Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

Triglycerides and cardiovascular disease

Nordestgaard, B. G., & Varbo, A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61177-6 · Cited by 1,419

Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease

Varbo, A., Benn, M., Tybjærg-Hansen, A., Jørgensen, A. B., Frikke-Schmidt, R., & Nordestgaard, B. G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1026 · Cited by 1,115

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107

Lipoprotein lipase: structure, function, regulation, and role in disease

Mead, J. R., Irvine, S. A., & Ramji, D. P. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0384-9 · Cited by 962

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

Dewey, F. E., Gusarova, V., Dunbar, R. L., O’Dushlaine, C., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612790 · Cited by 885

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

Segrest, J., Jones, M., Loof, H. D., Brouillette, C. G., Venkatachalapathi, Y. V., & Anantharamaiah, G. M. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41536-6 · Cited by 868

CLEARING FACTOR, A HEPARIN-ACTIVATED LIPOPROTEIN LIPASE

Korn, E. D. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66011-9 · Cited by 858

Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820

Reduction of Mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by Combined Treatment with Clofibrate and Nicotinic Acid

Carlson, L. A., & Rosenhamer, G. (1988) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1988.tb15891.x · Cited by 685

A specific apoprotein activator for lipoprotein lipase

LaRosa, J. C., Levy, R. I., Herbert, P. N., Lux, S. E., & Fredrickson, D. S. (1970) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(70)90468-7 · Cited by 668

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Borén, J., Bruckert, E., Catapano, A. L., Descamps, O. S., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70191-8 · Cited by 635

Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II

Breckenridge, W. C., Little, J. A., Steiner, G. A., Chow, A., & Poapst, M. E. (1978) · New England Journal of Medicine · doi:10.1056/nejm197806082982301 · Cited by 603

Physiological regulation of lipoprotein lipase

Kersten, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.013 · Cited by 574

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

Graham, M. J., Lee, R. G., Brandt, T. A., Tai, L.-J., Fu, W., Peralta, R., Yu, R., Hurh, E., Paz, E., McEvoy, B. W., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701329 · Cited by 573

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

Gaudet, D., Alexander, V. J., Baker, B. F., Brisson, D., Tremblay, K., Singleton, W., Geary, R. S., Hughes, S. G., Viney, N. J., Graham, M. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1400283 · Cited by 528

Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction

Jørgensen, A. B., Frikke-Schmidt, R., West, A. S., Grande, P., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs431 · Cited by 501

Plasma High-Density Lipoproteins

Tall, A. R., & SMALL, D. M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197811302992207 · Cited by 500

Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein

Brown, W. V., & Baginsky, M. L. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(72)80149-9 · Cited by 493

Targeting APOC3 in the familial chylomicronemia syndrome

Gaudet, D., Brisson, D., Tremblay, K., Alexander, V. J., Singleton, W., Hughes, S. G., Geary, R. S., Baker, B. F., Graham, M. J., Crooke, R. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1400284 · Cited by 491

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

Beisiegel, U., Weber, W., & Bengtsson-Olivecrona, G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8342 · Cited by 468

Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons

Beigneux, A. P., Davies, B. S. J., Gin, P., Weinstein, M. M., Farber, E., Qiao, X., Peale, F., Bunting, S., Walzem, R. L., Wong, J. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.002 · Cited by 445

Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat.

Wu, A. L., & Windmueller, H. G. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50321-5 · Cited by 443

Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis

Shih, D. M., Xia, Y.-R., Wang, X.-P., Miller, E. R., Castellani, L. W., Subbanagounder, G., Cheroutre, H., Faull, K. F., Berliner, J. A., Witztum, J. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910376199 · Cited by 423

Chylomicronaemia–current diagnosis and future therapies

Brahm, A. J., & Hegele, R. A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.26 · Cited by 356

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

Kast-Woelbern, H. R., Nguyen, C., Sinal, C. J., Jones, S. A., Laffitte, B. A., Reue, K., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0712 · Cited by 354

