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Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats

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RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy

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Fibroblast growth factor 8 ( FGF8 ) induces mitochondrial remodeling in chondrocytes via ERK / AMPK signaling pathway

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Coffee peel extracts ameliorate non-alcoholic fatty liver disease via a fibroblast growth factor 21–adiponectin signaling pathway

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β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight

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FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6

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The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice

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Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception

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FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study

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The effects of exercise on FGF21 in adults: a systematic review and meta-analysis

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Improvements in Exercise for Alzheimer’s Disease: Highlighting FGF21-Induced Cerebrovascular Protection

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Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

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Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity

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Focus on Alzheimer’s Disease: The Role of Fibroblast Growth Factor 21 and Autophagy

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Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases

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Fibroblast growth factor 21 is associated with increased serum total antioxidant capacity and oxidized lipoproteins in humans with different stages of chronic kidney disease

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Gender differences in the relationships between housework and metabolic markers: a longitudinal cohort study in China

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Myokines as biomarkers of frailty and cardiovascular disease risk in females

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Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse

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The Potential Role of Myokines/Hepatokines in the Progression of Neuronal Damage in Streptozotocin and High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

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Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection

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Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

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Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria

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Mitochondrial unfolded protein response in ischemia-reperfusion injury

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Invited review: Adrenocortical function in avian and non-avian reptiles: Insights from dispersed adrenocortical cells

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Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults

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FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway

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Adipose Tissue

Eckel, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809518-8.00002-7 · Cited by 11

Fibroblast Growth Factor 21 Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis

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Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level

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Fibroblast growth factor 21 inversely correlates with survival in elderly population – the results of the Polsenior2 study

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Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori

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Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice

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FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P‐MLKL/P‐RIP1/P‐RIP3 in neurons

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Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF‐21), and insulin‐like growth factor binding protein 2 (IGFBP‐2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum

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UPRmt-regulated mitokines: novel strategies for myocardial injury repair

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FGF21 restores metabolic function in Alzheimer’s disease via activation of PI3K/Akt signaling

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Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

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Stress-CARE: A Chinese music therapeutic model to treat stress and burnout syndromes

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Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice

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Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease

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The stimulatory effects of glucagon on cortisol and GH secretion occur independently from FGF-21

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Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects

Xu, J., Wu, F., Li, Y., Wang, F., Lin, W., Song, Q., Li, H., Fan, Y., Li, H., Chen, L., et al. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00676-7 · Cited by 4

FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway

Chen, L., Zheng, L., Qin, Y. H., Liu, B., Zheng, Y., Tong, X., Dai, M., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.053 · Cited by 2

Hepatic FGF21 Deletion Improves Glucose Metabolism, Alters Lipogenic and Chrna4 Gene Expression, and Enhances Telomere Maintenance in Aged Female Mice

Torres‐Oteros, D., Nicola‐Llorente, M., Sanz‐Lamora, H., Pérez‐Martí, A., Marrero, P. F., Canudas, S., Haro, D., & Relat, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010194 · Cited by 2

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 100

FGF21 gene therapy for healthy aging: Great promise, important questions

Kuro‐o, M. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.07.015

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

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FGF21 connects ER stress to sulfide signaling to enhance cellular resilience

Hatem, S., Ponti, A. K., & Hine, C. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.009

FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

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