Axonal transport and neurodegenerative disease

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993

The Molecular Motor Toolbox for Intracellular Transport

Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982

Kinesin Walks Hand-Over-Hand

Yildiz, A., Tomishige, M., Vale, R. D., & Selvin, P. R. (2004) · Science · doi:10.1126/science.1093753 · Cited by 965

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

Jordens, I., Fernandez-Borja, M., Marsman, M., Dusseljee, S., Janssen, L., Calafat, J., Janssen, H., Wubbolts, R., & Neefjes, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00531-0 · Cited by 811

Direct observation of single kinesin molecules moving along microtubules

Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y., & Yanagida, T. (1996) · Nature · doi:10.1038/380451a0 · Cited by 711

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

Tanaka, Y., Kanai, Y., Okada, Y., Nonaka, S., Takeda, S., Harada, A., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81459-2 · Cited by 654

Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration

Salehi, A., Delcroix, J.-D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.022 · Cited by 543

Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila

Hurd, D. D., & Saxton, W. M. (1996) · Genetics · doi:10.1093/genetics/144.3.1075 · Cited by 379

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport

Martin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3717 · Cited by 365

Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons

Black, M. M., Slaughter, T., Moshiach, S., Obrocka, M., & Fischer, I. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03601.1996 · Cited by 270

Kinesin superfamily motor proteins and intracellular transport

Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

Hirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

Dixit, R., Ross, J. L., Goldman, Y. E., & Holzbaur, E. L. F. (2008) · Science · doi:10.1126/science.1152993 · Cited by 1,012

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

Jawhar, S., Trawicka, A., Jenneckens, C., Bayer, T. A., & Wirths, O. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.027 · Cited by 623

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Liao, Y.-C., Fernandopulle, M. S., Wang, G., Choi, H., Hao, L., Drerup, C. M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.050 · Cited by 550

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

Gilley, J., & Coleman, M. P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000300 · Cited by 472

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth

Fallini, C., Bassell, G. J., & Rossoll, W. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds205 · Cited by 247

Competition between microtubule-associated proteins directs motor transport

Monroy, B. Y., Sawyer, D. L., Ackermann, B. E., Borden, M. M., Tan, T. C., & Ori-McKenney, K. M. (2018) · Nature Communications · doi:10.1038/s41467-018-03909-2 · Cited by 213

Autophagy for tissue homeostasis and neuroprotection

Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195

A combinatorial MAP code dictates polarized microtubule transport

Monroy, B. Y., Tan, T. C., Oclaman, J. M., Han, J. S., Simó, S., Niwa, S., Nowakowski, D. W., McKenney, R. J., & Ori-McKenney, K. M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.029 · Cited by 157

Mechanisms of protein toxicity in neurodegenerative diseases

Chung, C. G., Lee, H., & Lee, S. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2854-4 · Cited by 142

DTI analyses and clinical applications in Alzheimer’s disease

Oishi, K., Mielke, M. M., Albert, M., Lyketsos, C. G., & Mori, S. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-0007 · Cited by 134

Assessment of a white matter reference region for 11 C-UCB-J PET quantification

Rossano, S., Toyonaga, T., Finnema, S. J., Naganawa, M., Lu, Y., Nabulsi, N., Ropchan, J., De Bruyn, S., Otoul, C., Stockis, A., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19879230 · Cited by 126

Minireview: How Peptide Hormone Vesicles Are Transported to the Secretion Site for Exocytosis

Park, J. J., & Loh, Y. P. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0209 · Cited by 81

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

Reis, G. F., Yang, G., Szpankowski, L., Weaver, C., Shah, S. B., Robinson, J. T., Hays, T. S., Danuser, G., & Goldstein, L. S. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0938 · Cited by 80

Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Bhattacharyya, R., Black, S. E., Lotlikar, M. S., Fenn, R. H., Jorfi, M., Kovacs, D. M., & Tanzi, R. E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109134 · Cited by 77

In vivo quantitative whole‐brain diffusion tensor imaging analysis of APP/PS1 transgenic mice using voxel‐based and atlas‐based methods

Qin, Y.-Y., Li, M.-W., Zhang, S., Zhang, Y., Zhao, L.-Y., Lei, H., Oishi, K., & Zhu, W.-Z. (2013) · Neuroradiology · doi:10.1007/s00234-013-1195-0 · Cited by 42

A neurogenic perspective of Sarcopenia: time course study of sciatic nerves from aging mice

Krishnan, V. S., White, Z., McMahon, C. D., Hodgetts, S. I., Fitzgerald, M., Shavlakadze, T., Harvey, A. R., & Grounds, M. D. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw019 · Cited by 32

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Brzozowski, C. F., Hijaz, B. A., Singh, V., Gcwensa, N. Z., Kelly, K., Boyden, E. S., West, A. B., Sarkar, D., & Volpicelli-Daley, L. A. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01283-7 · Cited by 32