The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Purinergic signaling in the immune system
Open accessAbstract
Extracellular ATP and its metabolite adenosine are increasingly recognized as key mediators of the immune response. Depending on the concentration, ATP may act as an immunostimulant or an immunodepressant, while adenosine is generally acknowledged to be a potent immunosupressor molecule. Signals delivered by extracellular ATP and adenosine are detected and transduced by P2 and P1 receptors, respectively. Virtually all immune cells express P2 and P1 receptors, thus purinergic signaling affects all aspects of immunity and inflammation. This realization has prompted a burst of novel investigations aimed at the design and synthesis of P2- or P1-targeted drugs for the treatment of chronic inflammatory diseases and cancer. In this review we will summarize the most recent developments in this field.
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A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542
Immunity, inflammation and cancer: a leading role for adenosine
Antonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3613 · Cited by 765
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., & Di Virgilio, F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002599 · Cited by 668
P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release
Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., & Pelegrín, P. (2012) · The FASEB Journal · doi:10.1096/fj.12-205765 · Cited by 142
Cited by
Purinergic Signalling: Therapeutic Developments
Burnstock, G. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00661 · Cited by 398
Zinc signals and immune function
Haase, H., & Rink, L. (2014) · BioFactors · doi:10.1002/biof.1114 · Cited by 297
Mechanisms of ATP Release by Inflammatory Cells
Dosch, M., Gerber, J., Jebbawi, F., & Beldi, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041222 · Cited by 283
Burnstock, G., & Knight, G. E. (2018) · Purinergic Signalling · doi:10.1007/s11302-017-9593-0 · Cited by 248
Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0118 · Cited by 59
Metadata
- Authors
- Di Virgilio, F., & Vuerich, M.
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 191
- Pages
- 117-123
- ISSN
- 1566-0702 (ISSN-L)
- OpenAlex
- W1593579053
- Cited by
- 231
- References
- 6
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- green
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