Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle
Abstract
Background Lipid deposition in non-adipose tissue is associated with a propensity to obesity. Skeletal muscle mitochondrial dysfunction, evidenced by incomplete beta oxidation may contribute to ectopic lipid deposition during high fat diet-induced obesity. Berberine (BBR) has been proved to possess the properties of improving metabolic disorders in patients with obesity or type 2 diabetes mellitus. However, the precise mechanism remains obscure.Methods Mice were treated with berberine and metabolic profile were analyzed. Mitochondrial number and function were detected after berberine treatment in vitro and in vivo. The role of Adenosine 5'-monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) was verified after RNA interference or adenovirus infection.Results In the current study, we investigated the influence of berberine on the lipid deposition of skeletal muscle and found that berberine could increase the mitochondrial number and function both in vivo and in vitro. Furthermore, berberine promoted the expression of PGC-1α, the crucial transcriptional coactivator related to mitochondrial biogenesis and function, through AMPK pathway. Berberine reduced the basal oxygen consumption rates (OCR) but increased the maximal OCR in C2C12 myocytes, which indicated that berberine could increase the potential function of mitochondria.Conclusion Our results proved that berberine can protect the lean body mass from excessive lipid accumulation, by promoting the mitochondrial biogenesis and improving fatty acid oxidation in an AMPK/PGC-1α dependent manner.
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In an animal study, 5 mg/kg/day berberine treatment for four weeks increased mitochondrial number and function by promoting the AMPK/PGC1α signaling pathway.
“In an animal study, 5 mg/kg/day berberine treatment for four weeks was found to increase the mitochondrial number and function by promoting AMPK/PGC1α signaling pathway [94]”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [94]
Cites
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281 · see citing works
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
National, regional, and global trends in adult overweight and obesity prevalences
Stevens, G. A., Singh, G. M., Lu, Y., Danaei, G., Lin, J. K., Finucane, M. M., Bahalim, A. N., McIntire, R. K., Gutierrez, H. R., Cowan, M. J., et al. (2012) · Population Health Metrics · doi:10.1186/1478-7954-10-22 · Cited by 932 · see citing works
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works
Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes · doi:10.2337/db07-1552 · Cited by 535 · see citing works
Mitochondrial dysfunction and insulin resistance: an update
Montgomery, M. K., & Turner, N. A. (2014) · Endocrine Connections · doi:10.1530/ec-14-0092 · Cited by 530 · see citing works
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsøe, R., & Dela, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0594-3 · Cited by 519 · see citing works
Simoneau, J.-A., & Kelley, D. E. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.166 · Cited by 441 · see citing works
Berberine activates thermogenesis in white and brown adipose tissue
Zhang, Z., Zhang, H., Li, B., Meng, X.-J., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 439 · see citing works
Self-citationCITRATE SYNTHASE: Structure, Control, and Mechanism
Wiegand, G., & Remington, S. J. (1986) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.15.060186.000525 · Cited by 378 · see citing works
Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
Valero, T. (2014) · Current Pharmaceutical Design · doi:10.2174/138161282035140911142118 · Cited by 370 · see citing works
Aquilano, K., Vigilanza, P., Baldelli, S., Pagliei, B., Rotilio, G., & Ciriolo, M. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070169 · Cited by 347 · see citing works
Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes
Garesse, R., & Vallejo, C. G. (2001) · Gene · doi:10.1016/s0378-1119(00)00582-5 · Cited by 307 · see citing works
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
Hesselink, M. K. C., Schrauwen-Hinderling, V., & Schrauwen, P. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.104 · Cited by 242 · see citing works
Leng, S.-H., Lu, F., & Xu, L. (2004) · PubMed · Cited by 237 · see citing works
Effects of berberine on glucose metabolism in vitro
Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., & Chen, J. (2002) · Metabolism · doi:10.1053/meta.2002.34715 · Cited by 234 · see citing works
de Oliveira, M. R., Nabavi, S. F., Manayi, A., Daglia, M., Hajheydari, Z., & Nabavi, S. M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.01.017 · Cited by 192 · see citing works
Bioenergetic Profile Experiment using C2C12 Myoblast Cells
Nicholls, D. G., Darley-Usmar, V. M., Wu, M., Jensen, P. B., Rogers, G. W., & Ferrick, D. A. (2010) · Journal of Visualized Experiments · doi:10.3791/2511 · Cited by 186 · see citing works
The role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle
