Contributions of the insula to cognition and emotion

Gasquoine, Philip Gerard

doi:10.1007/s11065-014-9246-9

Cited by 400Psychosomatic Disorders and Their TreatmentsNeural and Behavioral Psychology StudiesNeuroscience and Music Perception

Contributions of the insula to cognition and emotion

Gasquoine, Philip Gerard·2014·Neuropsychology Review

DOI 10.1007/s11065-014-9246-9

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Abstract

Historically, the insula was considered primary gustatory cortex. Now it is known to play a more comprehensive role in the processing of sensory information, including acting as primary cortex for interoceptive information, including autonomic nervous system mediated changes. As such, it is critical for emotional feeling in accord with the James-Lange theory, a role previously ascribed to the limbic system. Neuroimaged abnormal grey matter volumes or activity levels in the insula have been associated with schizophrenia, eating disorders, anxiety and mood disorders, conduct disorder, autism, addiction, and chronic pain. The significance of these abnormal activity patterns remains theoretical. Neuropsychological studies have linked dominant insula injury with various symptoms of aphasia, but its exact role in language processing remains uncertain as most cases involve lesions that extend into perisylvian language zones. Functional neuroimaging studies have found insula hyper-activations, typically in conjunction with anterior cingulate cortex, for all manner of experimental tasks including those involving perception, intentional action, and consciousness. Such neuroimaged activity is unlikely to be task-specific, but rather reflective of generic changes in autonomic activity in response to salience, homeostatic incongruence, or cognitive challenge.

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Insula cortex is critical for integration of interoceptive and sensory information and regulating emotional response.
“Insula cortex is critical for integration of interoceptive and sensory information and regulating emotional response (Gasquoine, 2014).”
From Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders (2017) · cites this paper as Gasquoine, 2014

