Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process

Centers for Disease Control and Prevention

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

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Exerkines in health, resilience and disease

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Neurotrophin signalling in health and disease

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Physiology and role of irisin in glucose homeostasis

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FNDC5/irisin is not only a myokine but also an adipokine

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

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The myokine irisin increases cortical bone mass

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Molecular Biology of Atherosclerosis

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FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

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Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

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Exercise hormone irisin is a critical regulator of cognitive function

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Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

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Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation

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Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

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Evidence against a Beneficial Effect of Irisin in Humans

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Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

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Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

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Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

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Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

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Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?

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Parkinson's disease, insulin resistance and novel agents of neuroprotection

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Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

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Progress and Challenges in the Biology of FNDC5 and Irisin

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The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

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FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

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Irisin Enhances Osteoblast DifferentiationIn Vitro

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Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

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Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

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Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells

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Effects of the exercise‐inducible myokine irisin on malignant and non‐malignant breast epithelial cell behavior in vitro

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White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

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Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

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Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

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Roles of myokines in exercise-induced improvement of neuropsychiatric function

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High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption

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Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

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Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

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Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

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Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

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Effects of myokines on bone

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Irisin and musculoskeletal health

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Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

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Exploring the link between glucocerebrosidase mutations and parkinsonism

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High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

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Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults

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A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases

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Mental Training Enhances Cognitive Function and BDNF More Than Either Physical or Combined Training in Elderly Women With MCI: A Small-Scale Study

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Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons

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Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells

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Exercise-induced myokines and their effect on prostate cancer

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Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

Song, H., Wu, F., Zhang, Y., Zhang, Y., Wang, F., Jiang, M., Wang, Z., Zhang, M., Li, S., Yang, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110273 · Cited by 130

Irisin Prevents Disuse-Induced Osteocyte Apoptosis

Storlino, G., Colaianni, G., Sanesi, L., Lippo, L., Brunetti, G., Errede, M., Colucci, S. C., Passeri, G., & Grano, M. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3944 · Cited by 125

Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics

Provatopoulou, X., Georgiou, G. P., Kalogera, E., Kalles, V., Matiatou, M., Papapanagiotou, I., Sagkriotis, A., Zografos, G., & Gounaris, A. (2015) · BMC Cancer · doi:10.1186/s12885-015-1898-1 · Cited by 123

Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults

Tsai, C., Pan, C., Tseng, Y., Chen, F., Chang, Y.-C., & Wang, T.-C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113472 · Cited by 123

Irisin, Two Years Later

Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 122

Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway

Küster, O. C., Laptinskaya, D., Fissler, P., Schnack, C., Zügel, M., Nold, V., Thurm, F., Pleiner, S., Karabatsiakis, A., von Einem, B., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170447 · Cited by 122

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion

Natalicchio, A., Marrano, N., Biondi, G., Spagnuolo, R., Labarbuta, R., Porreca, I., Cignarelli, A., Bugliani, M., Marchetti, P., Perrini, S., et al. (2017) · Diabetes · doi:10.2337/db17-0002 · Cited by 122

Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease

de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15039 · Cited by 120

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

Estell, E. G., Le, P. T., Vegting, Y., Kim, H., Wrann, C. D., Bouxsein, M., Nagano, K., Baron, R., Spiegelman, B. M., & Rosen, C. J. (2020) · eLife · doi:10.7554/elife.58172 · Cited by 120

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

Palermo, A., Strollo, R., Maddaloni, E., Tuccinardi, D., D’Onofrio, L., Briganti, S., Defeudis, G., Pascalis, M. D., Lazzaro, M. C., Colleluori, G., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12672 · Cited by 118

FNDC5/Irisin inhibits pathological cardiac hypertrophy

Yu, Q., Kou, W., Xu, X., Zhou, S., Luan, P., Xu, X., Li, H., Zhuang, J., Wang, J., Zhao, Y., et al. (2019) · Clinical Science · doi:10.1042/cs20190016 · Cited by 115

The novel myokine irisin: clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women

