Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis
Abstract
Objective This meta-analysis sought to investigate the association between carotid intima-media thickness (c-IMT), flow-mediated dilation (FMD) and periodontitis (PD) and to assess the effect of periodontal treatment on c-IMT and FMD.Methods Electronic database searching, hand searching of bibliographic references of included papers, related reviews, and journals in relation to oral, cardiovascular and ultrasound imaging field was carried out. Random effects meta-analyses were performed to investigate the association of co-existence of increased c-IMT, impaired FMD and PD with potential changes in these variables following periodontal intervention.Results 2009 citations and 101 full text articles were screened, with 35 meeting the review inclusion criteria of which 22 suitable for quantitative analysis. Meta-analysis demonstrated that the diagnosis of PD was associated with a mean increase in c-IMT of 0.08 mm (95% C.I. = 0.07-0.09) and a mean difference in FMD of 5.1% compared to controls (95% C.I. = 2.08-8.11%). A meta-analysis of the effects of periodontal treatment on FMD showed a mean improvement of 6.64% between test and control (95% C.I. = 2.83-10.44%).Conclusions This review demonstrated an association between increased c-IMT, impaired FMD and PD. Data from intervention studies suggested a beneficial effect of periodontal treatment on FMD indicating an improvement in endothelial function. The findings support investigation of periodontitis treatment on cardiovascular outcomes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with periodontitis often present with systemic inflammation and endothelial dysfunction, which improves following successful periodontal treatment.
“These patients often present with systemic inflammation and endothelial dysfunction, 22 which improves following successful periodontal treatment.23”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [23]
Cites
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Stang, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9491-z · Cited by 17,396 · see citing works
Pihlstrom, B. L., Michalowicz, B. S., & Johnson, N. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67728-8 · Cited by 3,718 · see citing works
Lorenz, M. W., Markus, H. S., Bots, M. L., Rosvall, M., & Sitzer, M. (2007) · Circulation · doi:10.1161/circulationaha.106.628875 · Cited by 2,977 · see citing works
Mannheim Carotid Intima-Media Thickness Consensus (2004–2006)
Touboul, P., Hennerici, M. G., Meairs, S. P., Adams, H., Amarenco, P., Bornstein, N. M., Csiba, L., Desvarieux, M., Ebrahim, S. B. J., Fatar, M., et al. (2006) · Cerebrovascular Diseases · doi:10.1159/000097034 · Cited by 1,511 · see citing works
Assessment of flow-mediated dilation in humans: a methodological and physiological guideline
Thijssen, D. H. J., Black, M. A., Pyke, K. E., Padilla, J., Atkinson, G., Harris, R. A., Parker, B. A., Widlansky, M. E., Tschakovsky, M. E., & GREEN, D. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00471.2010 · Cited by 1,488 · see citing works
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326 · see citing works
Lockhart, P. B., Bolger, A. F., Papapanou, P. N., Osinbowale, O., Trevisan, M., Levison, M. E., Taubert, K. A., Newburger, J. W., Gornik, H. L., Gewitz, M. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31825719f3 · Cited by 1,038 · see citing works
Drozdzowska, B., Pluskiewicz, W., Halaba, Z. P., Misiołek, H., & Beck, B. R. (2005) · Cited by 984 · see citing works
Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-analysis
Ras, R. T., Streppel, M. T., Draijer, R., & Zock, P. L. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.047 · Cited by 624 · see citing works
Lorenz, M. W., Polak, J. F., Kavousi, M., Mathiesen, E. B., Völzke, H., Tuomainen, T.-P., Sander, D., Plichart, M., Catapano, A. L., Robertson, C. M., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60441-3 · Cited by 598 · see citing works
Periodontal Microbiota and Carotid Intima-Media Thickness
Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B. M., Jacobs, D. R., Sacco, R. L., & Papapanou, P. N. (2005) · Circulation · doi:10.1161/01.cir.0000154582.37101.15 · Cited by 489 · see citing works
Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases
Schenkein, H. A., & Loos, B. G. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12060 · Cited by 456 · see citing works
Beck, J. D., Elter, J. R., Heiss, G., Couper, D., Mauriello, S. M., & Offenbacher, S. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq1101.097803 · Cited by 414 · see citing works
Campbell, L. A., & Rosenfeld, M. E. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-06-0392 · Cited by 363 · see citing works
Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T. E., & Vita, J. A. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000078603.90302.4a · Cited by 361 · see citing works
Global periodontal disease epidemiology
