Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials
Open accessAbstract
Purpose Use the meta-analytic approach to examine the effects of aerobic exercise on high-density lipoprotein two cholesterol (HDL2-C) in adults. STUDY SOURCES: (1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list.Study selection (1) Randomized controlled trials; (2) aerobic exercise > or = 8 weeks; (3) adults > or = 18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL2-C in the fasting state.Data abstraction All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results Nineteen randomized controlled trials representing 20 HDL2-C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL2-C (X +/- S.E.M., 2.6 +/- 0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL2-C were independent of decreases in body weight, body mass index (kg/m2), and percent body fat.Conclusion Aerobic exercise increases HDL2-C in adults.
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The HDL2-C increase remained statistically significant even if each study was removed from the model.
“even if each study was removed from the model, the results still remained statistically significant.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [32]
Exercise-induced HDL2-C increase was not apparently associated with changes in body weight, body mass index, and body fat composition.
“exercise-induced HDL2-C increase was not apparently associated with changes in body weight, body mass index, and body fat composition.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [32]
Kelley et al.'s meta-analysis of 19 randomized controlled trials found HDL2-C increased by about 11% in subjects undergoing aerobic exercise, and the results were statistically significant.
“They included 19 randomized controlled trials and found that HDL2-C increased by about 11% in subjects undergoing aerobic exercise, and the results were statistically significant.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [32]
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- Authors
- Kelley, G. A., & Kelley, K. S.
- Affiliations
- West Virginia University (US)
- Corresponding author
- Kelley, George A.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 184
- Issue
- 1
- Pages
- 207-215
- ISSN
- 0021-9150 (ISSN-L)
- PMC
- PMC2447856
- OpenAlex
- W2046249078
- Cited by
- 109
- References
- 45
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 4
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL069802)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- aerobic exercise, HDL2, high-density lipoprotein, HDL subfractions, lipid metabolism, body weight, body mass index, fat mass, cardiovascular risk factors
- MeSH terms
- Adult, Coronary Disease, Female, Humans, Lipoproteins, HDL, Male, Risk Factors, Biomarkers, Exercise, Randomized Controlled Trials as Topic, Lipoproteins, HDL2
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