A new brain region for coordinating speech articulation

Dronkers, Nina F.

doi:10.1038/384159a0

Cited by 1,192Neurobiology of Language and BilingualismPhonetics and Phonology ResearchVoice and Speech Disorders

A new brain region for coordinating speech articulation

Dronkers, Nina F.·1996·Nature

DOI 10.1038/384159a0

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Abstract

Human speech requires complex planning and coordination of mouth and tongue movements. Certain types of brain injury can lead to a condition known as apraxia of speech, in which patients are impaired in their ability to coordinate speech movements but their ability to perceive speech sounds, including their own errors, is unaffected. The brain regions involved in coordinating speech, however, remain largely unknown. In this study, brain lesions of 25 stroke patients with a disorder in the motor planning of articulatory movements were compared with lesions of 19 patients without such deficits. A robust double dissociation was found between these two groups. All patients with articulatory planning deficits had lesions that included a discrete region of the left precentral gyrus of the insula, a cortical area beneath the frontal and temporal lobes. This area was completely spared in all patients without these articulation deficits. Thus this area seems to be specialized for the motor planning of speech.

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Damage to both banks of the superior central sulcus centred at MNI coordinates [−36, 1, 10] has consistently been associated with speech production impairments after stroke.
“damage to both banks of the superior central sulcus centred at MNI coordinates [−36, 1, 10] has consistently been associated with speech production impairments after stroke”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Dronkers, 1996
The left anterior insula contributes to articulatory planning.
“The contribution of the left anterior insula to articulatory planning was suggested in both functional imaging (Wise et al., 1999) and lesion (Dronkers, 1996) studies.”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Dronkers, 1996

Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Higher cortical functions in man
Lurii︠a︡, A. R., Teuber, H., Pribram, K. H., & Haigh, B. (1966) · Basic Books · Cited by 2,858 · see citing works
The neural correlates of the verbal component of working memory
Paulesu, E., Frith, C. D., & Frackowiak, R. S. J. (1993) · Nature · doi:10.1038/362342a0 · Cited by 2,230 · see citing works
HIGHER CORTICAL FUNCTIONS IN MAN
Newcombe, F. (1967) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.30.2.190-a · Cited by 1,397 · see citing works
Cardiovascular effects of human insular cortex stimulation
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272 · see citing works
Motor Speech Disorders
Darley, F. L., Aronson, A., & Brown, J. R. (2014) · Channel View Publications eBooks · doi:10.2307/jj.26931941 · Cited by 1,266 · see citing works
Motor Speech Disorders
Kokmen, E. (1976) · JAMA · doi:10.1001/jama.1976.03270020071039 · Cited by 1,006 · see citing works
Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain
Mesulam, M. M., & Mufson, E. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120102 · Cited by 654 · see citing works
THE ANATOMICAL BASIS OF CONDUCTION APHASIA
Damásio, H., & Damásio, A. R. (1980) · Brain · doi:10.1093/brain/103.2.337 · Cited by 458 · see citing works
Language localization and variability
Ojemann, G. A., & Whitaker, H. A. (1978) · Brain and Language · doi:10.1016/0093-934x(78)90061-5 · Cited by 345 · see citing works
Tactile-Vibration-Activated Foci in Insular and Parietal-Opercular Cortex Studied with Positron Emission Tomography: Mapping the Second Somatosensory Area in Humans
Burton, H., Videen, T. O., & Raichle, M. E. (1993) · Somatosensory & Motor Research · doi:10.3109/08990229309028839 · Cited by 267 · see citing works
Apraxia of speech in adults: The disorder and its management
Wertz, R. T., LaPointe, L. L., & Rosenbek, J. C. (1984) · Medical Entomology and Zoology · Cited by 246 · see citing works
Phonemic Variability in Apraxia of Speech
Johns, D. F., & Darley, F. L. (1970) · Journal of Speech and Hearing Research · doi:10.1044/jshr.1303.556 · Cited by 225 · see citing works
The insular lobe in primates including humans
Augustine, J. R. (1985) · Neurological Research · doi:10.1080/01616412.1985.11739692 · Cited by 224 · see citing works
Localisation of Lesions in Aphasia: Clinical-CT Scan Correlations in Stroke Patients
Mazzocchi, F., & Vignolo, L. A. (1979) · Cortex · doi:10.1016/s0010-9452(79)80051-9 · Cited by 205 · see citing works
Aphemia
Schiff, H. B. (1983) · Archives of Neurology · doi:10.1001/archneur.1983.04050110038005 · Cited by 183 · see citing works
A modality-specific somatosensory area within the insula of the rhesus monkey
Schneider, R. J., Friedman, D. P., & Mishkin, M. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90305-7 · Cited by 180 · see citing works
Mutism and auditory agnosia due to bilateral insular damage—Role of the insula in human communication
Habib, M., Daquin, G., Milandre, L., Royère, M. L., Rey, M. F., Lanteri, A., Salamon, G., & Khalil, R. (1995) · Neuropsychologia · doi:10.1016/0028-3932(94)00108-2 · Cited by 126 · see citing works
Apraxia of speech : physiology, acoustics, linguistics, management
Rosenbek, J. C., McNeil, M. R., & Aronson, A. (1984) · College-Hill Press eBooks · Cited by 118 · see citing works
Brain lesions associated with oral apraxia in stroke patients: A clinico-neuroradiological investigation with the CT scan
Tognola, G., & Vignolo, L. A. (1980) · Neuropsychologia · doi:10.1016/0028-3932(80)90122-0 · Cited by 118 · see citing works
Structure of the human brain
DeArmond, S. J. (1976) · Cited by 107 · see citing works
An Experimental Approach to the Problem of Articulation in Aphasia
Shankweiler, D., & Harris, K. S. (1966) · Cortex · doi:10.1016/s0010-9452(66)80008-4 · Cited by 103 · see citing works
Differential Language and Neurologic Characteristics in Cerebral Involvement
Halpern, H., Darley, F. L., & Brown, J. R. (1973) · Journal of Speech and Hearing Disorders · doi:10.1044/jshd.3802.162 · Cited by 54 · see citing works
Aphemia resulting from a left frontal hematoma
Ruff, R. L., & Arbit, E. (1981) · Neurology · doi:10.1212/wnl.31.3.353 · Cited by 33 · see citing works

