Cited by 285Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

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Autophagy and the hallmarks of aging

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Kaushik, Susmita, Tasset, Inmaculada, Arias, Esperanza, Pampliega, Olatz, Wong, Esther, Martinez-Vicente, Marta, Cuervo, Ana Maria·2021·Ageing Research Reviews

DOI 10.1016/j.arr.2021.101468PMC PMC8616816

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Abstract

Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.

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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Self-citation
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500
TFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365
Cellular Senescence: Defining a Path Forward
Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225
Functions of Lysosomes
de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832

Show all 316 references

Research works printed but not linked: 2

Lopez-Otin, 2021, Hallm. Health Cell, 184, 1929
Martinez-Lopez, 2017, System-wide benefits of intermeal fasting by autophagy, Cell Metab., 26, 10.1016/j.cmet.2017.09.020 · DOI

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Authors: Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M.
Affiliations: Albert Einstein College of Medicine (US)
University of the Basque Country (ES)
National University of Singapore (SG)
ORCID: Kaushik, Susmita
Tasset, Inmaculada
Arias, Esperanza
Pampliega, Olatz
Wong, Esther
Martinez-Vicente, Marta
Cuervo, Ana Maria
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2021-12
Volume: 72
Pages: 101468
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2021.101468
PMC: PMC8616816
OpenAlex: W3203834151
Cited by: 285
References: 316
Citations by year: 2026: 49 · 2025: 70 · 2024: 66 · 2023: 65 · 2022: 35
FWCI: 6.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 303 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Ageing Research Reviews (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Glenn Foundation for Medical Research
Michael J. Fox Foundation for Parkinson's Research
Instituto de Salud Carlos III
Federación Española de Enfermedades Raras (PI20/00728)
Ministerio de Ciencia e Innovación
Rainwater Charitable Foundation
Fundación BBVA
National Institutes of Health (AG031782, P30DK041296, DK098408, AG017617, DK124308, AG054108, AG021904, NS100717, P30AG038072)
Grace Science Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagy, hallmarks of aging, proteostasis, cell quality control, lysosomal degradation, lifespan extension, healthspan, geroprotective interventions, autophagy modulators
MeSH terms: Proteostasis, Aging, Autophagy, Humans, Longevity, Lysosomes

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