Park, H., Kim, H. C., Zhang, D., Yeom, H., & Lim, S.-K. (2018) · Endocrine · doi:10.1007/s12020-018-1814-y · Cited by 112

Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events

Aronis, K. N., Moreno, M., Pοlyzos, S. A., Moreno‐Navarrete, J. M., Ricart, W., Delgado, E., de la Hera, J., Sahin-Efe, A., Chamberland, J. P., Berman, R., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.101 · Cited by 111

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway

Peng, J., Deng, X., Huang, W. G., Yu, J., Wang, J., Wang, J., Yang, S., Liu, X., Wang, L., Zhang, Y., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.09.014 · Cited by 111

Neuronal Networks in Hypertension

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Irisin Peptide Protects Brain Against Ischemic Injury Through Reducing Apoptosis and Enhancing BDNF in a Rodent Model of Stroke

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Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates

Singhal, V., Lawson, E. A., Ackerman, K. E., Fazeli, P. K., Clarke, H., Lee, H., Eddy, K. T., Marengi, D. A., Derrico, N. P., Bouxsein, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100218 · Cited by 103

FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress

Lin, C., Guo, Y., Xia, Y., Li, C., Xu, X., Qi, T., Zhang, F., Fan, M., Hu, G., Zhao, H., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.06.013 · Cited by 103

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

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How does the skeletal muscle communicate with the brain in health and disease?

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Lower irisin level in patients with type 2 diabetes mellitus: A case‐control study and meta‐analysis

Zhang, C., Ding, Z., Lv, G., Li, J., Zhou, P., & Zhang, J. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12256 · Cited by 98

Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy

Xiang, L., Xiang, G., Yue, L., Zhang, J., & Zhao, L. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.036 · Cited by 98

Central and Peripheral Irisin Differentially Regulate Blood Pressure

Zhang, W., Chang, L., Zhang, C., Zhang, R., Li, Z., Chai, B., Li, J., Chen, E., & Mulholland, M. T. (2015) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-015-6580-y · Cited by 98

Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Lee, M. J., Lee, S. A., Nam, B. Y., Park, S., Lee, S., Ryu, H. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Oh, H. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.002 · Cited by 98

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

Belviranlı, M., & Okudan, N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8500-3 · Cited by 98

Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis

Qiu, S., Cai, X., Yin, H., Zügel, M., Sun, Z., Steinacker, J. M., & Schümann, U. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.006 · Cited by 96

Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis

Liao, Q., Qu, S., Tang, L., Li, L.-P., He, D., Zeng, C., & Wang, W. E. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0230-z · Cited by 94

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

Deng, X., Huang, W., Peng, J., Zhu, T., Sun, X.-L., Zhou, X.-Y., Yang, H., Xiong, J., He, H.-Q., Xu, Y.-H., et al. (2017) · Inflammation · doi:10.1007/s10753-017-0685-3 · Cited by 92

Irisin immunohistochemistry in gastrointestinal system cancers

Aydın, S., Kuloğlu, T., Özercan, M. R., Albayrak, S., Aydın, S., Bakal, Ü., Yılmaz, M., Kalaycı, M. Z., Yardım, M., Saraç, M., et al. (2016) · Biotechnic & Histochemistry · doi:10.3109/10520295.2015.1136988 · Cited by 90

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

Mo, L., Shen, J., Liu, Q., Zhang, Y., Kuang, J., Pu, S., Cheng, S., Zou, M., Jiang, W., Jiang, C., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1292 · Cited by 89

Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells

Ma, Y., Qiao, X., Zeng, R., Cheng, R., Zhang, J., Luo, Y., Nie, Y., Hu, Y., Yang, Z., Zhang, J., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700983rr · Cited by 89

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

Wang, K., Li, H., Wang, H., Wang, J., Song, F., & Sun, Y. S. (2018) · Mediators of Inflammation · doi:10.1155/2018/9070341 · Cited by 88

Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma

Shi, G., Tang, N., Qiu, J., Zhang, D., Huang, F., Cheng, Y., Ding, K., Li, W., Zhang, P., & Tan, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.148 · Cited by 87

The relationship between circulating irisin levels and endothelial function in lean and obese subjects

Hou, N., Han, F., & Sun, X. (2014) · Clinical Endocrinology · doi:10.1111/cen.12658 · Cited by 86

Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.

