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Re-establishing Broca's initial findings
Open accessAbstract
The importance of the left inferior pre-frontal cortex (LIPC) for speech production was first popularized by Paul Broca, providing a cornerstone of behavioral neurology and laying the foundation for future research examining brain-behavior relationships. Although Broca's findings were rigorously challenged, comprehensive contradictory evidence was not published until 130years later. This evidence suggested that damage to left anterior insula was actually the best predictor of motor speech impairment. Using high-resolution structural magnetic resonance imaging (MRI) in patients with chronic stroke, we reveal that LIPC involvement more accurately predicts acquired motor speech impairment than insula damage. Perfusion-weighted MRI provides complementary evidence, highlighting how damage to left inferior pre-frontal gyrus often includes insula involvement, and vice versa. Our findings suggest that Broca's initial conclusions associating acquired motor speech impairment with LIPC damage remain valid nearly 150years after his initial report on this issue.
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“In all cases, it is therefore difficult to determine which part of the lesion site is driving the observed behavioural effects”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Richardson et al., 2012
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Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Stereotaxic Display of Brain Lesions
Rorden, C., & Brett, M. (2000) · Behavioural Neurology · doi:10.1155/2000/421719 · Cited by 2,573
Circuitry and functional aspects of the insular lobe in primates including humans
AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776
Hécaen, H. (1983) · Neuropsychologia · doi:10.1016/0028-3932(83)90089-1 · Cited by 1,697
Improving Lesion-Symptom Mapping
Rorden, C., Karnath, H., & Bonilha, L. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.7.1081 · Cited by 1,347
A new brain region for coordinating speech articulation
Dronkers, N. F. (1996) · Nature · doi:10.1038/384159a0 · Cited by 1,192
Neural modeling and imaging of the cortical interactions underlying syllable production
Guenther, F. H., Ghosh, S. S., & Tourville, J. A. (2006) · Brain and Language · doi:10.1016/j.bandl.2005.06.001 · Cited by 879
Using human brain lesions to infer function: a relic from a past era in the fMRI age?
Rorden, C., & Karnath, H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1521 · Cited by 684
Cortical interactions underlying the production of speech sounds
Guenther, F. H. (2006) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2006.06.013 · Cited by 675
Arterial territories of the human brain
Tatu, L., Moulin, T., Bogousslavsky, J., & Duvernoy, H. M. (1998) · Neurology · doi:10.1212/wnl.50.6.1699 · Cited by 612
The Anatomy of Spatial Neglect based on Voxelwise Statistical Analysis: A Study of 140 Patients
Karnath, H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh076 · Cited by 583
An fMRI investigation of syllable sequence production
Bohland, J. W., & Guenther, F. H. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.173 · Cited by 561
Re-examining the brain regions crucial for orchestrating speech articulation
Hillis, A. E., Work, M., Barker, P. B., Jacobs, M. A., Breese, E., & Maurer, K. (2004) · Brain · doi:10.1093/brain/awh172 · Cited by 485
The contribution of the insula to motor aspects of speech production: A review and a hypothesis
Ackermann, H., & Riecker, A. (2004) · Brain and Language · doi:10.1016/s0093-934x(03)00347-x · Cited by 343
Apraxia of speech in adults: The disorder and its management
Wertz, R. T., LaPointe, L. L., & Rosenbek, J. C. (1984) · Medical Entomology and Zoology · Cited by 243
Classic Cases in Neuropsychology
(2004) · Psychology Press eBooks · doi:10.4324/9780203304112 · Cited by 230
Ackermann, H., & Riecker, A. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0257-x · Cited by 191
Clinical and anatomical correlates of apraxia of speech
Ogar, J. M., Willock, S., Baldo, J. V., Wilkins, D. P., Ludy, C. A., & Dronkers, N. F. (2006) · Brain and Language · doi:10.1016/j.bandl.2006.01.008 · Cited by 168
Differential effects of syntactic and semantic processing on the subregions of Broca’s area
Newman, S. D., Just, M. A., Keller, T. A., Roth, J. K., & Carpenter, P. A. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00285-9 · Cited by 150
