Reduced Reelin Expression Accelerates Amyloid- Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice
Open accessAbstract
In addition to the fundamental role of the extracellular glycoprotein Reelin in neuronal development and adult synaptic plasticity, alterations in Reelin-mediated signaling have been suggested to contribute to neuronal dysfunction associated with Alzheimer's disease (AD). In vitro data revealed a biochemical link between Reelin-mediated signaling, Tau phosphorylation, and amyloid precursor protein (APP) processing. To directly address the role of Reelin in amyloid-beta plaque and Tau pathology in vivo, we crossed heterozygous Reelin knock-out mice (reeler) with transgenic AD mice to investigate the temporal and spatial AD-like neuropathology. We demonstrate that a reduction in Reelin expression results in enhanced amyloidogenic APP processing, as indicated by the precocious production of amyloid-beta peptides, the significant increase in number and size of amyloid-beta plaques, as well as age-related aggravation of plaque pathology in double mutant compared with single AD mutant mice of both sexes. Numerous amyloid-beta plaques accumulate in the hippocampal formation and neocortex of double mutants, precisely in layers with strongest Reelin expression and highest accumulation of Reelin plaques in aged wild-type mice. Moreover, concentric accumulations of phosphorylated Tau-positive neurons around amyloid-beta plaques were evident in 15-month-old double versus single mutant mice. Silver stainings indicated the presence of neurofibrillary tangles, selectively associated with amyloid-beta plaques and dystrophic neurites in the entorhinal cortex and hippocampus. Our findings suggest that age-related Reelin aggregation and concomitant reduction in Reelin-mediated signaling play a proximal role in synaptic dysfunction associated with amyloid-beta deposition, sufficient to enhance Tau phosphorylation and tangle formation in the hippocampal formation in aged Reelin-deficient transgenic AD mice.
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Reduced Reelin expression in HRM mice exacerbates the accumulation of both Aβ and phosphorylated tau, whose production is inhibited by Reelin signaling.
“Reduced Reelin expression in HRM mice exacerbates the accumulation of both A and phosphorylated tau (94), whose production is inhibited by Reelin signaling (Ref.76 and reviewed in Ref. 31).”
From Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses (2017) · cites this paper as [94]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 1× · see citing works
“, 2006, 2008), in line with the reported endosomal localization and pH optimum of -secretase activity (Vassar et al., 1999).”
BackgroundGrundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577 · see citing works
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052 · see citing works
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748 · see citing works
Alzheimer’s disease β-amyloid peptides are released in association with exosomes
Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 2× · see citing works
“…data also fit with recent findings showing that the phenotype of accumulating microglia changes as AD-like pathology progresses in tgAPP-PS1 mice (Hickman et al., 2008), from a protective, A -clearing role during early phases to an enhanced production in inflammatory cytokine and loss in A…”
BackgroundResultWyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works
Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916 · see citing works
Haass, C., Koo, E., Mellon, A., Hung, A. Y., & Selkoe, D. (1992) · Nature · doi:10.1038/357500a0 · Cited by 901 · see citing works
McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836 · see citing works
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Bertram, L., & Tanzi, R. E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2494 · Cited by 747 · see citing works
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710 · see citing works
Characterization of the Drosophila melanogaster genome at the nuclear lamina
Pickersgill, H., Kalverda, B., de Wit, E., Talhout, W., Fornerod, M., & van Steensel, B. (2006) · Nature Genetics · doi:10.1038/ng1852 · Cited by 656 · see citing works
Selkoe, D. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05554.x · Cited by 627 · see citing works
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works
Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor
Estus, S., Golde, T. E., Kunishita, T., Blades, D. A., Lowery, D. E., Eisen, M., Usiak, M., QU, X., Tabira, T., Greenberg, B., et al. (1992) · Science · doi:10.1126/science.1738846 · Cited by 431 · see citing works
Furukawa, K., Sopher, B. L., Rydel, R. E., Begley, J. G., Pham, D. G., Martin, G. M., Fox, M., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67051882.x · Cited by 414 · see citing works
Liao, Y.-F., Wang, B.-J., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402034200 · Cited by 389 · see citing works
Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., & Ikezu, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060378 · Cited by 367 · see citing works
von Rotz, R. C., Kohli, B. M., Bosset, J., Meier, M. G., Suzuki, T., Nitsch, R. M., & Konietzko, U. (2004) · Journal of Cell Science · doi:10.1242/jcs.01323 · Cited by 348 · see citing works
Self-citationReelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β
Beffert, U., Morfini, G., Bock, H. H., Reyna, H., Brady, S. T., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209205200 · Cited by 306 · see citing works
Reelin modulates NMDA receptor activity in cortical neurons
Chen, Y., Beffert, U., Ertunc, M., Tang, T.-S., Kavalali, E. T., Bezprozvanny, I., & Herz, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1951-05.2005 · Cited by 299 · see citing works
Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting
Rajendran, L., Schneider, A., Schlechtingen, G., Weidlich, S., Ries, J., Braxmeier, T. M., Schwille, P., Schulz, J. B., Schroeder, C., Simons, M., et al. (2008) · Science · doi:10.1126/science.1156609 · Cited by 262 · see citing works
Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice
Knobloch, M., Konietzko, U., Krebs, D. C., & Nitsch, R. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.019 · Cited by 259 · see citing works
Self-citationReelin expression and glycosylation patterns are altered in Alzheimer’s disease
Botella-López, A., Burgaya, F., Gavín, R., García-Ayllón, M. S., Gómez-Tortosa, E., Peña-Casanova, J., Ureña, J. M., Del Río, J. A., Blesa, R., Soriano, E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601279103 · Cited by 221 · see citing works
Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth
Hoe, H.-S., Lee, K. J., Carney, R. S. E., Lee, J., Markova, A., Lee, J.-Y., Howell, B. W., Hyman, B. T., Pak, D. T. S., Bu, G., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4872-08.2009 · Cited by 219 · see citing works
Gao, Y., & Pimplikar, S. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261463298 · Cited by 218 · see citing works
Pathways by Which Aβ Facilitates Tau Pathology
Blurton-Jones, M. M., & LaFerla, F. M. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025242 · Cited by 195 · see citing works
Chin, J., Massaro, C. M., Palop, J. J., Thwin, M. T., Yu, G.-Q., Bien-Ly, N., Bender, A., & Mucke, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3758-06.2007 · Cited by 188 · see citing works
Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus
Qiu, S., Zhao, L. F., Korwek, K. M., & Weeber, E. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2561-06.2006 · Cited by 186 · see citing works
DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing
Hoe, H.-S., Tran, T. S., Matsuoka, Y., Howell, B. W., & Rebeck, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602162200 · Cited by 174 · see citing works
Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications
Khoury, J. E., & Luster, A. D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.004 · Cited by 171 · see citing works
de Rouvroit, C. L., Bergeyck, V. D., Cortvrindt, C., Bar, I., Eeckhout, Y., & Goffinet, A. M. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.7007 · Cited by 157 · see citing works
Jossin, Y., Gui, L., & Goffinet, A. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0023-07.2007 · Cited by 143 · see citing works
Utsunomiya-Tate, N., Kubo, K.-I., Tate, S.-I., Kainosho, M., Katayama, E., Nakajima, K., & Mikoshiba, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160272497 · Cited by 131 · cited 2× · see citing works
“…demonstrated to be required for proper Reelin-mediated signaling (Lambert de Rouvroit et al., 1999; Koch et al., 2002; Jossin et al., 2007) and potentially involved in abnormal oligomerization and aggregation of Reelin (Utsunomiya-Tate et al., 2000; Kubo et al., 2002; Yasui et al., 2007).”
BackgroundBeffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., & Herz, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4566-05.2006 · Cited by 121 · see citing works
Ohkubo, N., Lee, Y., Morishima, A., Terashima, T., Kikkawa, S., Tohyama, M., Sakanaka, M., Tanaka, J., Maeda, N., Vitek, M. P., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0434fje · Cited by 118 · see citing works
Beffert, U., Weeber, E. J., Morfini, G. A., Ko, J. P., Brady, S. T., Tsai, L., Sweatt, J. D., & Herz, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4084-03.2004 · Cited by 117 · see citing works
Reelin Signaling Facilitates Maturation of CA1 Glutamatergic Synapses
Qiu, S., & Weeber, E. J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00869.2006 · Cited by 115 · see citing works
Secreted Reelin molecules form homodimers
Kubo, K., Mikoshiba, K., & Nakajima, K. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00068-8 · Cited by 99 · see citing works
Apolipoprotein E receptors in the nervous system
Herz, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832d3a10 · Cited by 95 · see citing works
Age-related accumulation of Reelin in amyloid-like deposits
Knuesel, I., Nyffeler, M., Mormède, C., Muhia, M., Meyer, U., Pietropaolo, S., Yee, B. K., Pryce, C. R., LaFerla, F. M., Marighetto, A., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.011 · Cited by 94 · see citing works
Self-citationApoE receptor 2 controls neuronal survival in the adult brain
Beffert, U., Nematollah Farsian, F., Masiulis, I., Hammer, R. E., Yoon, S. O., Giehl, K. M., & Herz, J. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.029 · Cited by 84 · see citing works
Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., & Takagi, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700438104 · Cited by 84 · see citing works
Genetic Modulation of Tau Phosphorylation in the Mouse
Brich, J., Shie, F., Howell, B. W., Li, R., Tus, K., Wakeland, E. K., Jin, L., Mumby, M. C., Churchill, G. A., Herz, J., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00187.2003 · Cited by 83 · see citing works
Koch, S., Strasser, V., Hauser, C., Fasching, D., Brandes, C., Bajari, T. M., Schneider, W. J., & Nimpf, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf599 · Cited by 80 · see citing works
Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease
Sáez‐Valero, J., Costell, M., Sjögren, M. J. C., Andreasen, N., Blennow, K., & Luque, J. M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10554 · Cited by 78 · see citing works
The RELN Locus in Alzheimer's Disease
Seripa, D., Matera, M. G., Franceschi, M., Daniele, A., Bizzarro, A., Rinaldi, M., Panza, F., Fazio, V. M., Gravina, C., D’Onofrio, G., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14308 · Cited by 68 · see citing works
β-amyloid controls altered Reelin expression and processing in Alzheimer's disease
Botella-López, A., Cuchillo‐Ibáñez, I., Cotrufo, T., Mok, S. S., Li, Q., Jiménez, M. S. B., Dierssen, M., Soriano, E., & Sáez‐Valero, J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.006 · Cited by 64 · see citing works
The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines.
