High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
Open accessAbstract
Recently, novel dietary oils with modified fatty acid profiles have been manufactured to improve fatty acid intakes and reduce CVD risk. Our objective was to evaluate the efficacy of novel high-oleic rapeseed (canola) oil (HOCO), alone or blended with flaxseed oil (FXCO), on circulating lipids and inflammatory biomarkers v.a typical Western diet (WD). Using a randomised, controlled, crossover trial, thirty-six hypercholesterolaemic subjects consumed three isoenergetic diets for 28 d each containing approximately 36 % energy from fat, of which 70 % was provided by HOCO, FXCO or WD. Dietary fat content of SFA, MUFA, PUFA n-6 and n-3 was 6, 23, 5, 1 % energy for HOCO; 6, 16, 5, 7·5 % energy for FXCO; 11·5, 16, 6, 0·5 % energy for WD. After 28 d, compared with WD, LDL-cholesterol was reduced 15·1 % (P < 0·001) with FXCO and 7·4 % (P < 0·001) with HOCO. Total cholesterol (TC) was reduced 11 % (P < 0·001) with FXCO and 3·5 % (P = 0·002) with HOCO compared with WD. Endpoint TC differed between FXCO and HOCO (P < 0·05). FXCO consumption reduced HDL-cholesterol by 8·5 % (P < 0·001) and LDL:HDL ratio by 7·5 % (P = 0·008)v.WD. FXCO significantly decreased E-selectin concentration compared with WD (P = 0·02). No differences were observed in inflammatory markers after the consumption of HOCO compared with WD. In conclusion, consumption of novel HOCO alone or when blended with flaxseed oil is cardioprotective through lipid-lowering effects. The incorporation of flaxseed oil may also target inflammation by reducing plasma E-selectin.
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Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol; the remaining 18 trials included participants with normal and elevated LDL cholesterol.
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37,39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
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Cites
Lorenz, M. W., Markus, H. S., Bots, M. L., Rosvall, M., & Sitzer, M. (2007) · Circulation · doi:10.1161/circulationaha.106.628875 · Cited by 2,977 · see citing works
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705 · see citing works
A new predictive equation for resting energy expenditure in healthy individuals
Mifflin, M., St Jeor, S., Hill, L., Scott, B., Daugherty, S., & Koh, Y. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.2.241 · Cited by 2,544 · cited 1× · see citing works
“Diets were individualised to meet daily energy requirements for weight maintenance for each subject as determined by the Mifflin equation((16)), multiplied by a factor of 1·7 for medium physical activity.”
MethodPolyunsaturated fatty acids in the food chain in the United States
Kris-Etherton, P., Taylor, D. S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R. L., Zhao, G., & Etherton, T. D. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.179s · Cited by 1,023 · see citing works
Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
Hu, F. B., Manson, J. E., & Willett, W. C. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719008 · Cited by 902 · see citing works
Meta-analysis of the effects of flaxseed interventions on blood lipids
Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H., & Lin, X. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27469 · Cited by 264 · see citing works
Keogh, J. B., Grieger, J. A., Noakes, M., & Clifton, P. M. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000163185.28245.a1 · Cited by 160 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Mente A, de Koning L, Shannon HS, et al. (2009) A systema- tic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 169, 659-669.
- Roldan V, Marin F, Lip GY, et al. (2003) Soluble E-selectin in cardiovascular disease and its risk factors. A review of the lit- erature. Thromb Haemost 90, 1007-1020.
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Lane, K., Derbyshire, E., Li, W., & Brennan, C. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.596292 · Cited by 145 · see citing works
Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A. (2016) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2016.1161011 · Cited by 118 · see citing works
Jones, P. J., Senanayake, V. K., Pu, S., Jenkins, D. J., Connelly, P. W., Lamarche, B., Couture, P., Charest, A., Baril-Gravel, L., West, S. G., et al. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081133 · Cited by 115 · see citing works
Self-citationAkrami, A., Nikaein, F., Babajafari, S., Faghih, S., & Yarmohammadi, H. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.11.004 · Cited by 85 · see citing works
Hadi, A., Askarpour, M., Salamat, S., Ghaedi, E., Symonds, M. E., & Miraghajani, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104622 · Cited by 71 · see citing works
Jones, P. J. H., MacKay, D. S., Senanayake, V. K., Pu, S., Jenkins, D. J. A., Connelly, P. W., Lamarche, B., Couture, P., Kris-Etherton, P. M., West, S. G., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.010 · Cited by 56 · see citing works
“Briefly, plasma fatty acidswere extracted by the Folch method [21] using chloroform-methanol with added butylated hydroxytoluene, followed by methylation with methanolic hydrochloric acid with minor modifications [22].”
Self-citationAskarpour, M., Karimi, M., Hadi, A., Ghaedi, E., Symonds, M. E., Miraghajani, M., & Javadian, P. (2020) · Cytokine · doi:10.1016/j.cyto.2019.154922 · Cited by 54 · see citing works
Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00619-3 · Cited by 40 · see citing works
Haldar, S., Wong, L. H., Tay, S. L., Jacoby, J. J., He, P., Osman, F., Ponnalagu, S., Jiang, Y. R., Lian, H. P. R., & Henry, C. J. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa274 · Cited by 31 · see citing works
Gao, Z., Zhang, D., Yan, X., Shi, H., & Xian, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.904250 · Cited by 22 · see citing works
Hart, T. L., Damani, J. J., DiMattia, Z. S., Tate, K. E., Jafari, F., & Petersen, K. S. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100502 · Cited by 16 · see citing works
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37, 39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
- Authors
- Gillingham, L. G., Gustafson, J. A., Han, S.-Y., Jassal, D. S., & Jones, P. J. H.
- Affiliations
- University of Manitoba (CA)
- St. Boniface Hospital (CA)
- Corresponding author
- Jones, Peter J. H.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-09-29
- Volume
- 105
- Issue
- 3
- Pages
- 417-427
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2170830379
- Cited by
- 143
- References
- 7
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 13 · 2021: 17 · 2020: 16 · 2019: 13 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 6
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- canola oil, linseed oil, hypercholesterolemia, serum lipids, LDL cholesterol, HDL cholesterol, LDL/HDL ratio, total cholesterol, E-selectin, inflammatory markers, omega-3 fatty acids, omega-6 fatty acids, dietary fat, cardiovascular disease prevention, Western diet
- MeSH terms
- Rapeseed Oil, Adult, Cardiovascular Diseases, Cholesterol, Dietary Fats, Fatty Acids, Monounsaturated, Female, Humans, Hypercholesterolemia, Inflammation, Linseed Oil, Male, Middle Aged, Biomarkers, Cross-Over Studies, E-Selectin, Brassica rapa
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