Dye, B. A. (2011) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00413.x · Cited by 360 · see citing works
Oxidative Stress, Systemic Inflammation, and Severe Periodontitis
D’Aiuto, F., Nibali, L., Parkar, M. H., Patel, K., Suvan, J. E., & Donos, N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375830 · Cited by 357 · see citing works
Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D’Aiuto, F., Kastelein, J. J. P., & Loos, B. G. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12171 · Cited by 354 · see citing works
Assessment of atherosclerosis: the role of flow-mediated dilatation
Charakida, M., Masi, S., Lüscher, T. F., Kastelein, J. J. P., & Deanfield, J. E. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq340 · Cited by 288 · see citing works
Periodontal Diseases and the Risk of Coronary Heart and Cerebrovascular Diseases: A Meta‐Analysis
Khader, Y. S., Albashaireh, Z. S. M., & Al‐Omari, M. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.8.1046 · Cited by 264 · see citing works
Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis
Seinost, G., Wimmer, G., Skerget, M., Thaller, E., Brodmann, M., Gasser, R. N. A., Bratschko, R. O., & Pilger, E. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.09.059 · Cited by 253 · see citing works
Higashi, Y., Goto, C., Jitsuiki, D., Umemura, T., Nishioka, K., Hidaka, T., Takemoto, H., Nakamura, S., Soga, J., Chayama, K., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101535 · Cited by 250 · see citing works
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology
Reyes, L., Herrera, D., Kozarov, E., Roldán, S., & Progulske‐Fox, A. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12079 · Cited by 237 · see citing works
Baldassarre, D., Hamsten, A., Veglia, F., Fairé, U. D., Humphries, S. E., Smit, A. J., Giral, P., Kurl, S., Rauramaa, R., Mannarino, E., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.06.034 · Cited by 236 · see citing works
The effects of periodontal therapy on vascular endothelial function: A pilot trial
Elter, J. R., Hinderliter, A. L., Offenbacher, S., Beck, J. D., Caughey, M. C., Brodala, N., & Madianos, P. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.10.002 · Cited by 193 · see citing works
Gender Differences in the Relationship Between Periodontal Disease, Tooth Loss, and Atherosclerosis
Desvarieux, M., Schwahn, C., Völzke, H., Demmer, R. T., Lüdemann, J., Kessler, C., Jacobs, D. R., John, U., & Kocher, T. (2004) · Stroke · doi:10.1161/01.str.0000136767.71518.36 · Cited by 171 · see citing works
Piconi, S., Trabattoni, D., Cristina, L., Perilli, E., Borelli, M., Pacei, M., Rizzardini, G., Lattuada, A., Bray, D. H., Catalano, M., et al. (2008) · The FASEB Journal · doi:10.1096/fj.08-119578 · Cited by 160 · see citing works
Higashi, Y., Goto, C., Hidaka, T., Soga, J., Nakamura, S., Fujii, Y., Hata, T., Idei, N., Fujimura, N., Chayama, K., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.03.037 · Cited by 157 · see citing works
Pussinen, P. J., Nyyssönen, K., Alfthan, G., Salonen, R., Laukkanen, J. A., & Salonen, J. T. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000157982.69663.59 · Cited by 148 · see citing works
BECK, J., Eke, P. I., LIN, D., Madianos, P. N., Couper, D. J., MOSS, K. L., Elter, J. R., HEISS, G. M., & Offenbacher, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.017 · Cited by 125 · see citing works
Risk factors for atherosclerosis in cases with severe periodontitis
Buhlin, K., Hultin, M., Norderyd, O. M., Persson, L., Pockley, A. G., Rabe, P., Klinge, B., & Gustafsson, A. K. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01430.x · Cited by 124 · see citing works
Early Carotid Atherosclerosis in Subjects With Periodontal Diseases
Söder, P., Söder, B., Nowak, J., & Jogestrand, T. (2005) · Stroke · doi:10.1161/01.str.0000165916.90593.cb · Cited by 123 · see citing works
Mercanoğlu, F., Oflaz, H., Öz, O., Gokbuget, A. Y., Gençhellaç, H., Sezer, M., Nişancí, Y., & Umman, S. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.12.1694 · Cited by 114 · see citing works
Zahnd, G., Vray, D., Sérusclat, A., Alibay, D., Bartold, P. M., Brown, A. D. H., Durand, M., Jamieson, L., Kapellas, K., Maple-Brown, L. J., et al. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.05.004 · Cited by 100 · see citing works
Severe periodontitis in young adults is associated with sub‐clinical atherosclerosis
Cairo, F., Castellani, S., Gori, A. M., Nieri, M., Baldelli, G., Abbate, R., & Pini‐Prato, G. P. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01228.x · Cited by 98 · see citing works
Periodontitis and diabetes associations with measures of atherosclerosis and CHD
Southerland, J. H., MOSS, K. L., Taylor, G. W., Beck, J. D., Pankow, J. S., Gangula, P. R., & Offenbacher, S. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.01.026 · Cited by 90 · see citing works
Periodontal care may improve endothelial function
Blum, A., Kryuger, K., Eizenberg, M. M., Tatour, S., Vigder, F., Laster, Z., & Front, E. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.12.003 · Cited by 80 · see citing works
