The DOI matches its Crossref record; 313 of the 316 references it cites were found in a registry or an index.
Autophagy and the hallmarks of aging
Open accessAbstract
Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.
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“This subsequently led to the identification of some of the earliest disease-associated genes, including APP, PS1 and PS2 in AD, SNCA and LRRK2 in PD and MAPT and GRN in FTD.79–87”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [84]
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- Martinez-Lopez, 2017, System-wide benefits of intermeal fasting by autophagy, Cell Metab., 26, 10.1016/j.cmet.2017.09.020 · DOI
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The different autophagy degradation pathways and neurodegeneration
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Self-citationFrom geroscience to precision geromedicine: Understanding and managing aging
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Self-citationRedox regulation: mechanisms, biology and therapeutic targets in diseases
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Molecular mechanisms of aging and anti-aging strategies
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Metadata
- Authors
- Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M.
- Affiliations
- Albert Einstein College of Medicine (US)
- University of the Basque Country (ES)
- National University of Singapore (SG)
- ORCID
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 72
- Pages
- 101468
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC8616816
- OpenAlex
- W3203834151
- Cited by
- 285
- References
- 316
- Citations by year
- 2026: 49 · 2025: 70 · 2024: 66 · 2023: 65 · 2022: 35
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 303 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Ageing Research Reviews (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Glenn Foundation for Medical Research
- Michael J. Fox Foundation for Parkinson's Research
- Instituto de Salud Carlos III
- Federación Española de Enfermedades Raras (PI20/00728)
- Ministerio de Ciencia e Innovación
- Rainwater Charitable Foundation
- Fundación BBVA
- National Institutes of Health (AG031782, P30DK041296, DK098408, AG017617, DK124308, AG054108, AG021904, NS100717, P30AG038072)
- Grace Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy, hallmarks of aging, proteostasis, cell quality control, lysosomal degradation, lifespan extension, healthspan, geroprotective interventions, autophagy modulators
- MeSH terms
- Proteostasis, Aging, Autophagy, Humans, Longevity, Lysosomes
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