB signaling prevents age-associated features in these animal models, significantly extending their longevity. Our findings provide in vivo proof of principle for the feasibility of pharmacological modulation of the NF-κB pathway to slow down the progression of physiological and pathological aging.
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In mouse models of accelerated ageing, inflammation is exacerbated by overactivation of NF-κB, and blocking this pathway confers longevity.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,814 · see citing works
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918 · see citing works
Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 3,852 · see citing works
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2× · see citing works
“Since a proper clearance of senescent cells by the immune system seems to be crucial for homeostasis maintenance in aging and cancer (Baker et al. 2011; Kang et al. 2011), both NF-kB hyperactivation and the subsequent age-related immunological decline could be compromising an appropriate response against age-accumulat…”
BackgroundIntegrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350 · see citing works
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828 · see citing works
NF-κB, the first quarter-century: remarkable progress and outstanding questions
Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Lamin A Truncation in Hutchinson-Gilford Progeria
Sandre‐Giovannoli, A. D., Bernard, R., Cau, P., Navarro, C. L., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Münnich, A., Merrer, M. F. L., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,472 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Lamin A-Dependent Nuclear Defects in Human Aging
Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works
Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works
Wang, C.-Y., Cusack, J., Liu, R., & Baldwin, A. (1999) · Nature Medicine · doi:10.1038/7410 · Cited by 1,088 · see citing works
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419670 · Cited by 1,068 · see citing works
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 1,001 · see citing works
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901 · see citing works
The nuclear lamina comes of age
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 836 · see citing works
Phenotype and Course of Hutchinson–Gilford Progeria Syndrome
Merideth, M. A., Gordon, L. B., Clauss, S. B., Sachdev, V., Smith, A. C. M., Perry, M. B., Brewer, C. C., Zalewski, C. K., Kim, H. J., Solomon, B. I., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706898 · Cited by 740 · see citing works
Genomic instability in laminopathy-based premature aging
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650 · see citing works
Self-citationHutchinson–Gilford progeria syndrome: Review of the phenotype
Hennekam, R. C. M. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31346 · Cited by 574 · see citing works
Huang, T. T., Wuerzberger‐Davis, S. M., Wu, Z., & Miyamoto, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00895-x · Cited by 560 · see citing works
Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554 · see citing works
Self-citationAging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520 · see citing works
Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli
Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
Scaffidi, P., & Misteli, T. (2008) · Nature Cell Biology · doi:10.1038/ncb1708 · Cited by 500 · see citing works
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela, I., Cadiñanos, J., Pendás, A. M., Gutiérrez-Fernández, A., Folgueras, A. R., Sánchez, L. M., Zhou, Z., Rodríguez, F. J., Stewart, C. L., Vega, J. A., et al. (2005) · Nature · doi:10.1038/nature04019 · Cited by 466 · see citing works
Self-citationMotif module map reveals enforcement of aging by continual NF-κB activity
Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45785 · Cited by 462 · see citing works
Bergö, M. O., Gavino, B. J., Ross, J., Schmidt, W. K., Hong, C., Kendall, L. V., Mohr, A., Meta, M. D., Genant, H. K., Jiang, Y., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192460799 · Cited by 443 · see citing works
Splicing-directed therapy in a new mouse model of human accelerated aging
Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzmán, G., Varela, I., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002847 · Cited by 432 · see citing works
Self-citationPuzzles, promises and a cure for ageing
Vijg, J., & Campisi, J. (2008) · Nature · doi:10.1038/nature07216 · Cited by 407 · see citing works
Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suárez, M. F., Cau, P., Cadiñanos, J., Osorio, F. G., Foray, N., Cobo, J. L., et al. (2008) · Nature Medicine · doi:10.1038/nm1786 · Cited by 403 · see citing works
Self-citationProgeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works
Patrono, C., Patrignani, P., & Rodríguez, L. A. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113418 · Cited by 362 · see citing works
Signals from within: the DNA-damage-induced NF-κB response
Janssens, S., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401843 · Cited by 321 · see citing works
The nuclear envelope in genome organization, expression and stability
Mekhail, K., & Moazed, D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2894 · Cited by 295 · see citing works
Tilstra, J. S., Clauson, C. L., Niedernhofer, L. J., & Robbins, P. D. (2011) · Europe PMC (PubMed Central) · Cited by 290 · see citing works
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262 · see citing works
Nuclear initiated NF-κB signaling: nemo and ATM take center stage
Miyamoto, S. (2011) · Cell Research · doi:10.1038/cr.2010.179 · Cited by 253 · see citing works
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
Ugalde, A. P., Ramsay, A. J., Rosa, J. D. L., Varela, I., Mariño, G., Cadiñanos, J., Lü, J., Freije, J. M. P., & López-Otı́n, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.124 · Cited by 252 · see citing works
Self-citationDNA damage‐dependent NF‐κB activation: NEMO turns nuclear signaling inside out
McCool, K. W., & Miyamoto, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01101.x · Cited by 251 · see citing works
Diseases of the Nuclear EnvelopePreprint
Worman, H. J., Östlund, C., & Wang, Y. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000760 · Cited by 236 · see citing works
Puente, X. S., Quesada, V., Osorio, F. G., Cabanillas, R., Cadiñanos, J., Fraile, J. M., Ordóñez, G. R., Puente, D. A., Gutiérrez‐Fernández, A., Fanjul‐Fernández, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.04.010 · Cited by 209 · see citing works
Self-citationBeyond ATM: The protein kinase landscape of the DNA damage response
Bensimon, A., Aebersold, R. H., & Shiloh, Y. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.013 · Cited by 206 · see citing works
Gene therapy progress and prospects: Hydrodynamic gene delivery
Herweijer, H., & Wolff, J. A. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302891 · Cited by 189 · see citing works
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadiñanos, J., Pendás, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. P., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801096 · Cited by 163 · see citing works
Self-citationApoptosis and aging: increased resistance to apoptosis enhances the aging process
Salminen, A., Ojala, J., & Kaarniranta, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0597-y · Cited by 158 · see citing works
Mariño, G., Ugalde, A. P., Fernández, Á. F., Osorio, F. G., Fueyo, A., Freije, J. M. P., & López-Otı́n, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002696107 · Cited by 145 · see citing works
Self-citationPremature aging in mice activates a systemic metabolic response involving autophagy induction
Mariño, G., Ugalde, A. P., Salvador-Montoliu, N., Varela, I., Quirós, P. M., Cadiñanos, J., van der Pluijm, I., Freije, J. M. P., & López-Otı́n, C. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn120 · Cited by 143 · see citing works
Self-citationEdible vaccines: not quite ready for prime time
Bonetta, L. P. (2002) · Nature Medicine · doi:10.1038/nm0202-94 · Cited by 121 · see citing works
Sagelius, H., Rosengardten, Y., Hanif, M., Erdos, M. R., Rozell, B., Collins, F. S., & Eriksson, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.022913 · Cited by 88 · see citing works
Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions
Ramírez, C. L. J., Cadiñanos, J., Varela, I., Freije, J. M. P., & López-Otı́n, C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6349-3 · Cited by 83 · see citing works
Self-citationMechanisms of immunosenescence: lessons from models of accelerated immune aging
Saux, S. L., Weyand, C. M., & Goronzy, J. J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06297.x · Cited by 75 · see citing works
Osorio, F. G., Varela, I., Lara, E., Puente, X. S., Espada, J., Santoro, R., Freije, J. M. P., Fraga, M. F., & López-Otı́n, C. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00621.x · Cited by 69 · see citing works
Self-citationThe origin and implication of thymic involution.
