High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans
Open accessAbstract
Oleic acid consumption is considered cardio-protective according to studies conducted examining effects of the Mediterranean diet. However, animal models have shown that oleic acid consumption increases LDL particle cholesteryl oleate content which is associated with increased LDL-proteoglycan binding and atherosclerosis. The objective was to examine effects of varying oleic, linoleic and docosahexaenoic acid consumption on human LDL-proteoglycan binding in a non-random subset of the Canola Oil Multi-center Intervention Trial (COMIT) participants. COMIT employed a randomized, double-blind, five-period, cross-over trial design. Three of the treatment oil diets: 1) a blend of corn/safflower oil (25:75); 2) high oleic canola oil; and 3) DHA-enriched high oleic canola oil were selected for analysis of LDL-proteoglycan binding in 50 participants exhibiting good compliance. LDL particles were isolated from frozen plasma by gel filtration chromatography and LDL cholesteryl esters quantified by mass-spectrometry. LDL-proteoglycan binding was assessed using surface plasmon resonance. LDL particle cholesterol ester fatty acid composition was sensitive to the treatment fatty acid compositions, with the main fatty acids in the treatments increasing in the LDL cholesterol esters. The corn/safflower oil and high-oleic canola oil diets lowered LDL-proteoglycan binding relative to their baseline values (p = 0.0005 and p = 0.0012, respectively). At endpoint, high-oleic canola oil feeding resulted in lower LDL-proteoglycan binding than corn/safflower oil (p = 0.0243) and DHA-enriched high oleic canola oil (p = 0.0249), although high-oleic canola oil had the lowest binding at baseline (p = 0.0344). Our findings suggest that high-oleic canola oil consumption in humans increases cholesteryl oleate percentage in LDL, but in a manner not associated with a rise in LDL-proteoglycan binding.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cohort studies suggest that consumption of olive oil, but not mixed animal and plant sources of monounsaturated fat, is linked to lower risk; while vegetable oil sources of monounsaturated fat increase LDL cholesteryl oleate but reduce LDL proteoglycan binding.
“For instance, cohort studies suggest that consumption of olive oil, but not mixed animal and plant sources of monounsaturated fat, is linked to lower risk;352 while vegetable oil sources of monounsaturated fat increase LDL cholesteryl oleate but reduce LDL proteoglycan binding.357”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [357]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedA SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · cited 1× · see citing works
“Briefly, plasma fatty acidswere extracted by the Folch method [21] using chloroform-methanol with added butylated hydroxytoluene, followed by methylation with methanolic hydrochloric acid with minor modifications [22].”
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122 · cited 6× · see citing works
“The Mediterranean diet has also been shown to be effective in secondary prevention of coronary heart disease (CHD)2.”
InfluentialEffect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
Mensink, R. P., & Katan, M. B. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.8.911 · Cited by 1,477 · see citing works
Executive Summary: Heart Disease and Stroke Statistics—2010 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Brown, T. M., Carnethon, M. R., Dai, S., SIMONE, G. D., Ferguson, T. B., Ford, E. S., Furie, K. L., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192666 · Cited by 1,358 · see citing works
Mattson, F. H., & Grundy, S. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34389-3 · Cited by 1,354 · see citing works
Jakobsen, M. U., O’Reilly, E. J., Heitmann, B. L., Pereira, M. A., Bälter, K., Fraser, G. E., Goldbourt, U., Hallmans, G., Knekt, P., Liu, S., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27124 · Cited by 1,026 · cited 2× · see citing works
“In addition, the authors noted that some vegetable sources of MUFA likely contained trans fatty acids [29].”
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019 · see citing works
Comparison of Monounsaturated Fatty Acids and Carbohydrates for Lowering Plasma Cholesterol
Grundy, S. M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603203141204 · Cited by 763 · cited 1× · see citing works
“MUFA and polyunsaturated fatty acid (PUFA) or carbohydrate show that high MUFA diets reduce LDL-C, without decreasing HDL-C concentrations, compared to PUFAs [6], and do so without raising triglyceride levels as is typically observed with high carbohydrate diets [7].”
Mensink, R. P., & Katan, M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908173210705 · Cited by 542 · cited 1× · see citing works
“These results are consistent with previous clinical trials which consistently show hypocholesterolemic effects of both PUFA or MUFA consumption [34], and TG lowering by C22:6 n-3 consumption [35].”