The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism

Hato, T., Tabata, M., & Oike, Y. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.10.003 · Cited by 351

Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance

Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

Davies, B. S. J., Beigneux, A. P., Barnes, R. H., Tu, Y., Gin, P., Weinstein, M. M., Nobumori, C., Nyrén, R., Goldberg, I., Olivecrona, G., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.016 · Cited by 342

Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins

Nikkilä, E. A., Taskinen, M., Rehunen, S., & Härkönen, M. (1978) · Metabolism · doi:10.1016/0026-0495(78)90288-3 · Cited by 334

Apolipoprotein Specificity for Lipid Efflux by the Human ABCAI Transporter

Remaley, A. T., Stonik, J. A., Demosky, S. J., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Eggerman, T. L., Patterson, A. P., Duverger, N., Santamarina-Fojo, S., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4219 · Cited by 327

Regulation of the synthesis, processing and translocation of lipoprotein lipase

Braun, J. E., & Severson, D. L. (1992) · Biochemical Journal · doi:10.1042/bj2870337 · Cited by 320

A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice

Li, P., Ruan, X., Yang, L., Kiesewetter, K., Zhao, Y. C., Luo, H., Chen, Y., Guček, M., Zhu, J., & Cao, H. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.004 · Cited by 285

Contributions of Different Fatty Acid Sources to Very Low-Density Lipoprotein-Triacylglycerol in the Fasted and Fed States

Barrows, B. R., & Parks, E. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1709 · Cited by 282

High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance

Hortin, G. L., Sviridov, D. O., & Anderson, N. L. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.108175 · Cited by 270

Intracellular Trafficking and Secretion of VLDL

Tiwari, S., & Siddiqi, S. A. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241471 · Cited by 257

Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

Mak, P. A., Laffitte, B. A., Desrumaux, C. M., Joseph, S. B., Curtiss, L. K., Mangelsdorf, D. J., Tontonoz, P., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202993200 · Cited by 251

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway.

Sehayek, E., & Eisenberg, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55263-7 · Cited by 249

Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease

Toth, P. (2016) · Vascular Health and Risk Management · doi:10.2147/vhrm.s104369 · Cited by 237

Untitled work

(2001) · Medical Entomology and Zoology · Cited by 227

Further Characterization of Apolipoproteins from the Human Plasma Very Low Density Lipoproteins

Brown, W. V., Levy, R. I., & Fredrickson, D. S. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62574-8 · Cited by 214

Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages

Zannis, V. I., Cole, F. S., Jackson, C. L., Kurnit, D. M., & Karathanasis, S. K. (1985) · Biochemistry · doi:10.1021/bi00337a028 · Cited by 203

Lipoprotein lipase: physiology, biochemistry, and molecular biology

Ira, J. G. (2001) · Frontiers in bioscience · doi:10.2741/goldberg · Cited by 195

Current prospects of type II interferon γ signaling and autoimmunity

Green, D. S., Young, H. A., & Valencia, J. C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.774745 · Cited by 181

Regulation of triglyceride metabolism by Angiopoietin-like proteins

Mattijssen, F., & Kersten, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.010 · Cited by 180

Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets

Larsson, M., Vorrsjö, E., Talmud, P. J., Lõokene, A., & Olivecrona, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.495366 · Cited by 176

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

Fessler, M. B. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.07.010 · Cited by 173

Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II.

Kinnunen, P. K. J., Jackson, R. L., Smith, L. C., Gotto, A. M., & Sparrow, J. T. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.4848 · Cited by 167

Absorption of the n − 3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans

Nordøy, A., Barstad, L., CONNOR, W. E., & Hatcher, L. F. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.5.1185 · Cited by 152

Alterations in levels and interrelations of plasma apolipoproteins induced by diet

Schonfeld, G., Weidman, S. W., Witztum, J. L., & Bowen, R. M. (1976) · Metabolism · doi:10.1016/0026-0495(76)90084-6 · Cited by 152

Identification of circulating apolipoproteins synthesized by rat small intestine in vivo.