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Indefrey, P., & Levelt, W. J. M. (2004) · Cognition · doi:10.1016/j.cognition.2002.06.001 · Cited by 2,144 · see citing works
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Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T., & Dronkers, N. F. (2003) · Nature Neuroscience · doi:10.1038/nn1050 · Cited by 1,457 · see citing works
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Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000377 · Cited by 1,262 · see citing works
Immature Frontal Lobe Contributions to Cognitive Control in Children
Bunge, S. A., Dudukovic, N. M., Thomason, M. E., Vaidya, C. J., & Gabrieli, J. D. E. (2002) · Neuron · doi:10.1016/s0896-6273(01)00583-9 · Cited by 1,291 · see citing works
“…that anterior insula may play as important a role in cognitive control as the frontal and cingulate regionshave been observed for studies related to verbal articu- lation (Dronkers, 1996; lesion study) or phonological pro- which have received much attention. cessing (e.g., Paulesu et al., 1993).”
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Koelsch, S., Fritz, T., v. Cramon, D. Y., Müller, K., & Friederici, A. D. (2006) · Human Brain Mapping · doi:10.1002/hbm.20180 · Cited by 1,037 · see citing works
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“In humans, speech production research (Oh et al., 2014) and lesion symptom research (Cereda et al., 2002; Dronkers, 1996; Duffau et al., 2001; Starkstein et al., 1988) has also causally associated the insula with articulation.”
Background
Apraxia of speech involves lesions of dorsal arcuate fasciculus and insula in patients with aphasia
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Authors: Dronkers, N. F.
Affiliations: VA Northern California Health Care System (US)
Corresponding author: Dronkers, Nina F.
ORCID: Dronkers, Nina F.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1996-11
Volume: 384
Issue: 6605
Pages: 159-161
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/384159a0
OpenAlex: W1997482356
Cited by: 1,192
References: 25
Citations by year: 2026: 11 · 2025: 22 · 2024: 22 · 2023: 30 · 2022: 70 · 2021: 34 · 2020: 35 · 2019: 26 · 2018: 46 · 2017: 40 · 2016: 41 · 2015: 52 · 2014: 61 · 2013: 45 · 2012: 54
FWCI: 9.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
Health Sciences › Medicine › Physiology › Voice and Speech Disorders
Keywords: apraxia of speech, speech articulation, motor planning, articulatory movements, stroke, brain lesions, double dissociation, insula, speech motor control
MeSH terms: Adult, Aged, Apraxias, Brain Mapping, Cerebral Cortex, Cerebrovascular Disorders, Humans, Magnetic Resonance Imaging, Middle Aged, Psychomotor Performance, Speech, Tomography, X-Ray Computed

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A new brain region for coordinating speech articulation

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