(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368 · see citing works
Artaud-Wild, S. M., Connor, S. L., Sexton, G. J., & CONNOR, W. E. (1993) · Circulation · doi:10.1161/01.cir.88.6.2771 · Cited by 358 · see citing works
Grimsgaard, S., Bonaa, K., Hansen, J., & Nordøy, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.649 · Cited by 300 · cited 1× · see citing works
“While very little C20:5 n-3 was present in the DHA-enriched high oleic canola oil diet, C20:5 n-3 was elevated in plasma and in LDL CE at endpoint of the DHA-enriched high oleic canola oil diet possibly due to retro-conversion of C22:6 n-3 [32,33].”
Warensjö, E., Sundström, J., Vessby, B. O., Cederholm, T., & Risérus, U. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.203 · Cited by 280 · see citing works
Monounsaturated Versus Polyunsaturated Dietary Fat and Serum Lipids
Gardner, C. D., & KRAEMER, H. C. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1917 · Cited by 231 · see citing works
Rießen, R., Isner, J. M., Blessing, E., Loushin, C., Nikol, S., & Wight, T. N. (1994) · PubMed Central · Cited by 192 · see citing works
Fatty Acids in Serum Cholesteryl Esters as Quantitative Biomarkers of Dietary Intake in Humans
Zock, P. L., Mensink, R. P., Harryvan, J. L., de Vries, J. H. M., & Katan, M. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009074 · Cited by 186 · see citing works
Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores
Conquer, J. A., & Holub, B. J. (1997) · Lipids · doi:10.1007/s11745-997-0043-y · Cited by 148 · cited 1× · see citing works
“While very little C20:5 n-3 was present in the DHA-enriched high oleic canola oil diet, C20:5 n-3 was elevated in plasma and in LDL CE at endpoint of the DHA-enriched high oleic canola oil diet possibly due to retro-conversion of C22:6 n-3 [32,33].”
Gillingham, L. G., Gustafson, J. A., Han, S.-Y., Jassal, D. S., & Jones, P. J. H. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510003697 · Cited by 143 · cited 1× · see citing works
“Briefly, plasma fatty acidswere extracted by the Folch method [21] using chloroform-methanol with added butylated hydroxytoluene, followed by methylation with methanolic hydrochloric acid with minor modifications [22].”
Self-citationRumsey, S. C., Galeano, N. F., Arad, Y., & Deckelbaum, R. J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41409-9 · Cited by 136 · see citing works
Jones, P. J., Senanayake, V. K., Pu, S., Jenkins, D. J., Connelly, P. W., Lamarche, B., Couture, P., Charest, A., Baril-Gravel, L., West, S. G., et al. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081133 · Cited by 115 · see citing works
Self-citationGeppert, J., Kraft, V., Demmelmair, H., & Koletzko, B. (2006) · British Journal of Nutrition · doi:10.1079/bjn20051720 · Cited by 96 · see citing works
Ma, J., Folsom, A., Lewis, L., & Eckfeldt, J. H. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.2.551 · Cited by 80 · see citing works
Rudel, L. L., Haines, J., Sawyer, J. K., Shah, R., Wilson, M. S., & Carr, T. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119524 · Cited by 78 · see citing works
Self-citationDietary monounsaturated fatty acids appear not to provide cardioprotection.
Degirolamo, C., & Rudel, L. L. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0133-4 · Cited by 72 · cited 5× · see citing works
“Similarly, metabolic ward trials which compare diets high in SFA, MUFA and polyunsaturated fatty acid (PUFA) or carbohydrate show that high MUFA diets reduce LDL-C, without decreasing HDL-C concentrations, compared to PUFAs 6, and do so without raising triglyceride levels as is typically observed with high carbohydrat…”
InfluentialSelf-citationAssociations of low density lipoprotein particle composition with atherogenicity
Lada, A. T., & Rudel, L. L. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200402000-00005 · Cited by 71 · cited 1× · see citing works
“Notably, this concern is based on research in animal models which shows that elevated oleic acid consumption alters hepatic lipid metabolism, enriching LDL particles with cholesteryl oleate, and promoting the development of atherosclerosis [12,13].”
