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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

Deng, C. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.147 · Cited by 323 · see citing works

SIRT6 protects against pathological damage caused by diet‐induced obesity

Kanfi, Y., Peshti, V., Gil, R., Naiman, S., Nahum, L., Levin, E., Kronfeld‐Schor, N., & Cohen, H. Y. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00544.x · Cited by 311 · see citing works

Aging and disease: connections to sirtuins

Dönmez, G., & Guarente, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00548.x · Cited by 312 · see citing works

Metabolic reprogramming, caloric restriction and aging

Anderson, R. M., & Weindruch, R. H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.005 · Cited by 300 · see citing works

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

de Kreutzenberg, S. V., Ceolotto, G., Papparella, I., Bortoluzzi, A., Semplicini, A., Man, C. D., Cobelli, C., Fadini, G. P., & Avogaro, A. (2010) · Diabetes · doi:10.2337/db09-1187 · Cited by 299 · see citing works

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Li, Y., Xu, S., Giles, A. J., Nakamura, K., Lee, J. W., Hou, X., Dönmez, G., Li, J., Luo, Z., Walsh, K., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-173492 · Cited by 298 · see citing works

SRT1720 improves survival and healthspan of obese mice

Minor, R. K., Baur, J. A., Gomes, A. P., Ward, T. M., Csiszár, A., Mercken, E. M., Abdelmohsen, K., Shin, Y., Cantó, C., Scheibye‐Knudsen, M., et al. (2011) · Scientific Reports · doi:10.1038/srep00070 · Cited by 297 · see citing works

Sirtuin 1 in lipid metabolism and obesity

Schug, T. T., & Li, X. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.547211 · Cited by 292 · see citing works

Sirtuins at a glance

Nakagawa, T., & Guarente, L. (2011) · Journal of Cell Science · doi:10.1242/jcs.081067 · Cited by 289 · see citing works

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 270 · see citing works

A metabolic prosurvival role for PML in breast cancer

Carracedo, A., Weiss, D., Leliaert, A. K., Bhasin, M., de Boer, V. C. J., Laurent, G., Adams, A. C., Sundvall, M., Song, S. J., Ito, K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62129 · Cited by 269 · see citing works

Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training

Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works

The role of nutrition on epigenetic modifications and their implications on health

Jiménez-Chillarón, J. C., Díaz, R., Martínez, D., Pentinat, T., Ramón-Krauel, M., Ribó, S., & Plösch, T. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.012 · Cited by 266 · see citing works

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition

Lee, J., Padhye, A., Sharma, A., Song, G., Miao, J., Mo, Y.-Y., Wang, L., & Kemper, J. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.094524 · Cited by 259 · see citing works

Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms

Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262 · see citing works

Sirtuins, Cell Senescence, and Vascular Aging

Kida, Y., & Goligorsky, M. S. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.11.022 · Cited by 256 · see citing works

SIRT1 contributes to telomere maintenance and augments global homologous recombination

Palacios, J., Herranz, D., Bonis, M. L. D., Velasco, S., Serrano, M., & Blasco, M. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005160 · Cited by 254 · see citing works

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Bai, P., Cantó, C., Brunyánszki, A., Huber, A., Szántó, M., Cen, Y., Yamamoto, H., Houten, S. M., Kiss, B., Oudart, H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.013 · Cited by 250 · see citing works

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

Giralt, A., & Villarroya, F. (2012) · Biochemical Journal · doi:10.1042/bj20120030 · Cited by 253 · see citing works

Elevated micro RNA ‐34a in obesity reduces NAD + levels and SIRT 1 activity by directly targeting NAMPT

Choi, S., Fu, T., Seok, S., Kim, D., Yu, E., Lee, K. W., KANG, Y. Y., Li, X., KEMPER, B. W., & Kemper, J. K. (2013) · Aging Cell · doi:10.1111/acel.12135 · Cited by 249 · see citing works

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

Cantó, C., Sauve, A. A., & Bai, P. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.004 · Cited by 246 · see citing works

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

Uittenbogaard, M. N., & Chiaramello, A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140305224906 · Cited by 240 · see citing works

