Cited by 156Advanced Glycation End Products researchPhytochemicals and Antioxidant ActivitiesAlzheimer's disease research and treatments

Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Li, Yueqin, Peng, Yao, Shen, Yingbin, Zhang, Yunzhen, Liu, Lianliang, Yang, Xinquan·2023·Critical Reviews in Food Science and Nutrition

Abstract

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation, rearrangement and cross-linking between the active carbonyl groups of reducing sugars and the free amines of amino acids. The Maillard reaction is related to sensory characteristics in thermal processed food, while AGEs are formed in food matrix in this process. AGEs are a key link between carbonyl stress and neurodegenerative disease. AGEs can interact with receptors for AGEs (RAGE), causing oxidative stress, inflammation response and signal pathways activation related to neurodegenerative diseases. Neurodegenerative diseases are closely related to gut microbiota imbalance and intestinal inflammation. Polyphenols with multiple hydroxyl groups showed a powerful ability to scavenge ROS and capture α-dicarbonyl species, which led to the formation of mono- and di- adducts, thereby inhibiting AGEs formation. Neurodegenerative diseases can be effectively prevented by inhibiting AGEs production, and interaction with RAGEs, or regulating the microbiota-gut-brain axis. These strategies include polyphenols multifunctional effects on AGEs inhibition, RAGE-ligand interactions blocking, and regulating the abundance and diversity of gut microbiota, and intestinal inflammation alleviation to delay or prevent neurodegenerative diseases progress. It is a wise and promising strategy to supplement dietary polyphenols for preventing neurodegenerative diseases via AGEs-RAGE axis and microbiota-gut-brain axis regulation.

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Crossref · 10.1080/10408398.2022.2076064

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Authors
Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X.
Affiliations
  • Ningbo University (CN)
  • Guangzhou University (CN)
Corresponding author
  • Liu, Lianliang
  • Yang, Xinquan
Venue
Critical Reviews in Food Science and Nutrition
Published
2022-05-19
Volume
63
Issue
29
Pages
9816-9842
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W4280616897
Cited by
156
References
256
Citations by year
2026: 24 · 2025: 42 · 2024: 29 · 2023: 58 · 2022: 3
FWCI
22.93
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (32172210)
  • Zhejiang Provincial Natural Science Foundation (LY21C200005)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
dietary polyphenols, advanced glycation end products, RAGE, Maillard reaction, neurodegenerative diseases, gut microbiota, microbiota-gut-brain axis, oxidative stress, intestinal inflammation, AGE formation inhibition, dietary supplementation
MeSH terms
Brain-Gut Axis, Humans, Inflammation, Glycation End Products, Advanced, Dietary Supplements, Neurodegenerative Diseases, Polyphenols

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