Adhihetty, P. J., Uguccioni, G., Leick, L., Hidalgo, J., Pilegaard, H., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2009 · Cited by 168 · see citing works
The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance
Pagel-Langenickel, I., Bao, J., Pang, L., & Sack, M. N. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0003 · Cited by 154 · see citing works
Kaboli, P. J., Rahmat, A. B., Ismail, P., & Ling, K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.025 · Cited by 152 · see citing works
Yu, X., McCorkle, S. K., Wang, M., Lee, Y., Li, J., Saha, A. K., Unger, R. H., & Ruderman, N. B. (2004) · Diabetologia · doi:10.1007/s00125-004-1570-9 · Cited by 149 · see citing works
Salvadó, L., Barroso, E., Gómèz‐Foix, A. M., Palomer, X., Michalik, L., Wahli, W., & Vázquez‐Carrera, M. (2014) · Diabetologia · doi:10.1007/s00125-014-3331-8 · Cited by 100 · see citing works
Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation
Xiao, H., Sun, Z., Zhang, H.-B., & Zhang, D. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70883-6 · Cited by 84 · see citing works
Self-citationYépez, V. A., Kremer, L. S., Iuso, A., Gušić, M., Kopajtich, R., Koňaříková, E., Nadel, A., Wachutka, L., Prokisch, H., & Gagneur, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199938 · Cited by 80 · see citing works
Bioenergetic Profile Experiment using C2C12 Myoblast Cells
Nicholls, D. G., Darley-Usmar, V. M., Wu, M., Jensen, P. B., Rogers, G. W., & Ferrick, D. A. (2010) · Journal of Visualized Experiments · doi:10.3791/2511-v · Cited by 72 · see citing works
Ni, Y. X. (1988) · PubMed · Cited by 70 · see citing works
Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type 2 Diabetes
Devarshi, P. P., McNabney, S. M., & Henagan, T. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040831 · Cited by 55 · see citing works
Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status
Lu, J., Cao, Y., Cheng, K., Xu, B., Wang, T., Yang, Q., Yang, Q., Feng, X., & Xia, Q. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.04.006 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
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Sorted by citations
Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 360 · see citing works
Wang, S., Ren, H., Zhong, H., Zhao, X., Li, C., Ma, J., Gu, X., Xue, Y., Huang, S., Yang, J., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.2003176 · Cited by 110 · see citing works
Self-citationResearch progress on the pharmacological effects of berberine targeting mitochondria
Fang, X., Wu, H., Wei, J., Miao, R., Zhang, Y., & Tian, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.982145 · Cited by 72 · see citing works
Self-citationFan, J., Fan, J., & Khanzada, Z. (2025) · Muscles · doi:10.3390/muscles4030026 · Cited by 64 · see citing works
Chen, Y., Li, Q., Zhao, S., Sun, L., Yin, Z., Wang, X., Li, X., Iwakiri, Y., Han, J., & Duan, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115928 · Cited by 52 · see citing works
Cao, L., Li, Y. S., Smirnov, A., Voshtani, R., Wang, T., Shao, C., Candi, E., Melino, G., Shi, Y., & Fang, J. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01519-2 · Cited by 48 · see citing works
Sun, W., Shahrajabian, M. H., & Cheng, Q. (2021) · Israel Journal of Plant Sciences · doi:10.1163/22238980-bja10019 · Cited by 39 · see citing works
Sun, A., Yang, H., Li, T., Luo, J., Zhou, L., Chen, R., Han, L., & Lin, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1368950 · Cited by 37 · see citing works
Kong, Y., Yang, H., Nie, R., Zhang, X., Zhang, H., & Nian, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-02738-6 · Cited by 40 · see citing works
Self-citationJun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27 · see citing works
Senesi, P., Ferrulli, A., Luzi, L., & Terruzzi, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157772 · Cited by 26 · see citing works
Li, Y., Yang, S., Jin, X., Li, D. X., Lu, J., Wang, X., & Wu, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1082817 · Cited by 26 · see citing works
Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice
Yang, M., & Wang, J. (2022) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.68.228 · Cited by 20 · see citing works
Liu, Y., Wang, H., Geng, Y.-H., Han, L., Tu, S., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1112088 · Cited by 19 · see citing works
Li, J., Yi, X., Li, T., Yao, T., Li, D., Hu, G., Ma, Y., Chang, B., & Cao, S. (2022) · Endocrine Connections · doi:10.1530/ec-21-0625 · Cited by 18 · see citing works
Zhang, Y., Luo, C., Huang, P., Cheng, Y., Ma, Y., Gao, J., & Ding, H. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109780 · Cited by 22 · see citing works
Self-citationWu, Y., Yang, Y., Du, C., Peng, X., Fan, W., Chang, B., & Shan, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-89297-2 · Cited by 15 · see citing works
Targeting AMPK signaling: The therapeutic potential of berberine in diabetes and its complications
Mbara, K. C., Kheoane, P. S., & Tarirai, C. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100689 · Cited by 17 · see citing works