Definitions of periodontal disease in research
Preshaw, P. M. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01320.x · Cited by 73 · see citing works
A Pilot Study Into Measurements of Markers of Atherosclerosis in Periodontitis
Leivadaros, E., van der Velden, U., Bizzarro, S., ten Heggeler, J. M., Gerdes, V. E. A., Hoek, F. J., Nagy, T. O. M., Scholma, J. T., Bakker, S. J. L., Gans, R. O. B., et al. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.1.121 · Cited by 68 · see citing works
Fernandes, C. P., Oliveira, F. A. F., Silva, P. G. D. B., Alves, A. P. N. N., Mota, M. R. L., Montenegro, R. C., Burbano, R. M. R., Seabra, A. D., Filho, J. G. L., Lima, D. L. F., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.201 · Cited by 67 · see citing works
Lipoproteins and lipoprotein metabolism in periodontal disease
Griffiths, R. L., & Barbour, S. E. (2010) · Clinical Lipidology · doi:10.2217/clp.10.27 · Cited by 60 · see citing works
Refining exposure definitions for studies of periodontal disease and systemic disease associations
Demmer, R. T., Kocher, T., Schwahn, C., Völzke, H., Jacobs, D. R., & Desvarieux, M. (2008) · Community Dentistry And Oral Epidemiology · doi:10.1111/j.1600-0528.2008.00435.x · Cited by 59 · see citing works
Söder, P., Meurman, J. H., Jogestrand, T., Nowak, J., & Söder, B. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01145.x · Cited by 56 · see citing works
Hayashida, H., Saito, T., Kawasaki, K., Kitamura, M., Furugen, R., Iwasaki, T., Hayashida, Y., Nakazato, M., Sekita, T., Takamura, N., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.04.002 · Cited by 54 · see citing works
Franek, E., Blaschyk, R., Kolonko, A., Mazur-Psonka, L., Łangowska-Adamczyk, H., Kokot, F., & Więcek, A. (2006) · Journal of Nephrology · doi:10.1093/joneph/19.3.346 · Cited by 46 · see citing works
P eriodontitis and atherosclerosis: an observational study
Pinho, M. M., Faria-Almeida, R., Azevedo, E. I., Manso, M. C., & Martins, L. (2012) · Journal of Periodontal Research · doi:10.1111/jre.12026 · Cited by 40 · see citing works
Li, X., Tse, H., Yiu, K., Na, J., Chen, H., Li, L. S. W., & Jin, L. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01481.x · Cited by 38 · see citing works
Measurement of Atherosclerosis Markers in Patients With Periodontitis: A Case‐Control Study
López‐Jornet, P., Berná-Mestre, J. D. D., Berná-Serna, J. D. D., Camacho‐Alonso, F., Fernandez‐Millan, S., & Reus‐Pintado, M. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.110412 · Cited by 37 · see citing works
Vieira, C. L. Z., Cury, P. R., Miname, M. H., Martinez, L. R. C., Bortolotto, L. A., Giuliano, I. D. C. B., Santos, R. D., & Caramelli, B. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100496 · Cited by 34 · see citing works
Söder, B., & Yakob, M. (2007) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2007.00256.x · Cited by 28 · see citing works
Franek, E., Januszkiewicz-Caulier, J., Błach, A., Napora, M., Jedynasty, K., Budlewski, T., Gozdowskı, D., & Górska, R. (2012) · PubMed · Cited by 26 · see citing works
Ylöstalo, P., Anttila, S., Rajala, U., Päivänsalo, M. J., Keinanen-Kiukaanniemi, S. M., Sakki, T. K., & Knuuttila, M. L. E. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01572.x · Cited by 16 · see citing works
Aterosclerosis en sujetos con periodontitis
López, N., Chamorro, A., & Llancaqueo, M., V (2011) · Revista médica de Chile · doi:10.4067/s0034-98872011000600004 · Cited by 11 · see citing works
Carotid intima-media thickness in patients with chronic and aggressive periodontitis
Puhar, I., Lovrenčić‐Huzjan, A., Šodec-Šimičević, D., Strineka, M., Božić, D., & Plančak, D. (2012) · Acta Stomatologica Croatica · Cited by 10 · see citing works
Cairo, F., Nieri, M., Gori, A. M., Rotundo, R., Castellani, S., Abbate, R., & Pini‐Prato, G. P. (2009) · PubMed · Cited by 10 · see citing works
Li, P., Zhang, D. K., Zhang, J. R., & Chen, L. (2011) · PubMed · Cited by 7 · see citing works
Ruiz, Á. J., Latorre, C., Arregocés, F. M. E., Porras, J. V., Ferro, M. B., Uriza, L. F., Corro, M. M., Mejia, E., & Vargas, A. C. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nonsurgical and surgical treatment of periodontitis: how many options for one disease?
Graziani, F., Karapetsa, D., Alonso, B., & Herrera, D. (2017) · Periodontology 2000 · doi:10.1111/prd.12201 · Cited by 572 · see citing works
Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease
Liccardo, D., Cannavò, A., Spagnuolo, G., Ferrara, N., Cittadini, A., Rengo, C., & Rengo, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061414 · Cited by 509 · see citing works
“More in detail, in their analysis, Orlandi and coworkers observed that periodontal disease was associated with greater carotid intima-media thickness (c-IMT) and with impaired flow-mediated dilation (FMD), indicating the presence of atherosclerosis and endothelial dysfunction, respectively.”
