Cited by 454Rheumatoid Arthritis Research and TherapiesCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

COVID-19 infection and rheumatoid arthritis: Faraway, so close

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Favalli, Ennio Giulio, Ingegnoli, Francesca, De Lucia, Orazio, Cincinelli, Gilberto, Cimaz, Rolando, Caporali, Roberto·2020·Autoimmunity Reviews

Abstract

The outbreak of the new coronavirus infections COVID-19 in December 2019 in China has quickly become a global health emergency. Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. In this review we will critically analyse the evidences on either positive or negative effect of drugs commonly used to treat RA in this particular scenario, in order to optimize the current approach to RA patients.

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Crossref · 10.1016/j.autrev.2020.102523

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  • RA patients are at increased risk of infection compared to the general population due to disease-related impairment in immune system function and immunosuppressive drugs.

    “RA patients are at increased risk of infection compared to the general population owed to disease related impairment in immune system function and immunosuppressive drugs (Listing et al., 2013; Favalli et al., 2020).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Favalli et al., 2020

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Authors
Favalli, E. G., Ingegnoli, F., De Lucia, O., Cincinelli, G., Cimaz, R., & Caporali, R.
Affiliations
  • Istituto Ortopedico Gaetano Pini (IT)
  • University of Milan (IT)
Corresponding author
Favalli, Ennio Giulio
Venue
Autoimmunity Reviews
Publisher
Elsevier BV
Published
2020-05
Volume
19
Issue
5
Pages
102523
ISSN
1568-9972 (ISSN-L)
OpenAlex
W3011047976
Cited by
454
References
121
Citations by year
2026: 2 · 2025: 10 · 2024: 21 · 2023: 35 · 2022: 64 · 2021: 99 · 2020: 223
FWCI
16.31
Type
journal article
Language
en
Open access
Locations
  • Autoimmunity Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
COVID-19 pandemic, SARS-CoV-2, rheumatoid arthritis, antirheumatic drugs, immunosuppressants, corticosteroids, drug repurposing, autoimmune disease, immune dysfunction, COVID-19 treatment
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Arthritis, Rheumatoid, China, Humans, Pneumonia, Viral, Immunocompromised Host, Coronavirus Infections, Antirheumatic Agents, Pandemics

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