Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease

Lecanemab in early Alzheimer's disease

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212948 · Cited by 5,678 · see citing works

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial

Sims, J. R., Zimmer, J. A., Evans, C. D., Lu, M., Ardayfio, P., Sparks, J., Wessels, A. M., Shcherbinin, S., Wang, H., Monkul Nery, E. S., et al. (2023) · JAMA · doi:10.1001/jama.2023.13239 · Cited by 2,932 · see citing works

Apolipoprotein E: Far More Than a Lipid Transport Protein

Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · see citing works

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

Budd Haeberlein, S., Aisen, P. S., Barkhof, F., Chalkias, S., Chen, T., Cohen, S., Dent, G., Hansson, O., Harrison, K., von Hehn, C., et al. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2022.30 · Cited by 1,367 · see citing works

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Initiative, A. D. N., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., et al. (2017) · Nature · doi:10.1038/nature24016 · Cited by 1,220 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916 · see citing works

Reelin Is a Ligand for Lipoprotein Receptors

D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808 · see citing works

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Takahashi, H., Kerrisk, M. E., Vortmeyer, A., Wisniewski, T., Koleske, A. J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.036 · Cited by 572 · see citing works

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

Trommsdorff, M., Borg, J., Margolis, B. L., & Herz, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33556 · Cited by 540 · see citing works

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

Kadavath, H., Hofele, R. V., Biernat, J., Kumar, S., Tepper, K., Urlaub, H., Mandelkow, E., & Zweckstetter, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504081112 · Cited by 524 · see citing works

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Long, H., Cheng, Y., Zhou, Z.-W., Luo, H., Wen, D., & Gao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.648636 · Cited by 504 · see citing works

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works

ApoE-4 and Age at Onset of Alzheimer's Disease: The NIMH Genetics Initiative

Blacker, D., Haines, J. L., Rodes, L., Terwedow, H., Go, R. C. P., Harrell, L. E., Perry, R. T., Bassett, S. S., Chase, G., Meyers, D., et al. (1997) · Neurology · doi:10.1212/wnl.48.1.139 · Cited by 479 · see citing works

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

Forner, S., Baglietto-Vargas, D., Martini, A. C., Trujillo-Estrada, L., & LaFerla, F. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.002 · Cited by 430 · see citing works

A Critical Function for β-Amyloid Precursor Protein in Neuronal Migration Revealed by <i>In Utero</i> RNA Interference

Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., & Selkoe, D. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4701-07.2007 · Cited by 369 · see citing works

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Chen, Y., Durakoglugil, M. S., Xian, X., & Herz, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914984107 · Cited by 368 · see citing works

Reelin Activates Src Family Tyrosine Kinases in Neurons

Bock, H. H., & Herz, J. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01403-3 · Cited by 355 · see citing works

Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex

Jossin, Y., & Cooper, J. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2816 · Cited by 332 · see citing works

Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β

Beffert, U., Morfini, G., Bock, H. H., Reyna, H., Brady, S. T., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209205200 · Cited by 306 · see citing works

Reelin modulates NMDA receptor activity in cortical neurons

Chen, Y., Beffert, U., Ertunc, M., Tang, T.-S., Kavalali, E. T., Bezprozvanny, I., & Herz, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1951-05.2005 · Cited by 299 · see citing works

Physiological and pathological phosphorylation of tau by Cdk5

Kimura, T., Ishiguro, K., & Hisanaga, S. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00065 · Cited by 297 · see citing works

Role of tau protein in Alzheimer’s disease: The prime pathological player

Muralidar, S., Ambi, S. V., Sekaran, S., Thirumalai, D., & Palaniappan, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.327 · Cited by 278 · see citing works

Presenilin-1 mutations and Alzheimer’s disease.