Rodd, J. M., Longe, O. A., Randall, B., & TYLER, L. K. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.035 · Cited by 147
Arterial Territories of the Human Brain
Tatu, L., Moulin, T., Vuillier, F., & Bogousslavsky, J. (2012) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000333602 · Cited by 130
Distribution territories and causative mechanisms of ischemic stroke
Rovira, À., Grivé, E., Rovira, À., & Álvarez‐Sabín, J. (2005) · European Radiology · doi:10.1007/s00330-004-2633-5 · Cited by 122
Speech Motor ControlNew developments in basic and applied research
Maassen, B., & Lieshout, P. H. H. M. V. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199235797.001.0001 · Cited by 110
Infarct patterns in atherosclerotic middle cerebral artery versus internal carotid artery disease
Lee, P. H., Oh, S., Bang, O. Y., Joo, S. Y., Joo, I. S., & Huh, K. H. (2004) · Neurology · doi:10.1212/01.wnl.0000120761.57793.28 · Cited by 60
Cheng, B., Golsari, A., Fiehler, J., Rosenkranz, M., Gerloff, C. P., & Thomalla, G. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.185 · Cited by 33
Apraxia of Speech: Another Form of Praxis Disruption
Rothi, L. J. G., & Heilman, K. M. (2014) · Psychology Press eBooks · doi:10.4324/9781315804545-15 · Cited by 19
Paul Broca and the Origins of Language in the Brain
LaPointe, L. L. (2012) · Cited by 18
Ackermann, H., & Riecker, A. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199235797.003.0007 · Cited by 17
Broca's region revisited: Cytoarchitecture and intersubject variability
Amunts, K., Schleicher, A., B�rgel, U., Mohlberg, H., Uylings, H. B. M., & Zilles, K. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990920)412:2
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3 of the 34 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Auburtin, 1861, Reprise de la discussion sur la forme et le volume du cerveau, Bulletin of the Society of Anthropology, 2, 209
- Broca, 1861, Remarques sur le sie‘ge de la faculte´ du langage articule´: Suivies d’une observation d’aphemie, The Bulletin of the Society of Anatomy (Paris), 6, 330
- Broca, 1863, Localisation des fonctions cerebrales: Sie‘e du langage articule´, The Bulletin of the Society of Anthropology (Paris), 4, 200
- Broca, 1865, On the location of the faculty of articulate language in the left hemisphere of the brain, The Bulletin of the Society of Anthropology, 6, 337
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Sorted by citations
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Gasquoine, P. G. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9246-9 · Cited by 400
The language network as a natural kind within the broader landscape of the human brain
Fedorenko, E. G., Ivanova, A. A., & Regev, T. I. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00802-4 · Cited by 374
Broca’s Area Is Not a Natural Kind
Fedorenko, E. G., & Blank, I. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.01.001 · Cited by 272
Flowers, H. L., Silver, F. L., Fang, J., Rochon, E., & Martino, R. (2013) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2013.04.001 · Cited by 249
Damage to the anterior arcuate fasciculus predicts non-fluent speech production in aphasia
Fridriksson, J., Guo, D., Fillmore, P., Holland, A., & Rorden, C. (2013) · Brain · doi:10.1093/brain/awt267 · Cited by 172
Metadata
- Authors
- Richardson, J. D., Fillmore, P., Rorden, C., LaPointe, L. L., & Fridriksson, J.
- Affiliations
- University of South Carolina (US)
- Florida State University (US)
- Corresponding author
- Richardson, Jessica D.
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 123
- Issue
- 2
- Pages
- 125-130
- ISSN
- 0093-934X (ISSN-L)
- PMC
- PMC6659403
- OpenAlex
- W2137728507
- Cited by
- 109
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 39 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 5 · 2012: 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Scholar Commons (University of South Carolina) (submittedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC008355, R01DC009571)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Health Professions › Speech and Hearing › Voice and Speech Disorders
- Health Sciences › Medicine › Clinical Neurology › Neurological and metabolic disorders
- Keywords
- Broca's area, motor speech disorders, chronic stroke, speech production, perfusion-weighted MRI, structural MRI, history of neurology, brain-behavior relationship
- MeSH terms
- Aphasia, Broca, Cerebrovascular Circulation, Frontal Lobe, Humans, Magnetic Resonance Imaging, Stroke
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