Aw, D., & Palmer, D. B. (2011) · Europe PMC (PubMed Central) · Cited by 67 · see citing works
The Two-Faced NF-κB in the Skin
Sur, I., Ulvmar, M. H., & Toftgård, R. (2008) · International Reviews of Immunology · doi:10.1080/08830180802130319 · Cited by 55 · see citing works
Wang, Y., Panteleyev, A. A., Owens, D. M., Djabali, K., Stewart, C. L., & Worman, H. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn136 · Cited by 49 · see citing works
Reprogramming aging and progeria
Freije, J. M. P., & López-Otı́n, C. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.009 · Cited by 47 · see citing works
Self-citationColbert, L. H., Rosen, C. J., Goodpaster, B. H., Newman, A. B., Kritchevsky, S. B., Satterfield, S., Kanaya, A. M., Taaffe, D. R., & Harris, T. B. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52529_1.x · Cited by 39 · see citing works
Micromanaging aging with miRNAs
Ugalde, A. P., Español, Y., & López-Otı́n, C. (2011) · Nucleus · doi:10.4161/nucl.2.6.17986 · Cited by 36 · see citing works
Self-citationCell-Extrinsic Defective Lymphocyte Development in Lmna-/- Mice
Hale, J. S., Frock, R. L., Mamman, S. A., Fink, P. J., & Kennedy, B. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010127 · Cited by 30 · see citing works
NEMO shuttle: A link between DNA damage and NF-κB activation in progeroid syndromes?
Salminen, A., Suuronen, T., Huuskonen, J., & Kaarniranta, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.189 · Cited by 27 · see citing works
Cell autonomous and systemic factors in progeria development
Osorio, F. G., Ugalde, A. P., Mariño, G., Puente, X. S., Freije, J. M. P., & López-Otı́n, C. (2011) · Biochemical Society Transactions · doi:10.1042/bst20110677 · Cited by 24 · see citing works
Self-citationMicrocephalia with mandibular and dental dysplasia in adult Zmpste24‐deficient mice
Villafranca, F. D. C., Varela, I., Germanà, A., Montalbano, G., Freije, J. M. P., Vega, J. A., López-Otı́n, C., & Cobo, J. M. D. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00970.x · Cited by 17 · see citing works
Self-citationThe nuclear envelope from basic biology to therapy
Worman, H. J., & Foisner, R. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380253 · Cited by 14 · see citing works
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Self-citationChronic inflammation induces telomere dysfunction and accelerates ageing in mice
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 814 · see citing works
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Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796 · see citing works
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661 · see citing works
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Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 668 · see citing works
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 648 · see citing works
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Ovadya, Y., Landsberger, T., Leins, H., Vadai, E., Gal, H., Biran, A., Yosef, R., Sagiv, A., Agrawal, A., Shapira, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07825-3 · Cited by 578 · see citing works
Gruenbaum, Y., & Foisner, R. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034115 · Cited by 536 · see citing works
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Kubben, N., Zhang, W., Wang, L., Voss, T. C., Yang, J., Qu, J., Liu, G.-H., & Misteli, T. (2016) · Cell · doi:10.1016/j.cell.2016.05.017 · Cited by 489 · see citing works
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Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408 · see citing works
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Schreiber, K. H., & Kennedy, B. K. (2013) · Cell · doi:10.1016/j.cell.2013.02.015 · Cited by 384 · see citing works
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Zhao, Y., Simon, M. A., Seluanov, A., & Gorbunova, V. A. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00751-y · Cited by 393 · see citing works
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Cellular senescence: all roads lead to mitochondria
Martini, H., & Passos, J. F. (2023) · The FEBS Journal · doi:10.1111/febs.16361 · Cited by 334 · see citing works
Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333 · see citing works
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Kubben, N., & Misteli, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.68 · Cited by 320 · see citing works
Progeria: A Paradigm for Translational Medicine
Gordon, L. B., Rothman, F. G., López-Otı́n, C., & Misteli, T. (2014) · Cell · doi:10.1016/j.cell.2013.12.028 · Cited by 276 · see citing works
Self-citationNuclear genomic instability and aging
Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012239 · Cited by 275 · see citing works
Human T cell immunosenescence and inflammation in aging
Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Liu, Y., Drozdov, I. A., Shroff, R. C., Beltran, L. E., & Shanahan, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.111.300543 · Cited by 238 · see citing works
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases
Olivieri, F., Prattichizzo, F., Giuliani, A., Matacchione, G., Rippo, M. R., Sabbatinelli, J., & Bonafè, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101374 · Cited by 221 · see citing works
Mechanisms of vascular calcification in CKD—evidence for premature ageing?