Wu, A. L., & Windmueller, H. G. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40852-0 · Cited by 150

The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries

Goulbourne, C. N., Gin, P., Tatar, A., Nobumori, C., Hoenger, A., Jiang, H., Grovenor, C. R. M., Adeyo, O., Esko, J. D., Goldberg, I. J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.017 · Cited by 149

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

Berbée, J. F. P., van der Hoogt, C. C., Sundararaman, D., Havekes, L. M., & Rensen, P. C. N. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400301-jlr200 · Cited by 140

Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain

Grehan, S., Tse, E., & Taylor, J. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00812.2001 · Cited by 138

Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice

Jong, M. C., Rensen, P. C. N., Dahlmans, V. E. H., van der Boom, H., van Berkel, T. J. C., & Havekes, L. M. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32211-2 · Cited by 136

A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease

Kei, A. A., Filippatos, T. D., Tsimihodimos, V., & Elisaf, M. S. (2012) · Metabolism · doi:10.1016/j.metabol.2011.12.002 · Cited by 136

Liver X receptors at the intersection of lipid metabolism and atherogenesis

Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 135

Apolipoprotein A-V-heparin Interactions

Lõokene, A., Beckstead, J. A., Nilsson, S., Olivecrona, G., & Ryan, R. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501589200 · Cited by 135

Update on the molecular biology of dyslipidemias

Ramasamy, I. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.10.033 · Cited by 131

Diagnostic algorithm for familial chylomicronemia syndrome

Stroes, E., Moulin, P., Parhofer, K. G., Rebours, V., Löhr, J.-M., & Averna, M. (2017) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2016.10.002 · Cited by 130

National lipid association annual summary of clinical lipidology 2016

Bays, H. E., Jones, P. H., Orringer, C. E., Brown, W. V., & Jacobson, T. A. (2016) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.08.002 · Cited by 128

Drug-Induced Lipid Changes

Mantel-Teeuwisse, A. K., Kloosterman, J. M. E., der Zee, A. H. M., Klungel, O. H., Porsius, A. J., & de Boer, A. (2001) · Drug Safety · doi:10.2165/00002018-200124060-00003 · Cited by 127

Autoantibodies to lipoprotein lipase and dyslipidemia in systemic lupus erythematosus

Reichlin, M., Fesmire, J., Quintero‐Del‐Rio, A. I., & Wolfson‐Reichlin, M. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10624 · Cited by 127

LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias

Johansen, C. T., Dubé, J. B., Loyzer, M. N., MacDonald, A., Carter, D. E., McIntyre, A. D., Cao, H., Wang, J., Robinson, J. F., & Hegele, R. A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.d045963 · Cited by 125

The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism

Sha, H., Sun, S., Francisco, A. B., Ehrhardt, N., Xue, Z., Liu, L., Lawrence, P., Mattijssen, F., Guber, R. D., Panhwar, M. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.015 · Cited by 124

Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity

Dugi, K. A., Dichek, H. L., & Santamarina-Fojo, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25396 · Cited by 120

Two Hepatic Enhancers, HCR.1 and HCR.2, Coordinate the Liver Expression of the Entire Human Apolipoprotein E/C-I/C-IV/C-II Gene Cluster

Allan, C. M., Taylor, S., & Taylor, J. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29113 · Cited by 106

Diagnosis and Management of Type I and Type V Hyperlipoproteinemia

Gotoda, T., Shirai, K., Ohta, T., Kobayashi, J., Yokoyama, S., Oikawa, S., Bujo, H., Ishibashi, S., Arai, H., Yamashita, S., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.10702 · Cited by 99

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

Mysling, S., Kristensen, K. K., Larsson, M., Beigneux, A. P., Gårdsvoll, H., Fong, L. G., Bensadoun, A., Jørgensen, T. J. D., Young, S. G., & Ploug, M. (2016) · eLife · doi:10.7554/elife.12095 · Cited by 98