Yang, Z., Xu, C., Chen, Y., & Zhao, Q. (2015) · Europe PMC (PubMed Central) · Cited by 86

The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization

Ye, W., Wang, J., Lin, D., & Ding, Z. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.028 · Cited by 86

Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients

Sanchis‐Gomar, F., Alis, R., Pareja-Galeano, H., Solá, E., Víctor, V. M., Rocha, M., Hernández‐Mijares, A., & Romagnoli, M. (2014) · Endocrine · doi:10.1007/s12020-014-0170-9 · Cited by 85

High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

Faienza, M. F., Brunetti, G., Sanesi, L., Colaianni, G., Celi, M., Piacente, L., D’Amato, G., Schipani, E., Colucci, S. C., & Grano, M. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.046 · Cited by 85

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M. P., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.028 · Cited by 85

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis

Chen, R.-R., Fan, X., Chen, G., Zeng, G., Xue, Y., Liu, X., & Wang, C. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.01.031 · Cited by 84

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 83

Exercise therapy for functional capacity in chronic diseases: an overview of meta-analyses of randomised controlled trials

Pasanen, T., Tolvanen, S., Heinonen, A. O., & Kujala, U. M. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-097132 · Cited by 81

The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives

Flori, L., Testai, L., & Calderone, V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118954 · Cited by 81

Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice

Xue, Y., Hu, S., Chen, C., He, J., Sun, J., Jin, Y., Zhang, Y., Zhu, G., Shi, Q., & Rui, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.63505 · Cited by 81

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway

Li, Q., Jia, S., Xu, L., Li, B., & Chen, N. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1006 · Cited by 80

Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice

Hu, C., Zhang, X., Hu, M., Teng, T., Yuan, Y., Song, P. K., Kong, C., Xu, S., Ma, Z., & Tang, Q. (2022) · Aging Cell · doi:10.1111/acel.13556 · Cited by 80

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

Sahin-Efe, A., Upadhyay, J., Ko, B., Dincer, F., Park, K., Migdal, A. L., Vokonas, P., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.011 · Cited by 79

A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity.

Grygiel‐Górniak, B., & Puszczewicz, M. (2017) · PubMed · Cited by 78

The Emerging Role of Irisin in Cardiovascular Diseases

Fu, J., Li, F., Tang, Y., Cai, L., Zeng, C., Yang, Y., & Yang, J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022453 · Cited by 78

Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease

Lourenco, M. V., Ribeiro, F. C., Sudo, F. K., Drummond, C., Assunção, N., Vanderborght, B., Tovar-Moll, F. F., Mattos, P., Felice, F. G. D., & Ferreira, S. T. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12034 · Cited by 78

Circulating Irisin and Myostatin as Markers of Muscle Strength and Physical Condition in Elderly Subjects

Planella-Farrugia, C., Comas, F., Sabater, M., Moreno, M., Moreno‐Navarrete, J. M., Rovira, O., Ricart, W., & Fernández‐Real, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00871 · Cited by 77

Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

Inoue, K., Fujie, S. J., Hasegawa, N., Horii, N., Uchida, M., Iemitsu, K., Sanada, K., Hamaoka, T., & Iemitsu, M. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0602 · Cited by 76

Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice

He, Z., Li, H., Han, X., Zhou, F., Du, J., Yang, Y., Xu, Q., Zhang, S., Zhang, S., Zhao, N., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115573 · Cited by 76

Irisin prevents dexamethasone-induced atrophy in C2C12 myotubes

Chang, J. S., & Kong, I. D. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02367-4 · Cited by 74

Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway

Ye, X., Shen, Y., Ni, C., Ye, J., Xin, Y., Zhang, W., & Ren, Y. (2019) · Peptides · doi:10.1016/j.peptides.2019.170120 · Cited by 73

Irisin ameliorates septic cardiomyopathy via inhibiting DRP1-related mitochondrial fission and normalizing the JNK-LATS2 signaling pathway

Tan, Y., Ouyang, H., Xiao, X., Zhong, J., & Dong, M. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00992-2 · Cited by 72

Irisin deficiency disturbs bone metabolism

Zhu, X., Li, X., Wang, X., Chen, T., Tao, F., Liu, C.-J., Tu, Q., Shen, G., & Chen, J. J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29894 · Cited by 72

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts

Colaianni, G., Errede, M., Sanesi, L., Notarnicola, A., Celi, M., Zerlotin, R., Storlino, G., Pignataro, P., Oranger, A., Pesce, V., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4192 · Cited by 70

Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke

Tu, W., Qiu, H., Cao, J., Liu, Q., Zeng, X., & Zhao, J.-Z. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0651-2 · Cited by 69

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Maalouf, G.-E., & Khoury, D. E. (2019) · Journal of Obesity · doi:10.1155/2019/6561726 · Cited by 69

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69

Irisin promotes osteogenic differentiation of bone marrow mesenchymal stem cells by activating autophagy via the Wnt//β-catenin signal pathway

Chen, X., Sun, K., Zhao, S., Geng, T., Fan, X., Sun, S., Zheng, M., & Jin, Q. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155292 · Cited by 69

Increased levels of irisin in people with long‐standing Type 1 diabetes

Espes, D., Lau, J., & Carlsson, P. (2015) · Diabetic Medicine · doi:10.1111/dme.12731 · Cited by 67

Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

Zhang, D., Xie, T., & Leung, P. S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495395 · Cited by 65

Irisin ameliorates angiotensin II‐induced cardiomyocyte apoptosis through autophagy

Li, R., Wang, X., Wu, S., Yao, W., Chen, H., Xin, J., Li, H., Lan, J., Xue, K., Li, X., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28382 · Cited by 65

Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy

Hu, W., Wang, R., Li, J., Zhang, J., & Wang, W. (2015) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563215582072 · Cited by 63

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Duan, H., Ma, B., Ma, X., Wang, H., Ni, Z., Wang, B., Li, X., Jiang, P., Umar, M., & Li, M. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.12.049 · Cited by 62

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Geng, Z., Fan, W., Zhou, B. R., Ye, C., Tong, Y., Zhou, Y., & Xiong, X. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1857-8 · Cited by 62

Irisin prevents microgravity‐induced impairment of osteoblast differentiation in vitro during the space flight CRS‐14 mission

Colucci, S. C., Colaianni, G., Brunetti, G., Ferranti, F., Mascetti, G., Mori, G., & Grano, M. (2020) · The FASEB Journal · doi:10.1096/fj.202000216r · Cited by 62

Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts

Yano, N., Zhang, L., Wei, D., Dubielecka, P. M., Lei, W., Zhuang, S., Zhu, P., Qin, G., Liu, P. Y., Chin, Y. E., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2019 · Cited by 59

Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina

Efe, T. H., Açar, B., Ertem, A. G., Yayla, K. G., Algül, E., Yayla, Ç., Ünal, S., Bilgin, M., Çimen, T., Kırbaş, Ö., et al. (2016) · Korean Circulation Journal · doi:10.4070/kcj.2016.0079 · Cited by 58

Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women

Kim, J.-H., & Kim, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.024 · Cited by 58

Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

Zhao, Y., Wang, J., Yano, N., Zhang, L. X., Wang, H., Zhang, S.-Y., Qin, G., Dubielecka, P., Zhuang, S., Liu, P., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27037 · Cited by 57

10-Year Follow-Up After Revascularization in Elderly Patients With Complex Coronary Artery Disease.

