Cited by 232Lipid metabolism and disordersLipid metabolism and biosynthesisLipoproteins and Cardiovascular Health

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Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

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Wolska, Anna, Dunbar, Richard L., Freeman, Lita A., Ueda, Masako, Amar, Marcelo J., Sviridov, Denis O., Remaley, Alan T.·2017·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2017.10.025PMC PMC5705268

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Abstract

Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting as a cofactor of lipoprotein lipase (LPL), the main enzyme that hydrolyses plasma triglycerides (TG) on TRL. Here, we present an overview of the role of apoC-II in TG metabolism, emphasizing recent novel findings regarding its transcriptional regulation and biochemistry. We also review the 24 genetic mutations in the APOC2 gene reported to date that cause hypertriglyceridemia (HTG). Finally, we describe the clinical presentation of apoC-II deficiency and assess the current therapeutic approaches, as well as potential novel emerging therapies.

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Authors: Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T.
Affiliations: National Institutes of Health (US)
Philadelphia VA Medical Center (US)
University of Pennsylvania (US)
Corresponding author: Wolska, Anna
ORCID: Wolska, Anna
Dunbar, Richard L.
Freeman, Lita A.
Ueda, Masako
Amar, Marcelo J.
Remaley, Alan T.
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2017-12
Volume: 267
Pages: 49-60
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2017.10.025
PMC: PMC5705268
OpenAlex: W2767128978
Cited by: 231
References: 125
Citations by year: 2026: 18 · 2025: 28 · 2024: 20 · 2023: 35 · 2022: 34 · 2021: 44 · 2020: 25 · 2019: 15 · 2018: 11
FWCI: 1.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (ZIAHL006095)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: apolipoprotein C-II, triglyceride metabolism, triglyceride-rich lipoproteins, chylomicrons, VLDL, high-density lipoprotein, hypertriglyceridemia, transcriptional regulation, treatment options
MeSH terms: Animals, Chylomicrons, Gene Expression Regulation, Multigene Family, Humans, Hydrolysis, Intestinal Mucosa, Lipolysis, Lipoprotein Lipase, Lipoproteins, Lipoproteins, HDL, Lipoproteins, VLDL, Liver, Macrophages, Mutation, Transcription, Genetic, Triglycerides, Mice, Rats, Apolipoprotein C-II

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Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

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