Apolipoprotein Localization in Isolated Drusen and Retinal Apolipoprotein Gene Expression

Li, C., Clark, M. E., Chimento, M. F., & Curcio, C. A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1446 · Cited by 96

From fatty-acid sensing to chylomicron synthesis: Role of intestinal lipid-binding proteins

Buttet, M., Traynard, V., Tran, T. T. T., Besnard, P., Poirier, H., & Niot, I. (2013) · Biochimie · doi:10.1016/j.biochi.2013.08.011 · Cited by 95

Excess of Rare Variants in Non–Genome-Wide Association Study Candidate Genes in Patients With Hypertriglyceridemia

Johansen, C. T., Wang, J., McIntyre, A. D., Martins, R. A., Ban, M. R., Lanktree, M. B., Huff, M. W., Péterfy, M., Mehrabian, M., Lusis, A. J., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.960864 · Cited by 93

Effects of apolipoproteins on lipoprotein lipase activity of human adipose tissue

Ekman, R., & Nilsson‐Ehle, P. (1975) · Clinica Chimica Acta · doi:10.1016/0009-8981(75)90374-5 · Cited by 91

Partnership of PGC-1α and HNF4α in the Regulation of Lipoprotein Metabolism

Rhee, J., Ge, H., Yang, W., Fan, M., Handschin, C., Cooper, M. P., Lin, J. D., Li, C., & Spiegelman, B. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512636200 · Cited by 88

The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons.

Gin, P., Yin, L., Davies, B. S. J., Weinstein, M. M., Ryan, R. O., Bensadoun, A., Fong, L. G., Young, S. G., & Beigneux, A. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802579200 · Cited by 85

Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans

Gonzales, J. C., Gordts, P. L. S. M., Foley, E. M., & Esko, J. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67398 · Cited by 85

A diagnostic algorithm for the atherogenic apolipoprotein B dyslipoproteinemias.

de Graaf, J., Couture, P., & Sniderman, A. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0982 · Cited by 80

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

Takahashi, M., Yagyu, H., Tazoe, F., Nagashima, S., Ohshiro, T., Okada, K., Osuga, J.-I., Goldberg, I. J., & Ishibashi, S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m035568 · Cited by 79

Monogenic pediatric dyslipidemias: Classification, genetics and clinical spectrum

Rahalkar, A. R., & Hegele, R. A. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.10.007 · Cited by 77

Lipoproteins and Apolipoproteins during the Progression of Chronic Renal Disease

Grützmacher, P., März, W., Peschke, B., Gross, W., & Schoeppe, W. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000185138 · Cited by 75

NMR Structure of Human Apolipoprotein C-II in the Presence of Sodium Dodecyl Sulfate

MacRaild, C. A., Hatters, D. M., Howlett, G. J., & Gooley, P. R. (2001) · Biochemistry · doi:10.1021/bi002821m · Cited by 71

Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature

Joglekar, K., Brannick, B., Kadaria, D., & Sodhi, A. (2017) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018817695449 · Cited by 66

Evolutionary Duplication of a Hepatic Control Region in the Human Apolipoprotein E Gene Locus

Allan, C. M., Walker, D. W., & Taylor, J. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26278 · Cited by 64

New and emerging regulators of intestinal lipoprotein secretion

Xiao, C., Dash, S., Morgantini, C., & Lewis, G. F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.047 · Cited by 60

Hypertriglyceridemia: phenomics and genomics

Hegele, R. A., & Pollex, R. L. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0005-1 · Cited by 60

Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus

Shachter, N. S., Zhu, Y., Walsh, A., Breslow, J. L., & Smith, J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35732-1 · Cited by 59

Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide

Sakurai, T., Sakurai, A., Vaisman, B. L., Amar, M. J., Liu, C., Gordon, S. M., Drake, S. K., Pryor, M., Sampson, M. L., Yang, L., et al. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.229740 · Cited by 58

Global Structure and Dynamics of Human Apolipoprotein CII in Complex with Micelles: Evidence for Increased Mobility of the Helix Involved in the Activation of Lipoprotein Lipase,

Zdunek, J., Martinez, G. V., Schleucher, J., Lycksell, P.-O., Yin, Y., Nilsson, S. K., Shen, Y., Olivecrona, G., & Wijmenga, S. S. (2003) · Biochemistry · doi:10.1021/bi0267184 · Cited by 56

Subdomain Chimeras of Hepatic Lipase and Lipoprotein Lipase

Hill, J. S., Yang, D. D., Nikazy, J., Curtiss, L. K., Sparrow, J. T., & Wong, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30979 · Cited by 53

A Novel Apolipoprotein C-II Mimetic Peptide That Activates Lipoprotein Lipase and Decreases Serum Triglycerides in Apolipoprotein E–Knockout Mice

Amar, M. J., Sakurai, T., Sakurai-Ikuta, A., Sviridov, D. O., Freeman, L. A., Ahsan, L., & Remaley, A. T. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220418 · Cited by 51

Functional Analyses of Human Apolipoprotein CII by Site-directed Mutagenesis

Shen, Y., Lõokene, A., Nilsson, S., & Olivecrona, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105421200 · Cited by 51

Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries

Allan, C. M., Larsson, M., Jung, R. S., Ploug, M., Bensadoun, A., Beigneux, A. P., Fong, L. G., & Young, S. G. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m072520 · Cited by 48

Activation of lipoprotein lipase by native and acylated peptides of apolipoprotein C-II

Musliner, T. A., Herbert, P. N., & Church, E. C. (1979) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(79)90224-8 · Cited by 47

Reference intervals for serum apolipoproteins A-I, A-II, B, C-II, C-III, and E in healthy Japanese determined with a commercial immunoturbidimetric assay and effects of sex, age, smoking, drinking, and Lp(a) level

Sakurabayashi, I., Saito, Y., Kita, T., Matsuzawa, Y., & Goto, Y. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00591-5 · Cited by 46

Deregulated Lipid Sensing by Intestinal CD36 in Diet-Induced Hyperinsulinemic Obese Mouse Model

Buttet, M., Poirier, H., Traynard, V., Kévin, G., Tran, T. T. T., Sundaresan, S., Besnard, P., Abumrad, N. A., & Niot, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145626 · Cited by 45

A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis

Ueda, M., Dunbar, R. L., Wolska, A. T., Sikora, T. U., Escobar, M. D. R., Seliktar, N., deGoma, E. M., DerOhannessian, S. L., Morrell, L., McIntyre, A. D., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3903 · Cited by 44

The role of CREB-H transcription factor in triglyceride metabolism

Lee, A. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283508fed · Cited by 40

Developmental and Pharmacological Regulation of Apolipoprotein C-II Gene Expression

Andersson, Y., Majd, Z., Lefebvre, A., Martin, G., Sechkin, A. V., Kosykh, V., Fruchart, J., Najïb, J., & Staels, B. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.1.115 · Cited by 39

Post-Heparin LPL Activity Measurement Using VLDL As a Substrate: A New Robust Method for Routine Assessment of Plasma Triglyceride Lipolysis Defects

Filippo, M. D., Marçais, C., Charrière, S., Marmontel, O., Broyer, M., Delay, M., Merlin, M., Nollace, A., Valéro, R., Lagarde, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096482 · Cited by 36

Transactivation of the Human Apolipoprotein CII Promoter by Orphan and Ligand-dependent Nuclear Receptors

Kardassis, D., Sacharidou, E., & Zannis, V. I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17810 · Cited by 35

A Pressure-dependent Model for the Regulation of Lipoprotein Lipase by Apolipoprotein C-II