Shanahan, C. M. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.176 · Cited by 208 · see citing works
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
Correia‐Melo, C., Hewitt, G., & Passos, J. F. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-1 · Cited by 195 · see citing works
Hallmarks of aging and immunosenescence: Connecting the dots
Rodrigues, L. P., Teixeira, V. R., Alencar‐Silva, T., Simonassi-Paiva, B., Pereira, R. W., Pogue, R. E., & Carvalho, J. L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.006 · Cited by 187 · see citing works
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
Bárcena, C., Quirós, P. M., Durand, S., Mayoral, P., Rodríguez, F., Caravia, X. M., Mariño, G., Garabaya, C., Fernández-García, M. T., Kroemer, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.089 · Cited by 185 · see citing works
Self-citationThe Signaling of Cellular Senescence in Diabetic Nephropathy
Xiong, Y., & Zhou, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7495629 · Cited by 185 · see citing works
The ATM signaling network in development and disease
Stracker, T. H., Roig, I., Knobel, P. A., & Marjanović, M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00037 · Cited by 173 · see citing works
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models
García-García, V. A., Alameda, J. P., Page, A., & Casanova, M. (2021) · Cells · doi:10.3390/cells10081906 · Cited by 165 · see citing works
Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Neves, J., Sousa‐Victor, P., & Jasper, H. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.01.008 · Cited by 156 · see citing works
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Carrero, D., Soria-Valles, C., & López-Otín, C. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024711 · Cited by 153 · see citing works
Self-citationAIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
Di Micco, A., Frera, G., Lugrin, J., Jamilloux, Y., Hsu, E.-T., Tardivel, A., De Gassart, A., Zaffalon, L., Bujisic, B., Siegert, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602419113 · Cited by 143 · see citing works
Notch Signaling Mediates Secondary Senescence
Teo, Y. V., Rattanavirotkul, N., Olova, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Müller, M., Green, A. R., Adams, P. D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.104 · Cited by 149 · see citing works
Glossmann, H. H., & Lutz, O. M. D. (2019) · Gerontology · doi:10.1159/000502257 · Cited by 149 · see citing works
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 144 · see citing works
DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome
Gonzalo, S., & Kreienkamp, R. J. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.05.007 · Cited by 134 · see citing works
Functional Architecture of the Cell's Nucleus in Development, Aging, and Disease
Burke, B. E., & Stewart, C. L. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00006-8 · Cited by 122 · see citing works
Chronic inflammation and sarcopenia: A regenerative cell therapy perspective
Chhetri, J. K., Barreto, P. D. S., Fougère, B., Rolland, Y., Vellas, B. J., & Cesari, M. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.023 · Cited by 127 · see citing works
Kreienkamp, R., Graziano, S., Coll-Bonfill, N., Bedia‐Diaz, G., Cybulla, E., Vindigni, A., Dorsett, D., Kubben, N., Batista, L. F. Z., & Gonzalo, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.090 · Cited by 124 · see citing works
Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging · doi:10.18632/aging.102863 · Cited by 122 · see citing works
Hamczyk, M. R., Villa‐Bellosta, R., Quesada, V., Gonzalo, P., Vidak, S., Nevado, R. M., Andrés‐Manzano, M. J., Misteli, T., López-Otı́n, C., & Andrés, V. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809736 · Cited by 119 · see citing works
Self-citationDiverse lamin-dependent mechanisms interact to control chromatin dynamics
Camozzi, D., Capanni, C., Cenni, V., Mattioli, E., Columbaro, M., Squarzoni, S., & Lattanzi, G. (2014) · Nucleus · doi:10.4161/nucl.36289 · Cited by 118 · see citing works
Systemic DNA damage responses in aging and diseases
Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116 · see citing works
The role of epigenetics in renal ageing
Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., & Stenvinkel, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.78 · Cited by 114 · see citing works
Mouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113 · see citing works
Self-citationBiomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model
Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J., Miscuglio, M., Rouwkema, J., Dokmeci, M. R., Nissan, X., Ferreira, L., & Khademhosseini, A. (2017) · Small · doi:10.1002/smll.201603737 · Cited by 115 · see citing works
Adult Stem Cells and Diseases of Aging
Boyette, L., & Tuan, R. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3010088 · Cited by 108 · see citing works
Regulation of inflammation as an anti‐aging intervention
Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15061 · Cited by 108 · see citing works
Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice
Leung, T. H., Zhang, L. F., Wang, J., Ning, S., Knox, S. J., & Kim, S. K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70895 · Cited by 107 · see citing works
Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging
Wang, M., Pourzand, C., Lei, X., & Zhong, J. L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8135985 · Cited by 102 · see citing works
The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis
Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., et al. (2014) · Nature Communications · doi:10.1038/ncomms4555 · Cited by 98 · see citing works
Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
Gutiérrez‐Fernández, A., Soria‐Valles, C., Osorio, F. G., Gutiérrez‐Abril, J., Garabaya, C., Aguirre, A., Fueyo, A., Fernández‐García, M. S., Puente, X. S., & López‐Otín, C. (2015) · The EMBO Journal · doi:10.15252/embj.201490594 · Cited by 96 · see citing works
Self-citationAn overview of treatment strategies for Hutchinson-Gilford Progeria syndrome
Harhouri, K., Frankel, D., Bartoli, C., Roll, P., Sandre‐Giovannoli, A. D., & Lévy, N. (2018) · Nucleus · doi:10.1080/19491034.2018.1460045 · Cited by 96 · see citing works
NF-κB activation impairs somatic cell reprogramming in ageing
Soria‐Valles, C., Osorio, F. G., Gutiérrez‐Fernández, A., Angeles, A. D. L., Bueno, C., Menéndez, P. R., Martín-Subero, J. I., Daley, G. Q., Freije, J. M. P., & López-Otı́n, C. (2015) · Nature Cell Biology · doi:10.1038/ncb3207 · Cited by 95 · see citing works
Self-citationRetractedSarubbo, F., Ramis, M. R., Kienzer, C., Aparicio, S., Esteban, S., Miralles, A., & Moranta, D. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9759-0 · Cited by 92 · see citing works
Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?
Ashapkin, V. V., Kutueva, L. I., Kurchashova, S., & Kireev, I. I. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00455 · Cited by 95 · see citing works
The role of hydrogen sulfide in aging and age-related pathologies
Perridon, B. W., Leuvenink, H. G. D., Hillebrands, J., van Goor, H., & Bos, E. M. (2016) · Aging · doi:10.18632/aging.101026 · Cited by 89 · see citing works
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing
Cenni, V., D’Apice, M. R., Garagnani, P., Columbaro, M., Novelli, G., Franceschi, C., & Lattanzi, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.12.001 · Cited by 90 · see citing works
Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
Birch, J., & Passos, J. F. (2017) · BioEssays · doi:10.1002/bies.201600235 · Cited by 89 · see citing works
Zhang, L. J., Zhao, J., Mu, X., McGowan, S. J., Angelini, L. A., O'Kelly, R. D., Yousefzadeh, M. J., Sakamoto, A., Aversa, Z., LeBrasseur, N. K., et al. (2021) · Aging Cell · doi:10.1111/acel.13486 · Cited by 87 · see citing works
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works
Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging
Seegren, P. V., Harper, L. R., Downs, T. K., Zhao, X.-Y., Viswanathan, S. B., Stremska, M. E., Olson, R. J., Kennedy, J., Ewald, S. E., Kumar, P., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00436-8 · Cited by 88 · see citing works
An expanding GSK3 network: implications for aging research
Souder, D. C., & Anderson, R. M. (2019) · GeroScience · doi:10.1007/s11357-019-00085-z · Cited by 86 · see citing works
Lamin A involvement in ageing processes
