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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Acosta-Rodríguez, Victoria, Rijo-Ferreira, Filipa, Izumo, Mariko, Xu, Pin, Wight-Carter, Mary, Green, Carla B., Takahashi, Joseph S.·2022·Science
DOI 10.1126/science.abk0297PMC PMC9262309
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Abstract

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising the question of if it is calories, fasting, or time of day that is the cause of this increased life span. We show here that 30% CR was sufficient to extend the life span by 10%; however, a daily fasting interval and circadian alignment of feeding acted together to extend life span by 35% in male C57BL/6J mice. These effects were independent of body weight. Aging induced widespread increases in gene expression associated with inflammation and decreases in the expression of genes encoding components of metabolic pathways in liver from ad libitum–fed mice. CR at night ameliorated these aging-related changes. Our results show that circadian interventions promote longevity and provide a perspective to further explore mechanisms of aging.

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Metadata

Authors
Acosta-Rodríguez, V., Rijo-Ferreira, F., Izumo, M., Xu, P., Wight-Carter, M., Green, C. B., & Takahashi, J. S.
Affiliations
  • Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Animal Resources Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-06-10
Volume
376
Issue
6598
Pages
1192-1202
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.abk0297
PMC
PMC9262309
Cited by
390
References
27
Language
en

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