Chiarini, A., Prà, I. D., Jf, W., & Armato, U. (2006) · PubMed · Cited by 50 · see citing works
Doehner, J., Madhusudan, A., Konietzko, U., Fritschy, J., & Knuesel, I. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1333 · Cited by 43 · see citing works
Self-citationHaenggi, T., SCHAUB, M. C., & Fritschy, J. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0999-y · Cited by 35 · see citing works
Self-citationMadhusudan, A., Sidler, C., & Knuesel, I. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06884.x · Cited by 28 · see citing works
Self-citationRegulated Proteolysis of APP and ApoE Receptors
Hoe, H., & Rebeck, G. W. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8017-0 · Cited by 23 · see citing works
Neuropsychology in Alzheimer's disease and other dementia research
Savla, G. N., & Palmer, B. W. (2005) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000184413.36706.8e · Cited by 20 · see citing works
Increased vulnerability to kainate‐induced seizures in utrophin‐knockout mice
Knuesel, I., Riban, V., Zuellig, R. A., SCHAUB, M. C., Grady, R. M., Sanes, J. R., & Fritschy, J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01980.x · Cited by 17 · see citing works
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Flagged first, then by citations
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Sorted by citations
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457 · see citing works
Self-citationSystemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-151 · Cited by 400 · see citing works
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Orr, A. G., Hsiao, E. C., Wang, M. M., Ho, K., Kim, D. H., Wang, X., Guo, W., Kang, J., Yu, G.-Q., Adame, A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3930 · Cited by 289 · see citing works
Reelin and neuropsychiatric disorders
Ishii, K., Kubo, K.-I., & Nakajima, K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00229 · Cited by 185 · see citing works
Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments
Bartzokis, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.015 · Cited by 142 · see citing works
Pujadas, L., Rossi, D., Andrés, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., & Soriano, E. (2014) · Nature Communications · doi:10.1038/ncomms4443 · Cited by 129 · see citing works
Hinrich, A. J., Jodelka, F. M., Chang, J. L., Brutman, D., Bruno, A. M., Briggs, C. A., James, B. D., Stutzmann, G. E., Bennett, D. A., Miller, S. A., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505846 · Cited by 127 · see citing works
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses
Wasser, C. R., & Herz, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.766782 · Cited by 111 · see citing works
Canonical and non-canonical Reelin signaling
Bock, H. H., & May, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00166 · Cited by 107 · see citing works
Alzheimer disease pathology and the cerebrospinal fluid proteome
Dayon, L., Núñez Galindo, A., Wojcik, J., Cominetti, O., Corthésy, J., Oikonomidi, A., Henry, H., Kussmann, M., Migliavacca, E., Severin, I., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0397-4 · Cited by 101 · see citing works
Reelin depletion is an early phenomenon of Alzheimer's pathology
Herring, A., Donath, A., Steiner, K. M., Widera, M. P., Hamzehian, S., Kanakis, D., Kölble, K., ElAli, A., Hermann, D. M., Paulus, W., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-112069 · Cited by 92 · see citing works
Reelin protects against amyloid β toxicity in vivo
Lane-Donovan, C., Philips, G. T., Wasser, C. R., Durakoglugil, M. S., Masiulis, I., Upadhaya, A., Pohlkamp, T., Coskun, C., Kotti, T., Steller, L., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa6674 · Cited by 96 · see citing works
Lendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93 · see citing works
Pathophysiological function of ADAMTS enzymes on molecular mechanism of Alzheimer’s disease
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- Authors
- Kocherhans, S., Madhusudan, A., Doehner, J., Breu, K. S., Nitsch, R. M., Fritschy, J.-M., & Knuesel, I.
- Affiliations
- University of Zurich (CH)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-07-07
- Volume
- 30
- Issue
- 27
- Pages
- 9228-9240
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632461
- OpenAlex
- W2027080434
- Cited by
- 132
- References
- 63
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 3 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 6 · 2013: 11 · 2012: 22
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (117806, 310000)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- reelin, Alzheimer's disease, amyloid plaques, tau phosphorylation, APP processing, neurofibrillary tangles, hippocampus, entorhinal cortex, synaptic dysfunction, aging, dystrophic neurites
- MeSH terms
- Reelin Protein, Age Factors, Alzheimer Disease, Animals, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Humans, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Amyloid beta-Peptides, Extracellular Matrix Proteins, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, tau Proteins, Mice, alpha-Synuclein, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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