The DOI matches its Crossref record; 216 of the 217 references it cites were found in a registry or an index.
Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process
Abstract
Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin presents a decreasing trend with the extension of age and is also closely associated with a wide range of aging-related diseases. Currently, many studies on irisin are being conducted with respect to physiological functions for health promotion, and the prevention, treatment and rehabilitation of chronic diseases, as well as mechanisms associated with improving energy metabolic balance, enhancing cellular homeostasis by optimizing autophagy, promoting mitochondrial quality control, reducing reactive oxygen species (ROS) production, and mitigating inflammatory responses. These diseases include: metabolic diseases (obesity, type 2 diabetes, and bone metabolism); cardiovascular diseases (hypertension, coronary heart disease, cardiomyopathy and stroke); nervous system diseases (Alzheimer's disease, Parkinson's disease, and stroke); and others (cancer and sarcopenia). Although the current studies on irisin are relatively extensive, some studies have produced unexplained experimental results. This article introduces an overview of the generation, secretion, and tissue distribution, of irisin, and its targeting of tissues or organs for the prevention and treatment of above-mentioned chronic diseases is systematically summarized, with discussion of the underlying molecular mechanisms. This study is expected to improve the understanding of irisin, which may be beneficial to identify novel and effective targets for the screening, diagnosis, or therapy of these chronic diseases, or develop promising interventional strategies, effective drug candidates, functional foods, or exercise mimetics.
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“The stimulation of exercise and cold exposure enhance the generation and secretion of irisin from skeletal muscle, thereby inducing myogenesis, preventing muscle atrophy, improving energy metabolism, enhancing cellular homeostasis, and promoting mitochondrial quality control [98].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [98]
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1 retracted
Jiang, X., Cai, S., Jin, Y., Wu, F., He, J., Wu, X., Tan, Y., & Wang, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2989974 · Cited by 77
RetractedCenters for Disease Control and Prevention
Branum, A. (2007) · Sage eBooks · doi:10.4135/9781412952644.n74 · Cited by 6,434
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010
Yang, G., Wang, Y., Zeng, Y., Gao, G. F., Liang, X., Zhou, M., Wan, X., Yu, S., Jiang, Y., Naghavi, M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61097-1 · Cited by 1,984
Challenges in the diagnosis of Parkinson's disease
Tolosa, E., Garrido, A., Scholz, S. W., & Poewe, W. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00030-2 · Cited by 1,874
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Research works printed but not linked: 2
- Natalicchio, 2020, Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain, Diabetes Metab. Res. Rev., 36, 10.1002/dmrr.3238 · DOI · Paper page
- Yang, 2016, Swimming intervention mitigates HFD-induced obesity of rats through PGC-1α-irisin pathway, Eur. Rev. Med. Pharm. Sci., 20, 2123
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Park, M., & Choi, K. M. (2023) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2023.155577 · Cited by 106
Bone and muscle crosstalk in ageing and disease
Kirk, B., Lombardi, G., & Duque, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01088-x · Cited by 89
Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm
Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 83
Myokines: Metabolic regulation in obesity and type 2 diabetes
Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58
Zhang, Y.-S., He, X., Wang, K., Xue, Y., Hu, S.-H., Jin, Y.-S., Zhu, G., Rui, Y.-J., & Shi, Q. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.013 · Cited by 49
Metadata
- Authors
- Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N.
- Affiliations
- Wuhan Sports University (CN)
- Georgia Gwinnett College (US)
- Corresponding author
- Chen, Ning
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 80
- Pages
- 101680
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W4283791562
- Cited by
- 88
- References
- 217
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 32 · 2023: 13 · 2022: 1
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hubei Provincial Department of Education
- National Natural Science Foundation of China (31771318, 32071176)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- irisin, myokines, physical activity, cold exposure, aging, chronic disease, metabolic disorders, cardiovascular disease, neurodegenerative diseases, sarcopenia, autophagy, mitochondrial quality control, reactive oxygen species, inflammation, obesity, type 2 diabetes, bone metabolism, exercise mimetics, functional foods
- MeSH terms
- Aging, Diabetes Mellitus, Type 2, Fibronectins, Health Promotion, Humans, Peptides, Stroke
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