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Cited by 125Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS)

Oikawa, Shinichi, Yokoyama, Mitsuhiro, Origasa, Hideki, Matsuzaki, Masunori, Matsuzawa, Yuji, Saito, Yasushi, Ishikawa, Yuichi, Sasaki, Jun, Hishida, Hitoshi, Itakura, Hiroshige, Kita, Toru, Kitabatake, Akira, Nakaya, Noriaki, Sakata, Toshiie, Shimada, Kazuyuki, Shirato, Kunio·2009·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2009.03.029
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Abstract

Background JELIS was a large-scale clinical trial that investigated the effects of eicosapentaenoic acid (EPA) on coronary artery disease (CAD). In this paper, the data of patients registered in JELIS were analysed to compare the incidence of CAD between patients with impaired glucose metabolism (IGM) and normoglycemic (NG) patients. The effect of EPA on the incidence of CAD in patients with IGM was also assessed.Methods The 18,645 hypercholesterolemic patients registered in JELIS were divided into two groups. One group consisted of patients with IGM (n=4565), which included the patients who had diabetes mellitus and patients who had a fasting plasma glucose of 110mg/dL or higher, either at the time of registration or after 6 months. The other group consisted of NG patients (n=14,080). CAD incidence of the two groups over the average 4.6-year follow-up period was compared, and the effect of EPA was assessed.Results Compared to NG patients, IGM patients had a significantly higher CAD hazard ratio (1.71 in the non-EPA group and 1.63 in the EPA group). The treatment with EPA resulted in a 22% decrease in the CAD incidence (P=0.048) in IGM patients and an 18% decrease (P=0.062) in NG patients.Conclusions It was found that the CAD risk in IGM patients is higher than in NG patients, and that highly purified EPA is very effective in decreasing the incidence of CAD among Japanese IGM patients, even though the intake of fish is high.

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Crossref · 10.1016/j.atherosclerosis.2009.03.029

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Metadata

Authors
Oikawa, S., Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Sasaki, J., Hishida, H., Itakura, H., Kita, T., Kitabatake, A., Nakaya, N., Sakata, T., Shimada, K., & Shirato, K.
Affiliations
  • Nippon Medical School (JP)
  • Hyogo Prefectural Awaji Medical Center (JP)
  • University of Toyama (JP)
  • Yamaguchi University (JP)
  • Kobe University (JP)
  • Fujita Health University (JP)
  • Ibaraki Christian University (JP)
  • Kyoto University (JP)
  • Nakamura Gakuen University (JP)
  • Jichi Medical University (JP)
Corresponding author
Oikawa, Shinichi
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2009-10
Volume
206
Issue
2
Pages
535-539
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2009.03.029
OpenAlex
W2007616354
Cited by
125
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 14 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 12
FWCI
7.42
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
Mochida Pharmaceutical Company
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
eicosapentaenoic acid, coronary artery disease, impaired glucose metabolism, hypercholesterolemia, diabetes mellitus, omega-3 fatty acids, cardiovascular risk reduction, fasting blood glucose
MeSH terms
Adult, Aged, Coronary Artery Disease, Diabetes Mellitus, Female, Humans, Hypercholesterolemia, Japan, Male, Middle Aged, Eicosapentaenoic Acid, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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