ResultInfluentialPeriodontitis is associated with hypertension: a systematic review and meta-analysis
Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz201 · Cited by 394 · see citing works
Sideri, S., Papageorgiou, S. N., & Eliades, T. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.01.003 · Cited by 388 · see citing works
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S. V., Suvan, J. E., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 310 · see citing works
Zanoli, L., Briet, M. B., Empana, J. P., Cunha, P., Maki-Petaja, K. M., Protogerou, A. D., Tedgui, A., Touyz, R. M., Schiffrin, E. L., Spronck, B., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002508 · Cited by 194 · see citing works
Periodontitis and implant complications in diabetes
Nibali, L., Gkranias, N., Mainas, G., & Pino, A. D. (2022) · Periodontology 2000 · doi:10.1111/prd.12451 · Cited by 177 · see citing works
Seitz, M., Listl, S., Bartols, A., Schübert, I., Blaschke, K., Haux, C., & van der Zande, M. M. (2019) · Preventing Chronic Disease · doi:10.5888/pcd16.180641 · Cited by 168 · see citing works
“Mauri-Obradors et al (2017) (40) 0 1 1 0 0 1 1 0 0 0 0 4”
InfluentialThe oral microbiome and adverse pregnancy outcomes
Cobb, C., Kelly, P., Williams, K., Babbar, S., Angolkar, M., & Derman, R. (2017) · International Journal of Women's Health · doi:10.2147/ijwh.s142730 · Cited by 164 · see citing works
Periodontal therapy and cardiovascular risk
Orlandi, M., Graziani, F., & D'Aiuto, F. (2020) · Periodontology 2000 · doi:10.1111/prd.12299 · Cited by 155 · see citing works
Kuraji, R., Sekino, S., Kapila, Y. L., & Numabe, Y. (2021) · Periodontology 2000 · doi:10.1111/prd.12387 · Cited by 137 · see citing works
Links between atherosclerotic and periodontal disease
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.01.006 · Cited by 126 · see citing works
Periodontal disease and carotid atherosclerosis: A meta-analysis of 17,330 participants
Zeng, X., Leng, W., Lam, Y., Yan, B. P., Wei, X., Weng, H., & Kwong, J. S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.11.092 · Cited by 100 · see citing works
Poor Oral Health and Blood Pressure Control Among US Hypertensive Adults
Pietropaoli, D., Pinto, R. D., Ferri, C., Wright, J. T., Giannoni, M., Ortu, E., & Monaco, A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11528 · Cited by 96 · see citing works
Aguilera, E. M., Leira, Y., Catalina, Q. M., Orlandi, M., Cześnikiewicz‐Guzik, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13180 · Cited by 81 · see citing works
Graziani, F., Cei, S., Orlandi, M., Gennai, S., Gabriele, M., Filice, N., Nisi, M., & D’Aiuto, F. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12451 · Cited by 79 · see citing works
“PT is associated with improvement of the endothelial function and reduces biomarkers of atherosclerotic disease, especially in those already suffering from cardiovascular disease (CVD) and/or diabetes (Orlandi et al. 2014, Teeuw et al. 2014).”
BackgroundDoes Treatment of Periodontal Disease Influence Systemic Disease?
Borgnakke, W. S. (2015) · Dental Clinics of North America · doi:10.1016/j.cden.2015.06.007 · Cited by 79 · see citing works
Sleep disorders and oral health: a cross-sectional study
Carra, M. C., Schmitt, A., Thomas, F., Danchin, N., Pannier, B., & Bouchard, P. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1851-y · Cited by 67 · see citing works
Periodontitis and arterial stiffness: a systematic review and meta‐analysis
Schmitt, A., Carra, M. C., Boutouyrie, P., & Bouchard, P. (2015) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12467 · Cited by 65 · see citing works
“(Orlandi et al., 2014) Periodontal treatment was also found effective in improving endothelial function in patients with severe periodontitis.”
Jablonski, R. A., Kolanowski, A. M., Azuero, A., Winstead, V., Jones‐Townsend, C., & Geisinger, M. L. (2018) · Gerodontology · doi:10.1111/ger.12357 · Cited by 65 · see citing works
The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases
Irwandi, R. A., Chiesa, S. T., Hajishengallis, G., Papayannopoulos, V., Deanfield, J. E., & D’Aiuto, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915081 · Cited by 65 · see citing works
Makkar, H., Reynolds, M. A., Wadhawan, A., Dagdag, A., Merchant, A. T., & Postolache, T. T. (2018) · Pteridines · doi:10.1515/pteridines-2018-0013 · Cited by 64 · see citing works
Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal
Carra, M. C., Rangé, H., Caligiuri, G., & Bouchard, P. (2023) · Periodontology 2000 · doi:10.1111/prd.12528 · Cited by 67 · see citing works
Saffi, M. A. L., Rabelo, E. R., Polanczyk, C. A., Furtado, M. V., Montenegro, M. M., Ribeiro, I. W. J., Kampits, C., Rõsing, C. K., & Haas, A. N. (2018) · Oral Diseases · doi:10.1111/odi.12909 · Cited by 54 · see citing works
Periodontitis, coronary heart disease and myocardial infarction: treat one, benefit all
Nocini, R., Favaloro, E. J., Sanchis‐Gomar, F., & Lippi, G. (2020) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000928 · Cited by 53 · see citing works
Association between Bacterial Infection and Peripheral Vascular Disease: A Review
Wiśniewska, J., Ciecierski, M., Kędzia, A., & Budzyński, J. (2015) · International Journal of Angiology · doi:10.1055/s-0035-1547385 · Cited by 53 · see citing works
Sharma, S., Sridhar, S., McIntosh, A., Messow, C.-M., Aguilera, E. M., Del Pinto, R., Pietropaoli, D., Gorska, R., Siedlinski, M., Maffia, P., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105511 · Cited by 53 · see citing works
Chauhan, N., Mittal, S., Tewari, S., Sen, J., & Laller, K. S. (2019) · Journal of Endodontics · doi:10.1016/j.joen.2019.03.003 · Cited by 47 · see citing works
Polizzi, A., Nibali, L., Tartaglia, G. M., & Isola, G. (2024) · Journal of Periodontology · doi:10.1002/jper.24-0422 · Cited by 49 · see citing works
“Studies on surrogate indicators for cardiovascular outcomes indicated that NSPT was able to improve FMD 16 ; conversely, CIMT was found to be reduced in a preliminary interventional study, 17 while it was not improved following NSPT in a multicentric study.”