Self-citationRudel, L. L., Johnson, F., Sawyer, J., Wilson, M., & Parks, J. S. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.2.463s · Cited by 64 · see citing works
Self-citationDegirolamo, C., Shelness, G. S., & Rudel, L. L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800076-jlr200 · Cited by 58 · see citing works
Self-citationSenanayake, V. K., Pu, S., Jenkins, D. A., Lamarche, B., Kris‐Etherton, P. M., West, S. G., Fleming, J. A., Liu, X., McCrea, C. E., & Jones, P. J. H. (2014) · Trials · doi:10.1186/1745-6215-15-136 · Cited by 39 · see citing works
Self-citationMelchior, J., Sawyer, J. K., Kelley, K. L., Shah, R., Wilson, M. D., Hantgan, R. R., & Rudel, L. L. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m039644 · Cited by 32 · cited 6× · see citing works
“This approach introduces the possibility that there were differences in composition in the LDL particles used in the binding assay and those used to measure composition [16].”
InfluentialSelf-citationManning, J. M., Gebre, A. K., Edwards, I. J., Wagner, W. D., Rudel, L. L., & Parks, J. S. (1994) · Lipids · doi:10.1007/bf02536098 · Cited by 30 · cited 3× · see citing works
“have also been seen in other rodent and primate models, which have repeatedly demonstrated that consumption of MUFAs and SFA, as opposed to n-3 or n-6 PUFA, results in the production of LDL particles with an increased affinity for proteoglycans [17,27,28].”
Self-citationCohn, J. S., Rodriguez, C., Jacques, H., Tremblay, M., & Davignon, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.d300041-jlr200 · Cited by 29 · see citing works
Miller, C. D., Thomas, M. J., Hiestand, B. C., Samuel, M. P., Wilson, M. D., Sawyer, J. K., & Rudel, L. L. (2012) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2012.01378.x · Cited by 21 · see citing works
Self-citationEdwards, I. J., Gebre, A. K., Wagner, W. D., & Parks, J. S. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1778 · Cited by 21 · cited 1× · see citing works
“have also been seen in other rodent and primate models, which have repeatedly demonstrated that consumption of MUFAs and SFA, as opposed to n-3 or n-6 PUFA, results in the production of LDL particles with an increased affinity for proteoglycans [17,27,28].”
Parks, J. S., Gebre, A., Edwards, I., & Wagner, W. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41903-0 · Cited by 20 · see citing works
Rudel, L. L. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.06.008 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
“olive oil, but not mixed animal and plant sources of monounsaturated fat, is linked to lower risk,(352) whereas vegetable oil sources of monounsaturated fat increase LDL cholesteryl oleate but reduce LDL proteoglycan binding.(357) These results”
Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association
Sacks, F. M., Lichtenstein, A. H., Wu, J. H. Y., Appel, L. J., Creager, M. A., Kris-Etherton, P. M., Miller, M., Rimm, E. B., Rudel, L. L., Robinson, J. G., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000510 · Cited by 1,386 · see citing works
Self-citationThe Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders
Шрамко, В. С., Polonskaya, Y. V., Kashtanova, E. V., Stakhneva, E. M., & Ragino, Y. I. (2020) · Biomolecules · doi:10.3390/biom10081127 · Cited by 210 · see citing works
“Oleic acid (C18:1) ± can improve the blood lipid profile [65]; ↓ the risk of atherosclerosis [69]; ↑ TG concentrations; ↑markers of inflammation; ↑ the risk of developing heart failure [36,71]”
BackgroundCurrent Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease
Hammad, S. S., Pu, S., & Jones, P. J. H. (2015) · Lipids · doi:10.1007/s11745-015-4113-x · Cited by 201 · see citing works
Self-citationDietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
Wu, J. H. Y., Micha, R., & Mozaffarian, D. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0206-1 · Cited by 167 · see citing works
A role for proteoglycans in vascular disease
Wight, T. N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.019 · Cited by 161 · see citing works
Ganesan, K., Sukalingam, K., & Xu, B. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.11.003 · Cited by 160 · see citing works