Meyers, N. L., Larsson, M., Olivecrona, G., & SMALL, D. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.629865 · Cited by 34

Parallel increase of plasma apoproteins C‐II and C‐III in Type 2 diabetic patients

Béliard, S., Nogueira, J. P., Maraninchi, M., Lairon, D., Nicolay, A., Giral, P., Portugal, H., Vialettes, B., & Valéro, R. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02757.x · Cited by 34

Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions

Trusca, V. G., Fuior, E. V., Florea, I. C., Kardassis, D., Simionescu, M., & Gafencu, A. V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179572 · Cited by 33

Identification of a Lipoprotein Lipase Cofactor-binding Site by Chemical Cross-linking and Transfer of Apolipoprotein C-II-responsive Lipolysis from Lipoprotein Lipase to Hepatic Lipase

McIlhargey, T. L., Yang, Y., Wong, H., & Hill, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300315200 · Cited by 31

Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids

Provost, P. R., Boucher, É. L., & Tremblay, Y. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0238 · Cited by 31

A Short Proximal Promoter and the Distal Hepatic Control Region-1 (HCR-1) Contribute to the Liver Specificity of the Human Apolipoprotein C-II Gene

Vorgia, P., Zannis, V. I., & Kardassis, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4188 · Cited by 27

Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids

Kardassis, D., Roussou, A., Papakosta, P., Boulias, K., Talianidis, I., & Zannis, V. I. (2003) · Biochemical Journal · doi:10.1042/bj20021532 · Cited by 23

Autoimmune Severe Hypertriglyceridemia Induced by Anti-Apolipoprotein C-II Antibody

Yamamoto, H., Tanaka, M., Yoshiga, S., Funahashi, T., Shimomura, I., & Kihara, S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3619 · Cited by 23

The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport

Daniel, Z. C. T. R., Swali, A., Emes, R. D., & Langley‐Evans, S. C. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0541-3 · Cited by 23

Site-directed Mutagenesis of Apolipoprotein CII to Probe the Role of Its Secondary Structure for Activation of Lipoprotein Lipase

Shen, Y. H., Lõokene, A., Zhang, L., & Olivecrona, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022046 · Cited by 22

A single nucleotide substitution in the promoter region of the apolipoprotein C-II gene identified in individuals with chylomicronemia

Streicher, R., Geisel, J., Weisshaar, C., Avci, H., Oette, K., Müller‐Wieland, D., & Krone, W. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37463-0 · Cited by 21

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E

Millar, J. S., Lassman, M. E., Thomas, T. A., Ramakrishnan, R., Jumes, P. A., Dunbar, R. L., deGoma, E. M., Baer, A. L., Karmally, W., Donovan, D. S., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m074880 · Cited by 21

Tgif1 represses apolipoprotein gene expression in liver

Melhuish, T. A., Chung, D. D., Bjerke, G. A., & Wotton, D. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22713 · Cited by 20

Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells

Chun, E. M., Park, Y. J., Kang, H. S., Cho, H. M., Jun, D. Y., & Kim, Y. H. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.645 · Cited by 19

Molecular Genetics of ApoC-II and Lipoprotein Lipase Deficiency

Fojo, S. S., Gennes, J. L. D., Beisiegel†, U., Baggio, G., Stalenhoef, A. F. H., Brunzell, J. D., & Brewer, H. B. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5904-3_40 · Cited by 16

Mass determination of major plasma proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Hortin, G. L., & Remaley, A. T. (2006) · Clinical Proteomics · doi:10.1385/cp:2:1:103 · Cited by 14

Residents' Exposure to Educational Experiences in Facilitating Hospital Discharges

Young, E., Stickrath, C. R., McNulty, M. C., Calderon, A. J., Chapman, E. N., Gonzalo, J. D., Kuperman, E. F., Lopez, M., Smith, C. J., Sweigart, J. R., et al. (2017) · Journal of Graduate Medical Education · doi:10.4300/jgme-d-16-00503.1 · Cited by 14