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Volumetric MRI study of the insular cortex in individuals with current and past major depression
Takahashi, T., Yücel, M., Lorenzetti, V., Tanino, R., Whittle, S., Suzuki, M., Walterfang, M., Pantelis, C., & Allen, N. B. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.003 · Cited by 104 · see citing works
Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks
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The hidden side of intentional action: the role of the anterior insular cortex
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Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder
Klumpp, H., Post, D., Angstadt, M., Fitzgerald, D. A., & Phan, K. L. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-7 · Cited by 91 · see citing works
Anatomical and functional overlap within the insula and anterior cingulate cortex during interoception and phobic symptom provocation
Caseras, X., Murphy, K., Mataix‐Cols, D., López‐Solà, M., Soriano‐Mas, C., Ortriz, H., Pujol, J., & Torrúbia, R. (2011) · Human Brain Mapping · doi:10.1002/hbm.21503 · Cited by 81 · see citing works
Basal ganglia plus insula damage yields stronger disruption of smoking addiction than basal ganglia damage alone
Gaznick, N., Tranel, D., McNutt, A., & Bechara, A. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt172 · Cited by 72 · see citing works
“Semantic” Conduction Aphasia from a Posterior Insular Cortex Infarction
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Behavioral Effects of Damage to the Right Insula and Surrounding Regions
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Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder
Chen, S., Li, L., Xu, B., & Liu, J. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-39 · Cited by 68 · see citing works
Cortical association areas in the gustatory system
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Neglect After Right Insular Cortex Infarction
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The Working Brain: An Introduction to Neuropsychology, by
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Persistent denial of handicap after infarction of the right basal ganglia: a case study.
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Verbal memory impairment after left insular cortex infarction
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Anosognosia versus unilateral neglect. Coexistence and their relations to age, stroke severity, lesion site and cognition
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Description of sulcal organization of the insular cortex
Afif, A., & Mertens, P. (2009) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-009-0598-4 · Cited by 47 · see citing works
The role of insula in language: an unsettled question
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Perhaps Functional Neuroimaging has not told us Anything about the Mind (So Far)
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THE SEMINAL CONTRIBUTIONS OF JOHANN-CHRISTIAN REIL TO ANATOMY, PHYSIOLOGY, AND PSYCHIATRY
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Anterior insular volume is larger in patients with obsessive–compulsive disorder
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Apraxia of speech: a critical review
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Spatial neglect and perseveration in visuomotor exploration.
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The comprative anatomy of the insula
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Anosognosia for hemiplegia as a global deficit in motor awareness: Evidence from the non-paralysed limb
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Frontiers in Human Neuroscience: The Golden Triangle and Beyond
Decety, J., & Cacioppo, J. T. (2010) · Perspectives on Psychological Science · doi:10.1177/1745691610388780 · Cited by 27 · see citing works
Lesions to the posterior insular cortex cause dysarthria
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Brain Imaging, Cognitive Processes, and Brain Networks
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Hemianesthesia and Aphasia
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Von Monakow and diaschisis.
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Pure dysarthria due to an insular infarction
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Die Lokalisation im Grosshirn und der Abbau der Funktion durch kortikale Herde
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Isolated ataxia after pure left insular cortex infarction
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Understanding Emotions: Origins and Roles of the Amygdala
Šimić, G., Tkalčić, M., Vukić, V., Mulc, D., Španić, E., Šagud, M., Olucha-Bordonau, F. E., Vukšić, M., & Hof, P. R. (2021) · Biomolecules · doi:10.3390/biom11060823 · Cited by 556 · see citing works
Dynamic Resting-State Functional Connectivity in Major Depression
