The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Oxidative and nitrosative stress in Parkinson's disease
Open accessAbstract
Parkinson's disease (PD) is a common neurodegenerative disorder marked by movement impairment caused by a selective degeneration of dopaminergic neurons. The mechanism for dopaminergic neuronal degeneration in PD is not completely clear, but it is believed that oxidative and nitrosative stress plays an important role during the pathogenesis of PD. This notion is supported by various studies that several indices of oxidative and nitrosative stress are increased in PD patients. In recent years, different pathways that are known to be important for neuronal survival have been shown to be affected by oxidative and nitrosative stress. Apart from the well-known oxidative free radicals induced protein nitration, lipid peroxidation and DNA damage, increasing evidence also suggests that some neuroprotective pathways can be affected by nitric oxide through S-nitrosylation. In addition, the selective dopaminergic neurodegeneration suggests that generation of oxidative stress associated with the metabolism of dopamine is an important contributor. Thorough understanding of how oxidative stress can contribute to the pathogenesis of PD will help formulate potential therapy for the treatment of this neurodegenerative disorder in the future.
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“Caspase 3-S-nitrosation is antiapoptotic as it inhibits the activation of this effector caspase (424).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [424]
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Tyrosine hydroxylase and regulation of dopamine synthesis
Daubner, S. C., Le, T., & Wang, S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.017 · Cited by 1,092
Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 698
Basic mechanisms of neurodegeneration: a critical update
Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
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Metadata
- Authors
- Tsang, A. H. K., & Chung, K. K. K.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Corresponding author
- Chung, Kenny K.K.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 1792
- Issue
- 7
- Pages
- 643-650
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2093913750
- Cited by
- 300
- References
- 125
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 15 · 2017: 20 · 2016: 22 · 2015: 19 · 2014: 16 · 2013: 17 · 2012: 22
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Parkinson's disease, oxidative stress, nitrosative stress, dopaminergic neuron loss, protein nitration, lipid peroxidation, DNA damage, nitric oxide, S-nitrosylation, dopamine metabolism, neurodegeneration pathogenesis
- MeSH terms
- Animals, Humans, Nitric Oxide, Parkinson Disease, Oxidative Stress
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