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Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
Open accessAbstract
Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance.
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“Notably, the activation of AMPK by berberine may be dependent on SIRT1, as SIRT1-knockdown cells blocked AMPK activation and prevented the effect of berberine on diet-induced insulin resistance [95].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [95]
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“While the precise mechanisms of berberine needs further exploration, recent reports show that berberine supplementation protects from high-fat diet-induced mitochondrial dysfunction and hyperglycemia in skeletal muscle, partially attributed to an increase in mitochondrial biogenesis [95].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [95]
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Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
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Metadata
- Authors
- Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P.
- Affiliations
- Harvard University (US)
- Centro de Neurociências e Biologia Celular (PT)
- Corresponding author
- Palmeira, Carlos M.
- Rolo, Anabela P.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 1822
- Issue
- 2
- Pages
- 185-195
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3366688
- OpenAlex
- W2016281492
- Cited by
- 159
- References
- 61
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Portuguese Foundation for Science and Technology
- NIH/NIA
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- berberine, SIRT1, mitochondrial biogenesis, skeletal muscle mitochondria, mitochondrial dysfunction, high-fat diet, insulin resistance, AMPK, hyperglycemia, SIRT1 knockdown
- MeSH terms
- Animals, Berberine, Organelle Biogenesis, Cell Line, Glucose, Hormones, Hyperglycemia, Insulin Resistance, Male, Mitochondria, Mitochondria, Muscle, NAD, Obesity, Phosphorylation, Rats, Sprague-Dawley, Muscle, Skeletal, Myoblasts, Mice, Rats, AMP-Activated Protein Kinases, Sirtuin 1, Diet, High-Fat
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