Kaiser, R. H., Whitfield-Gabrieli, S., Dillon, D. G., Goer, F., Beltzer, M., Minkel, J., Smoski, M., Dichter, G., & Pizzagalli, D. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.352 · Cited by 438 · see citing works
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal, L., van Harmelen, A.-L., Chatzi, V., Lippard, E. T. C., Toenders, Y. J., Averill, L. A., Mazure, C. M., & Blumberg, H. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0587-x · Cited by 373 · see citing works
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 365 · see citing works
The neuroscience of positive emotions and affect: Implications for cultivating happiness and wellbeing
Alexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 329 · see citing works
Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity
Gilbert, J. P., & Man, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00359 · Cited by 274 · see citing works
The neurobiology of emotion regulation in posttraumatic stress disorder: amygdala downregulation via real‐time fMRI neurofeedback
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P. A., Paret, C., Kluetsch, R., Schmahl, C., Théberge, J., Neufeld, R. W. J., McKinnon, M. C., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23402 · Cited by 273 · see citing works
Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders
South, M., & Rodgers, J. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00020 · Cited by 270 · see citing works
“Insula cortex is critical for integration of interoceptive and sensory information and regulating emotional response (Gasquoine, 2014).”
Background
A review of definitions of fatigue – And a step towards a whole definition
Phillips, R. O. (2015) · Transportation Research Part F Traffic Psychology and Behaviour · doi:10.1016/j.trf.2015.01.003 · Cited by 252 · see citing works
Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Schizophrenia
Zhu, J., Zhuo, C., Xu, L., Liu, F., Qin, W., & Yu, C. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx051 · Cited by 153 · see citing works
Tai Chi Chuan and Baduanjin practice modulates functional connectivity of the cognitive control network in older adults
Tao, J., Chen, X., Egorova, N., Liu, J., Xue, X., Wang, Q., Zheng, G., Li, M., Hong, W., Sun, S., et al. (2017) · Scientific Reports · doi:10.1038/srep41581 · Cited by 144 · see citing works
A systematic review of the neural bases of psychotherapy for anxiety and related disorders
Brooks, S. J., & Stein, D. J. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/sbrooks · Cited by 134 · see citing works
The Insula: A Brain Stimulation Target for the Treatment of Addiction
Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133 · see citing works
Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype.
Nicholson, A. A., Sapru, I., Densmore, M., Frewen, P. A., Neufeld, R. W. J., Théberge, J., McKinnon, M. C., & Lanius, R. A. (2016) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2016.02.002 · Cited by 128 · see citing works
The Developing Brain in the Digital Era: A Scoping Review of Structural and Functional Correlates of Screen Time in Adolescence
Marciano, L., Camerini, A.-L., & Morese, R. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.671817 · Cited by 125 · see citing works
Shared Reading Quality and Brain Activation during Story Listening in Preschool-Age Children
Hutton, J. S., Phelan, K., Horowitz-Kraus, T., Dudley, J., Altaye, M., DeWitt, T., & Holland, S. K. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.08.037 · Cited by 105 · see citing works
Intact brain processing of musical emotions in autism spectrum disorder, but more cognitive load and arousal in happy vs. sad music
Gebauer, L., Skewes, J., Westphael, G., Heaton, P. F., & Vuust, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00192 · Cited by 103 · see citing works
Transcranial Magnetic Stimulation of Left Dorsolateral Prefrontal Cortex Induces Brain Morphological Changes in Regions Associated with a Treatment Resistant Major Depressive Episode: An Exploratory Analysis
Lan, M. J., Chhetry, B. T., Liston, C., Mann, J. J., & Dubin, M. (2016) · Brain Stimulation · doi:10.1016/j.brs.2016.02.011 · Cited by 96 · see citing works
Modulation of Distinct Intrinsic Resting State Brain Networks by Acute Exercise Bouts of Differing Intensity
Schmitt, A. G., Upadhyay, N., Martin, J. A., Rojas, S., Strüder, H. K., & Boecker, H. (2019) · Brain Plasticity · doi:10.3233/bpl-190081 · Cited by 93 · see citing works
Oxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions
Hu, J., Qi, S., Becker, B., Luo, L., Gao, S., Gong, Q., Hurlemann, R., & Kendrick, K. M. (2015) · Human Brain Mapping · doi:10.1002/hbm.22760 · Cited by 91 · see citing works
Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology
Orosco, L. A., Ross, A. P., Cates, S. L., Scott, S. E., Wu, D., Sohn, J., Pleasure, D., Pleasure, S. J., Adamopoulos, I. E., & Zarbalis, K. S. (2014) · Nature Communications · doi:10.1038/ncomms5692 · Cited by 90 · see citing works
The neural correlates of happiness: A review of PET and fMRI studies using autobiographical recall methods
