The DOI matches its Crossref record; 309 of the 314 references it cites were found in a registry or an index.
The road ahead for health and lifespan interventions
Open accessAbstract
Aging is a modifiable risk factor for most chronic diseases and an inevitable process in humans. The development of pharmacological interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases has been at the forefront of the aging field. Preclinical findings have demonstrated that species, sex and strain confer significant heterogeneity on reaching the desired health- and lifespan-promoting pharmacological responses in model organisms. Translating the safety and efficacy of these interventions to humans and the lack of reliable biomarkers that serve as predictors of health outcomes remain a challenge. Here, we will survey current pharmacological interventions that promote lifespan extension and/or increased healthspan in animals and humans, and review the various anti-aging interventions selected for inclusion in the NIA's Interventions Testing Program as well as the ClinicalTrials.gov database that target aging or age-related diseases in humans.
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“This imbalance might be alleviated by various interventions, including physical activity, calorie restriction and agents such as metformin, resveratrol and rapamycin10.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [10]
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
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Metadata
- Authors
- Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 59
- Pages
- 101037
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC7450388
- OpenAlex
- W3006812869
- Cited by
- 118
- References
- 314
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 11 · 2023: 10 · 2022: 26 · 2021: 20 · 2020: 20
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by-nc-nd)
- Hispana (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- anti-aging interventions, lifespan extension, healthspan, pharmacological interventions, age-related diseases, chronic disease prevention, model organisms, sex differences, species differences, biomarkers, clinical trials
- MeSH terms
- Aging, Animals, Health, Humans, Longevity
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