Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults: The Health, Aging, and Body Composition Study
Abstract
BACKGROUND: Increased levels of acute-phase reactants predict the onset of poor health outcomes. A U-shaped association has been reported between alcohol intake and health outcomes, which suggests that alcohol intake may modify levels of acute-phase reactants. We investigated the relationship between weekly alcohol intake and interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and plasminogen activator inhibitor-1 (PAI-1). METHODS AND RESULTS: Data are from year 1 of the Health, Aging, and Body Composition study, a biracial cohort of 3075 well-functioning men and women aged 70 to 79 years, living in Memphis, Tenn, and Pittsburgh, Pa. The analysis included 2574 persons (51.2% women; 40.1% black) with complete data. After adjustment for age, race, smoking status, history of diabetes, history of cardiovascular disease, physical activity, high-density lipoprotein cholesterol, antiinflammatory medications, statins, and total fat mass, alcohol intake showed a J-shaped relationship with mean IL-6 (P for quadratic term <0.001) and CRP (P=0.014) levels. The association was consistent in both men and women. Compared with subjects who consumed 1 to 7 drinks per week, those who never drank had an increased likelihood of having high levels of both IL-6 and CRP, as did those who drank 8 or more drinks per week. We found no relationship between alcohol intake and levels of TNF-alpha and PAI-1 (P=0.137 and 0.08, respectively). CONCLUSIONS: In well-functioning older persons, light alcohol consumption is associated with lower levels of IL-6 and CRP. These results might suggest an additional biological explanation to the epidemiological link between moderate alcohol consumption and cardiovascular events.
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In overweight, insulin-resistant women, combining a weight-loss programme with 4.2 g/d EPA+DHA increases adiponectin concentration.
“For example, one study showed an increase in adiponectin concentration when a weight-loss programme and 4•2 g/d EPA þ DHA were combined in overweight, insulin-resistant women (632) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [632]
In overweight insulin-resistant women, supplementation with 4.2 g/d EPA and DHA plus a weight-loss programme for 24 weeks did not affect CRP, TNF-alpha, or IL-6.
“¼ CRP, TNF-a,I L -6”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [632]
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- Authors
- Volpato, S., Pahor, M., Ferrucci, L., Simonsick, E. M., Guralnik, J. M., Kritchevsky, S. B., Fellin, R., & Harris, T. B.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Circulation
- Published
- 2004-02-10
- Volume
- 109
- Issue
- 5
- Pages
- 607-612
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1973089839
- Cited by
- 176
- References
- 25
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 6 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 12 · 2012: 11
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P60AG010484, P60 AG 10484-07, N01AG62106, N01-AG-6-2102, N01-AG-62103)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol consumption, inflammatory markers, interleukin-6, C-reactive protein, TNF-α, plasminogen activator inhibitor-1, acute phase proteins, older adults, J-shaped relationship, cardiovascular risk, Health, Aging, and Body Composition Study
- MeSH terms
- Aged, Alcohol Drinking, C-Reactive Protein, Female, Humans, Inflammation, Male, Prospective Studies, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Plasminogen Activator Inhibitor 1
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