Zong, G., Li, Y., Sampson, L., Dougherty, L., Willett, W. C., Wanders, A. J., Alssema, M., Zock, P. L., Hu, F. B., & Sun, Q. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx004 · Cited by 130 · see citing works
Guasch‐Ferré, M., Zong, G., Willett, W. C., Zock, P. L., Wanders, A. J., Hu, F. B., & Sun, Q. (2019) · Circulation Research · doi:10.1161/circresaha.118.313996 · Cited by 100 · see citing works
Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease
Joris, P. J., & Mensink, R. P. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0597-y · Cited by 77 · see citing works
Mah, E., Schulz, J. A., Kaden, V. N., Lawless, A. L., Rotor, J., Mantilla, L. B., & Liska, D. J. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.150037 · Cited by 70 · see citing works
Cunha, V. M. B., da Silva, M. P., de Sousa, S. H. B., Bezerra, P. D. N., Menezes, E. G. O., da Silva, N. J. N., Banna, D. A. D. D. S., Araújo, M. E., & de Carvalho, R. N. (2018) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2018.10.010 · Cited by 67 · see citing works
Cavalcanti, R. N., de Albuquerque, C. L. C., & Meireles, M. A. A. (2015) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2015.10.004 · Cited by 52 · see citing works
Akil, E., Pereira, A. D. S., El‐Bacha, T., Amaral, P. F. F., & Torres, A. G. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.282 · Cited by 51 · see citing works
Viegas, C., Gouveia, L., & Gonçalves, M. (2021) · Environmental Technology & Innovation · doi:10.1016/j.eti.2021.102048 · Cited by 49 · see citing works
Olive oil consumption and its repercussions on lipid metabolism
Tomé‐Carneiro, J., Crespo, M. C., Hazas, M. L. D. L., Visioli, F., & Dávalos, A. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa014 · Cited by 45 · see citing works
Ruuth, M. K., Lahelma, M., Luukkonen, P. K., Lorey, M. B., Qadri, S. U., Sädevirta, S., Hyötyläinen, T., Kovanen, P. T., Hodson, L., Yki‐Järvinen, H., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315766 · Cited by 38 · see citing works
Wang, Y., Jin, J., Wu, G., Wei, W., Jin, Q., & Wang, X. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2313181 · Cited by 35 · see citing works
“Compared with cholesterol polyunsaturated fatty acid esters, cholesteryl oleate is weakly bound to proteoglycans, which reduces the residence time of LDL particles in the arterial wall and decreases the development of atherosclerosis (Jones et al. 2015).”
microRNA and Metabolite Signatures Linked to Early Consequences of Lethal Radiation
Chakraborty, N., Gautam, A., Holmes‐Hampton, G. P., Kumar, V. P., Biswas, S., Kumar, R., Hamad, D., Dimitrov, G. I., Olabisi, A. O., Hammamieh, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62255-w · Cited by 31 · see citing works
Heleno, S. A., Rudke, A. R., Calhelha, R. C., Carocho, M., Barros, L., Gonçalves, O. H., Barreiro, M. F., & Ferreira, I. C. F. R. (2016) · Food & Function · doi:10.1039/c6fo01600f · Cited by 28 · see citing works
dos Santos, W. O., Rodrigues, A. M. D. C., & da Silva, L. H. M. (2022) · LWT · doi:10.1016/j.lwt.2022.113534 · Cited by 26 · see citing works
Wang, Q., Zhang, H., Jin, Q., & Wang, X. (2023) · Foods · doi:10.3390/foods12112129 · Cited by 27 · see citing works
“A pilot study with 50 participants demonstrated that blood concentrations of TG were significantly lower [17].”
BackgroundAn, W., Huang, Z., Mao, Z., Qiao, T., Jia, G., Zhao, H. Y., Liu, G., & Chen, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01163 · Cited by 26 · see citing works
de Oliveira, P. D., da Silva, D. A., Pires, W. P., Bezerra, C. V., da Silva, L. H. M., & Rodrigues, A. M. D. C. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110384 · Cited by 25 · see citing works
Sey, A. A., Pham, T. H., Kavanagh, V. B., Kaur, S., Cheema, M., Galagedara, L., & Thomas, R. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.05.002 · Cited by 23 · see citing works
“This gives phytosterols the ability to reduce serum cholesterol, as well as low density lipoprotein (LDL) levels in humans; known risk factors for developing cardiovascular disease (CVD) [16].”