Suardi, A., Sotgiu, I., Costa, T., Cauda, F., & Rusconi, M. (2016) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-016-0414-7 · Cited by 80 · see citing works
Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review
Vance, D. E., Bene, V. A. D., Kamath, V. J., Sandson, J., Billings, R., Cho, D., Byun, J. Y., Jacob, A. E., Anderson, J. N., Visscher, K., et al. (2023) · Neuropsychology Review · doi:10.1007/s11065-022-09573-0 · Cited by 86 · see citing works
A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82 · see citing works
Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis
Fathy, Y. Y., Hoogers, S. E., Berendse, H. W., van der Werf, Y. D., Visser, P. J., de Jong, F. J., & van de Berg, W. D. J. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00099-3 · Cited by 82 · see citing works
Continuous vs. intermittent neurofeedback to regulate auditory cortex activity of tinnitus patients using real-time fMRI - A pilot study
Emmert, K., Kopel, R., Koush, Y., Maire, R., Senn, P., Ville, D. V. D., & Haller, S. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.12.023 · Cited by 81 · see citing works
Prenatal Neurogenesis in Autism Spectrum Disorders
Kaushik, G., & Zarbalis, K. S. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00012 · Cited by 77 · see citing works
Anterior insula reflects surprise in value-based decision-making and perception
Loued-Khenissi, L., Pfeuffer, A., Einhäuser, W., & Preuschoff, K. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116549 · Cited by 66 · see citing works
Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study
Li, B., He, N., Qiao, Y., Xu, H., Lu, Y., Cui, P., Ling, H., Yan, F.-H., Tang, H., & Chen, S. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101691 · Cited by 75 · see citing works
Structural and Functional Alterations in Right Dorsomedial Prefrontal and Left Insular Cortex Co-Localize in Adolescents with Aggressive Behaviour: An ALE Meta-Analysis
Raschle, N., Menks, W., Fehlbaum, L., Tshomba, E., & Stadler, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136553 · Cited by 73 · see citing works
Brain responses to drug cues predict craving changes in abstinent heroin users: A preliminary study
Liu, S., Wang, S., Zhang, M., Xu, Y., Shao, Z., Chen, L., Yang, W., Liu, J., & Yuan, K. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118169 · Cited by 71 · see citing works
Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
Yang, Y., Liu, S., Jiang, X., Yu, H., Ding, S., Lu, Y., Li, W., Zhang, H., Liu, B., Cui, Y. J., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00052 · Cited by 66 · see citing works
Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review
Bu, L., Zhang, J., Lu, J., & Wu, J. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01418-9 · Cited by 68 · see citing works
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 63 · see citing works
Hurst Exponent Analysis of Resting-State fMRI Signal Complexity across the Adult Lifespan
Dong, J. Z., Jing, B., Ma, X., Liu, H., Mo, X., & Li, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00034 · Cited by 61 · see citing works
The thalamus is the causal hub of intervention in patients with major depressive disorder: Evidence from the Granger causality analysis
Yang, C., Xiao, K., Ao, Y., Cui, Q., Jing, X., & Wang, Y. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103295 · Cited by 59 · see citing works
Specific Changes in Brain Activity during Urgency in Women with Overactive Bladder after Successful Sacral Neuromodulation: A Functional Magnetic Resonance Imaging Study
Weissbart, S. J., Bhavsar, R., Rao, H., Wein, A. J., Detre, J. A., Arya, L. A., & Smith, A. L. (2018) · The Journal of Urology · doi:10.1016/j.juro.2018.03.129 · Cited by 60 · see citing works
Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
Malik, S., Jacobs, M., Cho, S.-S., Boileau, I., Blumberger, D., Heilig, M., Wilson, A., Daskalakis, Z. J., Strafella, A. P., Zangen, A., et al. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9800-1 · Cited by 58 · see citing works
Restoring the missing person to personalized medicine and precision psychiatry
Gómez-Carrillo, A., Paquin, V., Dumas, G., & Kirmayer, L. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1041433 · Cited by 59 · see citing works
Awake craniotomy versus craniotomy under general anesthesia for the surgical treatment of insular glioma: choices and outcomes
Gravesteijn, B. Y., Keizer, M. E., Vincent, A. J. P. E., Schouten, J. W., Stolker, R. J., & Klimek, M. (2017) · Neurological Research · doi:10.1080/01616412.2017.1402147 · Cited by 60 · see citing works
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes
Popovic, D., Ruef, A., Dwyer, D., Antonucci, L. A., Eder, J., Sanfelici, R., Kambeitz‐Ilankovic, L., Oztuerk, O. F., Dong, M. S., Paul, R., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.020 · Cited by 59 · see citing works
Insular epilepsy surgery
Laoprasert, P., Ojemann, J. G., & Handler, M. H. (2017) · Epilepsia · doi:10.1111/epi.13682 · Cited by 57 · see citing works
Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation
Rubin-Falcone, H., Weber, J., Kishon, R., Ochsner, K., Delaparte, L., Doré, B., Zanderigo, F., Oquendo, M. A., Mann, J. J., & Miller, J. M. (2018) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2017.11.002 · Cited by 53 · see citing works
Neuroinflammation and neuroprogression in depression: Effects of alternative drug treatments
Richardson, B., MacPherson, A., & Bambico, F. R. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100554 · Cited by 56 · see citing works
Neurogenic Background for Emotional Stress-Associated Hypertension
Fontes, M. A. P., Marins, F. R., Patel, T., de Paula, C. A., Machado, L. R. D. S., Lima, É. B. D. S., de Godoy, A. C. V., Viana, A. C. R., Linhares, I. C. S., Xavier, C. H., et al. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01235-7 · Cited by 52 · see citing works
Task-positive and task-negative networks and their relation to depression: EEG beamformer analysis
Knyazev, G. G., Savostyanov, A. N., Bocharov, A. V., Tamozhnikov, S. S., & Сапрыгин, А. Е. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.033 · Cited by 51 · see citing works
High-sensitivity neuroimaging biomarkers for the identification of amnestic mild cognitive impairment based on resting-state fMRI and a triple network model
Yu, E., Liao, Z., Tan, Y., Qiu, Y., Zhu, J., Zhang, H., Wang, J., Wang, X., Wang, H., Chen, Y., et al. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9727-6 · Cited by 51 · see citing works
Task-positive and task-negative networks in major depressive disorder: A combined fMRI and EEG study
Knyazev, G. G., Savostyanov, A. N., Bocharov, A. V., Brak, I. V., Osipov, E. A., Filimonova, E., Сапрыгин, А. Е., & Aftanas, L. I. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.003 · Cited by 51 · see citing works
Obstructive sleep apnea during REM sleep and daytime cerebral functioning: A regional cerebral blood flow study using high-resolution SPECT
Baril, A., Gagnon, K., Brayet, P., Montplaisir, J. Y., Carrier, J., Soucy, J., Lafond, C., Blais, H., d'Aragon, C., Gagnon, J., et al. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18814106 · Cited by 50 · see citing works
Altered neural processing of negative stimuli in people with internet gaming disorder: fMRI evidence from the comparison with recreational game users
Zhang, J., Dong, H., Zhao, Z., Chen, S., Jiang, Q. Y., Du, X., & Dong, G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.008 · Cited by 49 · see citing works
Behavioral Economic Considerations of Novel Addictions and Nonaddictive Behavior: Research and Analytic Methods
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
Functional connectivity gradients of the insula to different cerebral systems
Wang, R., Mo, F., Shen, Y., Song, Y., Cai, H., & Zhu, J. (2022) · Human Brain Mapping · doi:10.1002/hbm.26099 · Cited by 49 · see citing works
Neuropathological sequelae of Human Immunodeficiency Virus and apathy: A review of neuropsychological and neuroimaging studies
McIntosh, R. C., Rosselli, M., Uddin, L. Q., & Antoni, M. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.008 · Cited by 50 · see citing works
Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research
Guerin, A. A., Bonomo, Y. A., Lawrence, A. J., Baune, B. T., Nestler, E. J., Rossell, S. L., & Kim, J. H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00880 · Cited by 48 · see citing works
Cytoarchitecture, probability maps and segregation of the human insula
Quabs, J., Caspers, S., Schöne, C., Mohlberg, H., Bludau, S., Dickscheid, T., & Amunts, K. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119453 · Cited by 46 · see citing works
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
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Authors: Gasquoine, P. G.
Affiliations: The University of Texas System (US)
Corresponding author: Gasquoine, Philip Gerard
ORCID: Gasquoine, Philip Gerard
Venue: Neuropsychology Review
Publisher: Springer Science and Business Media LLC
Published: 2014-01-18
Volume: 24
Issue: 2
Pages: 77-87
ISSN: 1040-7308 (ISSN-L)
1573-6660
DOI: 10.1007/s11065-014-9246-9
OpenAlex: W1989986125
Cited by: 400
References: 136
Citations by year: 2026: 18 · 2025: 37 · 2024: 52 · 2023: 31 · 2022: 40 · 2021: 39 · 2020: 66 · 2019: 32 · 2018: 23 · 2017: 26 · 2016: 18 · 2015: 15 · 2014: 3
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychology Review (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords: insula, interoception, emotions, James-Lange theory, autonomic nervous system, schizophrenia, eating disorders, mood and anxiety disorders, autism spectrum disorder, addiction, chronic pain, aphasia, language processing, anterior cingulate cortex, salience, consciousness, cognitive challenge
MeSH terms: Animals, Autonomic Nervous System, Brain Mapping, Cerebral Cortex, Cognition, Emotions, Humans

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Contributions of the insula to cognition and emotion

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