Dentists' awareness about the link between oral and systemic health
Nazir, M., Izhar, F., Akhtar, K., & Almas, K. (2019) · Journal of Family and Community Medicine · doi:10.4103/jfcm.jfcm_55_19 · Cited by 45 · see citing works
Oral Healthcare and Cardiovascular Disease
Sanchez, P., Everett, B., Salamonson, Y., Ajwani, S., & George, A. (2017) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000388 · Cited by 43 · see citing works
Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men
Pasquale, L. R., Hyman, L., Wiggs, J. L., ROSNER, B. A., JOSHIPURA, K. J., McEvoy, M., McPherson, Z. E., Danias, J., & Kang, J. H. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.07.014 · Cited by 43 · see citing works
Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study
Wu, L., Li, B., Wang, X., Wang, C.-Y., Zi, H., Weng, H., Huang, Q., Zhu, Y.-J., & Zeng, X. (2019) · Military Medical Research · doi:10.1186/s40779-019-0223-8 · Cited by 39 · see citing works
Li, Y., Wu, X., Liu, M., Deng, K., Tullini, A., Zhang, X., Shi, J., Lai, H., & Tonetti, M. S. (2024) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13987 · Cited by 40 · see citing works
“Chronic periodontal inflammation contributes to the inflammatory burden of the individual and thereby affects general health (D'Aiuto et al., 2018; Orlandi et al., 2014; Tonetti et al., 2007).”
Sanchez, P., Everett, B., Salamonson, Y., Redfern, J., Ajwani, S., Bhole, S., Bishop, J., Lintern, K. J., Nolan, S., Rajaratnam, R., et al. (2019) · BMC Oral Health · doi:10.1186/s12903-018-0697-x · Cited by 37 · see citing works
The Epidemiologic and Clinical Findings of Patients with Buerger Disease
Igari, K., Inoue, Y., & Iwai, T. (2015) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2015.07.014 · Cited by 38 · see citing works
Merchant, A. T., & Virani, S. S. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0640-7 · Cited by 36 · see citing works
Seinost, G., Horina, A., Arefnia, B., Kulnik, R., Kerschbaumer, S., Quehenberger, F., Muster, V., Gütl, K., Zelzer, S., Gasser, R. N. A., et al. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.09.019 · Cited by 35 · see citing works
Periodontitis and risk of prevalent and incident coronary heart disease events
Winning, L., Patterson, C., Linden, K., Evans, A., Yarnel, J., McKeown, P., Kee, F., & Linden, G. J. (2020) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13377 · Cited by 34 · see citing works
“Successful periodontal therapy has a number of beneficial effects on surrogate markers of CHD including the following: CRP (D'Aiuto et al., 2013; Paraskevas et al., 2008; Teeuw et al., 2014), endothelial function (Tonetti et al., 2007), and carotid intima-medial thickness (Orlandi et al., 2014).”
BackgroundCardiovascular Diseases and Periodontitis
Hansen, P. R., & Holmstrup, P. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-96881-6_14 · Cited by 33 · see citing works
Anemia of inflammation associated with periodontitis: Analysis of two clinical studies
Nibali, L., Darbar, U. R., Rakmanee, T., & Donos, N. (2019) · Journal of Periodontology · doi:10.1002/jper.19-0124 · Cited by 32 · see citing works
Erythritol Functional Roles in Oral-Systemic Health
de Cock, P. (2018) · Advances in Dental Research · doi:10.1177/0022034517736499 · Cited by 32 · see citing works
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Ge, J., Zhu, X., Weng, C., Ding, Y. F., Zhao, J., Zhao, L., Wang, T., & Wu, Y. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00325-9 · Cited by 32 · see citing works
Flow-mediated dilatation to relieve puncture-induced radial artery spasm: A pilot study
Ying, L., Xu, K., Gong, X., Liu, X., Fan, Y., Zhao, H., Wang, F., Khurwolah, M. R., & Li, C. (2017) · Cardiology Journal · doi:10.5603/cj.a2017.0125 · Cited by 31 · see citing works
Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy
Arvanitidis, E., Bizzarro, S., Rodriguez, E. A., Loos, B. G., & Nicu, E. A. (2017) · Thrombosis Journal · doi:10.1186/s12959-016-0125-x · Cited by 29 · see citing works
Periodontal disease and cardiovascular disease: umbrella review
Arbildo-Vega, H. I., Cruzado-Oliva, F. H., Coronel-Zubiate, F. T., Meza-Málaga, J. M., Luján-Valencia, S. A., Luján-Urviola, E., Echevarría-Goche, A., Farje-Gallardo, C. A., Castillo-Cornock, T. B., Serquen-Olano, K., et al. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04907-1 · Cited by 26 · see citing works
“One SR [69] included reported that there was an association between PD and c–IMT/FMD.”