BackgroundBioremediation of cattle manure using microalgae after pre-treatment with biomass ash
Viegas, C. P., Gouveia, L., & Gonçalves, M. (2021) · Bioresource Technology Reports · doi:10.1016/j.biteb.2021.100681 · Cited by 23 · see citing works
Saedi, S., Noroozi, M. O., Khosrotabar, N., Mazandarani, S., & Ghadrdoost, B. (2017) · Medical Journal of the Islamic Republic of Iran · doi:10.18869/mjiri.31.5 · Cited by 23 · see citing works
Cole, R. M., Angelotti, A., Sparagna, G. C., Ni, A., & Belury, M. A. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202101132 · Cited by 21 · see citing works
Manninen, S. M., Lankinen, M. A., Erkkilä, A. T., Nguyen, S. D., Ruuth, M. K., de Mello, V. D., Öörni, K., & Schwab, U. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.017 · Cited by 22 · see citing works
Chronic consumption of thermally processed palm oil or canola oil modified gut microflora of rats
Ruan, M., Bu, Y., Wu, F., Zhang, S., Chen, R., Li, N., Liu, Z., & Wang, H. (2020) · Food Science and Human Wellness · doi:10.1016/j.fshw.2020.06.005 · Cited by 21 · see citing works
Spatial Heterogeneity as a Genetic Mixing Mechanism in Highly Philopatric Colonial Seabirds
Cristofari, R., Trucchi, E., Whittington, J. D., Vigetta, S., Gachot‐Neveu, H., Stenseth, N. C., Maho, Y. L., & Bohec, C. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117981 · Cited by 21 · see citing works
Utama, D. T., Jeong, H., Kim, J., & Lee, S. K. (2018) · Europe PMC (PubMed Central) · doi:10.5851/kosfa.2018.38.3.580 · Cited by 18 · see citing works
“In contrast with dietary monounsaturated fatty acids (MUFAs) such as oleic acid, SFAs are the main contributors to increasing low-density lipoprotein (LDL) levels in the blood (Jones et al., 2015).”
Olas, B. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.08.006 · Cited by 17 · see citing works
Health aspects of high-oleic oils
Riley, T. M., Petersen, K. H., & Kris‐Etherton, P. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822912-5.00002-2 · Cited by 15 · see citing works
Self-citationErkkilä, A. T., Manninen, S. M., Fredrikson, L., Bhalke, M., Holopainen, M., Ruuth, M. K., Lankinen, M. A., Käkelä, R., Öörni, K., & Schwab, U. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.08.060 · Cited by 13 · see citing works
Eskin, M., Iassonova, D. R., & Rempel, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822912-5.00001-0 · Cited by 11 · see citing works
Ramprasath, V. R., Thandapilly, S. J., Yang, S., Abraham, A., Jones, P. J. H., & Ames, N. P. (2015) · Trials · doi:10.1186/s13063-015-1014-5 · Cited by 10 · see citing works
Self-citationBest practices for design and implementation of human clinical trials studying dietary oils
MacKay, D., Jew, S., & Jones, P. J. H. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.10.003 · Cited by 10 · see citing works
Self-citationBuitimea‐Cantúa, N. E., Salazar‐García, M. G., Vidal‐Quintanar, R. L., Serna-Saldivar, S. O., Ortega‐Ramírez, R., & Buitimea-Cantúa, G. V. (2017) · Journal of Food Quality · doi:10.1155/2017/1253976 · Cited by 9 · see citing works
“This is relevant because oleic acid consumption is considered cardioprotective according to studies of the Mediterranean diet rich in olive oil [27].”
BackgroundGong, Y., Luo, M., Zhang, X., Qin, N., Zhu, W., Wang, L., Fu, J., & Dong, Z. (2025) · Aquaculture International · doi:10.1007/s10499-025-01992-z · Cited by 8 · see citing works
“Oleic acid is known for its capability to lower blood lipids, maintain balanced body weight, reduce inflammatory responses, and help preventing atherosclerotic disease (Jones et al. 2015).”
Maurya, R., Bhattacharjee, G., Gohil, N., Khambhati, K., Shakhreliya, S., Bhatnagar, A., Singh, P., Ramakrishna, S., & Singh, V. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.09.010 · Cited by 7 · see citing works
Steffen, H. L. M., Anderson, J. L. C., Poot, M. L., Yu, L., Connelly, M. A., Bakker, S. J. L., Öörni, K., & Tietge, U. J. F. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100083 · Cited by 7 · see citing works
“Finally, measures to enrich LDL in cholesteryl oleate such as canola oil appear to reduce the binding of LDL to proteoglycans (38), but prospective clinical studies addressing this concept are not available.”