Kelleher, R. J., & Shen, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619574114 · Cited by 255 · see citing works

Advances in the development of new biomarkers for Alzheimer’s disease

Klyucherev, T. O., Olszewski, P., Shalimova, A. A., Chubarev, V. N., Tarasov, V. V., Attwood, M. M., Syvänen, S., & Schiöth, H. B. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00296-z · Cited by 241 · see citing works

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

Qiang, L., Sun, X., Austin, T. O., Muralidharan, H., Jean, D. C., Liu, M., Yu, W., & Baas, P. W. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.045 · Cited by 222 · see citing works

Reelin expression and glycosylation patterns are altered in Alzheimer’s disease

Botella-López, A., Burgaya, F., Gavín, R., García-Ayllón, M. S., Gómez-Tortosa, E., Peña-Casanova, J., Ureña, J. M., Del Río, J. A., Blesa, R., Soriano, E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601279103 · Cited by 221 · see citing works

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

Hoe, H.-S., Lee, K. J., Carney, R. S. E., Lee, J., Markova, A., Lee, J.-Y., Howell, B. W., Hyman, B. T., Pak, D. T. S., Bu, G., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4872-08.2009 · Cited by 219 · see citing works

Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination

Bock, H. H., Jossin, Y., Liu, P., Förster, E., May, P., Goffinet, A. M., & Herz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306416200 · Cited by 213 · see citing works

Activation of a Dab1/CrkL/C3G/Rap1 Pathway in Reelin-Stimulated Neurons

Ballif, B. A., Arnaud, L., Arthur, W. T., Guris, D. L., Imamoto, A., & Cooper, J. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.038 · Cited by 208 · see citing works

<i>APOE</i> alleles predict the rate of cognitive decline in Alzheimer disease: A nonlinear model

Martins, C. A. R., Oulhaj, A., de Jager, C. A., & Williams, J. H. (2005) · Neurology · doi:10.1212/01.wnl.0000188871.74093.12 · Cited by 205 · see citing works

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Zhang, X., Wang, R., Hu, D., Sun, X., Fujioka, H., Lundberg, K., Chan, E. R., Wang, Q., Xu, R., Flanagan, M. E., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8680 · Cited by 200 · see citing works

The Central Fragment of Reelin, Generated by Proteolytic ProcessingIn Vivo, Is Critical to Its Function during Cortical Plate Development

Jossin, Y., Ignatova, N. G., Hiesberger, T., Herz, J., de Rouvroit, C. L., & Goffinet, A. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3408-03.2004 · Cited by 198 · see citing works

A CaMKII/Calcineurin Switch Controls the Direction of Ca2+-Dependent Growth Cone Guidance

Wen, Z., Guirland, C., Ming, G., & Zheng, J. Q. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.037 · Cited by 195 · see citing works

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

Lopera, F., Marino, C., Chandrahas, A. S., O’Hare, M., Villalba-Moreno, N. D., Aguillon, D., Baena, A., Sanchez, J. S., Vila-Castelar, C., Ramirez Gomez, L., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02318-3 · Cited by 192 · see citing works

Reelin and neuropsychiatric disorders

Ishii, K., Kubo, K.-I., & Nakajima, K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00229 · Cited by 185 · see citing works

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

Sekine, K., Kawauchi, T., Kubo, K., Honda, T., Herz, J., Hattori, M., Kinashi, T., & Nakajima, K. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.020 · Cited by 180 · see citing works

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

Hoe, H.-S., Tran, T. S., Matsuoka, Y., Howell, B. W., & Rebeck, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602162200 · Cited by 174 · see citing works

The roles of amyloid precursor protein (APP) in neurogenesis

Zhou, Z., Chan, C. H.-S., Ma, Q., Xu, X., Xiao, Z., & Tan, E. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.4.16986 · Cited by 169 · see citing works

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

Arbel‐Ornath, M., Hudry, E., Boivin, J. R., Hashimoto, T., Takeda, S., Kuchibhotla, K. V., Hou, S. S., Lattarulo, C. R., Belcher, A. M., Shakerdge, N. B., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0169-9 · Cited by 168 · see citing works

Increased intraneuronal resting [Ca²⁺] in adult Alzheimer’s disease mice

Lopez, J. R., Lyckman, A., Oddo, S., LaFerla, F. M., Querfurth, H. W., & Shtifman, A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05135.x · Cited by 162 · see citing works

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase

Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408127200 · Cited by 151 · see citing works

Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Xu, J., Chatterjee, M., Baguley, T. D., Brouillette, J., Kurup, P. K., Ghosh, D., Kanyo, J. E., Zhang, Y., Seyb, K. I., Ononenyi, C., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001923 · Cited by 144 · see citing works

Cajal-Retzius Cells Instruct Neuronal Migration by Coincidence Signaling between Secreted and Contact-Dependent Guidance Cues

Gil, C., Franco, S. J., Martínez‐Garay, I., Espinosa, A., Harkins-Perry, S. R., & Müller, U. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.040 · Cited by 143 · see citing works

Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

Utsunomiya-Tate, N., Kubo, K.-I., Tate, S.-I., Kainosho, M., Katayama, E., Nakajima, K., & Mikoshiba, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160272497 · Cited by 131 · see citing works

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

Pujadas, L., Rossi, D., Andrés, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., & Soriano, E. (2014) · Nature Communications · doi:10.1038/ncomms4443 · Cited by 129 · see citing works

Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

Ruiz, S. M. A., & Eldar-Finkelman, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.792364 · Cited by 126 · see citing works

Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an Apolipoprotein E receptor/disabled‐1/glycogen synthase kinase‐3β cascade

Ohkubo, N., Lee, Y., Morishima, A., Terashima, T., Kikkawa, S., Tohyama, M., Sakanaka, M., Tanaka, J., Maeda, N., Vitek, M. P., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0434fje · Cited by 118 · see citing works

A role of MAP1B in Reelin-dependent Neuronal Migration

González-Billault, C. E., del Rı́o, J. A., Ureña, J. M., Jimenez-Mateos, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simó, S., Torre, A. L., Gavı́n, R., et al. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh213 · Cited by 114 · see citing works

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges

Khanna, M. R., Kovalevich, J., Lee, V. M. ‐., Trojanowski, J. Q., & Brunden, K. R. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.006 · Cited by 112 · see citing works

Rho GTPases as therapeutic targets in Alzheimer’s disease

Aguilar, B. J., Zhu, Y., & Lu, Q. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0320-4 · Cited by 107 · see citing works

Secreted Reelin molecules form homodimers

Kubo, K., Mikoshiba, K., & Nakajima, K. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00068-8 · Cited by 99 · see citing works

The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents

Griebel, G., Stemmelin, J., Lopez-Grancha, M., Boulay, D., Boquet, G., Slowinski, F., Pichat, P., Beeské, S., Tanaka, S., Mori, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54557-5 · Cited by 97 · see citing works

Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates

Gyparaki, M. T., Arab, A., Sorokina, E. M., Santiago-Ruiz, A. N., Bohrer, C. H., Xiao, J., & Lakadamyali, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021461118 · Cited by 96 · see citing works

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

Matsuki, T., Pramatarova, A., & Howell, B. W. (2008) · Journal of Cell Science · doi:10.1242/jcs.027334 · Cited by 92 · see citing works

Reelin depletion is an early phenomenon of Alzheimer's pathology

Herring, A., Donath, A., Steiner, K. M., Widera, M. P., Hamzehian, S., Kanakis, D., Kölble, K., ElAli, A., Hermann, D. M., Paulus, W., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-112069 · Cited by 92 · see citing works

Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry

Yoshimura, Y., Ichinose, T., & Yamauchi, T. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.037 · Cited by 89 · see citing works

The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling

Nakano, Y., Kohno, T., Hibi, T., Kohno, S., Baba, A., Mikoshiba, K., Nakajima, K., & Hattori, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702300200 · Cited by 86 · see citing works

Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors

Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., & Takagi, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700438104 · Cited by 84 · see citing works

Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyondβ-Amyloid: Insights from Clinical Trials

Jia, Q., Deng, Y., & Qing, H. (2014) · BioMed Research International · doi:10.1155/2014/837157 · Cited by 80 · see citing works

Ca2+-dependent Cell Signaling through Calmodulin-activated Protein Phosphatase and Protein Kinases Minireview Series

Stull, J. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000030200 · Cited by 76 · see citing works

Importance of Reelin C-Terminal Region in the Development and Maintenance of the Postnatal Cerebral Cortex and Its Regulation by Specific Proteolysis

Kohno, T., Honda, T., Kubo, K., Nakano, Y., Tsuchiya, A., Murakami, T., Banno, H., Nakajima, K., & Hattori, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4119-14.2015 · Cited by 76 · see citing works

Cleavage within Reelin Repeat 3 Regulates the Duration and Range of the Signaling Activity of Reelin Protein

Koie, M., Okumura, K., Hisanaga, A., Kamei, T., Sasaki, K., Deng, M., Baba, A., Kohno, T., & Hattori, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536326 · Cited by 75 · see citing works

Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease

Kobro‐Flatmoen, A., Nagelhus, A., & Witter, M. P. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.012 · Cited by 74 · see citing works

Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins

Huang, Y., Magdaleno, S. M., Hopkins, R., Slaughter, C. A., Curran, T., & Keshvara, L. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.023 · Cited by 71 · see citing works

Phosphorylation of tau in apolipoprotein E-deficient mice

Genis, I., Gordon, I., Sehayek, E., & Michaelson, D. M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12007-q · Cited by 70 · see citing works

New Therapeutic Targets in Alzheimer's Disease

Coman, H. G., & Nemeş, B. (2017) · International journal of gerontology · doi:10.1016/j.ijge.2016.07.003 · Cited by 62 · see citing works

ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease

Li, Y., Macyczko, J. R., Liu, C.-C., & Bu, G. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.03.011 · Cited by 61 · see citing works

Neutrophils as a potential therapeutic target in Alzheimer’s disease

Aries, M. L., & Hensley‐McBain, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1123149 · Cited by 61 · see citing works

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Pao, P., Seo, J., Lee, A., Kritskiy, O., Patnaik, D., Penney, J., Raju, R. M., Geigenmüller, U., Silva, M. C., Lucente, D. E., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217864120 · Cited by 61 · see citing works

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex

Hirota, Y., Kubo, K., Katayama, K., Honda, T., Fujino, T., Yamamoto, T. T., & Nakajima, K. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23691 · Cited by 59 · see citing works

Akt signaling pathway: a potential therapy for Alzheimer’s disease through glycogen synthase kinase 3 beta inhibition

Limantoro, J., de Liyis, B. G., & Sutedja, J. C. (2023) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-023-00751-2 · Cited by 59 · see citing works

Phosphorylation of tau at serine 416 by Ca2+/calmodulin‐dependent protein kinase II in neuronal soma in brain

Yamamoto, H., Hiragami, Y., Murayama, M., Ishizuka, K., Kawahara, M., & Takashima, A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03307.x · Cited by 58 · see citing works

Functional Interactions of Fibrillar and Oligomeric Amyloid-β with Alpha7 Nicotinic Receptors in Alzheimer's Disease

Lilja, A. M., Porras, O., Storelli, E., Nordberg, A., & Marutle, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-101242 · Cited by 57 · see citing works

Molecular Insight into the Therapeutic Promise of TargetingAPOE4for Alzheimer’s Disease

Mamun, A. A., Uddin, M. S., Bashar, M. F. B., Zaman, S., Begum, Y., Bulbul, I. J., Islam, M. S., Sarwar, M. S., Mathew, B., Amran, M. S., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5086250 · Cited by 53 · see citing works

Discovery and validation of autosomal dominant Alzheimer’s disease mutations

Dominantly Inherited Alzheimer Network (DIAN), Hsu, S., Gordon, B. A., Hornbeck, R. C., Norton, J. B., Levitch, D., Louden, A., Ziegemeier, E., Laforce, R. J., Chhatwal, J. P., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0392-9 · Cited by 49 · see citing works

CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development

Dillon, G. M., Tyler, W. A., Omuro, K. C., Kambouris, J. A., Tyminski, C., Henry, S. M., Haydar, T. F., Beffert, U., & Ho, A. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.039 · Cited by 46 · see citing works

Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11α

Parisiadou, L., & Efthimiopoulos, S. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.015 · Cited by 42 · see citing works

Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage

Sato, Y., Kobayashi, D., Kohno, T., Kidani, Y., Prox, J., Becker‐Pauly, C., & Hattori, M. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv102 · Cited by 42 · see citing works

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1

Cao, L., Guan, P.-P., Liang, Y.-Y., Huang, X., & Wang, P. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00108 · Cited by 42 · see citing works

Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

Oka, M., Fujisaki, N., Akiko, M.-O., Ohtake, Y., Shimizu, S., Saito, T., Hisanaga, S., Iijima, K., & Ando, K. (2017) · The Journal of Biochemistry · doi:10.1093/jb/mvx038 · Cited by 40 · see citing works

Regulation of Reelin functions by specific proteolytic processing in the brain

Hattori, M., & Kohno, T. (2021) · The Journal of Biochemistry · doi:10.1093/jb/mvab015 · Cited by 34 · see citing works

APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD

Polsinelli, A. J., Lane, K. A., Manchella, M. K., Logan, P. E., Gao, S., & Apostolova, L. G. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12955 · Cited by 34 · see citing works

Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function

Kamceva, M., Benedict, J., Nairn, A. C., & Lombroso, P. J. (2016) · Neural Plasticity · doi:10.1155/2016/8136925 · Cited by 33 · see citing works

Identification of an ERK Inhibitor as a Therapeutic Drug Against Tau Aggregation in a New Cell-Based Assay

Siano, G., Caiazza, M. C., Ollà, I., Varisco, M., Madaro, G., Quercioli, V., Calvello, M., Cattaneo, A., & Primio, C. D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00386 · Cited by 30 · see citing works

Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner

Kohno, T., Ishii, K., Hirota, Y., Honda, T., Makino, M., Kawasaki, T., Nakajima, K., & Hattori, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1907-20.2020 · Cited by 30 · see citing works

Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice

Okugawa, E., Ogino, H., Shigenobu, T., Yamakage, Y., Tsuiji, H., Oishi, H., Kohno, T., & Hattori, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61380-w · Cited by 29 · see citing works

The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders

Mahaman, Y. A. R., Huang, F., Embaye, K. S., Wang, X., & Zhu, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.680118 · Cited by 22 · see citing works

Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153

Zhang, H., Chang, L., Zhang, H., Nie, J., Zhang, Z., Yang, X., Vuong, A. M., Wang, Z., Chen, A., & Niu, Q. L. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.05.027 · Cited by 21 · see citing works

PP1, PP2A and PP2B Interplay in the Regulation of Sperm Motility: Lessons from Protein Phosphatase Inhibitors

Ferreira, A. F., Santiago, J., Silva, J. V., Oliveira, P. F., & Fardilha, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315235 · Cited by 16 · see citing works

Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β

Kobro‐Flatmoen, A., Battistin, C., Nair, R. R., Bjorkli, C., Skender, B., Kentros, C. G., Gouras, G. K., & Witter, M. P. (2023) · Brain Communications · doi:10.1093/braincomms/fcad115 · Cited by 16 · see citing works

Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases

Lidón, L., Urrea, L., Llorens, F., Gil, V., Álvarez, I., Díez-Fairén, M., Aguilar, M., Pástor, P., Zerr, I., Alcolea, D. A., et al. (2020) · Cells · doi:10.3390/cells9051252 · Cited by 14 · see citing works

Therapeutic Targets for Alzheimer's Disease: Amyloid Vs. Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report

Gauthier, S. G., Boxer, A. L., Knopman, D. S., Sims, J., Doody, R. S., Aisen, P., Iwatsubo, T., Bateman, R. J., & Vellas, B. J. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.29 · Cited by 14 · see citing works

Biomarkers in Alzheimer's Disease: A Review

Chintamaneni, M., & Bhaskar, M. (2012) · ISRN Pharmacology · doi:10.5402/2012/984786 · Cited by 11 · see citing works

Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer’s Disease Patients

López‐Font, I., Lennol, M. P., Iborra‐Lázaro, G., Zetterberg, H., Blennow, K., & Sáez‐Valero, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147522 · Cited by 10 · see citing works

The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review

Mertaş, B., & Boşgelmez, İ. İ. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031222 · Cited by 35 · see citing works

P4‐336: Dissecting pathogenic ApoE pathways with the ADNI dataset: The case for reelin

Hemond, C. C., Ngo, K., Shen, L., Risacher, S. L., Kim, S., Saykin, A. J., & Greicius, M. D. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.09.081

Association Analyses of Reln Rs4298437 and Rs6943822 Polymorphisms with Alzheimer's Disease

Fehér, Á., Juhász, A., Pákáski, M., Kálmán, J., & Janka, Z. (2015) · European Psychiatry · doi:10.1016/s0924-9338(15)30620-9

Alzheimer’s Disease and Reelin

Botella-López, A., & Sáez‐Valero, J. (2008) · Springer eBooks · doi:10.1007/978-0-387-76761-1_26 · Cited by 1 · see citing works

Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer’s disease pathogenesis

Barger, S. W., & Moerman, A. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1781541

EPA-0412 – No association between reln rs362719 and rs7341475 polymorphisms and alzheimer's disease

Fehér, Á., Juhász, A., Gálfi, M., Pákáski, M., Kalman, J. L., & Janka, Z. (2014) · European Psychiatry · doi:10.1016/s0924-9338(14)77834-4