Paralinguistic processing in children with callosal agenesis: Emergence of neurolinguistic deficits
Abstract
Recent research revealed impaired processing of both nonliteral meaning and affective prosody in adults with agenesis of the corpus callosum (ACC) and normal intelligence. Since normal children have incomplete myelination of the corpus callosum, it was hypothesized that paralanguage deficits in children with ACC would be less apparent relative to their peers. The Familiar and Novel Language Comprehension Test (FANL-C) and Prosody Test were given to 18 children with ACC and normal intelligence and 17 controls matched for age (7-13 years), education, and IQ (83-122). When controlling for age, children with ACC were significantly poorer in comprehension of the precise meaning of both literal and nonliteral items on the FANL-C. Adults with ACC had previously been shown to have difficulty only on nonliteral items. The effect size for nonliteral comprehension in children with ACC was smaller than that seen in adults. There was only a trend for the child ACC group to perform worse on the recognition of affective prosody. Thus, while deficits in paralinguistic processing were apparent, children with ACC were not as clearly different from age peers as adults, and were equally deficient at comprehending literal and nonliteral expressions. The differences in results between adults and children with ACC are thought to reflect incomplete callosal development in normal children, and the importance of the corpus callosum in the early stages of the development of the ability to process literal language.
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The results are consistent with evidence from investigations of individuals with agenesis of the corpus callosum.
“Results reported here are consistent with evidence from investigations examining individuals with agenesis of the CC, pointing to the role that this structure plays in complex brain functions.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [48]
Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the corpus callosum.
“Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the CC, although not all individuals with these deficits meet full DSM-IV-TR criteria for autistic disorder.”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [48]
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Self-citation
- Authors
- Brown, W. S., Symingtion, M., VanLancker-Sidtis, D., Dietrich, R., & Paul, L. K.
- Affiliations
- New York University (US)
- University of California San Diego (US)
- Corresponding author
- Brown, Warren S.
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 93
- Issue
- 2
- Pages
- 135-139
- ISSN
- 0093-934X (ISSN-L)
- OpenAlex
- W2049408535
- Cited by
- 61
- References
- 29
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 4 · 2014: 7 · 2013: 2 · 2012: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- agenesis of the corpus callosum, emotional prosody, language comprehension, children
- MeSH terms
- Adolescent, Affect, Child, Corpus Callosum, Dominance, Cerebral, Female, Humans, Language Development Disorders, Male, Nerve Fibers, Myelinated, Peer Group, Psycholinguistics, Reference Values, Speech Acoustics, Speech Perception, Comprehension, Agenesis of Corpus Callosum
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