Wang, H., Wang, Z., Wang, D., Nie, K., Wu, W., Gao, Y., Shen, C., Jiang, X., Tang, Y., Su, H., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70524 · Cited by 10 · see citing works
Huang, Z., Shi, M., Zhang, C., Deng, Z., Qin, T., Wu, J., Zhang, X., Han, W., Li, S., Gao, B., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167635 · Cited by 9 · see citing works
Dietary Plant Extracts in Improving Skeletal Muscle Development and Metabolic Function
Xiang, J., Du, ., & Wang, H. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2087669 · Cited by 8 · see citing works
Wen, F., Hou, J., Ji, X., Chu, X., Liu, X., Shi, Z., & Song, Z. (2023) · Gene · doi:10.1016/j.gene.2023.147193 · Cited by 6 · see citing works
Berberine: A Negentropic Modulator for Multi-System Coordination
Tian, X. L., Chen, Q., He, Y., Cheng, Y., Zhao, M., Li, Y. W., Yu, M., Jiang, J., & Wang, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020747 · Cited by 5 · see citing works
Ding, L.-N., Cheng, Y., Xu, L.-S., Zhou, L.-Q., Guan, L., Liu, H.-M., Zhang, Y.-X., Li, R.-M., & Xu, J.-W. (2021) · Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy · doi:10.2147/dmso.s297351 · Cited by 4 · see citing works
Self-citationPeng, Z., Zeng, Y., Tan, Q., He, Q., Wang, S., & Wang, J. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149786 · Cited by 4 · see citing works
Systemic Pharmacotherapeutic Treatment of the ACTA1-MCM/FLExDUX4 Preclinical Mouse Model of FSHD
Lu‐Nguyen, N., Snowden, S. G., Popplewell, L. J., & Malerba, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136994 · Cited by 4 · see citing works
Effects of antidiabetic agents on lipid metabolism of skeletal muscle: A narrative review
Xu, M., Lv, D., Wei, H., Li, Z., Jin, S., Liu, Q., Zhang, Y., & Liu, Y. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16189 · Cited by 4 · see citing works
Self-citationLin, D., Zhou, J., Cao, Y., Wang, Z., Hsu, Y., Zheng, F., Li, H., Sun, S., Ren, H., Deng, L., et al. (2023) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29807 · Cited by 4 · see citing works
Hu, L., Zhang, Z., Xu, T., Ma, P., Wang, Z., Zhang, L., Chen, J., He, P., Yang, X., Du, G., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157608 · Cited by 3 · see citing works
Self-citationBerberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway
Guo, Y.-J., Wu, F., Gong, M.-M., Wu, W., Lu, F.-E., & Dingkun, W. (2026) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-026-3846-0 · Cited by 3 · see citing works
Demet, E. D. Ö., Uçar, K., Alpaslan, A., Aslan, D. T., Reçber, T., Gülsün, T., Çelebi̇er, M., & Göktaş, Z. (2025) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.70033 · Cited by 3 · see citing works
Park, K., Jung, S., Li, C., Ha, J., & Jeong, Y. (2025) · Nutrients · doi:10.3390/nu17121990 · Cited by 4 · see citing works
Wang, Q., Zeng, Z., Guo, L., Williams, K. E., Zhang, Y., Tang, H., Hu, H., Qin, G., Wang, K., & Wang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1531302 · Cited by 2 · see citing works
Self-citationNovel update of interventional strategies of vascular aging in humans
Qiu, Y., Liu, Y., Liu, X., & Tao, J. (2020) · Aging Medicine · doi:10.1002/agm2.12124 · Cited by 2 · see citing works
Chen, M., Ling, C., Chen, Y., Wang, H.-P., Qin, Y., Xu, J.-Y., Chen, G.-C., Shi, B.-M., Qin, L.-Q., & Yang, J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106114 · Cited by 2 · see citing works
Self-citationAn, X., Zhou, J., He, L., & Li, W. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03504-y · Cited by 1 · see citing works
How does berberine regulate metabolism through target cells?Preprint
Sun, A., Yang, H., Li, T., Luo, J., Zhou, L., Chen, R., Lin, Y., & Han, L. (2023) · doi:10.22541/au.168138767.79461299/v1
Cheng, C., Sha, W., Xu, B., Zhang, C., Xia, J., & Lei, T. (2024) · Research Square · doi:10.21203/rs.3.rs-3335328/v1
Wang, X., Teng, J., Yu, Z., Sun, Y., & Sun, F. (2026) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-026-05640-x
Han, L., Ho, C.-T., Ye, Z., Zhang, H., Zong, C., Kou, X., & Lu, M. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109641
Self-citationLiao, Y., Gui, Y., Li, T., Zhou, Q., Chen, X., & Chen, H. (2026) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x26500795
- Authors
- Yao, S., Yuan, Y., Zhang, H., Meng, X., Jin, L., Yang, J., Wang, W., Ning, G., Zhang, Y., & Zhang, Z.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhang, Yifei
- Zhang, Zhiguo
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 159
- Pages
- 66-75
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W3046490174
- Cited by
- 41
- References
- 38
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- berberine, ectopic fat deposition, skeletal muscle, mitochondrial biogenesis, AMPK, PGC-1α, fatty acid oxidation, mitochondrial dysfunction, high-fat diet-induced obesity, oxygen consumption rate, C2C12 myocytes
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Berberine, Diabetes Mellitus, Type 2, Humans, Lipids, Mitochondria, Muscle, Transcription Factors, Muscle, Skeletal, Mice
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