Ono, M., Serruys, P., Hara, H., Kawashima, H., Gao, C., Wang, R.-T., Takahashi, K., O'Leary, N., Wykrzykowska, J., Sharif, F., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.016 · Cited by 57

Serum levels of irisin predict short-term outcomes in ischemic stroke

Wu, H., Guo, P., Jin, Z. Y., Li, X., Yang, X., Tang, C., Wang, Y., & Ke, J. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.017 · Cited by 55

Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction

Hsieh, C., Ho, M.-Y., Wen, M., Chen, C., Hsieh, M., Lin, C., Yeh, J., Tsai, M., Yang, C., Wu, V. C., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.072 · Cited by 55

Irisin serum levels are positively correlated with bone mineral status in a population of healthy children

Colaianni, G., Faienza, M. F., Sanesi, L., Brunetti, G., Pignataro, P., Lippo, L., Bortolotti, S., Storlino, G., Piacente, L., D’Amato, G., et al. (2019) · Pediatric Research · doi:10.1038/s41390-019-0278-y · Cited by 55

Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa

Hofmann, T., Elbelt, U., Ahnis, A., Kobelt, P., Rose, M., & Stengel, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00202 · Cited by 54

Serum Irisin Predicts Mortality Risk in Acute Heart Failure Patients

Shen, S., Gao, R., Bei, Y., Li, J., Zhang, H., Zhou, Y., Yao, W., Xu, D., Zhou, F., Jin, M., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477867 · Cited by 54

Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

Kurdiová, T., Baláž, M., Mayer, A. E., Máderová, D., Belan, V., Wolfrum, C., Ukropec, J., & Ukropcová, B. (2014) · Peptides · doi:10.1016/j.peptides.2014.03.003 · Cited by 52

Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women

Yan, J., Liu, H.-J., Guo, W., & Yang, J. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.03.011 · Cited by 52

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

Serbest, S., Tiftikçi, U., Tosun, H. B., & Kısa, Ü. (2017) · Medical Science Monitor · doi:10.12659/msm.906293 · Cited by 52

Serum irisin level in myocardial infarction patients with or without heart failure

El-Mottaleb, N. A. A., Galal, H. M., Maghraby, K., & Gadallah, A. I. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0736 · Cited by 52

DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone

Metzger, C. E., Narayanan, S. A., Elizondo, J. P., Carter, A. M., Zawieja, D. C., Hogan, H. A., & Bloomfield, S. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-51550-w · Cited by 52

Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Huo, C.-J., Yu, X., Sun, Y., Li, H., Su, Q., Bai, J., Li, Y., Liu, K., Qi, J., Zhou, S., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114953 · Cited by 52

The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer

Coletta, A. M., Agha, N. H., Baker, F. L., Niemiro, G. M., Mylabathula, P. L., Brewster, A. M., Bevers, T. B., Fuentes‐Mattei, E., Basen‐Engquist, K., Gilchrist, S. C., et al. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06111-z · Cited by 52

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani, E., Tsakiridis, N., Kouvelioti, R., Jaglanian, A., & Klentrou, P. (2021) · Cancers · doi:10.3390/cancers13112628 · Cited by 52

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

Kim, H. K., Jeong, Y. J., Song, I.-S., Noh, Y. H., Seo, K. W., Kim, M., & Han, J. (2017) · Scientific Reports · doi:10.1038/srep43296 · Cited by 50

The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients

Zhu, L., Wang, G., Zhu, Y., Li, C.-G., Tang, Y., Jiang, Z., Yang, M. H., Ni, C., Chen, L., & Niu, W.-Y. (2017) · Bioscience Reports · doi:10.1042/bsr20170213 · Cited by 50

Lower irisin levels in coronary artery disease: a meta-analysis

Guo, W., Zhang, B., & Wang, X. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.17.02663-3 · Cited by 49

The Neuroprotective Effect of Irisin in Ischemic Stroke

Liu, Y., Zhu, C., Guo, J., Chen, Y., & Meng, C. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.588958 · Cited by 49