Triglyceride‐rich lipoprotein metabolism in women: roles of apoC‐ II and apoC‐ III

Ooi, E. M. M., Chan, D. C., Hodson, L., Adiels, M., Borén, J., Karpe, F., Fielding, B. A., Watts, G. F., & Barrett, P. H. R. (2016) · European Journal of Clinical Investigation · doi:10.1111/eci.12657 · Cited by 12

Apolipoprotein C-II deficiency: detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients

Capurso, A., Mogavero, A. M., Resta, F., Tommaso, M. D., Taverniti, P., Turturro, F., Rosa, M. L., Marcovina, S. M., & Catapano, A. L. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38495-9 · Cited by 12

STAT1 Interacts with RXRα to Upregulate ApoCII Gene Expression in Macrophages

Trusca, V. G., Albulescu, I. C., Kardassis, D., & Gafencu, A. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040463 · Cited by 10

Elevated expression of four apolipoprotein genes during the 32–35week gestation window in the human developing lung

Provost, P. R., & Tremblay, Y. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.06.013 · Cited by 9

Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth

Côté, M., Provost, P. R., Gérard-Hudon, M.-C., & Tremblay, Y. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-111 · Cited by 5

Structure of the human apolipoprotein C-II gene promoter.

Streicher, R., Avci, H., Munck, M., Siemeister, G., Geisel, J., Weisshaar, C., Müller‐Wieland, D., & Krone, W. (1996) · PubMed · Cited by 2

Clinical review on triglycerides

Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544

A Modern Approach to Dyslipidemia

Berberich, A. J., & Hegele, R. A. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab037 · Cited by 529

Multi-organ proteomic landscape of COVID-19 autopsies

Nie, X., Qian, L., Sun, R., Huang, B., Dong, X., Xiao, Q., Zhang, Q., Lu, T., Yue, L., Chen, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.004 · Cited by 403

Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia

Borén, J., Taskinen, M.-R., Björnson, E., & Packard, C. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00676-y · Cited by 315

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study

Pradhan, A. D., Paynter, N. P., Everett, B. M., Glynn, R. J., Amarenco, P., Elam, M., Ginsberg, H., Hiatt, W. R., Ishibashi, S., Koenig, W., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.09.011 · Cited by 319

Apolipoprotein C-II: the re-emergence of a forgotten factor

Wolska, A. T., Reimund, M., & Remaley, A. T. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000680 · Cited by 58

Abstract 498: A Novel Human APOC2 Mutation Causes Severe Hypertriglyceridemia Due to Decreased Fractional Clearance Rates of Very Low Density Lipoprotein apoB and Triglyceride and Increased Production Rates of Very Low Density Lipoprotein Triglyceride

Reyes‐Soffer, G., Matveyenko, A., Seid, H., Ngai, C. I., Thomas, T., Holleran, S., Ramakrishnan, R., & Ginsberg, H. N. (2019) · Arteriosclerosis Thrombosis and Vascular Biology

The role of high density lipoprotein apolipoprotein CII in triglyceride metabolism

Kashyap, M. L., Srivastava, L., Hynd, B. A., Perisutti, G., Brady, D., Gartside, P. S., & Glueck, C. J. (1978) · Lipids · doi:10.1007/bf02533853 · Cited by 24

Apolipoprotein C-II Deficiency with No Rare Variant in the APOC2 Gene

Takase, S., Osuga, J.-I., Fujita, H., Hara, K., Sekiya, M., Igarashi, M., Takanashi, M., Takeuchi, Y., Izumida, Y., Ohta, K., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.16592 · Cited by 7

Molecular Genetics of ApoC-II and Lipoprotein Lipase Deficiency

Fojo, S. S., Gennes, J. L. D., Beisiegel†, U., Baggio, G., Stalenhoef, A. F. H., Brunzell, J. D., & Brewer, H. B. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5904-3_40 · Cited by 16