The road ahead for health and lifespan interventions

The Hallmarks of Aging

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mTOR Signaling in Growth, Metabolism, and Disease

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DNA methylation age of human tissues and cell types

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Resveratrol improves health and survival of mice on a high-calorie diet

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Extending Healthy Life Span—From Yeast to Humans

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The World Report on Ageing and Health

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

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Senolytics improve physical function and increase lifespan in old age

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mTOR Signaling in Growth, Metabolism, and Disease

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HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

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World report on ageing and health

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Metformin improves healthspan and lifespan in mice

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From discoveries in ageing research to therapeutics for healthy ageing

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Rapamycin: one drug, many effects

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Spermidine in health and disease

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Metformin as a tool to target aging

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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

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Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081

Influence of TOR kinase on lifespan in C. elegans

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Frailty Defined by Deficit Accumulation and Geriatric Medicine Defined by Frailty

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Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967

Familial Risk and Heritability of Cancer Among Twins in Nordic Countries

Mucci, L. A., Hjelmborg, J., Harris, J. R., Czene, K., Havelick, D. J., Scheike, T., Graff, R. E., Holst, K. K., Möller, S., Unger, R. H., et al. (2016) · JAMA · doi:10.1001/jama.2015.17703 · Cited by 958

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948

Minocycline: Far beyond an Antibiotic

Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Inulin: Properties, health benefits and food applications

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865

Caloric restriction improves health and survival of rhesus monkeys

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

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Amyloid β-Protein and the Genetics of Alzheimer's Disease

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Autophagy in the Cellular Energetic Balance

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

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Metabolic Control of Longevity

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

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Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

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Identification of HSP90 inhibitors as a novel class of senolytics

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Targeting senescent cells alleviates obesity-induced metabolic dysfunction

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TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

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Rapamycin slows aging in mice

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Low methionine ingestion by rats extends life span.

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Interventions to slow aging in humans: are we ready?

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Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

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Small molecule SIRT1 activators for the treatment of aging and age-related diseases

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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

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Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice

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Biomarker development in the precision medicine era: lung cancer as a case study

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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

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FGF21 regulates metabolism and circadian behavior by acting on the nervous system

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The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

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The Clinical potential of Senolytic Drugs

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GDF11 increases with age and inhibits skeletal muscle regeneration

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Homocysteine lowering interventions for preventing cardiovascular events

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Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

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Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

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A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity

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The molecular targets of resveratrol

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NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

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Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

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