Irisin ameliorates high glucose‐induced cardiomyocytes injury via AMPK/mTOR signal pathway

Deng, J., Zhang, N., Chen, F., Yang, C., Ning, H., Xiao, C. Y., Sun, K., Liu, Y., Yang, M., Hu, T., et al. (2020) · Cell Biology International · doi:10.1002/cbin.11441 · Cited by 48

Irisin Protects Brain against Ischemia/Reperfusion Injury through Suppressing TLR4/MyD88 Pathway

Yu, Q., Li, G., Ding, Q., Lei, T., Li, J., Sun, L., Sun, X., & Yang, Y. (2020) · Cerebrovascular Diseases · doi:10.1159/000505961 · Cited by 47

Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

Yang, M., Chen, P., Jin, H., Xie, X., Gao, T., Yang, L., & Yu, X. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-133 · Cited by 46

Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy

Shelbaya, S., Abushady, M. M., Nasr, M. S., Bekhet, M. M., Mageed, Y. A.-A., & Abbas, M. (2018) · Current Diabetes Reviews · doi:10.2174/1573399813666170829163442 · Cited by 46

Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats

Ling, L., Chen, D., Tong, Y., Zang, Y.-H., Ren, X., Zhou, Y., Qi, X., Chen, Q., Li, Y., Kang, Y., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001654 · Cited by 46

Irisin treatment improves healing of dystrophic skeletal muscle

Reza, M. M., Sim, C. M., Subramaniyam, N., Ge, X., Sharma, M., Kambadur, R., & McFarlane, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21636 · Cited by 45

Role of Regular Physical Activity in Neuroprotection against Acute Ischemia

Raimondo, D. D., Rizzo, G., Musiari, G., Tuttolomondo, A., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239086 · Cited by 45

Expressions of irisin and urotensin II and their relationships with blood pressure in patients with preeclampsia

Zhang, L., Xie, Q., Tang, C., & Zhang, A. (2017) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2016.1273945 · Cited by 44

Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study

Hisamatsu, T., Miura, K., Arima, H., Fujiyoshi, A., Kadota, A., Kadowaki, S., Zaid, M., Miyagawa, N., Satoh, A., Kunimura, A., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.075 · Cited by 44

Effects of high-intensity interval training on mitochondrial supercomplex assembly and biogenesis, mitophagy, and the AMP-activated protein kinase pathway in the soleus muscle of aged female rats

Han, C., Lu, P., & Yan, S.-Z. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111648 · Cited by 44

Irisin protects the substantia nigra dopaminergic neurons in the rat model of Parkinson's disease.

Zarbakhsh, S., Safari, M., Aldaghi, M. R., Sameni, H. R., Ghahari, L., Lagmouj, Y. K., Jaberi, K. R., & Parsaie, H. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33444.7987 · Cited by 43

Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma

Huang, C., Chang, Y., Lee, H., Wu, J., Huang, J., Chung, Y., Hsu, S.-T., Chow, L., Wei, K., & Huang, F. (2020) · The FASEB Journal · doi:10.1096/fj.202000573rr · Cited by 43

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice

Bretland, K. A., Lin, L., Bretland, K. M., Smith, M. A., Fleming, S. M., & Crish, S. D. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12711 · Cited by 43

Exercise‐Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression

Jin, Z. Y., Zhang, Z., Ke, J., Wang, Y., & Wu, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1697070 · Cited by 43

Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage

Tu, T., Yin, S., Pang, J., Zhang, X., Zhang, L., Zhang, Y., Xie, Y., Guo, K., Chen, L., Peng, J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.640215 · Cited by 42

Excessive irisin increases oxidative stress and apoptosis in murine heart

Ho, M.-Y., Wen, M., Yeh, J., Hsieh, C., Chen, C., Hsieh, M., Tsai, M., Yang, C., Wu, V. C., Hung, K., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.005 · Cited by 41

Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer

Yang, B. C., & Leung, P. S. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.08.002 · Cited by 41

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation

Zang, Y.-H., Chen, D., Zhou, B. R., Chen, A., Wang, J., Gao, X.-Y., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106579 · Cited by 40

Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice

Colucci, S. C., Buccoliero, C., Sanesi, L., Errede, M., Colaianni, G., Annese, T., Khan, M. P., Zerlotin, R., Dicarlo, M., Schipani, E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910863 · Cited by 40

Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk

Bonfante, I. L. P., Chacon‐Mikahil, M. P. T., Brunelli, D. T., Gáspari, A. F., Duft, R. G., Oliveira, A. G., Araújo, T. G., Saad, M. J. A., & Cavaglieri, C. R. (2017) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000305 · Cited by 39

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

Altay, D. U., Keha, E. E., Karagüzel, E., Menteşe, A., Yaman, S. Ö., & Alver, A. (2018) · International braz j urol · doi:10.1590/s1677-5538.ibju.2017.0404 · Cited by 39

Irisin regulates thermogenesis and lipolysis in 3T3-L1 adipocytes

Vliora, M., Grillo, E., Corsini, M., Ravelli, C., Nintou, E., Karligiotou, E., Flouris, A. D., & Mitola, S. M. F. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130085 · Cited by 39

Irisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway

Zhang, D., Zhang, P., Li, L., Tang, N., Huang, F., Kong, X., Tan, X., & Shi, G. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s214260 · Cited by 38

Irisin regulates cardiac physiology in zebrafish

Sundarrajan, L., Yeung, C., Hahn, L., Weber, L. P., & Unniappan, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181461 · Cited by 35

Exercise training increases cardiac, hepatic and circulating levels of brain-derived neurotrophic factor and irisin in young and aged rats

Belviranlı, M., & Okudan, N. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0053 · Cited by 35

Irisin levels are not associated to resistance training-induced alterations in body mass composition in older untrained women with and without obesity

Tibana, R. A., Nascimento, D. D. C., de Souza, N. M. F., de Souza, V. C., Neto, I. V. D. S., Voltarelli, F. A., Pereira, G. B., Navalta, J. W., & Prestes, J. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0748-4 · Cited by 34

Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease

Pan, J.-A., Zhang, H., Yu, Q., Zhang, J.-F., Wang, C.-Q., Gu, J., & Chen, K. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.02.020 · Cited by 34

Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5/UCP1 Pathway

Liu, Y., Guo, C., Liu, S., Zhang, S., Mao, Y., & Fang, L. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s308893 · Cited by 32

The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin

Çelik, H. T., Akkaya, N., Erdamar, H., Gök, S., Kazancı, F. H., Demirçelik, B., Çakmak, M., & Yiǧitoǧlu, M. R. (2015) · Clinical Laboratory · doi:10.7754/clin.lab.2015.150420 · Cited by 31

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio, A., Marrano, N., Biondi, G., Dipaola, L., Spagnuolo, R., Cignarelli, A., Perrini, S., Laviola, L., & Giorgino, F. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3238 · Cited by 31

Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study

Zhang, R., Fu, T., Zhao, X., Qiu, Y., Hu, X., Shi, H., & Yin, X. L. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s275878 · Cited by 30

Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation

Lee, J., Park, J., Kim, Y. H., Lee, N. H., & Song, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222559 · Cited by 29

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan, R., Hakan, H., Eryılmaz, R., Huyut, Z., Sevim, M., Araz, Ş., Ertaş, K., & Taken, K. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.2.505 · Cited by 29

Irisin injection mimics exercise effects on the brain proteome

Dehghan, F., Zamani, S., Barreiro, C., & Jami, M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15493 · Cited by 29

Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design

Wu, L., Zhu, D., Tang, C.-H., Ge, B., Shi, J. F., Wang, B., Lu, Y., He, P., Wang, W., Lu, S., et al. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0415-3 · Cited by 28

Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats

Mohammadi, S., Oryan, S., Komaki‬, A., Eidi, A., & Zarei, M. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190184 · Cited by 27

The diagnostic and prognostic roles of serum irisin in bladder cancer

Esawy, M. M., & Abdel-Samd, K. M. (2019) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2019.100529 · Cited by 26

FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1

Fan, G.-H., Zhu, T.-Y., & Huang, J. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109665 · Cited by 26

Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats

Seo, D. Y., Bae, J. H., Kim, T. N., Kwak, H., Kha, P. T., & Han, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113863 · Cited by 26

Irisin promotes cementoblast differentiation via p38 MAPK pathway

Zhu, J., Wang, Y., Cao, Z., Du, M., Hao, Y., Pan, J., & He, H. (2020) · Oral Diseases · doi:10.1111/odi.13307 · Cited by 24

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging

Chen, Y., Ding, J., Zhao, Y., Ju, S., Mao, H. Z., & Peng, X. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211006049 · Cited by 24

Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway

Song, H., Xu, J., Lv, N., Zhang, Y., Wu, F., Li, H., Shao, L., Mu, Q., Wang, F., Tang, D., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.052 · Cited by 23

Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity

Yüksel, B., Demiral, İ., Zeybek, Ü., Çelik, F., Buyru, F., Yeh, J., & Baştu, E. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0083 · Cited by 23

Irisin has no effect on lipolysis in 3T3-L1 adipocytes or fatty acid metabolism in HepG2 hepatocytes

Wang, C., Wang, L., Li, W., Yan, F., Tian, M., Wu, C., Qi, L., Wang, X., Song, J., Hou, X., et al. (2014) · Endocrine · doi:10.1007/s12020-014-0458-9 · Cited by 22

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Xuan, X., Lin, J., Zhang, Y., Zhou, L., Xu, L., Jia, J., Zhao, B., Lin, Z., Zhu, Q. N., Li, L., et al. (2020) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4261 · Cited by 21

Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults

McCormick, J. J., King, K. E., Notley, S. R., Fujii, N., Boulay, P., Sigal, R. J., & Kenny, G. P. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103189 · Cited by 21

Irisin and Visfatin Predicts Severity of Diabetic Nephropathy

Mageswari, R., Sridhar, M. G., Nandeesha, H., Parameswaran, S., & Vinod, K. V. (2018) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-018-0749-7 · Cited by 20

Interplay of skeletal muscle and adipose tissue: sarcopenic obesity.

Park, M., & Choi, K. M. (2023) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2023.155577 · Cited by 106

Bone and muscle crosstalk in ageing and disease

Kirk, B., Lombardi, G., & Duque, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01088-x · Cited by 89

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 83

Myokines: Metabolic regulation in obesity and type 2 diabetes

Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58

Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-κB axis in adipocytes

Zhang, Y.-S., He, X., Wang, K., Xue, Y., Hu, S.-H., Jin, Y.-S., Zhu, G., Rui, Y.-J., & Shi, Q. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.013 · Cited by 49

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase

Sánchez, B., Muñoz-Pinto, M. F., & Cano, M. (2023) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.41 · Cited by 38

Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities

Trettel, C. D. S., Pelozin, B. R. D. A., Barros, M. P., Bachi, A. L. L., Braga, P. G. S., Momesso, C. M., Furtado, G. E., Valente, P. A., de Oliveira, E. M., Hogervorst, E., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1106529 · Cited by 56

Irisin, a mediator of muscle crosstalk with other organs: from metabolism regulation to protective and regenerative effects

Momenzadeh, S., Jami, M., Jalalvand, A., Esfarjani, F., Shahabi, S., & Zamani, S. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220217141918 · Cited by 13

Irisin and Autophagy: First Update

Pesce, M., Ballerini, P., Paolucci, T., Puca, I., Farzaei, M. H., & Patruno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207587 · Cited by 59

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

Chen, N., Li, Q., Liu, J., & Jia, S. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2660 · Cited by 170