BackgroundTran, A. H., Zaidi, A. H., Bolger, A. F., Brutto, Ó. H. D., Hegde, R., Patton, L. L., Rausch, J., & Zachariah, J. P. V. (2025) · Circulation · doi:10.1161/cir.0000000000001390 · Cited by 26 · see citing works
Singer, R. H., Stoutenberg, M., Feaster, D. J., Cai, J., Hlaing, W. M., Metsch, L. R., Salazar, C. R., Beaver, S. M., Finlayson, T. L., Talavera, G. A., et al. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0549 · Cited by 26 · see citing works
Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Zhao, M.-J., Qiao, Y.-X., Wu, L., Huang, Q. Y., Li, B., & Zeng, X. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00440 · Cited by 26 · see citing works
Martínez-Herrera, M., Abad‐Jiménez, Z., Donat, F. J. S., López‐Domènech, S., Silvestre‐Rangil, J., Márquez‐Arrico, C. F., Víctor, V. M., & Rocha, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072117 · Cited by 26 · see citing works
Janjua, S., Staziaki, P. V., Szilveszter, B., Takx, R. A. P., Mayrhofer, T., Hennessy, O., Emami, H., Park, J., Ivanov, A. V., Hallett, T. R., et al. (2017) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.116.005777 · Cited by 25 · see citing works
Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)
Jönsson, D., Orho‐Melander, M., Demmer, R. T., Engström, G., Melander, O., Klinge, B., & Nilsson, P. M. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12998 · Cited by 24 · see citing works
Hallikainen, J., Keränen, S., Savolainen, J., Närhi, M. V. O., Suominen, A. L., Ylöstalo, P., Kellokoski, J. K., Pyysalo, M. J., Pussinen, P. J., Rauramaa, T. H., et al. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01253-y · Cited by 24 · see citing works
Oral Microbiome and Preterm Birth: Correlation or Coincidence? A Narrative Review
Rapone, B., Ferrara, E., Montemurro, N., Converti, I., Loverro, M., Loverro, M. T., Gnoni, A., Scacco, S., Siculella, L., Corsalini, M., et al. (2020) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2020.4444 · Cited by 25 · see citing works
Left ventricular geometry and periodontitis in patients with the metabolic syndrome
Nibali, L., Donos, N., Terranova, V., Pino, A. D., Marca, S. D., Ferrara, V., Pisano, M., Scicali, R., Rabuazzo, A. M., Purrello, F., et al. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2667-8 · Cited by 23 · see citing works
“In particular, indexes of arterial thickness and dysfunction (including c-IMT), increased left ventricular mass and blood pressure have been reported in patients with periodontitis [10, 11, 27].”
BackgroundLamprecht, R., Rimmele, D. L., Schnabel, R. B., Heydecke, G., Seedorf, U., Walther, C., Mayer, C., Struppek, J., Borof, K., Behrendt, C., et al. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13021 · Cited by 23 · see citing works
Bizzarro, S., van der Velden, U., Teeuw, W. J., Gerdes, V. E. A., & Loos, B. G. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12763 · Cited by 22 · see citing works
“, 2014), markers of blood pressure such as endothelial function, flow- mediated dilatation and arterial stiffness (Orlandi et al., 2014; Tonetti et al., 2007), and also an improvement in the lipid profiles (D’Aiuto et al.”
BackgroundMartínez-Herrera, M., López‐Domènech, S., Donat, F. J. S., Silvestre‐Rangil, J., Bañuls, C., Víctor, V. M., & Rocha, M. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13027 · Cited by 21 · see citing works
“Although there have been recent reports of a significant connection between chronic periodontitis (CP) and endothelial dysfunction (Orlandi et al., 2014; Moura et al., 2017), to the best of our knowledge, no previous study has evaluated the association between oxidative stress and endothelial…”
BackgroundLavigne, S. E., & Forrest, J. L. (2020) · PubMed Central · Cited by 21 · see citing works
Association between periodontitis and pulse wave velocity: a systematic review and meta-analysis
Darnaud, C., Courtet, A., Schmitt, A., Boutouyrie, P., Bouchard, P., & Carra, M. C. (2021) · Clinical Oral Investigations · doi:10.1007/s00784-020-03718-2 · Cited by 21 · see citing works
Impact of anti‐infective periodontal therapy on parameters of vascular health
Jockel‐Schneider, Y., Bechtold, M., Haubitz, I., Störk, S., Fickl, S., Harks, I., Eigenthaler, M., Vollrath, O., Baulmann, J., & Schlagenhauf, U. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12849 · Cited by 20 · see citing works
Shiga, Y., Hosomi, N., Nezu, T., Nishi, H., Aoki, S., Nakamori, M., Ishikawa, K., Kinoshita, N., Imamura, E., Ueno, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239773 · Cited by 19 · see citing works
Guo, S., Gu, J., Jiang, Y., Cui, W., Chen, J., Li, L., Zheng, K., & Xu, Y. H. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111155 · Cited by 19 · see citing works
Periodontal therapy increases neutrophil extracellular trap degradation
Moonen, C. G. J., Buurma, K. G., Faruque, M. R. J., Balta, M. G., Liefferink, E., Bizzarro, S., Nicu, E. A., & Loos, B. G. (2019) · Innate Immunity · doi:10.1177/1753425919889392 · Cited by 21 · see citing works
Friman, G., Hultin, M., Nilsson, G. H., & Wårdh, I. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1543-8 · Cited by 19 · see citing works
Lavigne, S. E., & Forrest, J. L. (2020) · PubMed Central · Cited by 18 · see citing works
Lyu, J., Zhang, Y., Zhou, R., Ding, C., Ye, H., Fang, Q., Jiang, C., Chen, X., & Zhong, L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308793 · Cited by 17 · see citing works
The association between periodontitis and cardiovascular risks in asymptomatic healthy patients
Donders, M.-C., Veth, E. O., Hof, A. W. J. V. ’., de Lange, J., & Loos, B. G. (2021) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2021.200110 · Cited by 17 · see citing works
Effect of tooth loss and nutritional status on outcomes after ischemic stroke
Shiga, Y., Nezu, T., Hosomi, N., Aoki, S., Nishi, H., Naito, H., Kinoshita, N., Ueno, H., & Maruyama, H. (2019) · Nutrition · doi:10.1016/j.nut.2019.110606 · Cited by 17 · see citing works
Effect of interleukin-1β on ghrelin receptor in periodontal cells
Nokhbehsaim, M., Beisel-Memmert, S., Damanaki, A., Nanayakkara, S., Zhou, X., Jäger, A., & Deschner, J. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2417-y · Cited by 17 · see citing works
Vascular Endothelial Function in Periodontal Disease: Role of Inflammation
Higashi, Y., & Taguchi, A. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.045720 · Cited by 18 · see citing works
Arregocés, F. M. E., Rada, M. D. H., Martinez, M. J. S., Meza, F. J. H., Roa, N. S., Porras, J. V., & Uriza, C. L. (2021) · Medicine · doi:10.1097/md.0000000000024951 · Cited by 15 · see citing works
Okada, A., Murata, T., Matin, K., Ariyoshi, M., Otsuka, R., Yamashita, M., Suzuki, M., Wakiyama, R., Tateno, K., Suzuki, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257247 · Cited by 15 · see citing works
“Observational studies have shown that periodontal diseases are associated with FMD [10].”