BackgroundHow the Dietary Saturated/Monounsaturated Fatty Acid Ratio Modulates Brain Function in Older Adults
Kien, C. L., & Dumas, J. A. (2025) · Nutrients · doi:10.3390/nu17111897 · Cited by 3 · see citing works
“In regard to how OA might enhance atherosclerosis, higher OA appears to increase the LDL particle cholesteryl oleate content, which is associated with increased LDL–proteoglycan binding, thus enhancing the arterial retention of LDL and the consequent promotion of atherosclerosis [13,14].”
InfluentialLettreuch, S. H., Saidi, F., Castellano, J. M., & del Camino, M. (2022) · Phytothérapie · doi:10.3166/phyto-2022-0321 · Cited by 3 · see citing works
Li, W., Yang, Q., Zepeng, L., Wang, L., & Guo, P. (2018) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(17)61073-9 · Cited by 3 · see citing works
Malla, S., & Brewin, D. G. (2026) · GM crops & food · doi:10.1080/21645698.2025.2606493 · Cited by 2 · see citing works
Xu, H., Xu, X., & Sohouli, M. H. (2026) · Nutrition & Metabolism · doi:10.1186/s12986-026-01110-7 · Cited by 2 · see citing works
“Mechanistically, oleic acid modulates hepatic lipid handling by promoting LDL-receptor–mediated clearance and altering lipoprotein composition (e.g., increasing cholesteryl-oleate content in LDL) [29, 30], which reduces LDL atherogenicity and circulating concentrations [31].”
Hua, J., Hu, M., Wang, Y., Liu, Z., & Wang, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1766489 · Cited by 2 · see citing works
“Some studies have shown that it is able to reduce low-density lipoprotein cholesterol (LDL-c) level (9, 10).”
Rojo-López, M. I., Castelblanco, E., Real, J., Hernández, M., Falguera, M., Amigó, N., Julve, J., Alonso, N., Franch‐Nadal, J., Granado-Casas, M., et al. (2021) · Nutrients · doi:10.3390/nu13124369 · Cited by 1 · see citing works
“Consistently, the Mediterranean Diet (MDiet), which is rich in “healthy fats”, has been associated with lower serum LDL concentrations and hence a reduced risk of CV disease [6].”
BackgroundAbraham, A. (2017) · Mspace (University of Manitoba)
Innovative Lipid Biomarkers and Long-Term Outcomes
Anderson, J. L. C. (2021) · doi:10.33612/diss.192996734
Effects of Chemically Interesterified Palm Olein on Lipid Profiles in Hamsters
Idris, C. A. C., Kim, T.-T., Mutalip, S. S. M., & John, K. S. S. (2023) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.19.2.45
Hu, C., Lei, J., Li, X., Wang, D., Xu, T., Dong, J., & Ma, Y. (2026) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2026.116690
She, Y., Jia, K., Cardillo, A., Shamloo, M., León, A. S., Liu, X., Mollard, R. C., & MacKay, D. (2026) · Food & Function · doi:10.1039/d5fo04672f
Self-citation
- Authors
- Jones, P. J. H., MacKay, D. S., Senanayake, V. K., Pu, S., Jenkins, D. J. A., Connelly, P. W., Lamarche, B., Couture, P., Kris-Etherton, P. M., West, S. G., Liu, X., Fleming, J. A., Hantgan, R. R., & Rudel, L. L.
- Affiliations
- University of Manitoba (CA)
- St. Michael's Hospital (CA)
- Université Laval (CA)
- Pennsylvania State University (US)
- Wake Forest University Health Sciences (US)
- ORCID
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 238
- Issue
- 2
- Pages
- 231-238
- ISSN
- 0021-9150 (ISSN-L)
- PMC
- PMC4346138
- OpenAlex
- W2162228990
- Cited by
- 56
- References
- 37
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 4
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000127)
- National Heart, Lung, and Blood Institute (HL 49373, P01HL049373)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- linoleic acid, docosahexaenoic acid, dietary fatty acid composition, Mediterranean diet
- MeSH terms
- Rapeseed Oil, Adult, Canada, Cardiovascular Diseases, Cholesterol Esters, Corn Oil, Dietary Fats, Docosahexaenoic Acids, Double-Blind Method, Fatty Acids, Monounsaturated, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Proteoglycans, Risk Factors, Safflower Oil, Time Factors, United States, Cross-Over Studies, Oleic Acid, Linoleic Acid, Diet, Mediterranean, Risk Reduction Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