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

Saunders, L. R., Sharma, A., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., Willenbring, H., & Verdin, E. M. (2010) · Aging · doi:10.18632/aging.100176 · Cited by 237 · see citing works

SIRT6, a Mammalian Deacylase with Multitasking Abilities

Chang, A. R., Ferrer, C. M., & Mostoslavsky, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00030.2018 · Cited by 236 · see citing works

Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 240 · see citing works

The sirtuin family’s role in aging and age-associated pathologies

Hall, J. A., Dominy, J. E., Lee, Y., & Puigserver, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64094 · Cited by 235 · see citing works

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Higashida, K., Kim, S. H., Jung, S. R., Asaka, M., Holloszy, J. O., & Han, D.-H. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001603 · Cited by 228 · see citing works

Small-Molecule Allosteric Activators of Sirtuins

Sinclair, D. A., & Guarente, L. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134657 · Cited by 223 · see citing works

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

Bonda, D., Lee, H., Camins, A., Pallàs, M., Casadesús, G., Smith, M. A., & Zhu, X. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70013-8 · Cited by 221 · see citing works

AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

Hwang, J., Kwon, D. Y., & Yoon, S. H. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.03.005 · Cited by 221 · see citing works

Germline Energetics, Aging, and Female Infertility

Tilly, J. L., & Sinclair, D. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.007 · Cited by 220 · see citing works

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

Amat, R., Planavila, A., Chen, S. L., Iglesias, R., Giralt, M., & Villarroya, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022749 · Cited by 218 · see citing works

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.051 · Cited by 218 · see citing works

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

Xiong, S., Salazar, G., Patrushev, N. A., & Alexander, R. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163667 · Cited by 216 · see citing works

NAD and the aging process: role in life, death and everything in between

Chini, C. C. S., Tarragó, M. G., & Chini, E. N. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.003 · Cited by 208 · see citing works

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

Smith, J. J., Kenney, R. D., Gagne, D. J., Frushour, B. P., Ladd, W., Galonek, H. L., Israelian, K., Song, J. J., Razvadauskaite, G., Lynch, A. V., et al. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-31 · Cited by 210 · see citing works

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

Lee, D., & Goldberg, A. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489716 · Cited by 211 · see citing works

SIRT1 Activation by Small Molecules

Dai, H., Kustigian, L. M., Carney, D. P., Case, A. W., Considine, T., Hubbard, B. P., Perni, R. B., Riera, T. V., Szczepankiewicz, B. G., Vlasuk, G. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133892 · Cited by 211 · see citing works

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

Giralt, A., Hondares, E., Villena, J. A., Ribas, F., Díaz-Delfín, J., Giralt, M., Iglesias, R., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202390 · Cited by 210 · see citing works

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

Zhou, B., Li, C., Qi, W., Zhang, Y., Zhang, F., Wu, J., Hu, Y., Wu, D., Liu, Y., Yan, T., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2539-8 · Cited by 209 · see citing works

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Wang, Y., He, J., Liao, M., Hu, M., Li, W., Ouyang, H., Wang, X., Ye, T., Zhang, Y., & Ouyang, L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.028 · Cited by 206 · see citing works

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

Grant, R. W., & Dixit, V. D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00050 · Cited by 200 · see citing works

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., et al. (2014) · Diabetes · doi:10.2337/db13-0967 · Cited by 201 · see citing works

SIRT1 in Metabolic Health and Disease

Boutant, M., & Cantó, C. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_4 · Cited by 3 · see citing works

Metabolic benefits from Sirt1 and Sirt1 activators

Chaudhary, N., & Pfluger, P. T. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832cdaae · Cited by 100 · see citing works

Silencing Metabolic Disorders by Novel SIRT1 Activators

Sakamoto, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.005 · Cited by 5 · see citing works

The skinny on SIRT1 regulation

Schug, T. T. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.005629

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horváth, T. L., Sinclair, D. A., Pfluger, P. T., & Tschöp, M. H. (2012) · Physiological Reviews · doi:10.1152/physrev.00022.2011 · Cited by 712 · see citing works