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Moderate alcohol consumption and lower levels of inflammatory markers in US men and women
Abstract
Objective Moderate alcohol consumption is associated with substantially lower risk of cardiovascular disease (CVD). We assessed the relationship between alcohol intake and inflammatory markers to partially explain this beneficial effect.Methods and results From two large prospective studies, we sampled 959 healthy male and 473 healthy female health professionals with reported alcohol intake. Markers of inflammation were soluble tumor necrosis factor-alpha receptors 1 and 2 (sTNF-R1 and sTNF-R2), C-reactive protein (CRP), and interleukin-6 (IL-6). We found significant inverse linear trends for sTNF-R1 (p-trend<0.001 men; 0.03 women) and sTNF-R2 (p-trend=0.002 men; 0.08 women) with increasing alcohol intake. Compared to non-drinkers, men who consumed on average 1-2 drinks/day had 26% lower CRP (-0.66 mg/L, p=0.13), and 36% lower IL-6 (-1.12 pg/ml, p=0.02) levels. Among women, a similar though stronger association was observed at half drink per day. Compared to non-drinkers, both men and women who consumed 1-2 drinks/drinking day had significantly lower sTNF-R1 (-9% in men, -6% in women) and sTNF-R2 (-7% in men, -6% in women) levels as well as lower CRP (-10% in men, -32% in women) and IL-6 (-45% in men, -27% in women) levels.Conclusions Alcohol in moderation is associated with lower levels of inflammatory markers and may lower risk of CVD through these mechanisms.
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“Quercetin (1 g/d for 21 d) failed to attenuate muscle inflammation in ultramarathon runners (807) and in trained cyclists (808,809) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [809]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
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Metadata
- Authors
- Pai, J. K., Hankinson, S. E., Thadhani, R., Rifai, N., Pischon, T., & Rimm, E. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Pai, Jennifer K.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 186
- Issue
- 1
- Pages
- 113-120
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2040172623
- Cited by
- 149
- References
- 37
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 8 · 2012: 12
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA-11181, R01AA011181)
- National Heart, Lung, and Blood Institute (HL07575, R01HL035464, HL35464, T32HL007575)
- National Cancer Institute (CA-55075, CA67262)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- moderate drinking, inflammatory markers, C-reactive protein, interleukin-6, cardiovascular risk, sex differences, healthcare workers
- MeSH terms
- Acute-Phase Proteins, Adult, Aged, Alcohol Drinking, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Inflammation, Male, Middle Aged, Prospective Studies, Risk Factors, Severity of Illness Index, Sex Factors, United States, Biomarkers
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