Cenni, V., Capanni, C., Mattioli, E., Schena, E., Squarzoni, S., Bacalini, M. G., Garagnani, P., Salvioli, S., Franceschi, C., & Lattanzi, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101073 · Cited by 83 · see citing works
Effect of ageing on tactile transduction processes
Decorps, J., Saumet, J. L., Sommer, P., Sigaudo-Roussel, D., & Fromy, B. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.003 · Cited by 83 · see citing works
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 82 · see citing works
Choubey, D., & Panchanathan, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.002 · Cited by 82 · see citing works
Liu, C., Arnold, R., Henriques, G., & Djabali, K. (2019) · Cells · doi:10.3390/cells8101276 · Cited by 79 · see citing works
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Griveau, A., Wiel, C., Ziegler, D. V., Bergö, M. O., & Bernard, D. (2020) · Aging Cell · doi:10.1111/acel.13122 · Cited by 78 · see citing works
Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77 · see citing works
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
Rosa, J. D. L., Freije, J. M. P., Cabanillas, R., Osorio, F. G., Fraga, M. F., Fernández-García, M. S., Rad, R., Fanjul, V., Ugalde, A. P., Liang, Q., et al. (2013) · Nature Communications · doi:10.1038/ncomms3268 · Cited by 76 · see citing works
Self-citationCau, P., Navarro, C. L., Harhouri, K., Roll, P., Sigaudy, S., Kaspi, É., Perrin, S., Sandre‐Giovannoli, A. D., & Lévy, N. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.021 · Cited by 75 · see citing works
Sieprath, T., Corne, T., Nooteboom, M., Grootaert, C., Rajković, A., Buysschaert, B., Robijns, J., Broers, J. L. V., Ramaekers, F. C. S., Koopman, W. J. H., et al. (2015) · Nucleus · doi:10.1080/19491034.2015.1050568 · Cited by 76 · see citing works
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
Chen, W.-T., Ebelt, N. D., Stracker, T. H., Xhemalce, B., Van Den Berg, C. L., & Miller, K. M. (2015) · eLife · doi:10.7554/elife.07270 · Cited by 73 · see citing works
“In addition, based on our study and those of others, ATM inhibition could also be efficacious in the setting of other diseases involving oxidative stress and proinflammatory cytokines including inflammation, angiogenesis and aging (Osorio et al., 2012; Okuno et al., 2012).”
BackgroundInterleukin‐6 neutralization ameliorates symptoms in prematurely aged mice
Squarzoni, S., Schena, E., Sabatelli, P., Mattioli, E., Capanni, C., Cenni, V., D'Apice, M. R., Andrenacci, D., Sarli, G., Pellegrino, V., et al. (2021) · Aging Cell · doi:10.1111/acel.13285 · Cited by 72 · see citing works
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Cheng, H. S., Njock, M.-S., Khyzha, N., Dang, L. T., & Fish, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00422 · Cited by 69 · see citing works
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes
Kreienkamp, R. J., Croke, M., Neumann, M. A., Bedia‐Diaz, G., Graziano, S., Dusso, A., Dorsett, D., Carlberg, C., & Gonzalo, S. (2016) · Oncotarget · doi:10.18632/oncotarget.9065 · Cited by 67 · see citing works
Fang, C., Liu, B., & Wan, M. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01100-4 · Cited by 69 · see citing works
Kumar, R., Sharma, A., Gupta, M., Padwad, Y. S., & Sharma, R. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09576-z · Cited by 67 · see citing works
NF-κB signaling as a driver of ageing
Osorio, F. G., Soria‐Valles, C., Santiago‐Fernández, O., Freije, J. M. P., & López-Otı́n, C. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.04.003 · Cited by 67 · see citing works
Self-citationKovács, Z., Brunner, B., & Ari, C. (2021) · Nutrients · doi:10.3390/nu13072197 · Cited by 67 · see citing works
Lamin in inflammation and aging
Tran, J. R., Chen, H., Zheng, X., & Zheng, Y. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.03.004 · Cited by 66 · see citing works
Graziano, S., Kreienkamp, R., Coll-Bonfill, N., & Gonzalo, S. (2018) · Nucleus · doi:10.1080/19491034.2018.1454168 · Cited by 63 · see citing works
Bidault, G., Garcia, M., Capeau, J., Morichon, R., Vigouroux, C., & Béréziat, V. (2020) · Cells · doi:10.3390/cells9051201 · Cited by 65 · see citing works
DNA Damage: From Chronic Inflammation to Age-Related Deterioration
Ιωαννίδου, Ά., Goulielmaki, E., & Garinis, G. A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00187 · Cited by 61 · see citing works
