COVID-19 infection and rheumatoid arthritis: Faraway, so close
Open accessAbstract
The outbreak of the new coronavirus infections COVID-19 in December 2019 in China has quickly become a global health emergency. Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. In this review we will critically analyse the evidences on either positive or negative effect of drugs commonly used to treat RA in this particular scenario, in order to optimize the current approach to RA patients.
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RA patients are at increased risk of infection compared to the general population due to disease-related impairment in immune system function and immunosuppressive drugs.
“RA patients are at increased risk of infection compared to the general population owed to disease related impairment in immune system function and immunosuppressive drugs (Listing et al., 2013; Favalli et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Favalli et al., 2020
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McGonagle, D., Sharif, K., O'Regan, A., & Bridgewood, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102537 · Cited by 1,654 · see citing works
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Viral Infections, the Microbiome, and Probiotics
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- Authors
- Favalli, E. G., Ingegnoli, F., De Lucia, O., Cincinelli, G., Cimaz, R., & Caporali, R.
- Affiliations
- Istituto Ortopedico Gaetano Pini (IT)
- University of Milan (IT)
- Corresponding author
- Favalli, Ennio Giulio
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 19
- Issue
- 5
- Pages
- 102523
- ISSN
- 1568-9972 (ISSN-L)
- PMC
- PMC7102591
- OpenAlex
- W3011047976
- Cited by
- 454
- References
- 121
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 21 · 2023: 35 · 2022: 64 · 2021: 99 · 2020: 223
- FWCI
- 16.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, rheumatoid arthritis, antirheumatic drugs, immunosuppressants, corticosteroids, drug repurposing, autoimmune disease, immune dysfunction, COVID-19 treatment
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Arthritis, Rheumatoid, China, Humans, Pneumonia, Viral, Immunocompromised Host, Coronavirus Infections, Antirheumatic Agents, Pandemics
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