Characterization of the logopenic variant of primary progressive aphasia: A systematic review and meta-analysis
Abstract
The linguistic and anatomical variability of the logopenic variant of Primary Progressive Aphasia (lv-PPA) as defined by current diagnostic criteria has been the topic of an intense debate. The present review and meta-analysis aims at characterizing the profile of lv-PPA, by a comprehensive analysis of the available literature on the neuropsychological, neuroimaging, electrophysiological, pathological, and genetic features of lv-PPA. We conducted a systematic bibliographic search, leading to the inclusion of 207 papers. Of them, 12 were used for the Anatomical Likelihood Estimation meta-analysis on grey matter revealed by magnetic resonance imaging data. The results suggest that the current guidelines outline a relatively consistent syndrome, characterized by a core set of linguistic and, to a lesser extent, non-linguistic deficits, mirroring the involvement of left temporal and parietal regions typically affected by Alzheimer Disease pathology. Variations of the lv-PPA profile are discussed in terms of heterogeneity of the neuropsychological instruments and the diagnostic criteria adopted.
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Systematic reviews show that speech and language studies across neurodegenerative diseases span fewer than 20 languages, most tested in only a handful of papers.
“Also, as shown by systematic reviews, speech and language studies across neurodegenerative diseases span fewer than 20 languages, most of them tested in only a handful of papers. 4,5,47,81-83”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [81]
In a systematic review of logopenic variant primary progressive aphasia, 71.5% of findings came from speakers of English.
“In a systematic review of logopenic variant primary progressive aphasia, for instance, 71.5% of findings came from speakers of English. 81”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [81]
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Speech and language markers of neurodegeneration: a call for global equity
García, A. M., de Leon, J., Tee, B. L., Blasi, D. E., & Gorno-Tempini, M. L. (2023) · Brain · doi:10.1093/brain/awad253 · Cited by 102 · see citing works
- Authors
- Conca, F., Esposito, V., Giusto, G., Cappa, S. F., & Catricalà, E.
- Affiliations
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Corresponding author
- Cappa, Stefano F.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 82
- Pages
- 101760
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W4305070947
- Cited by
- 54
- References
- 113
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 10 · 2023: 12
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero della Salute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- logopenic variant primary progressive aphasia, primary progressive aphasia, diagnostic criteria, neuropsychological profile, neuroimaging, gray matter atrophy, left temporal lobe, left parietal lobe, Alzheimer disease pathology, electrophysiology, genetic characteristics, language deficits, diagnostic heterogeneity
- MeSH terms
- Alzheimer Disease, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Aphasia, Primary Progressive
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