Tan, C. Y., Wong, J. X., Chan, P. S., Tan, H., Liao, D., Chen, W., Tan, W. L. W., Ackers-Johnson, M. A., Wakimoto, H., Seidman, J. G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.314794 · Cited by 62 · see citing works
The anti-aging mechanism of ginsenosides with medicine and food homology
Tian, T., Ko, C.-N., Luo, W., Li, D., & Yang, C. (2023) · Food & Function · doi:10.1039/d3fo02580b · Cited by 62 · see citing works
Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner
Schuliga, M. J., Read, J. M., Blokland, K. E. C., Waters, D. W., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Jaffar, J., Westall, G. P., Reid, A. T., et al. (2020) · Clinical Science · doi:10.1042/cs20191160 · Cited by 60 · see citing works
Ageing mechanisms that contribute to tissue remodeling in lung disease
Schuliga, M. J., Read, J. M., & Knight, D. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101405 · Cited by 62 · see citing works
Kubben, N., Brimacombe, K. R., Donegan, M., Li, Z., & Misteli, T. (2015) · Methods · doi:10.1016/j.ymeth.2015.08.024 · Cited by 61 · see citing works
Panickar, K. S., & Jewell, D. E. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0017 · Cited by 58 · see citing works
Liao, C., & Kennedy, B. K. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00003-2 · Cited by 55 · see citing works
Back and forth in time: Directing age in iPSC-derived lineages
Cornacchia, D., & Studer, L. (2017) · Brain Research · doi:10.1016/j.brainres.2015.11.013 · Cited by 56 · see citing works
Chen, Q., Tang, L., Zhang, Y., Wan, C., Yu, X., Dong, Y., Chen, X., Wang, X., Li, N., Xin, G., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120089 · Cited by 55 · see citing works
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach
Pio‐Lopez, L., Valdeolivas, A., Tichit, L., Rémy, É., & Baudot, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87987-1 · Cited by 54 · see citing works
Systemic DNA damage responses: organismal adaptations to genome instability
Ermolaeva, M., & Schumacher, B. (2014) · Trends in Genetics · doi:10.1016/j.tig.2013.12.001 · Cited by 51 · see citing works
MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling
Soria‐Valles, C., Gutiérrez‐Fernández, A., Osorio, F. G., Carrero, D., Ferrando, A. A., Colado, E., Fernández-García, M. S., Bonzón‐Kulichenko, E., Vázquez, J., Fueyo, A., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600094 · Cited by 51 · see citing works
Self-citationNuclear Lamins and Oxidative Stress in Cell Proliferation and Longevity
Shimi, T., & Goldman, R. D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-8032-8_19 · Cited by 50 · see citing works
Premature aging syndromes: From patients to mechanism
Foo, M. X. R., Ong, P. F., & Dreesen, O. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.10.003 · Cited by 52 · see citing works
- Authors
- Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C.
- Affiliations
- Universidad de Oviedo (ES)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-09-26
- Volume
- 26
- Issue
- 20
- Pages
- 2311-2324
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3475803
- OpenAlex
- W2101185010
- Cited by
- 276
- References
- 76
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 18 · 2023: 11 · 2022: 21 · 2021: 21 · 2020: 17 · 2019: 26 · 2018: 33 · 2017: 18 · 2016: 27 · 2015: 22 · 2014: 19 · 2013: 16 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- nuclear lamina, accelerated aging, NF-κB activation, ATM signaling, NEMO, prelamin A, lamin A/C, inflammatory cytokines, systemic inflammation, ZMPSTE24, laminopathies, longevity
- MeSH terms
- Aging, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cells, Cultured, DNA-Binding Proteins, Humans, Inflammation, Longevity, Membrane Proteins, Metalloendopeptidases, Nuclear Proteins, Protein Precursors, Sodium Salicylate, Signal Transduction, Transcriptional Activation, NF-kappa B, Cellular Senescence, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, Nuclear Lamina, Lamin Type A, Intracellular Signaling Peptides and Proteins, Mice, Transcription Factor RelA, Ataxia Telangiectasia Mutated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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