Cited by 302Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingRedox biology and oxidative stress

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Oxidative and nitrosative stress in Parkinson's disease

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Tsang, Anthony H.K., Chung, Kenny K.K.·2009·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2008.12.006

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Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder marked by movement impairment caused by a selective degeneration of dopaminergic neurons. The mechanism for dopaminergic neuronal degeneration in PD is not completely clear, but it is believed that oxidative and nitrosative stress plays an important role during the pathogenesis of PD. This notion is supported by various studies that several indices of oxidative and nitrosative stress are increased in PD patients. In recent years, different pathways that are known to be important for neuronal survival have been shown to be affected by oxidative and nitrosative stress. Apart from the well-known oxidative free radicals induced protein nitration, lipid peroxidation and DNA damage, increasing evidence also suggests that some neuroprotective pathways can be affected by nitric oxide through S-nitrosylation. In addition, the selective dopaminergic neurodegeneration suggests that generation of oxidative stress associated with the metabolism of dopamine is an important contributor. Thorough understanding of how oxidative stress can contribute to the pathogenesis of PD will help formulate potential therapy for the treatment of this neurodegenerative disorder in the future.

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Authors: Tsang, A. H. K., & Chung, K. K. K.
Affiliations: Hong Kong University of Science and Technology (HK)
Corresponding author: Chung, Kenny K.K.
ORCID: Tsang, Anthony H.K.
Chung, Kenny K.K.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2009-07
Volume: 1792
Issue: 7
Pages: 643-650
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2008.12.006
OpenAlex: W2093913750
Cited by: 300
References: 125
Citations by year: 2026: 4 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 15 · 2017: 20 · 2016: 22 · 2015: 19 · 2014: 16 · 2013: 17 · 2012: 22
FWCI: 3.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1968 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Parkinson's disease, oxidative stress, nitrosative stress, dopaminergic neuron loss, protein nitration, lipid peroxidation, DNA damage, nitric oxide, S-nitrosylation, dopamine metabolism, neurodegeneration pathogenesis
MeSH terms: Animals, Humans, Nitric Oxide, Parkinson Disease, Oxidative Stress

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Oxidative and nitrosative stress in Parkinson's disease

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