BackgroundDing, L., You, Q., Jiang, Q., Cao, S., & Jiang, S. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13006 · Cited by 14 · see citing works
Association between subclinical atherosclerosis and oral inflammation: A cross‐sectional study
Papi, P., Pranno, N., Murro, B. D., Pompa, G., Polimeni, A., Letizia, C., Petramala, L., Concistrè, A., Aguilera, E. M., Orlandi, M., et al. (2022) · Journal of Periodontology · doi:10.1002/jper.22-0026 · Cited by 15 · see citing works
“Different systematic reviews of observational studies 24,44 highlighted how patients with periodontitis exhibit higher c-IMT values, although the heterogeneity of definitions adopted for periodontitis and c-IMT measurements could have influenced the results of the included studies and, more…”
Chen, T., Lin, C., Chien, S., Chang, S., & Chen, C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26268 · Cited by 14 · see citing works
“In addition to the earlier meta-analyses (Blaizot, Vergnes, Nuwwareh, Amar, & Sixou, 2009; Chistiakov, Orekhov, & Bobryshev, 2016; Orlandi et al., 2014; Sfyroeras, Roussas, Saleptsis, Argyriou, & Giannoukas, 2012), the evidence supporting the presence of live P. gingivalis or their secreted…”
ResultRegulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo
Nokhbehsaim, M., Damanaki, A., Nogueira, A. V. B., Eick, S., Beisel-Memmert, S., Zhou, X., Nanayakkara, S., Götz, W., Cirelli, J. A., Jäger, A., et al. (2017) · Mediators of Inflammation · doi:10.1155/2017/4916971 · Cited by 14 · see citing works
The link between periodontitis and erectile dysfunction: a review
Bizzarro, S., & Loos, B. G. (2019) · BDJ · doi:10.1038/s41415-019-0724-6 · Cited by 14 · see citing works
The Effects of Antimicrobial Mouthwashes on Systemic Disease: What Is the Evidence?
Alrashdan, M. S., Leão, J. C., Doble, A., McCullough, M. J., & Porter, S. R. (2023) · International Dental Journal · doi:10.1016/j.identj.2023.08.012 · Cited by 12 · see citing works
Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study
Shearer, D. M., Thomson, W. M., Cameron, C., Ramrakha, S., Wilson, G., Wong, T. Y., Williams, M. J. A., McLean, R. M., Theodore, R. F., & Poulton, R. (2018) · Community Dentistry And Oral Epidemiology · doi:10.1111/cdoe.12414 · Cited by 12 · see citing works
“Circumstantial evidence for a possible causal link between periodontal inflammation and endothelial dysfunction has arisen from cross‐sectional studies,(20,55) a review(56) and a meta‐analysis.(57) In addition, a number of RCTs have provided baseline data on impaired endothelial function in participants with periodont…”
Tong, C., Wang, Y., & Chang, Y. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16152635 · Cited by 12 · see citing works
“Studies have clearly demonstrated that CA was associated with CP by systematic review and meta-analysis [8,9].”
BackgroundNon-pharmacological Strategies Against Systemic Inflammation: Molecular Basis and Clinical Evidence
Pinto, R. D., Pietropaoli, D., Monaco, A., Desideri, G., Ferri, C., & Grassi, D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200403122600 · Cited by 11 · see citing works
Effects of Obesity on Bone Healing in Rats
Damanaki, A., Beisel-Memmert, S., Nokhbehsaim, M., Abedi, A., Rath-Deschner, B., Nogueira, A. V. B., & Deschner, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413339 · Cited by 11 · see citing works
Aarabi, G., Raedel, M., Kreutzburg, T., Hischke, S., Debus, E. S., Marschall, U., Seedorf, U., & Behrendt, C. (2020) · VASA · doi:10.1024/0301-1526/a000846 · Cited by 11 · see citing works
Green Tea from the Far East to the Drug Store: Focus on the Beneficial Cardiovascular Effects
Landini, L., Rebelos, E., & Honka, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201102104902 · Cited by 11 · see citing works
Could the periodontal therapy improve the cardiologic patient health? A narrative review
Bertoldi, C., Salvatori, R., Pinti, M., & Mattioli, A. V. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102699 · Cited by 12 · see citing works
Shimizu, Y., Yamanashi, H., Kitamura, M., Miyata, J., Nonaka, F., Nakamichi, S., Saito, T., Nagata, Y., & Maeda, T. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13755 · Cited by 10 · see citing works
Fujitani, T., Aoyama, N., Hirata, F., & Minabe, M. (2020) · Clinical and Experimental Dental Research · doi:10.1002/cre2.312 · Cited by 10 · see citing works
“Previous reports have shown associations between endothelial function as judged using other methods and systemic inflammation, cardiovascular diseases, and periodontal disease (Amar et al., 2003; Kitta et al., 2009; Kusunose et al., 2016; Matsuzawa, Sugiyama, Sumida, et al., 2013; Moura et al., 2017; Orlandi et al., 2…”
BackgroundDo Childhood Infections Contribute to Adult Cardiometabolic Diseases?
