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The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease
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Use of LXR agonists is complicated by side effects induced by activation of LXR/RXR in the liver causing hepatic steatosis and hypertriglyceridemia.
“Currently, use of LXR agonists is complicated by side effects induced by activation of LXR/RXR in the liver causing hepatic steatosis and hypertriglyceridemia [50, 51].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [50]
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine · doi:10.1038/nm820 · Cited by 1,158
Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.022 · Cited by 561
25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon
Reboldi, A., Dang, E. V., McDonald, J. G., Liang, G., Russell, D. W., & Cyster, J. G. (2014) · Science · doi:10.1126/science.1254790 · Cited by 444
Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., Gratton, E., Parks, J., & Tontonoz, P. (2015) · eLife · doi:10.7554/elife.08009 · Cited by 281 · cited 2×
“…of LXR SUMOylation, suggesting instead that LXR suppresses TLR4 signaling by depleting cholesterol in lipid rafts via ABCA1 transactivation (Ito et al., 2015), another group has reported that the anti-inflammatory activity of LXR agonists is intact or even increased in Abca1−/−Abcg1−/−…”
Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & Heneka, M. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6546-10.2011 · Cited by 190
Lee, J. H., Park, S. M., Kim, O. S., Lee, C. S., Woo, J. H., Park, S. J., Joe, E.-H., & Jou, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.021 · Cited by 161 · cited 2×
“Interestingly, in astrocytes, the LXRs transrepress interferon-γ-induced genes by yet a different mechanism, one that does not involve NCoR and that involves differential SUMOylation of the two LXR proteins (Lee et al., 2009).”
Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123729 · Cited by 142
Bischoff, E. D., Daige, C. L., Petrowski, M., Dedman, H., Pattison, J., Juliano, J., Li, A. C., & Schulman, I. G. (2010) · The Journal of Lipid Research · doi:10.1194/jlr.m900096 · Cited by 91
The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice
Hong, C., Marshall, S. M., McDaniel, A. L., Graham, M., Layne, J. D., Cai, L., Scotti, E., Boyadjian, R., Kim, J., Chamberlain, B. T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.001 · Cited by 87
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Sorted by citations
Shao, F., Wang, X., Wu, H., Wu, Q., & Zhang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.825086 · Cited by 250
Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.025 · Cited by 231
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- Fessler, M. B.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 181
- Pages
- 1-12
- ISSN
- 0163-7258
- PMC
- PMC5743771
- Cited by
- 173
- References
- 9
- Language
- en
- Funders
- National Institute of Environmental Health Sciences (Z01 ES102005)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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