Burgner, D. P., Liu, R., Wake, M. A., & Uiterwaal, C. S. P. M. (2015) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000882 · Cited by 9 · see citing works
“There is evidence that endotoxin and DNA from periodontal pathogens are present in atherosclerotic lesions,(32) and that interventions that aggressively treat periodontitis may reverse adverse inflammatory cardiovascular risk phenotypes.(33,34)”
Dewake, N., Ishioka, Y., Uchida, K., Taguchi, A., Higashi, Y., Yoshida, A., & Yoshinari, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103365 · Cited by 9 · see citing works
“They also described a beneficial effect of periodontal treatment on FMD, indicating an improvement in the endothelial function [13].”
BackgroundAssociations Among Tooth Loss, Periodontitis, and Carotid Intima-Media Thickness: the Nagahama Study
Fukuhara, S., Watanabe, T., Yamazaki, T., Yamanaka, S., Nakao, K., Asai, K., Kashiwagi, M., Yamazaki, A., Umebachi, C., Setoh, K., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63801 · Cited by 9 · see citing works
Cross‐sectional association between oral health and retinal microcirculation
Samietz, S., Jürgens, C., Ittermann, T., Holtfreter, B., Pink, C., Schipf, S., Biffar, R., Völzke, H., Kocher, T., & Tost, F. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12872 · Cited by 9 · see citing works
“Chronic periodontitis is associated with cardiovascular disease and has systemic effects on large vessels and endothelial function (Orlandi et al., 2014).”
BackgroundUriza, C. L., Roa, N. S., Porras, J. V., Poveda, J. C. V., Otero, L., Ruiz, Á. J., & Arregocés, F. M. E. (2024) · Biomedicines · doi:10.3390/biomedicines12071425 · Cited by 8 · see citing works
“Furthermore, Orlandi et al. (2014), in a systematic review and meta-analysis, evaluated the association between carotid IMT and periodontal disease, reporting that patients with periodontal disease had a higher average carotid IMT (0.08 mm) than those without periodontal disease [4].”
BackgroundInfluentialACE insertion/deletion polymorphism is associated with periodontal disease in Korean population
Kang, S. W., Han, S. Y., Lim, S. B., Cho, K. B., & Ban, J. Y. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.12.003 · Cited by 8 · see citing works
Association of periodontal disease with atherosclerosis in 70-year-old Japanese older adults
Kitamura, M., Ikebe, K., Kamide, K., Gondo, Y., Yamashita, M., Takedachi, M., Nozaki, T., Fujihara, C., Yamada, S., Kashiwagi, Y., et al. (2020) · Odontology · doi:10.1007/s10266-020-00567-z · Cited by 8 · see citing works
Chansawang, K., Lertpimonchai, A., Siripaiboonpong, N., Thienpramuk, L., Vathesatogkit, P., Limpijankit, T., & Charatkulangkun, O. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03670-1 · Cited by 8 · see citing works
Dental Calculus Links Statistically to Angina Pectoris: 26-Year Observational Study
Söder, B., Meurman, J. H., & Söder, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157797 · Cited by 8 · see citing works
“[22,23] However, overall scientific evidence is still weak in this regard.”
BackgroundPeriodontal Disease and Cardiovascular Disease
Zeng, X., Li, N., Zhang, L., Rong, R., & Liu, M. (2017) · Heart and Mind · doi:10.4103/hm.hm_19_17 · Cited by 8 · see citing works
“44%).[9] Another systematic review and meta-analysis based on 25 controlled periodontal intervention trials also revealed that periodontal treatment improved endothelial function and reduced biomarkers of atherosclerotic disease.”
BackgroundOral health complications in Brazilian and French diabetic older people: A comparative study
Lima, D. L. F., Saintrain, M. V. D. L., Neri, J. R., Beck, O., Malet, P., Moizan, J. A. H., & Doucet, J. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2019.103905 · Cited by 7 · see citing works
Exploring the periodontal disease—ischemic stroke link
Sen, S., & Mascari, R. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0138 · Cited by 7 · see citing works
- Authors
- Orlandi, M., Suvan, J., Petrie, A., Donos, N., Masi, S., Hingorani, A., Deanfield, J., & D’Aiuto, F.
- Affiliations
- University College London (GB)
- Great Ormond Street Hospital (GB)
- Corresponding author
- Orlandi, Marco
- ORCID
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 236
- Issue
- 1
- Pages
- 39-46
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1999544578
- Cited by
- 164
- References
- 62
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 13 · 2023: 12 · 2022: 13 · 2021: 13 · 2020: 32 · 2019: 19 · 2018: 13 · 2017: 18 · 2016: 8 · 2015: 9 · 2014: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Funders
- Medical Research Council (MR/K006584/1)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- periodontitis, carotid intima-media thickness, flow-mediated dilation, periodontal treatment, endothelial function, cardiovascular risk, oral health and cardiovascular disease
- MeSH terms
- Brachial Artery, Carotid Artery Diseases, Cross-Sectional Studies, Disease Susceptibility, Endothelium, Vascular, Humans, Periodontal Diseases, Periodontitis, Vasodilation, Comorbidity, Causality, Case-Control Studies, Hemorheology, Disease Progression, Controlled Clinical Trials as Topic, Plaque, Atherosclerotic, Carotid Intima-Media Thickness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
